The UMD-DYSF mutations database
Statistics module

This database includes 81 references and 1174 mutations

	Predicted impact of all previously reported missense variations
	The UMD-Predictor® tool (Frederic et al. 2009) predicts the pathogenicity of missense variants localized in the coding sequence.

	Global Analysis
	Gives a summary of mutation types.

Position   Studies the distribution of mutations at the nucleotide level to identify preferential mutation sites

	Potential Stop codons
	Displays all codons from a specific exon that can be mutated in a stop codon by a single substitution.

	Mutation map
	This feature displays the distribution of the various mutations along the gene and the protein.

	Deletion map
	This feature displays the distribution of the large deletions reported along the gene and the protein.

	Stop codon map
	Displays the exon phasing and the position and number of reported nonsense mutations.

	Geographic Distribution
	Displays geographic origin of patients.

	Binary comparison
	Displays the distribution of the various mutations along the gene for two chosen subsets of the database.

	Stat exons
	Studies the distribution of mutations in the different exons. It enables detection of a statistically significant difference between observed and expected mutations

	Distribution by exon
	Displays the partition of each type of mutation in each exon

	Structure
	Studies the distribution of mutations both in the various structural domains of the protein and in the highly conserved domains