New Amino Acid	Number of residues (positions)	Number of mutations
Arg	2 (13, 22)	5
Deletion	17 (3, 27, 36, 83, 83, 89, 103, 103, 168, 223, 223, 254, 259, 404, 414, 444, 565)	100
indels	2 (565, 565)	2
Insertion	2 (83, 565)	6
Leu	8 (41, 175, 254, 270, 301, 376, 432, 432)	12
Pro	9 (22, 27, 48, 143, 175, 221, 223, 413, 551)	35
Trp	2 (39, 152)	2