New Amino Acid	Number of residues (positions)	Number of mutations
Arg	2 (156, 281)	12
Asp	3 (156, 305, 419)	6
Cys	3 (42, 156, 532)	14
Deletion	3 (208, 509, 513)	5
Glu	1 (281)	1
Gly	4 (200, 281, 386, 520)	4
indels	3 (190, 190, 190)	4
Insertion	7 (111, 111, 200, 449, 472, 507, 507)	29
Ser	2 (214, 505)	4
Val	4 (42, 156, 187, 505)	7