UMD TP53

TP53

TP53 and cancer

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TP53 and cancer

P53 FUNCTION

TP53 mutations (TP53; MIM # 191170) are found in 50% of human cancers (figure below).



The unique feature of TP53 compared to other tumor suppressor genes is its mode of inactivation. While most tumor suppressor genes are inactivated by mutations leading to absence of protein synthesis (or production of a truncated product), more than 80% of TP53 inactivations are missense mutations that lead to the synthesis of a stable full-length protein (figure below). This selection to maintain mutant TP53 in tumor cells is believed to be required for both a dominant negative activity of wt TP53 expressed by the remaining allele, but also for a gain of function that transforms mutant TP53 into a dominant oncogene.

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For more information about TP53 mutation and cancer go to the p53 web site: http//p53.free.fr