The UMD-MEN1 mutations database
Record ID: 1419

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.IVS1-6G>A (c.1-6G>A)p.Met1?HeterozygousLIKELY NEUTRAL

wt codonwt aamutant codonmutant aamutational eventmutation type
ATGMetspl-6Spl.G->ATs

StructureKey Residue (HCD)Pyrimidin doubletCpG
 NoNo

Other variation(s) reported for this sample: c.628_631delACAG

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): Csp6 I, Rsa I
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Acceptor
ccgcccgccgccAT
16.9 _
ccgcccaccgccAT
17 _
0.4 %

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
01-MA26-O12I-ProbandMale40

Phenotypic groupDisease
ModeratePlease contact curator

Reference


Reference IDPubMed IDReference
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