For each amino acids are displayed the number of residues in the MSH2 protein and its frequency; the expected number of mutations if events were randomly distributed and the observed number of mutations affecting these residues. A click on the an amino acid gives access to a detailed table of substitutions and other mutations.
A click on the "Detailed view of mutations at the AA level" will display a summary table of all events.
| Amino Acid | Number in the protein | Expected number of mutations | Observed number of mutations | ||
|---|---|---|---|---|---|
| Ala | 69 | (7.38 %) | 119 | 92 | (5.71 %) |
| Arg | 37 | (3.96 %) | 63.8 | 170 | (10.55 %) |
| Asn | 46 | (4.92 %) | 79.3 | 81 | (5.02 %) |
| Asp | 48 | (5.13 %) | 82.8 | 34 | (2.11 %) |
| Cys | 13 | (1.39 %) | 22.4 | 69 | (4.28 %) |
| Gln | 59 | (6.31 %) | 101.7 | 165 | (10.24 %) |
| Glu | 74 | (7.91 %) | 127.6 | 165 | (10.24 %) |
| Gly | 57 | (6.1 %) | 98.3 | 122 | (7.57 %) |
| His | 12 | (1.28 %) | 20.7 | 13 | (0.81 %) |
| Ile | 57 | (6.1 %) | 98.3 | 88 | (5.46 %) |
| Leu | 93 | (9.95 %) | 160.3 | 235 | (14.58 %) |
| Lys | 70 | (7.49 %) | 120.7 | 70 | (4.34 %) |
| Met | 26 | (2.78 %) | 44.8 | 23 | (1.43 %) |
| Phe | 47 | (5.03 %) | 81 | 30 | (1.86 %) |
| Pro | 28 | (2.99 %) | 48.3 | 24 | (1.49 %) |
| Ser | 55 | (5.88 %) | 94.8 | 81 | (5.02 %) |
| Stop | 1 | (0.11 %) | 1.7 | 0 | (0 %) |
| Thr | 48 | (5.13 %) | 82.8 | 36 | (2.23 %) |
| Trp | 3 | (0.32 %) | 5.2 | 5 | (0.31 %) |
| Tyr | 25 | (2.67 %) | 43.1 | 54 | (3.35 %) |
| Val | 67 | (7.17 %) | 115.5 | 55 | (3.41 %) |