The UMD-MSH2 mutations database
Amino acids modifications

This function takes into account only small rearrangements.

For each amino acids are displayed the number of residues in the MSH2 protein and its frequency; the expected number of mutations if events were randomly distributed and the observed number of mutations affecting these residues. A click on the an amino acid gives access to a detailed table of substitutions and other mutations.
A click on the "Detailed view of mutations at the AA level" will display a summary table of all events.

wt AA
Mutant AA		ALAARGASNASPCYSGLNGLUGLYHISILELEULYSMETPHEPROSERTHRTRPTYRVAL
ALA
7
.
.
2
.
.
2
1
.
.
.
.
.
.
2
1
2
.
.
1
ARG
.
6
.
.
50
1
.
15
.
.
12
.
1
.
2
.
.
.
.
.
ASN
.
.
11
.
.
.
.
.
2
3
.
4
.
.
.
.
1
.
.
.
ASP
.
.
4
1
.
.
1
52
.
.
.
.
.
.
.
.
.
.
1
1
CYS
.
2
.
.
.
.
2
.
.
.
.
.
1
.
6
.
.
9
.
GLN
.
9
.
.
.
3
3
.
2
.
.
.
.
.
.
.
.
.
.
.
GLU
1
.
.
1
.
4
7
2
.
.
.
1
.
.
.
.
.
.
.
3
GLY
.
3
.
1
1
.
7
6
.
.
.
.
.
.
.
.
.
.
.
.
HIS
.
2
.
4
.
2
.
.
.
.
.
.
.
2
.
.
.
1
.
ILE
.
.
1
.
.
.
.
.
.
.
.
.
.
.
1
1
.
.
7
LEU
.
1
.
.
.
1
.
.
1
1
45
.
1
2
11
1
.
.
.
3
LYS
.
1
1
.
.
2
36
.
.
5
.
18
2
.
.
.
1
.
.
.
MET
.
.
.
.
.
.
.
.
.
24
.
.
.
.
.
12
.
.
.
PHE
.
.
.
.
.
.
.
.
.
.
2
.
.
6
.
7
.
.
.
.
PRO
16
19
.
.
.
4
.
.
.
.
99
.
.
.
2
1
5
.
.
.
SER
.
4
31
.
.
.
.
1
.
5
.
.
.
1
2
5
1
.
.
.
THR
44
.
.
.
.
.
.
.
.
3
.
.
3
.
.
1
3
.
.
.
TRP
.
.
.
.
.
.
.
2
.
.
1
.
.
.
.
.
.
.
.
TYR
.
.
1
7
9
.
.
.
8
.
.
.
.
.
.
.
.
.
3
.
VAL
12
.
.
.
.
.
.
11
.
1
6
.
1
.
.
.
.
.
.
Deletion
30
31
23
16
9
26
52
73
.
35
47
15
188
18
1
39
7
.
6
56
Insertion
11
.
9
.
.
9
2
15
.
26
17
6
.
1
2
8
3
.
14
26
STOP
.
115
.
.
.
117
55
9
.
.
8
25
.
.
.
25
.
5
20
.