For each amino acids are displayed the number of residues in the MEN1 protein and its frequency; the expected number of mutations if events were randomly distributed and the observed number of mutations affecting these residues. A click on the an amino acid gives access to a detailed table of substitutions and other mutations.
A click on the "Detailed view of mutations at the AA level" will display a summary table of all events.
| Amino Acid | Number in the protein | Expected number of mutations | Observed number of mutations | ||
|---|---|---|---|---|---|
| Ala | 55 | (9 %) | 127.2 | 68 | (4.81 %) |
| Arg | 39 | (6.38 %) | 90.2 | 371 | (26.26 %) |
| Asn | 14 | (2.29 %) | 32.4 | 6 | (0.42 %) |
| Asp | 27 | (4.42 %) | 62.4 | 78 | (5.52 %) |
| Cys | 7 | (1.15 %) | 16.2 | 17 | (1.2 %) |
| Gln | 29 | (4.75 %) | 67.1 | 78 | (5.52 %) |
| Glu | 49 | (8.02 %) | 113.3 | 100 | (7.08 %) |
| Gly | 49 | (8.02 %) | 113.3 | 86 | (6.09 %) |
| His | 12 | (1.96 %) | 27.8 | 65 | (4.6 %) |
| Ile | 19 | (3.11 %) | 43.9 | 16 | (1.13 %) |
| Leu | 66 | (10.8 %) | 152.6 | 162 | (11.46 %) |
| Lys | 31 | (5.07 %) | 71.7 | 27 | (1.91 %) |
| Met | 9 | (1.47 %) | 20.8 | 11 | (0.78 %) |
| Phe | 21 | (3.44 %) | 48.6 | 35 | (2.48 %) |
| Pro | 44 | (7.2 %) | 101.8 | 58 | (4.1 %) |
| Ser | 39 | (6.38 %) | 90.2 | 84 | (5.94 %) |
| Stop | 1 | (0.16 %) | 2.3 | 0 | (0 %) |
| Thr | 29 | (4.75 %) | 67.1 | 69 | (4.88 %) |
| Trp | 9 | (1.47 %) | 20.8 | 35 | (2.48 %) |
| Tyr | 20 | (3.27 %) | 46.3 | 37 | (2.62 %) |
| Val | 42 | (6.87 %) | 97.1 | 10 | (0.71 %) |