Edtaln : Multiple alignment ------------------------------------------------------------------------------- Le consensus est matrialis par une squence de caractres qui, selon la situation rencontre en une position donne, seront les suivants : "." si le caractre majoritaire a une reprsentation >= 20% ":" si le caractre majoritaire a une reprsentation >= 40% "+" si le caractre majoritaire a une reprsentation >= 60% "*" si le caractre majoritaire a une reprsentation >= 80% le caractre lui-mme, si celui-ci est identique pour l'ensemble des squences. ------------------------------------------------------------------------------- 1 Homo sapiens ENSP00000305941 Ensembl 2 Pan troglodytes XM_514197 NCBI 5 Mus musculus ENSMUST00000060479 Ensembl 4 Rattus norvegicus XM_001065756 NCBI 3 Canis familiaris XM_545710 '' 6 Monodelphis domestica ENSMODT00000005208 Ensembl 7 Gallus gallus XM_419417 NCBI 8 Takifugu rubripes SINFRUT00000162785 Ensembl 9 Gasterosteus aculeatus ENSGACT00000021506 '' 10 Strongylocentrotus purpuratus XM_788345.2 NCBI 11 Ciona savignyi ENSCSAVT00000003863 Ensembl 12 Ciona intestinal ENSCINT00000009921 '' 10 20 30 40 50 60 1 -------------MNCPVLSLGSGFLFQVIE------MLIFAYFASIS-LTESRGLFPRL 40 2 -------------MNCPVLSLGSGFLFQVIE------MLIFAYFASIS-LAESRGLFPRL 40 3 -------------MHYLALSPG--FLCYTIK------TLILAYLASVLVLAASQGVFPRL 39 4 -------------MYYLALSSG--FLGQAIK------TSILAYLASVL-LAASQGVFPRL 38 5 -------------MRRPARALGPRPLTRVPE------ALLFASFAAIS-LAAPQGLFPRL 40 6 -------------MNYLAHSWDYRFLFHVIG------TLILAYFASIP-LASSQGLFPRL 40 7 MPTDLEEPEAEEIMAMLVKEDKTCKEKRSLDEKKKKNATVEREIRTEMERENSQGHFPRL 60 8 ----------------------------------------------------TQGNFPQM 8 9 -----------------------------------TMYLLHSVHVLVRDLPAKEGHFPRM 25 10 ------------------------------------------------------------ 0 11 -------------------------------YTFTCLILTSFLQLVTAQLGGRVGSNPPL 29 12 ------------------------------------------------------GTNPPL 6 C :.....:.: ::...:. .::.::.::.. +:.::*.+*++ 70 80 90 100 110 120 1 ENVGAFKKVSIVPTQAVCGLPDRSTFCHSSAAAESIQF--CTQRFCIQDCPYR---SSHP 95 2 KNVGAFKKVSIVPTQAVCGLPDRSTFCHSSAAAESIQF--CTQRFCIQDCPYR---SSHP 95 3 ENVGAFRKVSTVPTHATCGFPGPSTFCRSPVAAEHVQL--RTERLCIQDCPYR---SASP 94 4 ENVGAFKKVSIVPTHATCGYPGPSTFCRSAVAAEHAQL--CAERLCIQDCPYR---SASP 93 5 ENVGAFKSLTLVPPQATC---GRSTFCHPSAAAEGLGL--CTQRLCIQDCPHR---SSPP 92 6 QNVGALKNVSIVPTQATCGLPGRSAFCHSSIAAESIQY--CTQRFCIQDCPYR---SSSP 95 7 ENVGAFKNVSTVPTQATCGLPDRSTFCHSSVAAESIMS--CTQRFCVQECPYR---SSPP 115 8 ENIAAYKPISTFPSRSTCGLPERSSYCQSASSHNDLVT--CYQAFCVQDCPYR---SSTP 63 9 ENVAAFKPVSTSPPRSTCGVPERGAYCQPPSSRTELTA--CSQAFCVQECPYR---YSTP 80 10 ------------------------------------------------------------ 0 11 EDVAKFKPISTTPPSATCGMNGRTDFCEPAENAEGLQQGACNVKVCNQNCPARDRINDAP 89 12 EDVAKFKPISTTPPSATCGMNGRADFCAPVDSEEGLRENACNIKICNQGCPGRDRENDAA 66 C ++*:++*.:*::*::++**:+:++:+*:::.:++.::. *::::*:*:**+* +:.* 130 140 150 160 170 180 1 TYT-ALFSAGLSSCITPDKNDLHPNAHS-------------NSASFIFG-NHKSCFSSPP 140 2 TYT-ALFSAGLSSCITPDKNDLHPNAHS-------------NSTSFIFG-NHKSCFSSPP 140 3 LYT-ALLEG-LRSCIPADDGDLHPYSRS-------------SSVSFMFG-SHQNCP-SLR 137 4 PYT-ALLEG-LRSCIPADHGDLHPYSRS-------------NSTSFIFG-SHKNCP-SLQ 136 5 VYT-ALLPAGLRSCITLDKHDLCPACQS-------------NATSFIFG-NQQDCFSSPP 137 6 SYI-ALFSEGLRSCITTDKNDLHPDSPS-------------NSTSFIFG-NLKDCFSLPH 140 7 SYR-LLFPEGLGTCVTEDKKDLPPGSFS-------------NASSFIFH-NQKDCFSTPP 160 8 PFAPLLLRSHRSNCVTEDVNDTRPGTETENRSGSSSERISGGSSSVLFQPSRSGCVLSPP 123 9 PHAPLLLPAHRSACINEDSNDTRPGTTTGSEEGS------GGSSSVLFRVVQDGCLVSPP 134 10 ------------------------------------------------------------ 0 11 PRYVNLLQGDAGICVTPDFADIARRGSS----------------SYVFLNDRSCRFIPSG 133 12 PRFLKLLEGDAGTCVTPDFADMPRRGSA----------------SYVFLNDRACRFIPSG 110 C ::: :*:..::.:*:+.*::*::+.. + ::.*::*: :.:.+::::: 190 200 210 220 230 240 1 SPKL---MASFTLAVWLKPEQQGVMCVIEKTVD----GQIVFKLTISEKETMFYYRTVNG 193 2 SPKL---MASFTLAVWLKPEQQGVMCVIEKTVD----GQIVFKLTISEKETVFYYRTVNG 193 3 APRL---AAELTLAVWLKLEQGGTMCVIEKTVD----GQIVFKVTISDKETMFYYRTVNG 190 4 APRL---AAEFTLAVWLKPERGSTMCVLEKTAD----GQIVFKVTISERETMFYYRTVNG 189 5 SPRL---EASFTLAVWLKPEQEGVMCVIEKTAD----GQIVFKLTISEKETIFYYRTVNG 190 6 SPRL---ATSFALAVWLKPEQEGVMCVIEKAVD----GQIVFKLTISEKETMFYYRTVNG 193 7 LLRL---SASFTLTVWLKPEQEGVMCVIEKAID----GQTVFKLTISEKETMFYYRTVNG 213 8 SQKLG-VLGSLTLAVWIKPRSSEEMMLLEKSSA----EGLLFSVTLSDQALTLRHGQTP- 177 9 SQTLG-VLGSLTLALWIKPSSPGEMMLLEKSSG----QRLIFSVTVSEQMVTLRYGPTP- 188 10 ------------MSYREPPLDQHNTILERRSST----NEIIYALVVSSSSITFDYRTAEG 44 11 VPRMGSRHGQFTMSVWLKQTRGNAGVILEKIAGPGRHKKVILLVMVGSFSIVMQYLTTDN 193 12 VPRMG-RRGHFTMAVWLKQRRGNAGVILEKIAGPGRHKQVVFLVLVGSFSIVLQYRAVDG 169 C :+:+. .::+*++**+*+::.::+:::**:.: :+:+*::+:*:::::+:*+++:+ 250 260 270 280 290 300 1 LQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNARTLSGSITDF-ASG 252 2 LQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNARTLSGSITDF-ASG 252 3 LQPPIKVMTPGRILMRKWIHLTVQVHQTAISFFVDGLEENSTAFDTRTLHDSVTDS-VSS 249 4 LQPPIKVMTPGRILMKKWIHLSVQVHETEVSFFVDGLEENSTAFDTRTLRDSITDS-APS 248 5 LQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGLEEDNTAFDARTLSGSIIDF-ASG 249 6 LQPPIKVMTLGRILVKKWIHLSVQVHHTKISFFINGLEDDHTAFDVRTLHGPVTDL-APG 252 7 LQPPIKIMTLGRILVKKWIHLSVQVHHSRISFFLNGWEDDSTPFDSRILVGTVADTNADG 273 8 --LAISFRTKGRIPLKSWTHLVLQVTNIKQSARLK------------------------N 211 9 --LTVGFRTEGRLTRDKWTHLVLQVYDRRVSLFLDGLEEDGTPFDTQPLTARLSAISEGG 246 10 ---AKFLQIQTGVQVSQWQHVAIQVFGTKASFFINGLEVDGTPFETMNLQGEIADD-STA 100 11 --RPQYSMIPINFPPDTWQHLAIQVHKTDISVFINGVESDMTPFATTVLQSRMADINDQP 251 12 --RPQYKMIPVNFPSDNWQHLAIQVYGTAISVFINGVETDGTPFATSVLESRMTDINNQP 227 C :::++::++:+++:::+W:H*::QV+.+:+S+*:+*:*.+.*:*::::*.::::*..:.: 310 320 330 340 350 360 1 TVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQSHCRCPGSHPRVH 312 2 TVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQSHCRCPGSHPRVH 312 3 VIQVGQSLNGSEQFVGRMQDFRLYNVSLTNREILEVFSGDFPHLHIQPHCRCPGSHPRVH 309 4 TVLIGQSLNGSELFVGRMQDFRLYNVSLTNREILELFSGDLPHLHIQSHCRCPGSHPRVH 308 5 TTQIGQSLNGLEQFVGRMQDFRLYQVALTNREIQEVFSGDLLRLHIQSHCRCPGSHPRVH 309 6 AVRIGQSSKGSEQFIGRMQDFRLYQVALPNRDILEIFSGELLYLHTQSECRCPVSHPRVH 312 7 TLKIGQSFTGLEQFVGRMQDFRFYPVALTNRDILEVFSGRFPHLHTQSECRCPGSHPRVH 333 8 GIYVNMT--GSNQFIGWMQDFRFYPATLANREIMEVYSGVLPKIHAQPECRCPQTHPRVH 269 9 AMWVGLSSNGSNQFIGRMQDFRFYPVALTNREVVEVYSGVLPNLHSQSECRCPPSHPKVH 306 10 QTRVGQRMTGTDQFVGRMQDLYFYQVTLTNRELEELATEMFPKVHAQSDCRCPDSHPRVN 160 11 LIRVGQRYRATGQYVGRMQDFRWYDRALTNNEIVEIATGMFPEVDIQPNCLCPEGFPRVH 311 12 IIRVGQRVRATGQYVGRMQDFRWYDRALTNSEIEEIATGVFPEVNILPNCLCPEGFPRVH 287 C :..:**+::*::**+G*MQD**:Y:++L*N***:E::+*::+.+*:*+:C*CP:+*P*V* 370 380 390 400 410 420 1 PLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTIS 372 2 PLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTIS 372 3 PSVQQYCIPNGAGDTPEHRMSRLNPEAHPLSFINDDDVATSWISHVFTNITQLYEGVAIS 369 4 PSVQQYCIPNGVEDTLQHRVSRLNPEAHPLSFINDDDVATSWISHVFTDITQLNQGVAIS 368 5 PSVQRYCIPNDAEDTTTDRVLRLNPEAHPLSFVNDNDIGTSWVSHVFTNISQLHQGVTIS 369 6 PLVQRYCLPNDADDTTNDRVLRLNSEAHPLSYINDNDIGTSWISHVFKNMTELENGVAIT 372 7 PLIQRYCIPNGADDTTNDRVLRLDAEAHPLYYINDDDIGTTWISSVFANAAGLDHGVSIT 393 8 PLVERYCIPSGVEDTTNDRVLRLNLNAHPLSYMNDQDMGTSWISKIMS-TQELDEGVTIT 328 9 PLIERYCIPNGVEDTTNDRVLRLNLNGHPLSYINDQDMGTSWLSKIMT-TQELDEGVTLT 365 10 PLEERYCLKNGEADTTVDQISRLNQDSHPLEFANDGDLGSYWVSTLTG-----GNSITVD 215 11 PLEPRYCIPNGVPDTSPLRRLRVDPDAHPLAYINDDDSSTTWISSLG---IYMPGGLTVN 368 12 PLEQRYCIPNGVPDTSPQRRLRVDPDAHPLAYINDDDSSTTWISSLG---IYMPGGLTIN 344 C P+:+*YC***+:.DT:.:*+:R*+::*HPL+::ND:D.+*+W:S.:::::::+..*+++: 430 440 450 460 470 480 1 VDLENGQYQVFYIIIQFFSPQPTEIRIQRKKEN----------SLDWEDWQYFARNCG-A 421 2 VDLENGQYQVFYIIIQFFSPQPTEIRIQRKKEN----------SLDWEDWQYFARNCG-A 421 3 IDLENGQYQVLKVITQFSSLQPVAIRIQRKKAD----------SSPWEDWQYFARNCS-V 418 4 IDLENGQYQVFQITIRFSSPQPVAMRIQRKKAD----------KSLWEDWQYFARNCS-V 417 5 IDLENGQYQVFYIIIQFLSPQPTAIKIQRKKED----------SLDWEDWQYFARNCR-A 418 6 IDLENGQYQVFYIVLQFFSPQPTGIQIQRKKMN----------HLDWEDWQYFARNCS-D 421 7 IDLQNGQYQVFYIILQFFSPHPEAIRIERKKRD----------DLNWEDWQYFAKNCS-I 442 8 VDLANGQYQVFYVIVQFGGLLPETVLIQRRKVDPTDLDGDHRMEQPWLDWQYMARNCS-V 387 9 VNLVNGQYQIFYVIVQFGGLLPESVLIQRRRLDLTVLESDTSTEQPWSDWQYMARNCS-V 424 10 IDLGSRVYQVFYVVLQFYSPQSTDLTISYRSDA----------STPWQVWQYYAQDCQNA 265 11 IDLENGEYQIFYIVLQFYSPQPRGITISRFSNG---------TDGDMQLWGHFADDCRIR 419 12 INLENGEYEIFYIVLQFYSPQPKGITISRFSND---------TDGDMQLWGHFADDCRIR 395 C +*L+**+Y*+**+::*F.*++*:.+:I+*:+.: .:::*:+W**+A++C: . 490 500 510 520 530 540 1 FGMKNNGDLEKPDSVNCLQLS--NFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEF 479 2 FGMKNNGDLEKPDSVNCLQLS--NFTPYSRGNVTFSILTPGPNYRPGYNDFYNTPSLQEF 479 3 WGMKDNEDLENPNSVNCLQLP--DFIPFSHGNVTFDLLTSGQKHRPGYNDFYNSSVLQEF 476 4 WGMKNNGDLENPNSVNCLQFP--DFIPFSHGNVTFDLLTSGQKHRPGDYDFYNSSLLQEF 475 5 FGMENNGELENPDSVNCLQLP--TFTPYSHGNVTFSILTPGPNHRPGYNDFYNTPSLQEF 476 6 FGMKNNDRLENPDSVNCLQLP--NFTPYSRGNVTFSILTPEPNRRPGYNNFYKTPSLQEF 479 7 FGMDNNGSLEKPDSVNCLQLP--SFTPYSYGNLTFSVLTPEPNHRPGYNDFYNTPSLQEF 500 8 FQMQNNGPLLKSDSVNCMQLP--KDVPFSGGNITFSLLTPEPNLRPGYNDFYNNPALQKM 445 9 FEMRNNGPLLRPDSVNCLQLP--SNVPFSGGNITFSLLTPEPNLRPGYSDFYNTPALQKM 482 10 FGLDNNGELDTPTSVNCIQFP--SDIPYSKGNITFQLLAPEPVARPGYNDFYNTPALLEF 323 11 FRYENNQPLNSPTDVNCIQFPPEHEIPYQRSNITFNLLPQEPHPRPGYNDFYGTPDLMQF 479 12 FRYENNQPLNSPTDVNCIQFPPEHEIPYQRSNITFNLLSQPPNARPGYNDFYGTPGLMDF 455 C *++:*N+.L:.*:*VNC+Q+* .::P+*:*N:TF::L++:*+.RPG***FY++*:L++* 550 560 570 580 590 600 1 VKATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCS 539 2 VKATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCS 539 3 MRATQIRLHFHGQYYPAGHTVDWRHQYYAVDEIIVSGRCQCHGHAETCDRTRRPYRCLCS 536 4 MTATQIRLYFRGLFYPAWHTVDSRHRYYAVDEITIIGRCQCHGHAETCDRTRRPYQCLCS 535 5 VKATQIRIHFHGQYYTTETPVSLRHSYYAVDEITITGRCQCYGHADKCDTSSQPYRCLCS 536 6 VKATQIRIHLFGQYYTTESSVNFRHRYYGVDEITISGRCNCHGHANDCDMISKPYRCFCS 539 7 VKATQVRIHMRGQYHTNESWVNFRHRYYGVNEVTVSGRCNCHGHADNCDTAMEPYRCLCI 560 8 VHASQVRIHVSGQYYTRESTVNQRHRYYAIKEITISGRCECHGHANHCDTSLTPYRCLCT 505 9 VHATQVRMHLSGQYHTVADGVNQGHRFYAINEITISGRCECHGHADHCDTSVTPYHCLCL 542 10 VRAKEVRIVMDGHYHVNPS--SARHMYYGIEELTISARCDCNGHADTCDITTDPYICNCL 381 11 VLASKVQIRFQYQYFTTPAYVNIKHQYYGMDGIKVVGRCNCNGHAESCNTTVNPYQCNCL 539 12 VMASKVQIRLQYQYFTTPEYVNIKHQYYGMDGIKVIGRCNCNGHAEACDTSVSPYQCNCL 515 C *:A++:*:+:.***:+::..*+.+H:*Y::+**+++*RC:C+GHA:.C*+:..PY:C+C: 610 620 630 640 650 660 1 QESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFR 599 2 QESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDLFPFEHFR 599 3 PHSFTEGPQCDRCSPLYNDKPFRSGDNVNAFNCKPCQCHGHASSCHYDASVDPFPLEHNR 596 4 PHSFTEGPQCGRCSPLYNDKPFRSGNKVHAFNCKPCQCHGHASSCHYDASMDPFPLEYNR 595 5 LESFTQGRHCDHCLPLYNDKPFQQGDQVNAFNCKPCQCNNHSRSCHYNISVDPFPFEHHR 596 6 QESYTEGRHCDRCLPLYNDKPFHQGDQVHAFNCKPCQCNNHSRSCHYDKTMDPFPAEYYR 599 7 KESYTEGSNCDRCLPLYNDKPFRPGDQVHAYNCKPCQCYSHAVSCHYDLEMDPFPQEYYR 620 8 PESHTEGYNCHRCAALYNDKPFRSGDQLQPMSCRPCQCHGHALSCHYDVTADDQPDEHYR 565 9 PESHTEGNNCQRCAPLYNDKPFKSGDQLQPLNCRSCQCHGHASTCHYDVRADDQPDEHYR 602 10 ASSFTTRIDCGECLPLYNDKPFRHGDQINAYNCKPCQCYGHASSCFYNETLDVSPDRHDR 441 11 EYSNTDGYQCERCKPLYNNKPFRLGDTVSSYDCQQCECHQHALSCHYEAELDPNSGDHFR 599 12 DYSNTEGYQCERCKPLFNNKPFRIGDTDSSYDCQQCECHQHALSCHYEEGLDPNPGDHFR 575 C .:S:T+*..C:*C:*L*N*KPF+.G*++.+:+C++C*C::H+.*C*Y:.:.D+:*.++.R 670 680 690 700 710 720 1 GGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIG 659 2 GGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDKVGTGNGSILCDQIG 659 3 GGGGVCDDCQHHTTGRHCESCQDYFYRSVGADPAAPDACKLCDCNRAGTRNGSLHCDPIG 656 4 GGGGVCDDCQHHTTGRNCESCQDYFYRPIGADPADPEVCKHCDCNRDGTRNGSLLCDLVG 655 5 GGGGVCEDCEHNTTGRNCELCKDYFFRPVGADPSALDVCKPCDCDKVGTRNGDFLCDKIG 656 6 GGGGVCDNCQHNTTGRNCELCKDYLFRQVGADPSARDICKPCDCYEVGTKNGSLLCDQIG 659 7 GSGGVCDNCQHNTTGRNCELCKDFHYRQAGADLSAIDVCKPCDCYATGTKNKSLLCDNIG 680 8 GGGGICDNCIHNTTGRNCELCISGFFRLEGFDPTSPNVCQPCDCNIAGTVNSSLICAQVG 625 9 GGGGVCDNCMHNTMGKNCELCVPGFFKQAGADTTSVHLCQPCKCNTAGTVNSSMECAQVG 662 10 GGGGVCSNCQDNTNGQQCDQCVEGFFKLDGVPLDSTDICNPCECSPNGTVAGDLMCEEVN 501 11 GGGGVCDDCMHNTAGRYCEKCAPLFYRLADKALEAVDVCKPCNCHRGGVVNETMDCAKVD 659 12 GGGGVCDDCLHNTAGRHCEQCATLFYRMSERALEAVDVCKPCGCLRAGVVNETMDCAKID 635 C G*GG*C*:C:**T+G*+C*:C:::*:*::*++::+.++C+*C+C...G*:*:+::C:::+ 730 740 750 760 770 780 1 GQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVD---GDITCHQNSGQCK 716 2 GQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVD---GDITCHQNSGQCK 716 3 GQCDCKRRVSGRQCLQCQDGFYDLQALDPDGCRPCNCNPSGTVD---GDITCHQNSGQCS 713 4 GQCDCKRRVSGRRCFRCHIGFYGLQALDPDGCRPCDCNPSGTVD---GDITCHHNSGQCS 712 5 GQCNCKRHVSGRQCNQCQNGFYNLQESDPDGCSACNCSTSGTVD---GDITCHQNSGQCK 713 6 GQCNCKRHVSGRQCNQCQDGFYNLQELAPDGCSPCNCNTSGTVD---GDITCHQNSGQCK 716 7 GQCNCKRHVSGRQCNQCQEGFYNLQQSNPDGCSPCNCNTSGTVN---GDITCHQNSGQCK 737 8 GQCQCKVAVTGRQCESCLPGWSGLKASNPNGCIRCNCSEVGTINTSAGAPSCDQKTGQCQ 685 9 GQCPCKAAVTGRRCVDCLPGWYGLKASNPNGCTRCNCSDAGIIDTSTGDPSCNQDTGLCH 722 10 GQCNCKTYTSGRSCDTCQNGYYNLDASNPNGCEPCGCISAGTIN---SDISCHQQTGLCN 558 11 GQCECKPRVKARRCNTCVDGYFNLRRENPHGCESCNCTLPGTVN---RTITCTPRTGQCR 716 12 GQCECKPRVRSRRCNICVDGFFNLRRDNPEGCDNCNCTLSGTVN---RTITCTPRTGQCR 692 C GQC:CK::*+*R:C::C:.G+++L::::P:GC::C*C::+G*+: ++*+C++::G*C: 790 800 810 820 830 840 1 CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQ 776 2 CKANVIGLRCDRCNFGFKFLRSFNDDGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQ 776 3 CKANVIGLRCNRCNFGFKFLQSFNGDGCEPCQCNLHGSVNQLCDPLSGQCACKKEAKGLK 773 4 CKANVIGLRCDRCSFGFKFLRSLNADGCEPCHCNLHGSVNQLCDPLSGQCVCKKEAKGLR 772 5 CKANVIGLRCDHCNFGYKFLRSFNDDGCEPCQCNLHGSVSKLCNPLSGQCECKKEAKGLQ 773 6 CKGNVIGLKCDRCNFGFKILRSFNKDGCEPCHCNLYGSVNKFCNPLSGQCKCKKDAKGLQ 776 7 CKANVIGPRCDSCNFGFKALRYSNEDGCEPCWCNSHGSVNQFCNPLTGQCNCKEQVKGLL 797 8 CKANVTGLSCDRCEFGYWNLS--HPDGCIPCDCDPLGSLSQFCEPRGGQCDCKPGVRGRR 743 9 CKPHITGLSCDRCEFGYWNLS--HPDGCVPCDCSPLGSLSLFCEPEAGQCECKPGVGGQR 780 10 CKDNVIGDKCDRCNFGFYNLAASNLFGCLPCGCNSDGSTSIYCDPSNGQCQCRPSSQGRT 618 11 CRPNVRGKRCADCQFGYKNLTDSNIDGCEPCNCNRVGSRDQYCDPLTGQCFCKENVEGMF 776 12 CKSNVRNKRCTDCQFGFKNLTDSNIDGCEPCNCNRVGSRDQYCDPITGQCFCKENVEGMF 752 C C*:**+*++C+:C:FG++:L:::*.*GC+PC.C*::GS::::C:P::GQC.C*::::G:. 850 860 870 880 890 900 1 CDTCRENFYGLDVT-NCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFY 835 2 CDTCRENFYGLDVT-NCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNVY 835 3 CDSCRENFYGLPWS-ACEVCDCSKAGSQPGTVCDTETGQCVCKPNVGGRQCSQCKAGYFN 832 4 CDVCRENFYGLPWS-ACEVCDCNRAGTQAGTVCDAETGQCVCKPSVGGRRCSECKEGYFN 831 5 CDTCREHFYGLDIT-SCKACDCDMAGSLSGTVCDAKTGQCMCKPSVGGRQCNECLEGYFY 832 6 CDACVENFYGLDID-GCKLCDCNTEGTLSGTVCDAKTGQCTCKPNVGGRRCDECLDGYYQ 835 7 CDTCVDNFYGLDVT-GCKACECNIAGSFAGTVCDARTGQCACKPNIGGRQCNECLDGYHR 856 8 CDSCGRGSYGLKLEGSCSSCNCSTEGALPGTICHPHTGQCVCKASRF---CDTCRHGYHT 800 9 CDYCGRGSYGLRLEGSCAPCNCSQEGTVPGTECDPHAGHCVCKEHVEGLRCDTCRHGYHT 840 10 CDECRDGFYGLAAD-GCSECDCDDAGTEPGAPCDKASGQCVCKANVQGVRCDQCEASYYN 677 11 CDKCENGFWGLSAS-GCQTCGCDSAGTEPGTTCDKETGQCVCKAHTQGRTCNECTDEYYN 835 12 CDKCQNGFWGLSST-GCQPCGCDGAGTEAGTTCDKDTGQCVCKAHTQGRTCNECVDEYYN 811 C CD.C:::**GL:.: :C:.C:C:.+G:::G*:C+:.*G*C:CK::+:*+:C::C:.+*.: 910 920 930 940 950 960 1 LRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLT----I 891 2 LRQNNSFLCLPCNCDKTGTINGSLLCDKSTGQCPCKLGVTGLRCNQCEPHRYNLT----I 891 3 LYQNDSHLCLTCNCEKMGTVNGSLRCDKSTGQCPCKLGVTGLRCHQCKPHRFNLT----M 888 4 LRQNDSHLCLPCNCEKTGTVNGSLLCDKSTGQCPCKLGVTGLRCHQCEPHRFNLT----V 887 5 LQQNDSFLCLPCNCDKTGTVNGSLLCDKSTGQCPCKLGVTGLHCNQCVPHRYNLT----S 888 6 LRQNNSFFCLPCNCNKAGTVNDSLLCDKSTGQCPCKAGVRGLQCNHCEPHRYNLT----I 891 7 IQVNHSFVCLPCDCDKAGTVNGSLLCDKSTGQCPCKAGVIGLQCNQCMLHTYNLS----M 912 8 LERRNSLGCLPCTCDIYGTVP-GKVCDEWTGHCPCQEGVEGSQCTNCAPNYYNRSENFQK 859 9 LEQRNSLGCLPCECDVHGTVP-EGVCDMWTGQCPCREGVEGARCTNCAHNYYKS---LLI 896 10 LQASNSQGCSPCSCNTEGTISGSTVCDATTGQCVCKVNVLGRTCNTCAPNTFGLE----A 733 11 LTPTNPQGCETCSCDHRGTTNGSLVCDKQSGQCSCKQYVAGRVCNLCRGNTFGLR----D 891 12 LVATNPQGCETCSCDHRGTTNASLVCDKQNGQCSCKEHVDGRVCNLCRGNTFGLR----A 867 C *.::+*::C++C:C+:.GT:++*+:C*+:*G*C+C*:+V:G::C+:C.+:::+*: . 970 980 990 1000 1010 1020 1 DNFQHCQMCECDSLGTLPGT-------ICDPISGQCLCVPNRQGRRCNQCQPGFYISPGN 944 2 DNFQHCQMCECDSLGTLPGT-------ICDPISGQCLCVPNRQGRRCNQCQPGFYISPGN 944 3 DNPQGCQACDCDSLGTLPGS-------MCDPISGQCLCLPHRQGRRCEQCQPGFYSSPSN 941 4 DNLQGCQACECDSLGTLPGS-------TCDPVSGQCLCLPHRQGRRCERCQPGFYSSPGN 940 5 GNFQGCQMCECDSLGTLPGT-------ICDPISGQCLCLPNRQGRRCNQCQPGFYISPGN 941 6 SNLQGCQMCECDSLGTLADA-------VCDQISGQCPCLPNHQGRQCNQCKPGFYVSPGN 944 7 RNLLGCQRCDCDAKGTLAGT-------VCDHVSGQCVCLPHRQGRRCNECKPGFYFSPSS 965 8 EGFWGCVPCICDPRGTVPGS-------VCDTTTGQCVCIPTHYGQDCSVCRPGFYLSP-D 911 9 QGTTSCVPCICDLKGAVTGS-------VCDSITGQCVCVPTRYGKNCSSCRPGFYLSA-D 948 10 ANEDGCESCGCDATGTQTGSNG--DVLVCDQNSGQCSCLTNRLGRTCDICDEGFYEPPSG 791 11 SLVTGCEACNCDPRGTSLGDQLSPNELVCDSNSGQCACLPSREGRSCNQCSPGFYLPGNN 951 12 TLVSGCEACNCDPRGTSLGDQLSPNELVCDSNSGQCACLPSREGRRCDQCSPGFYLPANN 927 C .+.:+C:.C:CD::G*::*: .:CD::*GQC:C+*:*:G*:C::C:*GFY.++:+ 1030 1040 1050 1060 1070 1080 1 ATGCLPCSCHTTGAV-NHICNSLTGQCVCQDAS----IAGQRCDQCKDHYFGFDPQTG-- 997 2 ATGCLPCSCHTTGAV-NHTCNSLTGQCVCQDAS----IAGQRCDQCRDHYFGFDPQTG-- 997 3 ATGCLPCLCHTAGAV-SHICNSVTGQCSCHDPS----TTGRSCHQCQESYFRFDPLTG-- 994 4 ATGCLPCSCHTAGAV-SHICNSVTGQCSCRDPS----TTGQSCHQCQDHYFGFDPRTG-- 993 5 ATGCLPCSCHKMGAV-HHICNSLTGQCICQDAS----VAGESCDHCRDLYFGFDPQTG-- 994 6 KTGCLPCSCHTAGAV-HQVCNSLTGQCICQGAS----IIGQRCDHCKDHYFGFDPLAG-- 997 7 VTGCLPCLCHTAGSV-NQVCDKLTGQCICQDVS----VTGRTCERCKEHHFGFDSVTG-- 1018 8 QNVCVECDCHPMGAS-QRGCDSQTGQCLCVHPS----VGGRRCDQCRDMFYGFNPGLG-- 964 9 QSACAECDCHPMGAS-QRGCESHSGQCVCAHPS----VGGRRCDQCPEMFFGFNPGLGSL 1003 10 GRGCLSCDCQPLSTEPSTFCDTLTGQCQCRLGSP--GLTGRRCDGCMEEYFNYNPSTG-- 847 11 ETGCLVCDCHPVGSV-SQTCNNVTGMCPCKPEQEGAGLTGRRCDECAASYWSFHPLFG-- 1008 12 ATGCLVCDCHQVGSV-SQTCNNVTGMCPCKPAET--GLTGRRCDECAANFWNFHPLFG-- 982 C :+*C*:C:C*:.*++ ::.C++:*G*C.C:::* ..:G:+C+:C.::+++*:*.:G 1090 1100 1110 1120 1130 1140 1 -RCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQ 1056 2 -RCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQ 1056 3 -RCRPCHCHVAGASNGTCDAVTGQCFCKEFVTGSKCDTCVPGASHLDVNNLLGCSKTPSQ 1053 4 -RCQPCHCHLEGALNETCDVVTGQCFCKEFVTGSKCDICVPGASHLDVNNLFGCSKTPSQ 1052 5 -RCQPCNCHLSGALNETCHLVTGQCFCKRFVTGSKCDTCVPRASHLDVNNPLGCSKTPSQ 1053 6 -RCQPCNCHLPGALNGSCHLVTGQCFCKQFVTGLKCDDCVPGASHLDIHNLFGCSKTPSQ 1056 7 -RCQHCNCHPAGAISGTCHLVTGQCVCKQFVTGLKCDNCVPNASNLDVHNLFGCSKTPFQ 1077 8 -RCQSCACDLMGSVNGSCHPDSGVCSCKLLVAGDKCDGCQAGATHFDPKNHFGCSKAPSQ 1023 9 TRCQPCACDPGGSINGSCHPDLGLCECKLLVTGDKCDVCQPEASHFDPESHFGCSRAPSQ 1063 10 -MCSPCDCDPRGSLNTSCDSNTGQCDCKDLVTGRRCDTCQISSSNLQASNPQGCSKTPAQ 906 11 -KCETCNCHVPGSISAECNPVTGQCPCKDNVIGSQCDTCRHGSSHMSENNPMGCYSHPEQ 1067 12 -TCQQCGCHAPGSESSDCNPVTGQCPCKGNVIGTHCDTCRPGSSHMSENNPMGCYSHPEQ 1041 C +C++C:C+:.G::+::C::+*G*C:CK.:V+G:+CD:C:+:+**++::*::GC*++P:Q 1150 1160 1170 1180 1190 1200 1 QPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLL 1116 2 QPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLL 1116 3 QPPPRGWVQSSSTINVSWSPPECPNAHWLTYTLFRNGSEIYTTEDEHPYYTQYFLDTSLS 1113 4 QPPPRGRVQSSSAINLSWSPPDFPNAHWLTYTLFRDDSEIYTTDDQHPYXXXYFLDTSLS 1112 5 QPPPRGQVQSSSAINLSWSPPDSPNAHWLTYGLFRDSSEIYTTEDQYPYSIQYFSDADLS 1113 6 QPPPRGQVQSSSTINLSWHPPDSPNAHWLTYSLFRDGIEIYMTEDKYPYGVHNFTDTALL 1116 7 QPPPTGEVLNSSAISLSWNSPDSPNSNRLIYLLYRDEAKIYTAEDYYPYSIHTFIDTALS 1137 8 QPAPVGFAVNYSSIKLSWHPPDSPNSNRLSYTLIRDAHTVHNIQRSYPFSPESFEDGGLF 1083 9 QPAPVGSALSYSSIRLSWNPPDSPNSNRLKYTLVRDGESVHSIQSYYPFSPESFEDTTLF 1123 10 QPPPVWQAVNPFSILLTWGPPDEPNGNILTYLLYRNNTLVYNGTAANPLGIQQFEDQNLS 966 11 QAAPEQTEVKSRYIVITWNPPDLPNGDILSYKLYRNNEIVHTVNDSSPFTVKRFNDTGLL 1127 12 QAAPEQGEVKPRWIVVRWNPPDLPNGDILAYKLFRNDEIVYSVNDSSPFTGKQYNDTSLL 1101 C Q*+P:+::::++:I:++W:*P*:PN:::L:Y.L:R+:.::+:::+.:P:::::*.D+.L: 1210 1220 1230 1240 1250 1260 1 PYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPE-GNLTLSYIIPIGSDSVTLTWTTLSNQ 1175 2 PYTKYSYYIETTNAHGSTRSVAVTYKTKPGVPE-GNLTLSYIIPIGSDSVTLTWTTLSNQ 1175 3 PHTAYSYYIETSNVHSSTRSIPVIYETKPEVSE-GHLNLTHIIPVGSDSITLTWTGLSNS 1172 4 PHTAYSYYIETSNVHSSTRSIPVIYKTKPEGSE-GHLNLTHIIPVASDSITLVWTGLSNH 1171 5 PYTSYSYYIETASVHGSTRSAAVTYKTKPGVPE-GNLNLSYIIPISSDSVTLAWNSPSNR 1172 6 PYTSYSYHLLTTNVHGSERSATVIYRTKSGTPE-GNLNLHYVFPVSPYSVTLYWTAPLNN 1175 7 PYTFYSYYVQASNIHGFTRSASVTYRTKSGTPT-GSLHLNPVFPVSHHSALLYWTAPSND 1196 8 PYTNYSYWLITANVAGVTTSTSASFQTLAAPPDKEQLHLTLVGQPRPTSASFNWSSPPND 1143 9 PYTNYSYWLVTANVAGTTISASASYQTLGAPPEVEQLHLNLVGQPGPSTASFDWSAPRND 1183 10 PFTTYSYYVQSANEAGRATSPVVIAQTPDAIPA--GFDVLTITNVQARSADFSWSQPADI 1024 11 PYTNYDYHVDTSNVGGEVSSPNLRVQSLAGIPT--GIPPLSVSRVRARTALFEWAEPDVA 1185 12 PYTNYDYHVDTSNVGGMVSSPTLRVRTLAGVPT--GIPPLSVSRVRARRAIFEWGEPAVA 1159 C P+T.Y*Y:::*:*+:*:+:S..+.+.*::::*: :.+.+..::::.::+:::.W:.+:+. 1270 1280 1290 1300 1310 1320 1 SGPIEKYILSCAPLA-GGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHSLPI 1234 2 SGPIEKYILSCAPLA-GGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHSLPI 1234 3 SDPVAKYVLSCTPVD-STEPCVSYEGPETSATIWNLVPFTQYCFSVQGCTNESCFYSLPI 1231 4 SGPIEKYVLSCTPVD-HTEPCVSYEGPETSATIRNLVPFTQYCFSVQGCTNGSCLYSSPI 1230 5 SGPIEKYILSCVPFD-GGQPCVPYEGHETSATIWNLAPFTKYHFSVQACTSGGCLQSSPL 1231 6 SGPIEKYILSCTPLD-SIQPCGAYEGLDTLATIWNLIPFTKYHFSVQACTSGGCLHSLPL 1234 7 SGPIEKYILTCTVLV-DLQPCGQYEGLETSAIIWNLMPFTKYVFSVQACTSGGCLESQPV 1255 8 TGPVERFILSTTESAHGSQPVLHFSGLSTQAVVTGLQPFTQYTVVLEACSSGGCTSTPPL 1203 9 TGPVERFVLSSVESS-GAEPVIHYSGLSTEAVASGLKPFTQYTVRLEACSSGGCTSTPPM 1242 10 SATVTQYILTSMTPSKPDPPTQHFNGLATSYQATDLIPFTNYTFYLTVCTPGSCGQGRAT 1084 11 HGPIETYVLQSLTTEEDDAVEVHYNGLAKRAEIDTLQPFTNYTFTLRACTSGGCGDSLPL 1245 12 HGPIETYVLQSVTTADDDSVEVHYRGLATRTEIESLRPFTNYTFTLRACTSGGCGDSLPL 1219 C +**+*:*:L+:::.. :.:*:::*:G::*:*:+::L.PF*:Y:*:::+C*+*+C:.+:*: 1330 1340 1350 1360 1370 1380 1 TVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRR-LRSTKE-TTSE 1292 2 TVTTAQAPPQRLSPPKMQKISSTELHVEWSPPVELNGIIIRYELYMRR-LRSTKE-TTSE 1292 3 IVTTAQAPPQTQGPPTVWKISPTELRIEWSPPVDSNGIIISYELYMRR-WLS------TE 1284 4 TVTTAQAPPQRQEPPTVWKISPTELKVEWSRPVDSNGVIIRYELYMKR-WPS------TE 1283 5 TVMTAQAPPRRLGPPEVRMISSTELRVEWSPPLEPNGIIIRYELYMKR-LRSDGE-TTSA 1289 6 IITTAQAPPQGMDPPTVQTISSTELYIEWHPPEEPNGIIIRYELHMRR-LQSNDE-QTMT 1292 7 TVITAQAPPEGLKPPVIENISSTELSVEWSAPEKPNGIIIRYELYMRKKLKPFDD-QPPP 1314 8 SFLTADAPPQNQPPPTISALGPHSLQAYWEPPSQPNGVITRYEVFLRGPIKLQNPSTLNN 1263 9 SLLTASAPPQHQPTPRVSATGPHTLHASWEPPSQPNGVITRYELFLHGPIESQNP-LLAV 1301 10 LAYTPQAPPQGVMDPNATALSQSSVFVSWDHPTEANGIITHYELFFRG-YPGPDGTIDPP 1143 11 IVITPEAKPGQQLPPEITAISNTSLLVSWEPPVEANGIIHQYEVMMRG-KPGRDGAHYPL 1304 12 VVITPEAKPAQQLPPVITPISNTSLVVSWEPPQEANGIIHQYEVMMRG-KPGPDGAHYPL 1278 C :+:T++A*P+.: *P.:..+*:+:*.+:W:+P.::NG+I:+YE+:++: :.: :. .... 1390 1400 1410 1420 1430 1440 1 ESRVFQSSGWLSPHSFVESAN--ENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSVSS 1350 2 ESRVFQSSGWLSPHSFVESAN--ENALKPPQTMATITGLEPYTKYEFRVLAVNMAGSVSS 1350 3 ESLVFESHGLVSSHSALQSVNPSKNLLQQPQASTFISGLEPHTEYAFRVLAVNMAGRVSS 1344 4 ESLVFESHGWFHSHPASPSANQSENVLQDPQVSTVLSGLDPHTEYAFRVLAVNMAGSVSS 1343 5 ESRVFQSSGWLSPHPFVESAN--ENALKPPQTATTITALEPYTEYAFQVLAVNMAGSVPS 1347 6 ESRVFQYSGWLNPQTVTASAN--ENALTPPQTTTIITGLEPYTKYEFSVVAVNMAGSVSS 1350 7 EIRVFQSSGWLSPQPVLESAN--ENALAPPQTSTTVSDLEPFTEYEFYVLAVNMAGSVSS 1372 8 ERRVFVSSDWVDSFGSLEAPPTNQSTFLPPHNSTTVTGLQAFSTYQMRVASTNLAGSATS 1323 9 EKRVFVSAGWLDPSVSPEERLTNGSSVPPPESSTIVGNLQAFSTYEMRVVSINMAGSVTS 1361 10 ETRIFYPAGWFNPRPVLTPLE---DPAEPPVTNFTHTGLDAFTRYQYRVTARNLAGTGHS 1200 11 QKVVFITHGAYNPRRTSSPGY---NPLPQPKTNFTQENLEPFTEYEFFVSSSNSLGSVQS 1361 12 QKVVFQSHGAYNPWHTSSPGY---NPLPQPKTNFTQNNLQPFTEYEFFVSSSNSLGSVQS 1335 C *:+*F:+:*+::+:...:::: :+:+.+P:+:++:::L:+:*:Y:+:V:+:N+*G**:S 1450 1460 1470 1480 1490 1500 1 AWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADN--VTRGKVVGYDINMLSEQSPQ 1408 2 AWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADN--VTRGKVVGYDINMISEQSPQ 1408 3 AWASERTGESVPVFMAPPSVSPLSPHSLSVSWEKPAEN--FTRGEIIGYKISMVSEHFPL 1402 4 AWASERTGESAPVFMAAPSVSPLSPYSLSVSWEKPAEN--FTRGEIIGYKISMVSERSPQ 1401 5 TWTSERTGESVPAFMTPPSVSPLSPHSLNVSWEEPAEN--VTRGEVVGYKINMVSEQSPH 1405 6 DWISERTGESAPVFMPPPSVFPLSPYSLNVSWMKPENN--ATRGEIVEYKVNLISEQILH 1408 7 DWMSGRTAEAAPVFMPSPSVFPLSPYSLNVSWKKPEDN--LSRGEVMGYSISLMTEQRFL 1430 8 TWTTARTMEGVPEWIAPPVVSALSSTSLRVEWNSSEGHGVIARGQVIEYQVSLLTEQTNN 1383 9 GWTTARTLEGVPELMAPPEVSALSSTSLNVSWSATEGHGIIARGQVTEFRVNLLNEQTNN 1421 10 SWTTVRTAEAAPLSTPAPSVLGVSSSELNITWPQPQDN--EIRGVVISYRLYRYITSDDP 1258 11 PWVTARTLEGDPVFMTSPTLEAVSSFEVNITWEAPDPVT-EARGNVVMYQVILTQNTTSG 1420 12 PWVTARTLEGTPVAMGSPMLEAISSFEVNITWEAPDPVM-EVRGNVVMYQVILTQNNTSG 1394 C .W.::RT:E::P++*.:P+*::+S::+*+:+W::*:.+ .:RG:+::*.:::.:+:.:. 1510 1520 1530 1540 1550 1560 1 QSIPMAFSQLLH-TAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAP 1467 2 QSIPMAFSQLLH-TAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAP 1467 3 HDVPVMCSKMVH-FAKSQDQSYIVRGLEPYRTYSFTVSLCDSVGCVTSALGSGQTLAAAP 1461 4 RDVPVMCSKLVH-FAESQDQSYIVQRLKPYRTYSFTVSLCYSVGCVTSALGEGQTLAAAP 1460 5 QAIPTAVSQVLY-TATSQELSYIVKELKPYRIYNFTISLCNSIGCVTSASGAGRTLAAAP 1464 6 QQPSLEVSQVLY-TAEAHEFFYVVRGLKPYRTYHFTISLCNLIGCVTSDPGMGQTLATAP 1467 7 P----TFSQVLH-IAEAHELSYIATGLKPYRTYNFTITLCNQIGCVTSEPGMGQTLAAAP 1485 8 PHAPPLISHVMHRMRPSEQSVYVVEGLKPFQVYNFTVTVCTKTGCITSLPGAGQTLPAAP 1443 9 PYAPPVISQVLHRVGPSSQPVHLVEGLKPYHVYNFTITLCTSTGCISSLPSTGRTLPAAP 1481 10 FAPPQTQELVYS--GDGSGMFFVLGSLEPYSIHTFSIEACNSIGCILSPRSSGRTLPTAP 1316 11 NPNAPPYEDVIY-SCGPTISHFLAKGFKPYTSHNITMKLCNSVSCVFGDPSRVTTLPAAP 1479 12 NPNAPPFEDVIY-SCGPTIQHFVAVGFKPYTSHNITMKLCNSISCVFSEPSRVTTLPAAP 1453 C . .+...+:+:: .:.:::.:+.+.+**P*:.+:**::*C++:*C++*::+.*:TL:*AP 1570 1580 1590 1600 1610 1620 1 AQLRPPLVKGINSTTIHLRWFPPEELNGPSPIYQLERRESSLPALMTTMMKGIRFIGNGY 1527 2 AQLRPPLVKGINSTTIHLRWFPPEELNGPSPIYQLERRESSLPALMTTMMKGIRFIGNGY 1527 3 AQLRPPMVTGVNSTTVHIRWLPPAGVNGPPPLYHLERKKSSLPAATAAVTKGTRFVGHGY 1521 4 AQLRSPMVTGVTSTTVHIRWLPPAEVNGPPPLYRLERRESFLPAATAARTKGTRFMGDGY 1520 5 TQLRPPMVERINSTTIRVRWLAPEELNGPSPMYQLERRESSLSAPTAIMMKGTRFTGNGY 1524 6 VHVRAPHVEGINCTVMKISWLPPGELNGPSPIYLLERRETSLPALDTEMIKGIRFIGNGY 1527 7 RKFGAPHVEGINSTTVKISWNEPEELNGPSPTYQVERMDSSLATWSTEVAKGVRFPGNGY 1545 8 TGLSPPRLYPVNGTSILIDWDHPAQFNGPQPLYQVERTDVSLSEPQDPVIRGTRFPGNSY 1503 9 TGLSPPQLHPVNETTIQVGWDPPAQLNGPNPLYQVERADVSLSDPHSPVVRGTRFSGNGY 1541 10 EGQGPPMVDGFNSSAMQVRWDPPIMQNGPNPSYQVQSIVASLSRTPPRVERGARFTGGGY 1376 11 SGQPSPTAAEREEHSITLNWEDPAKVNGPRPEFSLLRSSVAFSNPPIEMSRGVRFPGHSY 1539 12 VGQAPPSAHGRDQHSIDLSWEDPAKVNGPRPEFSLMRSPVAFSNPPIEMSRGVRFPGHSY 1513 C .:::+P.+.+:+:+::.::W.:P:::NGP:P.*:++*:::+*:::...:.:G:RF.G:+Y 1630 1640 1650 1660 1670 1680 1 CKFPSSTHPVNTDFTGIKASFRTKVPE-------GLIVFAASPGN----QEEYFALQLKK 1576 2 CKFPSSTHPVNTDFTGIKASFRTKVPE-------GLIVFAASPGN----QEEYFALQLKK 1576 3 CRFPRTAH---ADFIGIKASFRTRVPE-------GLILLALSPGD----QEEYFTLQLKN 1567 4 CRFPRTAH---PDFIGIKASFWTRVPE-------GLILLALHPDN----QEEYFALQLKS 1566 5 YKFPSSTHPVNTDFTGIKASFRTRVPE-------GLIVFAASPGN----QEEYFALQLKN 1573 6 YKFPSSTLPINTDFTGIKVNFRTREPD-------GLIMLAVSPGN----QEEYFALQLKS 1576 7 YRFASSTLPANAYFTGIKVKFKTKEPD-------GLIFFSASPGN----QEEYIALQLRS 1594 8 HQFPSHTLPVNRDFTGIELSFKTHSAD-------GLLLAAFSPGN----QEEFVAIQIKD 1552 9 YQFPSDTLPVNTDFTGVELSFRTHSPN-------GLLLCAFSPGN----QEEFLAIQLKN 1590 10 YLFSGNILP-FSSYTGIEFEFRVSRPSDALSPASALLMFAASDGE----QEEMIVVQLRE 1431 11 IKFPPSVLPRDASYSGVLFWFRTYEPD-------CLLFLAASPLSSGGIRQEYLVIHLKD 1592 12 ITFAPDILPRDASYSGILFWFRTYEPD-------CLLFLAASPLSSGGLRQEYLVIQLKD 1566 C ::F+::::*:::+++G*:::F+*.:*: +L:.:*:**++ **E+:+:***. 1690 1700 1710 1720 1730 1740 1 GRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNG 1636 2 GRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNG 1636 3 GRPYFLYNSQGTLVEVTPTDDPSQGYRDGEWHEIIAVRHQAFGQITLDGQYTGSSSSLNG 1627 4 GRPYFLYNPQGSLVEVTTADDHSQQYSDGQWHEITAIRHQSFGQITLDEQYTDSSASLNG 1626 5 GRPCFLFDPQGSSMEVTTTNDGGKQYSDGKWHEIIAIRHQAFGQITLDGQYTGSSATQNG 1633 6 GRPYFLYDPQGSAVVVTTTNDNGKQYNDGRWHQVTATRHQALGQITVDGHFIGSSSASSG 1636 7 GRPYFLFDPQGSAVAVTPTNDGGKEYNDNSWHQIIATRIQALGNITVDGQYTGSSSATSG 1654 8 GRPYFLFDPQGSAVVVTVQGDGGRRYNDGRWHSITATRRGAVGTIIVNNQYRGSKSASSG 1612 9 GQPYFLFDPQGSAVAVRAQGDGGRRYDDGQWHSIIAARRGAVGTIVVNNQYRGSASASSG 1650 10 GRPWFIFDPQGGVAGATP-NDGGRTYDDGLWHKVVVSRAGSVGSITVDDMYTGTVTAPTA 1490 11 GRPWFLFDAQNNPTSVTPTNDEMRRYDDGKWHRLEVNRFNRDGYIELDIVNIGSKRSSSG 1652 12 GRPWFLFDAQNNPTSVTTNNDNMKRYDDGKWHRLEVNRFNRDGYIEVDVIYTGSKTSTSG 1626 C G**+F*+*+Q*+.+:**::+D:+::Y.D*:WH:+:+.R::+:G:I+:*::*+**:::.:* 1750 1760 1770 1780 1790 1800 1 STVIGDNTGVFLGGLPRSYTILRKD----PEIIQKGFVGCLKDVHFMKNYNPSAIWEPLD 1692 2 STVIGDNTGVFLGGLPQSYTILRKD----PEIIQKGFVGCLKDVHFMKNYNPSAIWEPLD 1692 3 SSVTGGYTGLFVGGVPQGHSVLQKR----LEIIQRGFVGCLKDVFIMKGYSPSGTWLPLD 1683 4 SSVTGGYTRLFVGGLPQGHTILQKR----PEIVRRGFVGCLKDVSILKGSSPSGTWLPLD 1682 5 STIIGGNTGVFVGGLPQGYTILRKD----PDIIQKGFVGCVKDMYFMKKYNPFAIWEPLV 1689 6 STIIGENTGVFVGGLPWGYTILRKD----IEIIQKGFVGCLKDVFFKKSHNPFEVWEPLE 1692 7 STIIGENTGVFVGGLPQGYAVVRRDE-GMKMVIQKGFVGCLSDLFLKKKYTPYEYWESLN 1713 8 SIIIGENTGVFIGGLPENFTLLREDP-GDARLVPRGFSGCLRDMRF-LTDSHSDEWEDLD 1670 9 STIIGENTGIFIGGLPEDLTLLRQDS-GDAQLVRQCFSGCLRDVSFKMADGPSEEWKPLD 1709 10 STIIGATTGLYVGGLPVNFDLRRSET-GDLAVIRSNLIGCLRNIRIETAHVPTPIWRDLD 1549 11 TTVIGVNDGVYIGGVPSNFNLGRSNDQGDSVAILTSLIGCVKNIQVQRDGALG-EWSNVT 1711 12 TTVIGVNDGIYVGGVPGNFTLGRPNDQGDNVAVLKSLIGCVKNIQVQRDGALG-EWSNVS 1685 C *+:*G.+**:+:GG+P:::+:+*:: ::.::+::++:GC+++:.:.: :.+:..W::*: 1810 1820 1830 1840 1850 1860 1 WQSSEEQINVYNSWEGCPASLN-EGAQFLGAGFLELHPYMFHGGM-NFEISFKFRTDQLN 1750 2 WQSSEEQINVYNSWEGCPASLN-EGAQFLGAGFLELHPYMFHGGM-NFEISFKFRTDQLN 1750 3 WQSSEEQVNVHPSWEGCPTNLE-EGVQFLGAGFLELPSDTFHAAK-DFEISLKFQTDQLN 1741 4 WQSSEEQVNVHHSWEGCPTDLE-EGVQFLGAGFLELRSDTFHAAK-DFEISLKFQTDQLN 1740 5 WQSAEEQVNVYNSWEGCPTSLQ-DGAQFLGTGFLELHPYIFHGGM-DFEISFKFRTDQLN 1747 6 WQNAEEQMNAYSSWEGCPNALR-EGAHFLGTGFLEIYPYVFPGGM-DFEISFKFRTDQMN 1750 7 WQNAEEQNNVYHIWEGCPTVLS-EGAHFLGKGFLELYSGVFSGGQ-EFEISFKFRTDQLN 1771 8 WTAATRNAASYASWEGCPLQSV-DGAHFLGHGYLEIDGDVFRGGQ-DFEISMEFRTDQLN 1728 9 WEKATKKVAVYESWEGCPLQTV-QGAHFLGHGFLEMVGDVFSGGE-DFDIYMDFRTDQLN 1767 10 YSNALERVQVPGGWQGCPTQLE-RGVHFLGKGYLSLPEGTFNGGS-SFTLSLEMRTHYQT 1607 11 WDTAEDWHRAYEPWQGCPVQLDRPAVHFLGRGHLEMSTKLGTLDLTSWEVSFDFRTNFAS 1771 12 WDEAQHWYRAYEPWQGCPVELDRPAVHFLGRGHLEMAEKLGVLDQNAWEISLDFRTNFAS 1745 C *::+++:::++.+W+GCP:.*. :*::FLG.G+L*:....*:++. :****::**T++++ 1870 1880 1890 1900 1910 1920 1 GLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVIIKKEGS 1810 2 GLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVIIKKEGS 1810 3 GLLLFIHNTEGPDFLAVELKRGLLSFKFNSSLVFTRVDLRLGLADCDGKWNTVSIKKEGS 1801 4 GLLLFIHNTEGLDFLAMELKSGLLSFQLNSSRILTRVEVRLGRTHCDGKWNRVTIRREGS 1800 5 GLLLFIYNKDGPDFLAIELKSGILSFRFNTSLTFTQVDLRLGMSYCDGKWNKVIIKKKDS 1807 6 GLLLFVYNKDGPDFLATELKSGLLSFLLKTSITFTQVDLWLGLSYCDGKWNKVTVKKAGS 1810 7 GLLLFVYNKDGPDFLAIELKSGILNVLLKTGIVFTQVDLWLGLSYCDGNWNKVTVNKEGS 1831 8 SLLIFAYNKYTEDFMLVEIEAGLLSVILAADGHMTELNMWVGLSYCGGDWKKLSLAKRGL 1788 9 ALLLFTYGTQTDDYMLVELEAGLLSFVLAAEGYVTELSMWVGLSYCDGDWKPLSLAKRGS 1827 10 GLVLFAYHQTG-SYLLIQIVAGTLQIQVSTGTGSPVILSIPNTSLCDGLWKSLFITKVAN 1666 11 GILFYATGSGQNFILAYLLSGIVRCIVSVG-ENEIELQLDSATPPCDGLWHQFKFINNNA 1830 12 GILLYATGSQDNILIVYLLNGVVRCLLSSGSAQDTEIQIDSTLPPCDGDWHELKVLNNAG 1805 C *****.++::+:++++.+*::*:*::.::::. :*::::.:+++:C+G:W:::.::+:++ 1930 1940 1950 1960 1970 1980 1 FISASVNGLMKHASESGDQ---PLVVNSPVYVGGIPQELLNSYQHLC------LEQGFGG 1861 2 FISASVNGLMKHASESGDQ---PLVVNSPVYVGGIPQELLNSYQHLC------LEQGFGG 1861 3 VVSVRVNALKKSTSQAGGQ---PLLVNSPVYLGGIPRELQDAYRHLT------LEPGFRG 1852 4 MVSVGVNELTKSTSRAGDQ---PPLLTSPVYLGGIPQELQASYRHLT------LEQGFRG 1851 5 LIAASMNELRECVSQSRAQ---PLMVNSPVYVGGTPQELQDSYKHLS------LEQGFGG 1858 6 VISASLNELMEHVSESSAQ---PLMVNSPFYVGGIPPLLRDTYKELS------LEQGFGG 1861 7 VVSASVNELREQTLEPNVQ---QLKVNSPVYIGGIPSEIQNIYKDLG------SELGFGG 1882 8 LIFAAVDDWAEEVRGEAAR----LSVDSALYLGGVPMELHHPALHSHRHGLGGCIRALII 1844 9 LISAAVNDWAEETRGEAVR----LRVDSPLYLGGVPMELTHAFTLST------LLYSLTG 1877 10 QLSASINGGASTGIQLSSS---SLSLMSSLHLGGVRDDSEAAGFLDTIEMN---TQGFGG 1720 11 QISIRVDNLESQIHRIETP-AAVFELTENLYIGGAPVLILNELFAKIEEG----ARSFGG 1885 12 QIFFRLDSVESDRMRVNFQSPSVFDLSTGLFVGGAPVQVLKELVTKIDEG----ARSYGG 1861 C .+++:++.+.:..:....+ :+ +:*+:*:GG:*.++...:.::. .. :::+++* 1990 2000 2010 2020 2030 2040 1 CMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSA-VNCRGNDSILVYQGKEQSVYEGG 1920 2 CMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSA-VNCRGNDSILVYQGKEQSVYEGG 1920 3 CVKEVAFARGVVVNLASVSSRAVRVNQDGCLSSDST-VNCGGNDSILVYRGSQQSVYESG 1911 4 CVKEVAFTRGAVVNLASVSSRAVRVNQDGCLSSDST-VNCGGNDSILVYRGSRQSVYESG 1910 5 CMKDVKFARGAVVNLASVSSSAVRVNLDGCLSTDSD-VNCRGNDSILVYQGKEQSVYESG 1917 6 CMKDVKFTRGAVVNLASVSSSAVRVNLDGCLSTDRA-VNCRGNDSILVYQGKEPSVYESG 1920 7 CMKDVKFTRGAVVNLASVSSSAVRVNLDGCLSTDSA-VNCRGNDSILVYRGKEQSVYENG 1941 8 HSGETNPPISQTIDLNLASRRSLRVYLDGCPTSESR-YNCRGNDSVLVYSGRTPSATDST 1903 9 CTSHRQWSLTQSVNLSVASRRSVRVYLDGCPTGESH-YNCRGNDSVLVYSGRKTQATDHS 1936 10 CMRQLTIDN-TAVNLTHDMTGILNVYLDGCPPITSSSIQCSDPQSVSVYDGSTMNFTDNG 1779 11 CMRNLQVDG-RSINLARDVTLAVNVDLDGCPVIEPVPASCMEAPISVVYTGMEQQHTDSG 1944 12 CIRNLEVDG-RRINLSRDVTLAVNVDLDGCPIKD-ADTSILIPDILNEGSGLPQPINSTL 1919 C *:::::::::::+*L+::+:.+*+V:*DGC:::++: :+*:++**:+**.G::++::::+ 2050 2060 2070 2080 2090 2100 1 ----LQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWD 1976 2 ----LQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWD 1976 3 ----LQPFTEYLYRVTASHEGGAVSSDWSRGRTLGTAPQSVPTPSRAQSINGSSVEVAWN 1967 4 ----LQPFTEYLYRVTASHKGGSVSSDWSRGRTLGSAPHSVPTPSRAQSINGYSVEVAWN 1966 5 ----LQPFTEYLYRVVASHEGGSVYSDWSRGRTPGAAPQSVPTPSRVRSVNGYSIEVTWD 1973 6 ----LQPFTEYLYRVVASNEGGSAESLWSRGRTKGTAPQSVPTPSRAHSINGYSIQVTWD 1976 7 ----LQPFTEYLYRVVASNEGGSVSSAWTRARTRESVPQNVPTPSRVHSINGYSIEVTWD 1997 8 ----LQPFSEYLYRFVAMATGGWAAGPWQRSRSRGKAPRSVPSPTVVQILDGFSATVSWS 1959 9 ----LQPFTEYLYRFVAVAAGGWAAGPWQRGRSRGKVPRSVPPPSTVQSLNGFSAMVSWG 1992 10 ----LHVFTEYLYQVTATNIAGSTDGAWAAGRTREGAPIGLSPPIDPVSITGYVIQLQWQ 1835 11 LDQS--VFTRYLYKVTSSNAGGQAQSEWMITRSGEGIPHTVPTPYNENALSGWQIEMEWR 2002 12 SQNSSQCIETYLYKVASANAGGQAQSDWMITRSGEGVPHTVPTPYNEETGSGREIKLEWR 1979 C **+***YLY+*:*+::*G::.+:W:++R+.+.+P:+**+P+::.+:+G:++:+:W: 2110 2120 2130 2140 2150 2160 1 EP--VVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNT--SNLTGILTGLLPFKNYAVTL 2032 2 EP--VVRGVIEKYILKAYSEDSTRPPHMPSASAEFVNT--STLTGILTGLLPFKNYAVTL 2032 3 EPA-VVKGVLEKYVLKAYSEDSSQ-PRVPSASTELHDT--STHSGVLIGLHPFHSYTVTL 2023 4 EPA-MVKGVLEKYILKAYSEDSAQ-PHMPSASTEFNNT--DIRTGILTGLHPFHSYAVTL 2022 5 EPV-VVRGVIEKYVLRAYSEDDPHSPRRPSATSELFNT--STLTGILTGLLPFKNYAVTL 2030 6 KPV-GVRGIIEKYIVKAYDKNGHH---VPAASVEFVNT--SALTGILTGLLPFKNYAVTL 2030 7 KPA-GVIGVIEKYILKAYEEDGPS---VPITIAELADT--SMLTGIVTGLRPFTNYAVTL 2051 8 PPSGDIRGLIDRYELKAYSRDQPE---VPPVKVTYSH---GEFTGVLSGLTPSTKYLVTV 2013 9 PPTGDLRGLIDRYELKAYNRDQPE---EPPIKAIYLAN--GNLTGVLPGLTPSTRYIITV 2047 10 RPS-GNTGLLTQYILSAYNLDLPD---IAPVQAVFTDTTFSENIGNITDVIPYTNYDVSV 1891 11 RPL-RTNGVIDNYTLTAVEIERGKVNLSMVQTATFAGN---IHIGNITGLTPWTSYSINL 2058 12 RPL-RTNGVIDNYTLTAVESAVP-IKNGTVVTATFNGD---IHIGNITGLTPWTSYSINL 2034 C :P. .::G++::Y:*+A*::+.: :..+::::::.:+ :.:+G:++**.P:::Y:+++ 2170 2180 2190 2200 2210 2220 1 TACTLAGCTESSH---------ALNISTPQEAPQEVQPPVAKSLPS-SLLLSWNPPKKAN 2082 2 TACTLAGCTESSH---------ALNISTPQEAPQEVQPPVAKSLPS-SLLLSWNPPKKAN 2082 3 TACSRAGCTESSQ---------ALSISTPQEAPQEVQAPVAVALPN-SLSFFWSLPRQAN 2073 4 TACSRAGCTESSR---------ALSISTPQEAPQEVQAPVAEALPN-SLSFFWSPPRQAN 2072 5 TACTLAGCTESSH---------ALNISTPQEAPQEVQPPTAKSLPN-SLVLSWNPPKKAN 2080 6 TACTLAGCTESTQ---------ALNISTPQEAPEEVQPPLAKSLPN-TLLLLWNPPKKAN 2080 7 TACTLAGCTESLH---------ALNISTPQEAPEDVQLPTATTFPT-SLLVGWSPPKTPN 2101 8 SACGPPGCTESPRDNRAQESDLRSHFTTPEEVPDAVSSPVTVTYPS-ALYLTWDPPARPN 2072 9 SACSPVGCTESLLNDNGDDNDLRSSLTTPEEAPDVVFPPAAVSSPS-VLYVTWEPPARPN 2106 10 TACTAGGCSESSA----------VSVRTREEAPSGVQSPEALSKTARTITAGWALPDRPN 1941 11 RACTVSGCSNSSG---------TIVVTTPEEVPEGVAEPFSEVTPH-NMTIRWPVPLHSN 2108 12 KACTVSGCSNSSG---------SIIVTTPEEIPEGVRDPTSSVTPY-NMTIKWLPPIYAN 2084 C +AC+::GC+*S+. :::::T*:E+P::V+:P:+.::*. :+.:.W.+P:.:N 2230 2240 2250 2260 2270 2280 1 GIITQYCLYMDGRLIYSGSEENYIVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLP 2142 2 GIITQYCLYMDGRLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLP 2142 3 GIITQYSLYVDGRLVYTGKGQNYTVTDLRVFAAYEIIVGACTQAGCTNSSQVILHTAQLP 2133 4 GIITQYSLYMDGRLVYTGKGQNYTVTDLRVFTAYEITVGACTRAGCTNSSRVILHTAQLP 2132 5 GVITQYSLYMDGMLIYSGSGENYTVTDLAVFTPHQFLLSACTHVGCTNSSLVILYTAQLP 2140 6 GIITQYSLYMDDTLIYTGLRENYTVTDLAVFTPHQFLLTACTLVGCTNSSQVTLFTAQLP 2140 7 GIITQYTLYMNGVPIYFGNGTRCVVKDLAVFTPHQFLLTACTIAGCTNSSQVTLFTAQLP 2161 8 GRITEYLLYHNNQIVYRGQDRQHNITGLGVYSTHVLALSACTSMGCSNSSQVTVLTSQLP 2132 9 GGITEYLLYHNNQMVYRGKDRQHNITGLRVYSTHVLVLSACTKVGCTNSSQVTLLTSQLP 2166 10 GIITSYQLQLNSVTVYTGTARNYTLSGLSVFNPYRLVLIACTQIGCSSSAEVTITTSELA 2001 11 GPITRYDLFHNDSVVYSGRSTFHVISGLPIYTPQNFRLEACTTAGCNTSDEVTLYSGQLP 2168 12 GQITRYDLFHNGTVVYSGFNTFHVIPGLPIYTPQNIRLEACTLAGCNTSEEVTLYSGQLP 2144 C G:IT:Y.L+:::.::Y:G...::::+:L:*+++::::*:ACT.:GC++S+:V:*:*:*L* 2290 2300 2310 2320 2330 2340 1 PEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTI-WSVIYNSTELFQ 2201 2 PEHVDSPVLTVLDSRTIYIQWKQPRKISGILERYVLYMSNHTHDFTI-WSVIYNSTELFQ 2201 3 PEQVDPPGLTVLDSRTIHVRWKQPRQLNGILERYILYILNPIHNSTM-WSVVYNSTEKLQ 2192 4 PERVDPPVLAILDSRTVHIQWKQPRQLNGILERYILYTLNPTHNSTV-WDVVYNSTENLQ 2191 5 PEHVDSPLLTVLDSRTIYVQWKQPRNVNGILERYILYISNHTRDFTI-WDVIYNSTELFQ 2199 6 PDNIDAPILTVLDSRTIYVQWKQPEKLNGILERYILYMADHEQNITI-WNVIYNNTELFQ 2199 7 PSHVDAPVLTILDSRTIYVQWKEPLELNGILDRYVIYIANNEQNFTK-WDVIYNSTELFL 2220 8 PGPLQAPTLTLLDSRTILVEWSRPTQANGVLEFYSIFLS---RDGSK-PVLIYNSSELFE 2188 9 PGPLHRPRLTLLDSRTILVEWSRPSHVNGVLEFYSIFLS---LEGAE-PVLVYNSSELFE 2222 10 PSSVDPPTLFPRSPRSIEARWTAPSQPNGILQRYVLYSS--TVNGVV-GDAVYNTSDLFT 2058 11 PLYVDQPMVTVRGPYTVEVRWLEPPILNGILERYILYLRDETKNDTMHGRVAYNSTMRLL 2228 12 PLYIDQPMATVRGPYTVEVRWLEPPILNGILERYILYLHDDSAEEIPPGRVVYNSTMMLL 2204 C P:.+*.P.**:+++**+.+:W::P:.:*G*L**Y:+*.::.:.:.+. :.+:YN*++++: 2350 2360 2370 2380 2390 2400 1 DHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSW 2261 2 DHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKALSYLPDSFNVSW 2261 3 AHVLHHLSPGGLYLIRLRVCTGGGCTTSEPSQALMEETIPEGVPAPRAHSYSPDSFNISW 2252 4 THLLYHLSPGCLYLIKLGACTGGGCTTSEPSQALMDETVPEGVPAPRAHSHSPDSFNISW 2251 5 DHQLRHLSPGNKYLIKLGACTGGGCTVSEASEALTDEGAPEGVPTPKAHSSSPHSFNISW 2259 6 DHTIRHLLPGTRYLIKLAACTGGGCKISEISIALTDETVPEGVPAPTAQSYSSDSFNISW 2259 7 DFTIRHLFPGTEYLIKLAACTGGGCSISEASTAVTDESTPEGVPAPKAQSYSSDSFNISW 2280 8 DHTLRSLSPGTAYTITVAACTGGGCTLSPPSQAHTEESSPENVPAPLATPLSPHAFNVSW 2248 9 DHTLRDLTPGTVYSITIAACTGGGCTLSPPGRAQTEESTPENVPAPLVTPLSPNALNVSW 2282 10 DFIINDLSPGTVYYLSVAACTGGGCTISAQSSVRTEESIPEGVPAPIITAASPLELVVTW 2118 11 DHTITDLIAGTPYQITLAACTGGGCVLSTPTLCRTSESVPEEIAEPSLEATSPSTIQASW 2288 12 DHTLTDLIAGTQYQITVAACTGGGCTFSSPTPCRTSESVPEEIDAPTLVATSPNMIQASW 2264 C **:+::*:*G:.Y:*:+:*CTGGGC+.S::+.+:*:E:.PE+***P.+.::**::++:*W 2410 2420 2430 2440 2450 2460 1 TEPEYPNGVITSYGLYLDGILIHNSSELS--YRAYGFAPWSLHSFRVQACTAKGCALGPL 2319 2 TEPEYPNGVVTSYGLYLDGILIHNSSELS--YRAYGFAPWSLHSFRVQACTTKGCALGPL 2319 3 TEPEYPNGVITTYELYLDDTLIHNSSGLS--CHAYGFDPGSLHTFQVQACTAKGCALGPL 2310 4 TEPGHPNGVITTYELYLDGTLIHNSSELS--CHAYGFDPGSLHTFQVQACTAKGCALGPL 2309 5 TEPEYPNGVITSYGLYLDGILIHNSSELS--YHAYGFAPWSLHSFRVRACTAKGCALGPL 2317 6 TKPEYPNGVLTTYGLYIDGVLMQNLSCLT--YYAHGFAPWSLHSFRVQACTAKGCALGPL 2317 7 AKPEYPNGIITSYGLYMDGVLIQNSSQLN--CYAYGLAPWSLHSFRVQACTAKGCALGPL 2338 8 TLPHTPNGIITSFGLWLDGVQILNSSSTQRFFVVDGLEPWSRHILRLQACTARGCGKGPM 2308 9 TPPDTPNGIITSYGLWLDGALISNSSSSLRFLVVEGLSPWSRHLLRLQACTARGCGKGPM 2342 10 THPTQPNGVIISYALVQNGIVIQNSTSMS--YTASNLSPWSLHVFRVEACTSKGCTFGPE 2176 11 LRPNLPNGDITLYSLFHNDKLIHNSTSPS-TTEIGDLLPWSRHTFRVRVCTARGCSFGPE 2347 12 SEPALPNGDITLYSLYHNDRLVHNSTTPS-MTDMVDLLPWSRHTFRVRVCTARGCSFGPE 2323 C +:P::PNG:**:*:L+:++.**:N*+.:+ :.+:+::P*S+H:***+*CT*+GC::GP: 2470 2480 2490 2500 2510 2520 1 VENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYT 2379 2 VENRTLEAAPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTYSVLFTGIFYVDPVGNNYT 2379 3 VGNRTLEAPPEGVVNVLVKPEGSREAHVRWDAPAHPNGRLTYSVHFTGSFYADQAGDNYT 2370 4 VENRTLEAPPEGTVNLFVKPEGSREAAVRWDAPPHPNGRLTYSVLITGNFYADQAGDNYT 2369 5 VENRTLEAPPEGTVNVFVKTEGSRKAHVRWEAPSHPNGHLTYSVLFTGLFYADQADNNYT 2377 6 VENRTNEAPPEGAVTVFVILEGPREVKLKWEAPLSPNGRLTYAVFFTGLFYVEQVKYNYS 2377 7 VEARTMEAPPEGAVDVFATVDGSKEAQLKWLAPNKPHGQLTYTVFFTGLFYADQANANYS 2398 8 VEARTLEMAPEGAVLLELNHVSSRSLRARWTAPSRPNGNLIYTLHYKSKD---------- 2358 9 VEVRTLQMAPEGPILLELTNQSSRSLRARWTAPPRPNGNLGYTLYYKSKVYRERRDDKLI 2402 10 GSGRTLEAPPQGSIDLAVFTMGSRSVKATWTSPAQPNGMLVYEVLFTGIFYVAPEASNYA 2236 11 ASIRTLESAPQGRVQLSVTVLGASTIEAKWEEPEQQNGLLTYTVLCTGLFYKELSGNEIQ 2407 12 ASIRTLESPPQGRVQLSVTVLGASTIETMWEEPEHQNGHIMYTVICTGLFYTERPGQGIK 2383 C ++:RT**++P+G.*:::+:..*++.:.::W:+P .**G.*+*:*::**:**.::.:.++: 2530 2540 2550 2560 2570 2580 1 LLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVL 2439 2 LLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPVTIAMPPGAPDGVL 2439 3 LLSGTKTIRGIEGSRLWVLVDGLVPCSHYMVQVNASNSRGSVLSDPVSVEMPPGAPDGLL 2430 4 LLSSTKTVHSSKGDRLWVLVDRLVPCSNYTVQVNASNSQGSVLSDRVSVEMPPGAPDGLL 2429 5 LLNGTQVMHSGEETNLWVLIEGLVPFTDYTVQVNVSNSQGSLISDPITFAMPPGAPDGVL 2437 6 LLNDTQILYHTEEANLWVPISGLVPFSNYTVEVNASNSQGSVISDPITIKMPPGAPDGVL 2437 7 VVNGTRILCSSNESNVWVPIKGLIPFSNYTVQVKASNSQSSLMSDTITIVMPPGAPDGVM 2458 8 ---GDGVLDRSTAAGSWLTVTDLQPYTNYSFWIRGCNTQGCVDSLRVNVTTPPAAPDGLS 2415 9 FPYGEGVLDGSTAAGAWLSVTDLHPYTNYIFWIRGCNTEGCVESLPLNVTTPPAAPDGLS 2462 10 LVTETRALYNGTIANEIVDITGLIPYSAYTIQVRAYNTEGSILSNQRTVTMPTGNADGVL 2296 11 TIRETRNLLNTTDSQEWIRINDLVPYSDYVVKVNASNTAGYLISNLRSISMPPGLPYGLK 2467 12 AVRDSRNMLNSTESQEWMRINDLVPFSDYTVKVNASNSAGYVISNQRSISMPPGLPYGVN 2443 C ::::+.::.::::.::*+:+.:L+P:::Y++:*+:+N+:*+::*::.::.*P**+**G:: 2590 2600 2610 2620 2630 2640 1 PPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSD 2499 2 PPRLSSATPTSLQVVWSTPARNNAPGFPRYQLQMRSGNSTHGFLELFSNPSASLSYEVSD 2499 3 SPRLAAAAPTSLQVVWSTPARNNAPGSPRYQLQMRPGPSTHGRLELFPIPSASLSYEVTG 2490 4 SPRLAAATPTSLQVVWSTPARNNAPGSPRYQLQMRPDPSTRGLLELFPIPSALLSYEVTG 2489 5 PPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRPGHSTHGFLELFSSPSASLSYEVRD 2497 6 PPRLSSATPTSLQVVWSTPVRNNAPGSPSYRLQMRPSHSMDGILDLFSDPSASVSYVIGD 2497 7 PPRLSSATPTSLQVVWSTPVRNNAPGAPSYRLQMRQRHSAGDILELLSSPTASLQHSIRD 2518 8 PPRLVHATSRSLTVSWAAPAHSNAPGPLLYSLQMRATQ-QRPVIRLLENVTDTFSYHVAD 2474 9 PPRLAHRTSASLNVSWSGPAHSNAPGPLRYSLQMRTSP-QRPVIRLVENATETFAYHVEG 2521 10 PPTLISTGPTSIQATWTEPARNNAPGDPSFQLRYRPANQPGNQIDVFSNSVRVTSYTLTG 2356 11 SPQLMSHSP-SILAQWRDPVRNNAPGNSMFQLVYRAVNPPATEVALFVSETRQMSYNLTG 2526 12 PPQLTSHSPDSILAQWEDPVRNNAPGNSMFQLLYRTVSPPGNEIALFTSETRQMSYNLTG 2503 C +P+L:+++*+S+++:W+:P+**NAPG:+:++L++R:..::.:.::*+:::::::**:::: 2650 2660 2670 2680 2690 2700 1 LQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKPG--PVVPPILLDVKSRMMLVTWQHPR 2557 2 LQPYTEYMFRLVASNGFGSAHSSWILFMTAEDKPG--PVVPPILLDVKSRMMLVTWQHPR 2557 3 LQPFTVYEFRLVATNGFGTAYSAWTPLMTTEDKPG--PIDAPILINVKARMLSVIWRQPA 2548 4 LQPFTVYEFRLVATNGFGSAYSDWTPLMTTEDKPG--PMDAPVLN-VKAGMMSVAWRKPT 2546 5 LQPYTEYEFRLVASNGFGSAPSSWILFVTTEDKPG--PVDPPILLDVKSRMMLVTWQHPL 2555 6 LQPFTTYELRLIASNEYGSTYSDWTSLVTTEDKPG--PIDPPFLLDVSPRTMTLKWQHPS 2555 7 LQPYTEYEVRVVASNGYGHAYSNWTSMTTAEDKPG--PLDPPLLLNATSRAASITWQHPL 2576 8 LSPHTQYWFRVVVVHTHGQTLSPWASLLTAEDVPG--TMDPPIVSELHPNSATITWTPPS 2532 9 LSPYTQYMLRVVISHAHGQTVGPWATLRTAEYSPG--PVDTPVVSRLQSRSVTTTWVPPS 2579 10 LQAFNEYEFRVIAINNAGQTLSQWAAVFTREDVPG--PIDPPMATDVRPYSTIVTWEFPD 2414 11 LEPHTKYEFQLVASNPYGSTVSEWAAIFTQQDRPTPSSWILQLCFEIDSWSLHITWESPS 2586 12 LEAYTEYEFQLVGSNPFGSTSSGWASIYTKQDRPT--SMDPPIVYEIDSWSVHVTWESPS 2561 C L+*:*:Y++*+*++*::G::.*.W:.:.T:**:P* +.++*::::::::::.:+W::P: 2710 2720 2730 2740 2750 2760 1 KSNGVITHYNIYLHGR--LYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQ 2615 2 KSNGVITHYNIYLHGR--LYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQ 2615 3 KCNGAITHYNIYLHGR--LYLTVSGRVTNYTVVPLHPYKAYHFQVEACTSQGCSKSPSSE 2606 4 ECNGAITHYNIYQHGR--LYLTVSGGVTNCTVVHLRPHTAYQFQIEACSSKGCSMSPASE 2604 5 KCNGVITHYSIYQHGH--LSLKTSGNVTNCTVIHLRPYTPYKFQVEACTSKGCSLSPESQ 2613 6 RPNGVITHYNIYKNGH--FHSKLSGKISNSTMLNLHPNASYHFQLEGCTSKGCSLSPETR 2613 7 KQNGIITHYNIYQNGE--LCATVSGASSNYTVEDLHPYTVYEFQVEGCTYKGCSLSPKTP 2634 8 PPNGIITNYSLCVCPSSVCSR-IPGNITTSSLMDLLPFQTYTLQMEACTRVGCSVSGMSE 2591 9 QPNGIITKYTLYHLHTSIVSVAVPGNTSSYTFFNLPPYQNYSLQVEACTSVGCSVSGMSQ 2639 10 TPNGIITSIKLYQNNV--LKTTLAGNATQLLIDDLTPFSDYMFSVEMCNTVGCTRSPDSI 2472 11 QPNGVVSSFRLFENDR--LRVELPGNTTELRADGLTPFSTYSYR-----WWGCTSSAESN 2639 12 QPNGIVGSFRLIENER--LRTELPGNFTEFRADNLSPFTTYSYRVEACTEAGCTSSETSA 2619 C ::NG:**:+::+.::: +.:..:G+:+:.+:..L:P::.Y.+++*+*+::GC+:S+:*. 2770 2780 2790 2800 2810 2820 1 TVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTL 2675 2 TVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTL 2675 3 TVWTLPGNPEGIPSPQLFPYTPTSIIVTWQPSAHLDLLVENVTIERRVKGKKEVRNLVTL 2666 4 TVWTLPGTPEGIPGPELLPYTPTKIIVSWQPPTHLDGLVENITIERRVKEQEEVRSLVIL 2664 5 TVWTLPDAPEDIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIDRRVQGEEEVTTLVTL 2673 6 TVWTLPDAPEDIPNPELYSDTPTSVSISWKLPLFPNGQLENFTIQRKSKGMEQVTTLVTL 2673 7 AIRTLPDVPEGIPAPELYSDTPTSVVISWQPPAHPNGLVENLTIERRVKGTKELSTVVTL 2694 8 SFRTLPAAPEGVPAPHLYSETPTSVLLSWGAPEWSNAPLERWVIERKVAGSKQVSTVGSL 2651 9 HFRTLPAPPEGVPAPHLYSDTPTSVLLSWGAPEWSNGPLERWLIERRVTGTKRVSTVGHL 2699 10 TYTTPQAAPSGQSPPVLSSPTPTSVQLSWSPPSMPNGVLTGYEIERRHQGFTAIFSVVSV 2532 11 RVTTSAAAPEDFQAPILRSDSPSSVFISWKQPTYSHGILGNYKLERRLNSSDPENSEITL 2699 12 SVTTSAAAPEDFQAPTLRSDSPSSVFVSWRRPTYSHGILDNYKLERRLNTSDPENSPVTL 2679 C :+:T++:+P*+:+:P:L.*+*P***::*W::*:::+*::++.:**R*+:+.::+.::++* 2830 2840 2850 2860 2870 2880 1 PR----SHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPS--RPAGVQP 2729 2 PR----SHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPS--RPAGVQP 2729 3 AR----SQAMKFIDNDPALRPWTRYEYRVLGSTLDGGTNSSAWVEVTTRPC--RPSGVQP 2720 4 PR----SQAVRFIDNDPALRPWTHYEYRVLGSTLNGGTNSSAWVEVTTRPS--RPSGVQP 2718 5 PR----SHSMRFIDKTPALSPWTKYEYRVLMSTLNGGTNSSAWAEVTTRPS--RPAGVQP 2727 6 PL----NHSMKFVDQTSALSPWTTYEYRILMSTLNGGTNSSAWVEVTTRPS--RPAGVQP 2727 7 PF----SQSMSYIDQSTALSPWQKFEYRILMSTVNGGTNSSAWSEVTTRPS--RPAGVQI 2748 8 PAD---SPPLSFLDVSSALSPWTNYQYRLLLHNQAGNTTG-PWVNITTRPS--RPAGLSP 2705 9 PPD---PPPLSFLDSSSALSPWTSYQYRLSLHNQAGNTTG-PWANVTTRPS--RPAGLSP 2753 10 AA----GAPRAYLDLSAAITPYTAYEYRVKVTNAAG-SSTSQWASVITKEA--PPGGVRE 2585 11 LGSFAPSQSPRYLDEGMELRPYTGYQYRVVASTLAGGSTISEWSTIRTRPRPVRPGGVLA 2759 12 LGSFVPSQLPRYLDESIDLRPYTSYQYRVVASTLAGGSTISEWSTIRTRPG--RPGGVLA 2737 C +: +::::+:D.::**:P+*.*+YR++:+++:G++::*:W::++T**+ *P:G*:+ 2890 2900 2910 2920 2930 2940 1 PVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTS--AVLSQKVTHLIPFT 2787 2 PVVTVLEPDAVQVTWKPPLIQNGDILSYEIRMPDPHITITNVTS--AVLSQKVTHLIPFT 2787 3 PTVRVLAPDTVEVSWKAPLMQNGDILSYEIRMPEPLIKMTNMSS--IMLSHLVKHLIPFT 2778 4 PTVHVLGPDAVEVTWKAPLIRNGDIVSYEIRMPDPLIEITNVTS--FVLSHLVKHLIPFT 2776 5 PVVHVLGPHTAEVTWKPPLIQNGDMLSYEIRMPDPHITITEVTS--SGLSRVITHLIPFT 2785 6 PEVLVLGPDMAKIIWSPPLIPNGNILSYEVCMPDPRIRVTPSGSNTSLLSQIMSHLIPFT 2787 7 PDAEVQGPHSVKVSWKPPLIQNGEILNYEIRMPDPRIVIAGNSA--STLSYLVTNLLPYT 2806 8 PKVNVLGPESLQVTWSPPLNPNGEIHGYEIRLPEPHISHNSGNT--SDLNVTVTDLIPCT 2763 9 PRVKVTGPESLQVTWSPPLIPNGEIHGYEIRLPEPRIFHESGKA--SEFSIPVTALVPYT 2811 10 PSVTVLGPDSVMVSWEEPAMSNGEILSYTIRMPDPRIYLDQTNMT----SYIVYNLVPYT 2641 11 PSVQISSSESATIRWQSPTQENGPIIRYEISFPEPKIPIIDISQ----RDYNITDLIPYT 2815 12 PSVVVSGSESAHIQWQRPVQENGPIIRYEISFPEPKIQIYDITQ----RDYNITTLIPYT 2793 C P.*.*++*:::.+:W::P+::NG:*::Y**++P:P.I.::..:: :.++..++:L+P:T 2950 2960 2970 2980 2990 3000 1 NYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKP 2847 2 NYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKP 2847 3 NYSVTIVACSGGNGYLAGCTESPPTLATTHPAPPQELAPLSVILLSESDVGISWQPPSKP 2838 4 NYSVSIVACSGGHGYLGGCTESLPTFATTHPALPQELTPLSISLLGQSYVGISWQPPSKP 2836 5 NYSVTIVACSGGNGYLGGCTESLPTQVTTHPTLPQGINPLLVIPLSESYVGISWQPPSRP 2845 6 NYSVTIVACSGGGGHLGGCTESLPTHIITHPTIPQGIGTLSVTPVSESYIGVSWQPPSRP 2847 7 NYSITVVACSGGNGLLGGCTESLPTSVTTPSTAPEGISPLSVTPISESFIAISWQPPLRP 2866 8 NYSITVLACSTGGGHIGGCTESLPTSATTLPTIPEGLQPLSVVAISESFLAVSWQPPRRP 2823 9 NYSITVLACSNGGGHVGGCTESLPTPAATLPTIPEGLEPLSVVAVSESFLAISWQPPSRP 2871 10 DCSVTIEACTAG-----GCTQSNPTLVTTDPTLPFGQSPPRGDAITQTYISVIWSPPVRP 2696 11 RYQVTITACTIG-----GCTESPSTNIMTEPDVPRGLAAPVATPISERYVNVQWRPPTYP 2870 12 SYQITITACTIG-----GCTESPTTDVMTDADVPRGLAPPVATPISERYVNVQWRPPTFP 2848 C +**+*+:AC+:G:+::+GCT*S+*T :+T:*+.P:+:.*+++.::**++:.:+W+PP::P 3010 3020 3030 3040 3050 3060 1 NGPNLRYELLRRKIQQPLASN-----------PPEDLNRWHNIYSGTQWLYEDKGLSRFT 2896 2 NGPNLRYELLRRKIQQPLASN-----------PPEDLNRWHNIYSGTQWFYEDKGLSRFT 2896 3 NGPNLRYELLRCKIQQPLASN-----------PPEDLNLWHNIYSGTRWFYKDKGLSRFT 2887 4 NGPNLRYELLRRKIQQPLASN-----------PPEDLNLWHNIYSGTRRFYEDKGLSRFT 2885 5 NGPDLRYELLRRKIQQPLASN-----------PPEDLNLWHNIYSGTQWFYEDKGLSRFT 2894 6 NGPHLRYELLRRKIQQPLASN-----------PPEDLNLWRTIYSGTQRFYEDKGLSRYT 2896 7 NGPHLRYELLRRKIQQPLASN-----------PPEDLNLWHNIYSGTQWFYEDKGLSRYT 2915 8 NGPNIRYKLLRRKTQQPLATASVPTETAPSPPPPEDLHRWLHVYSGTKLFYQDKGLSRFT 2883 9 NGPNIRYKLLRRKTHQPLAVAAVPKVTAVSPPPSEDLHRWLHVYSGTKLFYQDKGLSRFT 2931 10 NGPNIRYELHRQKLREPLSTG-----------PVQGLNFWQFIYNGEDTTFQDFGLSTFT 2745 11 NGPGVYYELSRTILFQPLLVQ-----------QPTYINVSENIFTGNGLIYEDRSLQKFT 2919 12 NGPGIYYELSRTIISQPLLVD-----------QPSYINVTENIFTTNGLIYEDRSLQRFT 2897 C NGP::*Y*L+R+*++*PL+:: **++**:*:+**+*+::+*+D+*L***T 3070 3080 3090 3100 3110 3120 1 TYEYMLFVHNSVGFTPSR-EVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQG 2955 2 TYEYMLFVHNSVGFTPSR-EVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQG 2955 3 TYEYKLFVHNSVGFTPSR-EVTVTTLAGSPERGATVTASILNHTAIDVRWKKPTFQDLQG 2946 4 TYEYKLFVHNSLGFTPSQ-EVTVTTLAGSPERGATVTASILNHTAIDVRWKRPTFQDLQG 2944 5 TYEYQVFVHNSVGFTPSQ-GATVTTLAGLPERGANLTATVLNHTAIHVTWAKPTFQDLQG 2953 6 TYEYKLIVHNIVGYAPSK-EAIVTTLAGLPEKSATLEIQDLNHTAIRVGWSRPTLKDLQG 2955 7 TYEYKLIVHNEVGYTSSE-EVIATTLAGLPEKGSILIARAVNHTAVEVEWSKPTLQDLQG 2974 8 HYQYQLEVHNDVGFSTGE-MVYAVTMAGIPHHRPSVSAYAINHTAVQVNWTQPTLQDLQG 2942 9 RYHYQLVVHNDVGRSSGE-IVTAVTMAGVPHHPPSLSAHAVNHTAVQVTWTQPSLQDLQG 2990 10 TYIYRITVYNDIGSATSDPSDEVTTLAGQPTVAGTISAVAMDHISVLLNWTTPSLLQLQG 2805 11 TCEYRLSVFNSVGSMASN-SSIVTTHAGVPTSPAELYVAIHNHTSAYIWWEPPDIYELQG 2978 12 TCEYRLSVFNTVGSMASN-STRVTTHAGFPSSPGVLEVAIHNHTSALLWWRPPDLFALQG 2956 C **+Y.*:V+N:*G:::*. :::+*T+AG:P::::.+:+..:*H*+:.+.W.:P+:++LQG 3130 3140 3150 3160 3170 3180 1 EVEYYTLFWSSATSNDS--LKILPDVNSHVIGHLKPNTEYWIFISVFNGVHSINSAGLHA 3013 2 EVEYYTLFWSSATSNDS--LKILPDVNSHVIGHLKPNTEYWIFISVFNGVHIINSAGLHA 3013 3 DVEYYTLFWSSGTSEES--LKIFPDVDFHVIGQLSPNVEYQVFLLVFNGVHAINSTVVHV 3004 4 DVEYYTLFWSSGTSVES--LKIFPDVDFHVIGHLAPNVEYQVFLLVFNGVHAINSTVVRV 3002 5 DVEYYTLFWSSATSNES--LKILPDVNSHVISHLNPNTEYRIFLSVFNGVHSISGEVLHA 3011 6 DVEYYTLIWSSATSNES--LKILPDVNCFVIGDLKPNTEYQIFICVFNGAHSINSEVLHV 3013 7 DVEYYILSLNSTADGRS--LRIQADENYIVIGDLQPNTEYQIFFQVFNGAHSINSEVVHV 3032 8 EVESYFLSIEAAMFIQN--LILPPSTVSTIIRDLWPSTTYLVSLQVSNGAHNTTKASVNV 3000 9 QVEFYFLTIMSAQLSKV--LVFPPEILSAVISNLWPSTTYLLSLQVSNGAHNTTKVEVNV 3048 10 DVVNYFILVSSPSRQYE--LTYDPGVSSDLLTSLMPNTEYEFRQVIYNGAFNITSLPAVT 2863 11 KVHYYYIRYYSDRNSSDLIRKFPPSTSSWVVSDLLPGTTYVFTLDVDNGAHNVTSSPVQA 3038 12 RVHNYYIRYYSTRNDSDRIHKFPPATTSWVVSNLYPGTMYVFTLDVDNGAHNVTSAPVQA 3016 C :V++Y:+:::*:::..: *+:.*:::+:*+:.L.P+*+Y.:::.*:NG:*:+:+.:::: 3190 3200 3210 3220 3230 3240 1 TTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKLYKTGMNVPGSFI 3073 2 TTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKLYKTGMNVPGSFI 3073 3 TMWEEEPQGMLPPEVVIINSTAVRVIWTSPSNPNAVVTESSVYVNNKLYKTGTDAPGSFV 3064 4 TTWEEEPRGMRPPEVVIINSTAVRVIWTSPSNPNAVITESSVYANNELHKAGAGAPGSFT 3062 5 TTFDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSVYVNNKLYKTGMNVPGSFI 3071 6 TTRDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSVYVNNKLYKTGMNAPGSFV 3073 7 ITSDGEPEGMFPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKQYKTGMNEPGSFL 3092 8 TTEDGEPEGMMAPEVIPVNSSVARVLWLPPQQPNGAVTGYHVYVNDRLHGSVDNSSGSYL 3060 9 TTQDGEPAGISAPEMVPVNSSIVRVLWSPPLQPNGAVTGYSIYLNDHLHGSVDNSSGSYL 3108 10 LTLDG---GFAAPLISVLSPSAVNVMWLPPTQPNGDITQYVIYLDGERHGSVESNQLLYI 2920 11 TTDDGAPVGVGTPVINAISPSQLRVSWHAPEQPNGRIVTYNIKIDQITIVTNMTEAGSYI 3098 12 TTDDGAPMGVGIPVINSISPSQLRVSWLAPLQPNGRIVTYCILINNNSYVTNMTEAGSYT 3076 C ** **+*:G+::P+++:+++:++*V:W::P::PN*:+*:*+:*:*+:+::+:::.:**:: 3250 3260 3270 3280 3290 3300 1 LRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSP 3133 2 LRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSP 3133 3 LEDLSPFTIYDIQVEVCTKDACVKSNGTQVSTAEDTPSDISIPVIRGITSRSLQIDWTTP 3124 4 LEDLSPFTIYDIQVEVCTKDACVKSSGTQVSTAEDTPSGISIPIIRDITSRSLQIDWTAP 3122 5 LRDLSPFTIYDIQVEVCTKYACVKSNGTQFTTVEDTPSDIPTPTIHGITSRSLQVDWMSP 3131 6 LGDLSPFTIYDIQVEVCTKYACVKSQGTKITTVEDTPCEIAAPKIHIISSRSLQIDWESP 3133 7 LADLSPFTVYDIQIEACTVYACVRSNGTQITTVEDEPEQLSAPVIHVIGSRSLQINWVSP 3152 8 LGDLLPFTVYNIQVKVCTVYACVWSDVTQTTTVEDLPADLVTPHAQVITPRVVRLDWSHP 3120 9 LGNLLPFTVYNVQVEVCTVYACVRSNITQTTTVEDLPADLAPPHAHVINPRVVRLDWSHP 3168 10 MAGLQPYTIYSIQVEVCTEYDCLLSNATVVTTLEIPPSGVTAPNLLVLGPRALEVSWASP 2980 11 VNDLRPYTVYNIKIEACTVYACDEGNSTQATTLETNPSDISPPNIQLAGANSVEIQWNEP 3158 12 VNNLRPYTVYNIKIEACTVYACAESNTTQATTLENNPTNIDAPTIQLAGTNSVGLEWSVP 3136 C +.+L:P+T:Y:**+*+CT:**C+:*+:T*.*T:E+:P::+..P.+..+::*++::+W.:P 3310 3320 3330 3340 3350 3360 1 RKPNGIILGYDLLWKTWYPCAKTQKLV--------QDQSDELCKAVRCQKPESICGHICY 3185 2 RKPNGIILGYDLLWKTWYPCTKTQKLV--------QDHSDELCKAVRCQKPEYICGHICY 3185 3 ANPNGIILGYDVLRKTWRPCSETQKLT--------DKPRDELCKAVKCQYPGKVCGHTCY 3176 4 GNPNGIILGYDVLRKTWRLCSETQKLT--------DKPRDELCKAVKCQYPGNVCGHTCY 3174 5 GKPNGIILGYDLLRK-KHSCPKIQKLR--------KDHSGVLCKAVKCQKPKSVCGHRCY 3182 6 AQPNGLILGYELLRKTWYSCTISQKVI--------GNQNDGFCRIIRCQKPDNICGHMCY 3185 7 RQPNGIILGYEVLRKAFKRCTPAARSS--------RNTR--MCIPLECKKHENVCGEVCY 3202 8 SRPNGIMLGYEILRRTLRSCAPGSAVITSSLGEGSVGGLGSRCSYLECPATHGVCGMSCF 3180 9 GRPSGIMLGYDVLRRTLRSCAIGSTGVTSSV-EDVPGGVRFRCLYLQCLASHGVCGTACF 3227 10 ASPNGIILGYEIQRREYQPCSDRPSTP--------SDGSESSCGYVECLRSESVCGNQCY 3032 11 RKPNGIIRSYQIHRRAMLQCKENQPEID-----------ERSCTYVKCVRGERVCATQCY 3207 12 RRPNGIIRSYQIHRRAMLPCTQNQPEID-----------ERSCTYVKCPRGQKVCSTECY 3185 C :.P*G****Y:.+*:::.:C...+::. ...:.:C::+:C::::.+C*: C* 3370 3380 3390 3400 3410 3420 1 SSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTG--VCCGGRIQEAQPNHQCCSGYYAR 3243 2 SSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTG--VCCGGRIQEAQPNHQCCSGYYAR 3243 3 SPGTKVCCDGLLYDPQPGYSCCEDKYIALSPNATG--VCCGGRMWEAQPDHQCCSGHYAR 3234 4 SPGTKVCCDGLLYDPQPGYSCCEEKYIALLPNSTG--VCCGGRQREAQPDHQCCSGHYIR 3232 5 SPEAKVCCNGVLYDLQPGHHCCEEKYIPFILNSTV--VCCGGRIREAQPNHRCCSGYYAR 3240 6 SPESKVCCNGILYDLKLGYVCCEDNYIPFGPNSSR--ICCGGRMHEIQPKYQCCSGYYTR 3243 7 HPEMKVCCNGILHDNKPGFQCCEDKYIPFILNSPG--VCCGGQIHAVQPKHQCCGGYYTR 3260 8 HTDTQVCCDGRIYTKRPGHHCCQSSYLSWSNSSNP--VCCSGKLLQLLPNHQCCGEYYVP 3238 9 DPDVQVCCSGFLYTKKPRHECCEGSYLGSSNSSNP--VCCNGKLLPASPDHHCCRGNYIH 3285 10 S-GLQACCDGILHEPQSGYQCCDTNYLPAPVNASTPYVCCGGQFHTEQIDHECCNGQYVQ 3091 11 SPTNQICCNGVLHDVDSMKRCCGQNYVAITSHSSD--VCCGGRLHPWLEGHSCCSGKYIE 3265 12 SPTAKVCCGGVLYNVDAMKECCDRNYVLVRSHITD--VCCGGRLHSNVEGYRCCSGKYLE 3243 C ++:.+*CC:G:*+:::++:.CC+.:Y:::..++:: *CC*G+.:::++.*:CC+*:Y.: 3430 3440 3450 3460 3470 3480 1 ILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGR---QIV 3300 2 ILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGG---QIV 3300 3 ILPGEICCPDERHNRVSVGFGDACCGTMPYATSGSQVCCAGRLQDGYRQQCCGG---EMV 3291 4 ILPGEICCPDERHNRVSVGFGDACCGTMPYATSGSQVCCAGKLQDGYRRQCCGG---EMV 3289 5 MLPGEVCCPDEQHNRVSTGIGDSCCGRLPYSTSGNQICCAGRLHDGYGQQCCGG---QIV 3297 6 VLPGEICCLDDEYKRVSVGIGDTCCKNIPYSTSGNQICCAGVLHDGYKQQCCGG---KVV 3300 7 ILVGEVCCPNEEQNRVSVGIGDSCCHGMPYSTSGNQICCGGSLHDSFSQQCCGG---EVV 3317 8 VKSNEYCCPDHSWGRVSVGLGDSCCGGVPYSLRGGQLCCSGTLHDGFGVHCCGG---RLV 3295 9 VKTNEKCCPDHEQGRVSVGPGDRCCGGVPYSMKGGQLCCSGRLRDGYGVQCCGG---RIV 3342 10 VFPGQICCPDPDENRVAVGSGDACCAGVPYDSSGPQICCAGQFADGMSGQCCGG---VMV 3148 11 VRKMEMCCKDPIEDRVAVGVGDACCGGVPYSDNGLQICCDGVLHDGFNRQCCGALLTQVV 3325 12 VGEMEVCCQDPIEDRVSVGVGDSCCGGVPYTDNGLQICCDGSLHDGFERQCCGG---MVV 3300 C :::+*:CC+*:.::RV**G:GD:CC+::PY+:+G:Q+CC:G:*+D*:::+CCG* ..V 3490 3500 3510 3520 3530 3540 1 SNDLECCGGEE-GVVYNRLPGMFCCGQDYVNMSDTICCS-ASSGESKAHIKKN----DPV 3354 2 SNDLECCGGEE-GVVYNRLPGMFCCGQDYVNMSDTICCS-ASSGESKAHVKKN----DPV 3354 3 SQDFQCCGGGEEGMVYSYLPGMLCCGQDYVNMSETICCS-ASSGESKAHVRKD----DPT 3346 4 SQDFKCCGGGEEGMVYSSLPGMLCCGQDYVNMSDTICCS-ASSGDSKAHVRGS----DPM 3344 5 SKDLECCGGEEEGMPYSRLPGMFCCGQDYVNMSDTICCS-ASSGESKAHVKKN----DPV 3352 6 SKELVCCGGEEEGSIHISLPEMFCCGQDYVNMSDTICCS-ASSGESKAHVKKN----DPV 3355 7 STDLVCCGDEEKGTAYEAHTGMFCCGQEYVNVSDTICCS-GSSGESLAHVRKN----DQV 3372 8 EDTLVCCSDADGGEVHTYVPGFICCGQDYINSSTSLCCV-SHDGKPTTHPAGN----ATV 3350 9 DDFLVCCGDAERGDAHTYTPGFACCGTEYINSSTSLCCV-GNDGYPTLHAAGN----ATV 3397 10 AASQTCCSEGDMGVAYLPVEDNVCCGTEYVNMVISLCCT-SESGIAETYTYDTPDAKQQS 3207 11 SADKICCGNSIDGAVYVAVDTNVCCGLQYLPRNLTLCCEDADTNQAKAHLVLN---MTSS 3382 12 TSDKQCCGNTIDGAVYDQNDSNICCGLQYLPRNLTKCCEDHDTKQARAHLVLN---MTST 3357 C + +:.CC*::+.G.:+..:++::CCG+:Y+*:+:+:CC: ::+*:::+*:.:+ ::: 3550 3560 3570 3580 3590 3600 1 PVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKE-CR--ILCPASMEATE 3411 2 PVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKE-CR--ILCPASMEATA 3411 3 PVKCCGTELSPESQRCCDGVGYNPLKYVCSDEISAGMAMKETRV-CA--TICPATMKATA 3403 4 PVRCCHTELIPESQQCCDGVGYNPVKYVCSDEISAGMATEETRV-CA--TVCPATMRATA 3401 5 PVKCCETELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETRE-CG--TLCPASLEATA 3409 6 PIKCCETELIPETQECCNGVGYNPLKYVCSDKISAGMMMKEIKE-CRPASLCPISKKDAA 3414 7 PVKCCETELIPKSEECCNGVGYNPLKYVCSDKISAGMMMKVKEE-CKANTLCPLPMEKTA 3431 8 TLKCCGSKVIHQEEECCNGIGFNPERHVCADRPTPGLPTQ--------GALCPIAAAQTA 3402 9 TLQCCGSKVIHQEEECCNGIGYDPQRHVCADEPTPGLLIQVCER-MCVGAVCPVAAASTA 3456 10 NDQCCGSQRISPSQACCNEVGYNPGSRVCADRSST-----AQGH-CGIGTVCPISQAVSS 3261 11 DQKCCSTELVSSQQACCNGNGYDSGSSVCADEATIQLADRTMRQNCGRGNLCTRSQSRLA 3442 12 EQKCCSTELVSSDEACCHGNGYDPQASVCADVATIELADRSMKQSCGRGSLCTLTQSMLA 3417 C ::+CC:++++:.:+.CC+*+G*+*:::VC:D::+.+::::::.: *. ::+C*:::.:+* 3610 3620 3630 3640 3650 3660 1 HCGRCDFNFTSHICT-----VIRGSHNSTGKASIEE-MCSSAEETIHTGSVNTYSYTDV- 3464 2 HCGRCDFNFTSHICT-----VIRGSRNSTGKASIEE-MCSSAEETIHTGSVNTYSYTDV- 3464 3 HCGRCDFNATTHICT-----VMRGPLNPTGKKAVEG-LCSAAEEIVHSGDVNTHSFIDR- 3456 4 HCGQCDFNATTHICT-----VSRGPLNPIGKETAEG-LCSTAEEIVHSGDENTRSFIDT- 3454 5 YCGRCDFNFTSHICT-----MIRGPHISTGKESAEE-ICSYAEETVHTGSVNTFSFTDV- 3462 6 YCGRCDFNLTSHVCA-----LIRNPQQSPQKLSYED-TCPSAEETVYTGNTSTYSFTDV- 3467 7 HCGKCDFDPRENICA-----WIKSSQSTTGEEIKEN-VCPVEEETVYTGSPNQYSFTDL- 3484 8 YCGTCDLNPSLTTCT-----WVI--HTHTEGVETEGHLCLSHEEVLYSGDANTHTFTDS- 3454 9 YCGLCDLDPSTSSCT-----WVLSAHTHTEKLPSEGSLCPSHEDVVYSGDANRYTFTDS- 3510 10 YCDRCDFDANIDTCYSVDASYITSSPSGPGTPSGSNGLCPSALISIYTSGPNIYSYLDP- 3320 11 ACDRCDFNRDQYDCFR------AQKLRPESRSQRLNDVCPTSYVAVYTGPSDVFSFLGKY 3496 12 ACDRCDFNRDQFDCFR------ARRLRSDTRNRRTDAICPTSYIAVYTGPPNVFTYQDT- 3470 C :C++CD*+.:.::C: .:::...::::.: +. :C:::++:+:+*..*::++:*. 3670 3680 3690 3700 3710 3720 1 -NLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRK 3523 2 -NLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPMWTKIDNLEDTIVLNWRK 3523 3 -DLKPSTVYEYRISAWNSYGRGFSQSVRASTREDVPEGVKAPRWARTGKHEDVIFLQWEE 3515 4 -DLEPSTVYEYRVSVWNSYGRGFSQSVRASTREDVPQGVTAPRWARTGNHEDVIFLTWKE 3513 5 -NLEPYMTYEYRISAWNRYGRGFSKAIRARTKEDVPEGVSPPRWTKMDNLEDVIILNWKK 3521 6 -NLEPYTMYEYRIAAWNSHGQGFSKVAKTSTKQDVPQGVSPPTWTKMDNREDVIVLNWKK 3526 7 -NLEPFVTYEYRVAAWNSHGRGFSEISRAVTKQDVPQGVSPPKWAKVDNREDMILLNWEE 3543 8 -DLEPFTVYQYRVRGWNSFGRGSSPVTTVTTLEDKPWGVAPPHWRRLGERDDIIRLQWQA 3513 9 -DLEPFTTYEYRVRGWNSFGRGSSDVTTVTTSEDKPWGVAPPRWSRVGERDDIIQLLWHA 3569 10 -GLSPYTRYEYLISAINAAGSSNSGLSNATTDEDIPVQVQAPEWSVEMGVLDTIQLAWDP 3379 11 GELDAYTTYEYKVMAENKIGVGESSSSDITMPQSRPSGVMPPDWSSDGR--DAITLLWQP 3554 12 -ELEAYTTYEYKVVAENKVGVGESSSAEITMPQSKPSEVLPPDWTSDGR--DAITLSWKP 3527 C :L:*:+:Y*Y+::++N+:G+*:S...:::*:+*:P:*V:+P.W:: ::.:D.I.L:W.. 3730 3740 3750 3760 3770 3780 1 PIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVA 3583 2 PIQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVA 3583 3 PMQSNGPIIHYILFRDGRERFQGTALSFTDTQGIQPLQEYSYQLKACTAAGCAVSCKVVA 3575 4 PTQSNGPITHYILLRDGRERFQGAALSFTDTQGIQPLQEYSYQLKACTAAGCADSCKVVA 3573 5 PIQSNGPIIYYILLRNGIECFQGTSLSFSDSKGIEPFQEYSYQLKACTVAGCAVSSKVVA 3581 6 PIQPNGVIIHYIVLRNGIERFRGTEMSFVDTNGVHPYQEYSYQLRVCTVSGCTDSYQVVA 3586 7 PLQPNGLIIHYIVLRNGIERFRGTEMSFRDTSGIQPYHEYSYQLRACTVAGCADSSKVVA 3603 8 PARPNGEITHYVILRDGQERYRGDEHSFTDVGGIRPFQEYRYQLRACNRAGCADSMQVVA 3573 9 PARRNGDITHYIILRNGQERYRGEENSFTDVGGIRPFREYTYQLRVCNRAGCTDSSQVVA 3629 10 PQQPNGIIVTYILRRDGIEIYRGADTSHSDNTGIQPFQHYSYTLSACTRVGCAASQPVVA 3439 11 PTQPNGEITRYVLLRDGLEIWRGLALRHTDSFQILSYREYEYTLRACTSVGCSSSIPIRA 3614 12 PKKPNGEITRYILLRDGLEIWRGLALRHTDSFQILSYREYEYTLKACTSVGCSSSVPVRA 3587 C P.+:NG:I::Y*+*R:G:E+:+G:.:*+:D. **:*:+*Y+Y+L:*C*:+GC+:S::**A 3790 3800 3810 3820 3830 3840 1 ATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGL---IHTDTTDR 3640 2 ATTQGVPESILPPSITALSAVALHLSWSVPEKPNGVIKEYQIRQVGKGL---IHTDTTDR 3640 3 ATTQRSPENVPPPNITAQSSETLHLSWSVPEKMKDAIKAYQLWLDGKGL---IYTDTSDR 3632 4 TATRGVLESVPPPNITAQSPETLHLSWSVPEKRNDAIKEYQLWLDGKGL---IYTDTNDR 3630 5 ATTQGVPESVLPPRVRAPSAEALHLSWSIPEKPNGIIKEYQLRQTGRGL---IYSGTSDR 3638 6 ATIQGVPESVLPPKITALSAEVLYLSWRVPEKPNGIIREYRIYQSGKGL---IHIDNKGK 3643 7 VTVQGVPESVQPPDVSALNSTALRLSWIAPKKPNGIIREYQVSQVGKGL---IYSDTGSR 3660 8 VTVQGVPEGVQPPAVTALSSSSLQLTWSEPTHPNGIVQQYHLNQTGGGT---IFTHNGGP 3630 9 VTAQGVPEDVQPPEVTALSPFSLHVSWSEPTRPNGNIQQYRLNQTGVGT---ICTHIDGP 3686 10 ATLQAAPENLFDPTLAALTSESILITWQEPGLPNGVIQEYSILQTGVAEP--IYRGGPEG 3497 11 TSVQGVPEFVPSPTALVTGPNTVLLTWLPPPRANGLLQRYTLNDTNVGTIHTMRPTLSSN 3674 12 TSVQGIPEFVSPPNALVTGPNSVLLTWLPPPRANGLLQRYTLNDTKVGAIHTIQPGPGTN 3647 C :+:**+*E:+.*P.::*:+.:.+:*+W::P:::**.+::Y::.+:*:*: *::::.:: 3850 3860 3870 3880 3890 3900 1 RQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVEL 3700 2 RQHTVTGLQPYTNYSFTLTACTSAGCTSSKPFLGQTLQAAPEGVWVTPRHIIINSTTVEL 3700 3 RQHTVTGLQPYTNYSFTLAVCTSVGCTSSEPCVGQTLQAAPQGVWVTPRHIIINSTTVEL 3692 4 RQHTVTGLQPHTNYSFTLSACTSVGCTSSEPSVGQTLQAAPQGVWVTPRHIIINSTTVEL 3690 5 RQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVEL 3698 6 MEHTVTGLCAYTNYSFTLTACTSVGCTTSQPIVSRTLQAAPQGVWSIPRHIIINSTTVEL 3703 7 MHHTVSGLQPYTNYSFLLTACTSAGCASSQPLSGQTLQAAPHGVWPKPHHIIVSSTEVEI 3720 8 KAYTVTGLQPFSEYSFVLLACTAAGCGASSPSTGRTLQASPAGVWSKPRHLIVTTAVVEL 3690 9 RNYTATGLQPYTDYSFVLVACTAVGCGASLPSTGRTMQASPAGVWSSPRHVVINTSAVEL 3746 10 FQFTHTDLEPFTVYEYRLQACTSAGCSQSNPVSIITMQAAPEGLMQ-PTHVVVSSTILEL 3556 11 LRFEHNGLDPYTEHSYILTACTSAGCTDSEETTVTTEESKPEGVWVPTATLPLDLIHVDL 3734 12 LRYEHNNLEPYSAHSYILTACTSAGCTDSEQVTVTTNQAKPEGVWIPATSLPLDLVNVDL 3707 C :::*++*L+*+*:**+:L:*CT*+GC+:S:*..+:T+**+P:G**::*+*:+::++:*** 3910 3920 3930 3940 3950 3960 1 YWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSAS 3760 2 YWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSAS 3760 3 YWNPPERPNGLISQYQLRRNGSLLLVGGRDNQSFTDSNLEPGSRYIYKLEARTGGGSSWS 3752 4 YWNPPERPNGVISQYRLRRNGSLLLVGGRDDQSFTDKNLEPNSRYIYTLEARTGGGSSLS 3750 5 YWNPPEKPNGLISQYQLSRNGTLVFLGGSEEQNFTDKNLEPNSRYIYKLEATSGGGSSPS 3758 6 YWNEPEKPNGLISKYQLHRNGTVIFLGGREDQNFTDDSLEPKSSYVYQLEVHTGGGSNTS 3763 7 YWSEPEIPNGLITQYRLFRDEEQIFLGGSRDLNFTDVNLQPNSRYVYQLEASTWGGSNTS 3780 8 YWDPPQQPHGHISQYKLKRDGQTVFTGDHDDQNYTDTGLRPHRRYVYELEASTEGGTAVS 3750 9 YWDQPLQPNGHISQYRLNRDGDTIFTGDHREQNYTDTGLLPNRRYVYELQASTGGGTGVS 3806 10 YWFEPSQPNGVITSYILYRDDELVYSGNNSVLTYVDTGLTPNTRYEYLVSAMTVAGGSNS 3616 11 LWTEPLRPNGAIQEYSP---WQLVFVGQSDVFNYTDTISYPRAKIQYQLGAMNGAGFGLS 3791 12 YWTEPLQPNGPIQEYSS---WQLIYAGRPTIFSYTDVISFPGAKIQYQLGAMNEAGFGLS 3764 C *W.:P:.P*G:*++Y:*.*:+.+.+:G::..++:*D.:*:P::+*.Y.*++.+++G::.S 3970 3980 3990 4000 4010 4020 1 DDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLA 3820 2 DDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNLLLNDGSVTPLA 3820 3 EDYLVQMPLWTPEDIHPPCNVTVLGSDSIFVAWPTPGNLLPKIPVEYSILLSGGSVTLLV 3812 4 EEYLVQMPMWTPEDVHPPCNVTVLGSDSIFVAWPAPGILLPKIPVEYSILLSGGNMMLLT 3810 5 DDYIVQTPMLTPEEIQPPYNITVIGPYSIFVAWTPPGILIPKMPVEYNVLLNAGSVAPLT 3818 6 DDYVVQTPESTPEEIYAPYNVTVVDPYSIFVAWSPSETHVPKVPLQYNVLLNPGSVEPLI 3823 7 DKYVIQTPVGTPEKIHVPYNVTVIDAYSIFLAWDMPGIFTVDTPLEYNVLLNASSPTLLV 3840 8 EKYSIQTPSSCPTGIQPPHSVTVLGPRSVSLAWTPPAQLDDSQPVNYRVLLNPGSDMSEI 3810 9 DKYVIQTPVSCPTGIQPPHNVTVLAPNSIFLAWTTPAQLNSSEPVNYMVLLNPESDGAIL 3866 10 SVHVAQTPFITPEGIPPPT-LRVLSASSIEATWTQPTVPN-GIIRQYGIVILSGTQDERR 3674 11 EIHDVQMPIVVPP-ARPVVSATVLSPTVIRVEWELS-LPTSEYNYSVVVQHSGNRELLRL 3849 12 EIHDVRMPRVVPP-QQPVLEATVLSPTVIRADWSFP-SSVPEFNYSVNE---GNKNLMRI 3819 C ::+.+*+P.:+P+.+.**:+:*V::+:**+:+W.:*:::.:.:+::*::++:.++:..:. 4030 4040 4050 4060 4070 4080 1 FSVGHHQSTLLENLTPFTQYEIRIQACQ-------------NGSCGVSSRMFVKTPEAAP 3867 2 FSVGHHQSTLLENLTPFTQYEIRIQACQ-------------NGSCGVSSRMFVKTPEAAP 3867 3 FSVRHRQSAHLKNLSPFTQYEIRIQACQ-------------NGGCGVSPGTYVRTLEAAP 3859 4 FSVGLRQSAYLKNLAPFTQYEIRIQACQ-------------EVGCGVSPGTHVRTLEAAP 3857 5 SSVGHHQSILLENLAPFTQYEIRIQACQ-------------NGSCGVSSRTFVKTSEAAP 3865 6 YPVGHHHLTVVKNLTPYTQYEVRIQACQ-------------NGDCGVSSGTLVTTFEAAP 3870 7 KPAGRAHFAFVDGLDPFTLYEIRIQACQ-------------NGGCGVGGRTYSRTAEAPP 3887 8 HHAGLDLQLTVRALQPFSNYLIRVQACQ-------------TEGCGVGKGVYVQTLEDVP 3857 9 RPAGQDRQLTVTGLEPFTAYHIRVQACQ-------------TDGCGVGEGFYVQTLESAP 3913 10 LVATSVTMLVVDNLTPYTRYDMRVQACG-------------DSGCGVGPRAYARTFEAAP 3721 11 IPTGSDMTQVIEDLTPHTTYRIRVMACMPLSGD--SEGTNSTENCNVGQSTLSETFSAPP 3907 12 IPSGNEMSKVVEGLTPHTSYHIRVMTCFPYSGDDDSETTNTTDNCNVGRSALTQTSAAPP 3879 C .::*:.::..:::L:P+*:Y:*R:**C+ :::C*V:.:::+.T.**+P 4090 4100 4110 4120 4130 4140 1 MDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEE-----ESVLFVWSEGA 3922 2 MDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEE-----ESVLFVWSEGA 3922 3 VGLMPPLLKALGSSCIEVKWMPPTRPNGIITSYVVHRRPADTEE-----ESLLFVWSEGA 3914 4 VGLMPPLLKALGSHCIEVKWTPPTRPNGIITSYVIHRRPADTEE-----ESLLFVWSEGA 3912 5 VDLNSPVLKALGSACIEVKWMPPKKPNGVITSYFLHRRPAGIEE-----ESLLFVWSEGA 3920 6 LDLKPPFLLTMGPTSILIRWLPPTKPNGIIIKYFIYRRTVGIEG-----ESLLFIWSEGS 3925 7 LELSPPTIKAMGSALIEVKWAPPKKPNGIITNYFIHRRPVGSQE-----DLLLFIWAEGA 3942 8 EGLLPPRITAAGASVLEVYWSPPSKPNGLITSYHIYRRPMETEE-----ELLVFIWSSGP 3912 9 EGLRPPTVKAAGPRVLEIHWSPPKKPNGLITSYYIYRRPLGTEE-----ALLVFIWSSGP 3968 10 EEQGPPTLVSTGPSVVEVSWDPPARPNGIIQQYYVYRRQYRTTQ-----ELLVFLTTT-E 3775 11 AGQDKPTLKATGGRAVDIKWKEPTHPNGVIQGYFLHRKLANPSN-IVPIEKRIYSGNPTT 3966 12 SGQQIPTLTATGGRSVEIEWEEPLHPNGVITSYQIHRKLSNPDDGLVPIEKRIYTGEANT 3939 C .:+.:P:++*:G:.::*::W.*P.:PNG:I::Y:+:R*+:::++ *:+:*:++:+: 4150 4160 4170 4180 4190 4200 1 LEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAPWAQATSAHSVL 3982 2 LEFMDEGDTLRPFTLYEYRVRACNSKGSVESPWSLTQTLEAPPQDFPAPWAQATSAHSVL 3982 3 LEFTDDTGTLRPFTLYEYRVRAWNSQGAVDSPWSTIQTLEAPPRGLPAPRVQATSAHSAM 3974 4 LEFTDDTDTLRPFTLYEYRVRAWNSKGVVDSPWSSVQTLEAPPQDLPAPWVQVTSAHSVL 3972 5 LEFTDASDTLMPFTLYEYRVRAHNSRGSVESQWSSARTLEAPPQDLPAPWVQATSAHSVL 3980 6 LEFTDASDTLKPFTLYEYRVRAHNSKGSVESPWSSAQTMEAPPMGMQAPQVQATSAYSVL 3985 7 LEFIDASDALQPFTLYEYRVRAQNAVGSVDSLWASTQTLEASPWGMAAPWAQATSAYSVR 4002 8 LEFFDASPVLQPFSYFQYRVRAQNSKGSVLSQWASARTLQAKPKNMPAPTGTPTGAYSAH 3972 9 LEFYDASPALWPFSYLQYRVRSQNSKGSVLSQWALAQTLQAEPQDMASPTVTPSGAYSAR 4028 10 QSFVNAGGGLTAFNLYEYRVRVENSQGSTDSPWASIRTQESVPVGLAAPNLVAVSPYAVQ 3835 11 FNYIDTDPELIPFTEYKYKVTSTTNEGNAVSDWASVSTKQDAPTGVSPPILQAVSAFAVN 4026 12 FTYTDTDAELVPYTEYKYRITCTSDQGDAESDWESVTTKQAVPTGISAPMLQAVSAFAIN 3999 C ++*:*::::L.**++*+Y***+.*+:G++:S:W:+.:T++*:P::.:*P::+++**:++: 4210 4220 4230 4240 4250 4260 1 LNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIG 4042 2 LNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIG 4042 3 LNWTEPEAPNGLISQYHVIYQERPDAAAPGSSTVHAFTVTGTSRQAHLFGLEPFTTYHIG 4034 4 LNWTEPEAPNGLISQYHVIYQERPDEAAPGSSTVHAFTVKGSSRQAHLFGLEPFTTYHIG 4032 5 LNWTKPESPNGIISQYHVVYRERPDDSTVNISTVHAFTVMGTSHQAHLFGLEPFTTYHIG 4040 6 LNWTKPESPNGIISQYRIIYQERQKDPTFNVPTVTAFTVMGTRHQAHLFGLEPFTTYHIG 4045 7 LNWTQPVFPNGVITLYRVVYQEKRSDPTFSIPAVTALTVTGGKHQAHLFGLKPFTTYHVH 4062 8 LKWSPPQQPNGVISRHRLVYRKHQQDPTLNSTAVAALTVEGSIFEATIYGLEPYSQYSLQ 4032 9 LKWSQPGRPNGPISHYRLVYEKHQQDPTLNSTDVTALTVEGSVREASVFGLEPYSQYSLR 4088 10 GTWTPPSSPNGIIAYYRIEYQERPNDPTATPAIVTAATVEGTVLQTTFYGLLPFTSYQVR 3895 11 ASWDAPLYPNGVIASYRIEHREIGDDPTIPPPIVTSLTVPSDLKAATFSGLRPFTAYHVR 4086 12 ATWEVPFHPNGVITSYRIEHQEVGGDPTIQRPILTALTVPSALTAATFSGLQPFTMYQVR 4059 C +:W+.P::PNG:I+.*+::*+*:::*+*.::::*:*:TV.*:::+*:::GL+P**:Y::: 4270 4280 4290 4300 4310 4320 1 VVAANHAGEIL-SPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYN 4101 2 VVAANHAGEIL-SPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYN 4101 3 VVAVNSAGKVS-SPWTLIKTLESAPSGLMNFTVEQREKGRALLLQWSEPVKTNGVIKAYN 4093 4 VAAVNRAGKVS-SPWTLIKTLESAPSGLMNFTAEQREGGRALLLQWSEPVRTNGVIKAYN 4091 5 IVATNQAGEVS-SPWTVVQTLESSPSGLGNFTVEQQENGRALLLQWSEPVRTNGVIKTYH 4099 6 IVAVNLVGEVS-SPWTTVCTLESSPSGLSNFTVERKEDGHALLLQWSEPVRTNGVIKAYN 4104 7 IVAVNNAGQVS-SPWTSVRTLEASPSGLSNFTVEKKENGRALLLKWSEPSEPNGIIKTYN 4121 8 VEALNSAGSVS-SPWVDIRTLEASPAHLTNFTVEQREQGRALLLSWEQPRTPNGIITMYH 4091 9 VEAVNEAGSVS-SPWVTIMTLEASPAGLANFTVEQREQGRALLLVWDEPSAPNGIITMYN 4147 10 IIAINGAGETS-GPWGSVTTLQGVPGDIGQLTVEQQSNGLALLLRWDEPGQPNGVITNYF 3954 11 ILAVNQAGMEGRSEWRRVKTLSAAPSEVAELSVEKNPSGRSVILTWEEPALPNGEIHEYN 4146 12 IVAVNQAGMVGRGDWRREKTSPAPPSEVAELSVEKSEDGRSVSLTWDEPALPNGEIQIYN 4119 C ::A:N.*G:++ **W:.:.T*+::P+++.+++*E+.*:G****L:W:*P.::NG:I:.Y+ 4330 4340 4350 4360 4370 4380 1 IFSDG---FLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAG-CAHSAPQPLWTDEAPPDS 4157 2 IFSDG---FLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAG-CAHSAPQPLWTDEAPPDS 4157 3 IFNDG---VLEYSGLGRQFLFRRLAPFTLYTLILEACTTAG-CAHSVPQPLWTEEAPPDT 4149 4 VFSDG---LPEYSGLGRQFLFRRLAPFTLYILTLEACTAAG-CAHSVPQTLWTEEAPPDS 4147 5 VFSDG---SLEYSGPTRRFLFRRLLPFTAYALHLEACTGAG-CACSGAQRLRTGEAPPRS 4155 6 IFSDG---GLEYTGLSRQFLFRRLEPFTLYVLTLEACTMAG-CTLSTPQALWTAEAPPTS 4160 7 IFSDD---NLEYSGLSRQFLFRRLEPYTLYTLLLEACNEAG-CTRSPPQPIRTDEAPPVS 4177 8 LYNEG---NLEFSGLSRNFLFRRLEPWTMYSLTLEACTSAG-CTRTSPQDITTAAAPPAS 4147 9 LYSEG---NMEFSGLLRSFLFRRLEPWTTYSLILEACTVAG-CTHTLPQLVTTVAAPPAL 4203 10 IYEDEYLIAPIYTGLTREFLFRRLTPYTEYVVVLEACTNVG-CGRGNPQTVRTAEVAPAN 4013 11 IYEPKESEEPIYSGRVRQYEFRRLTPYTQYSLVLESCTGPGLCTRSPTISFWTAETRPES 4206 12 VYEPEVSEIPVYSGRARQFDFRRLTPYTRYTLVLESCTGPGLCTRSPTTTFWTAETIPES 4179 C :::++ .:+**G+.R+**FRRL.P:T:Y:*:LE*C*.+G C::+.+*.::T:*++P.+ 4390 4400 4410 4420 4430 4440 1 QLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCF------EGKAWGNQTIQADEKI 4211 2 QLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCF------EGKAWGNQTIQADEKI 4211 3 QMAPTIQSVGPTNVRLHWSQPASPNGKIIHYEVIRRRS------EEEDWGNTTWQADGNT 4203 4 QMAPTIQSVEPTSVRLHWSQPANPNGKIIRYEVIRRRL------QGEDWGNRTVQADENT 4201 5 QAPPTVQWAGPGGVGLRWAAPLHPRGRIVRYEVVRRCL------DGPARGNQTLRADGAA 4209 6 QLAPTIQSVEATSIELSWSEPINPNGKIIHYEVIHRCF------KGYAGGNRTTEADEKI 4214 7 QMAPIIQAVNATNIELSWLKPINPNGKIIRYEVIHRCT------KENAAGYRATMEDEKI 4231 8 QHPPKPLFIGPDSVSLSWCPPTQPNGPIGEYFLLGRTLS---EDIGRGRSNEEDVEDGKV 4204 9 QPPPRPLFIGPDRVTLTWGPPSQPNGPIGEYYLLGRIL----EEVEIGRSNEEDTESGKV 4259 10 QAPPTLGFVNSTAVVLNWKAPVNPNGAITQYDVIRRSARPTSPDRRKRNTDESAFTVTVV 4073 11 QLPPSIRDTNTTTVTISWSKPARANGRIRSYEVYRKQVF-----YQFRRQITDSNVDGDV 4261 12 QSPPIVQGRTSNSVTLTWRKPARPNGRIRSYQIYR-------------RQIEDPNSDGEV 4226 C Q.:P:::::.:+:*.*:W:.P.:**G:I::Y++:+*:. .:.:::+.: .:*::: 4450 4460 4470 4480 4490 4500 1 VFTEYN-TERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPV 4270 2 VFTEYN-TERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPV 4270 3 VFTEYN-TQGNAWVYNDTGLQPWRQYAYRICAWNSAGHTCSSWNVVRTLQAPPDGLSPPE 4262 4 VFTEYN-TEGNGWVCTDTGLQPWGLYSYRICTWNSAGHTCSSWSVVRTSQAPPDGLSPPE 4260 5 VFTEYD-TERSAFTYNDTGLQPWTRCEYRIRTWNSAGHTCSSWAAARTTQAPPEGLSPPG 4268 6 VFTEYN-TERNTFAYNDKGLQPWTLYEYKIRTWNSAGHTDSPWSAVKTKQAPPEGLLPPD 4273 7 VFTEYN-TESNTFVYNDKGLQPWTRYEYKIRTWNAAGYTDSSWTAAMTSQTAPKGLTAPR 4290 8 LFRESSPAHSESFSYTVTGLRPWTRYEFSIRAHNPAGHISSPWVTVTTKQAPPLGLAPPT 4264 9 LFRESSPQHADSVSYTVTGLRPWTQYQFTVRTHNPAGHTHSPWVTVTTRQAPPRGLAPPK 4319 10 IHSEYN-TDAEDYSFIDNSLQPYRIYEFRIQSINSQGSVDSDWVQVDTDQAAPVGVAPPT 4132 11 IYNIFD-PEHEVYNYTDSGLRPFTRYQYKIRTSTAAGHVDSNWVTVETHQAPPEGISAPV 4320 12 IFDVLD-PVHDVYNYTDAGLRPYSRFQYKIRTSTSIGHVDSSWVAVETHQAPPEGISPPV 4285 C :*:*+: +:.:.:.*:*:*L+P++:+:+:*:+:*+*G*+:S:W:.*:T.Q**P:G+:*P. 4510 4520 4530 4540 4550 4560 1 ISYVSM-NPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVT-FNYTDEELLPFST 4328 2 ISYVSM-NPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVT-FNYTDEELLPFST 4328 3 ISYVSM-SPLQLLISWLPPRHSNGVIQGYRLQRDGVLPALNFNAST-FSYMDSQLLPFST 4320 4 VSYVST-SPLQLLISWFAPRHTNGVIQSYRLQRNGVFAAASFNSST-FSYTDGQLLPFTT 4318 5 IAGVSV-SPPRLLISWTPPERPNGIIQSYRLRRNGALYPFSFDAVT-FNYTDEDLLPFST 4326 6 LVFESF-NPRRLIISWAPPAQPNGIIHSYRLQRNEALYPFNFDAET-FNYTDDELLPYSE 4331 7 LSLESV-NPRKVLVSWDAPAQPNGILQSYRLLKNDVLYPFSFDAAT-FNYMDEDLLPYSM 4348 8 VRHLKD-QPSKVWVSWTPPVEPNGVLQSYRIQRNNVSFSFSFDPTV-LNYTDEELLPFSK 4322 9 VSHLQG-QPSAVLVSWTPPLEPNGILQSYRIERNNVSFSFSFDPIV-LSYMDEGLLPFST 4377 10 VNHITN-TPGSLVIGWTPPTESNGIITGYRLQRN-SSTPFSFEADYGFQFTDMNLQAFTV 4190 11 VTHPHDRSSASLEISWYPPQHVNGEMQIYKLQRG-NSTPFIFPPDQ-LRYTDVGLQPYTD 4378 12 VVPPADRSPTALQVSWNLPTQVNGELQTFKMQRG-NSTPLSFPPDQ-FQYKDINLRPYTM 4343 C ::.::. :* .+:+*W.+P.::NG::*+**++*+.:::+++F::.: +:*+D:.L+*++: 4570 4580 4590 4600 4610 4620 1 YSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITK 4388 2 YSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAISATQMNVCWSPPTVQNGKITK 4388 3 YSYAILACTGGGCCTSEPTNITTPEVPPSEVSPPVLWDISAHQMNVSWSPPSIPNGKIVK 4380 4 YSYAVLACTGGGCCTSEPTNITTPEASPAGVSPPVLWAIGAHQINVSWSPPSVPNGKIAK 4378 5 YSYAVVACSSGGCSTSKPSSTTTPQAAPAGLSPPAPRAISATQINVSWSPPLIHNGNITK 4386 6 YSYAVIACTAEGCSTSQVSTIKTPEAAPALVNPPSLWALTATQINASWSPPPTPNGEIIR 4391 7 YRYAVVACTMGGCSTSEPAAIRTLEAAPALVDPPSLQAVSSTQVNASWAPPQIQNGDITK 4408 8 YSFAIIACTSEGCITSGHTNITTLEAPPASVEPPRVNSFTSTSIDISWNKPLTQNGEVTE 4382 9 YSYSVIACTSEGCITSPHTNITTLEAPPATVEIPTADSVTSNSINISWSKPLTQNGEVTE 4437 10 YVYTITVCTQGGCTMSSATSIRTLETAPTFVDPPSPVPISSSQIMVNWTTPSIASGEIMQ 4250 11 YEYSITACTAGGCTTSDTTVTRTYEEAPQFVAPPNVVAFNSTSLQTSWESPGTQNGIIVS 4438 12 YEYTISACTAGGCSTSEVTQARTFEQAPHYVAPPSAVAFNATSLQTTWQSPGTENGKIVS 4403 C Y+*+:.*C*:+GC:*S.:+.+:T:*++P:.*:*P.::+:::++:+:+W::P.::*G:*:: 4630 4640 4650 4660 4670 4680 1 YLVRYDN-KESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENM 4447 2 YLVRYDN-KESLAGQGLCLLVSHLQPYTQYNFSLVACTNGGCTASVSKSAWTMEALPENM 4447 3 YLLQCDG-EEHLAGQGLSFLLSNLQPSTQYNISLVACTSGGCTASRTTSAWTKEAPPENM 4439 4 YLLHCDG-EEHLAGQDLSLLLSNLRPFTQYNVSLVACTKGGCTASRVASAWTMEAPPEDM 4437 5 YLLRVDG-KEYLAGQSLSLLVSGLQPSTRYNFSLVACTDGGCTASASKPAWTTEAPPQNM 4445 6 YFLQFDD-QEYHAGKNLSGVVSQLQPYTEYEFTLIACTIGGCTASKAKSIRTMEAPPQSM 4450 7 YILKLNN-EEYYPGKNLQMLISNLQPYTQYDFELVACTAGGCTSSTVQSVTTMEAPPLNM 4467 8 YLLKLNN-QESYRGTDQNTVLSGLRPHTAYQLILLACTSGGCTTSTPISTVTDEAPPTDL 4441 9 YVLKLNN-EETYRGRELNTELLDLRPHTSYHLVLYACTNGGCTASATMSAVTEEAPPTGL 4496 10 YRLKVDD-EVRYSGLGLSTTISGLIPHQEYTFVLEACTSGGCTDSPEALARPFEAPPTGM 4309 11 YKVFVDN-ELRYQGNETETMLTRFLPFRVYSVALEACTNSGCRRSIPVQVRTLEGIPSGM 4497 12 YTLYGDDNEVMYQGNKTEALITGLLPFRFYSIALEACTNSGCRRSITTQVRTLEAAPIDM 4463 C Y:+..+: :+.::G:.+:.::+.*:P.+:Y:::L:ACT:*GC*:S ..+::*:E*+P.:* 4690 4700 4710 4720 4730 4740 1 DSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYT--GLETRYRDFT-----LT 4500 2 DSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYT--GLETRYHDFT-----LT 4500 3 DPPTLHITGPESIEITWTPPRNPHGLIRSYELRRDGAIVYV--GLETRYHDFT-----LA 4492 4 DPPTLHVMGPESIEITWAPPRNPHGQIRSYELRRDGAIVYI--GLETRYHDFI-----LT 4490 5 DPPKLQVTGSESIEITWRPPRNPNGQITSYELRRDGTIVYT--GLETRYHDFT-----LT 4498 6 SSPKVQATGSESVEITWKVPARPNGQITNYEVKRDGEIIYT--GMETRYHDLN-----LS 4503 7 EAPRLLVMGSESIEITWKSPAKPNGKITSYELRRDDVLVYS--GQETRYLDFT-----LT 4520 8 PAPNLKVTGPESLEISWAPPEHPNGAITGYELRRDGEVIYV--GTETRYHDFS-----LS 4494 9 ASPTLKVTGPESVEVIWRPPEHPNGIITGYELRRDGEVIYV--GTEVHYHDFT-----LV 4549 10 NPPSLRVLSATALEASWSEPNEPNGIISRYELRRDGKLVYD--GDAQRYQDFGDGGLGLT 4367 11 SAPDLHVTGAHSIEVTWHAPSEPNGNIIRYEVRRNGELVSISDGLINRYDDYE-----LI 4552 12 APPDLHVTGANSIEVTWQPPVEPNGNIIRYEVRRNGDLVSISDGRITRYHDFE-----LT 4518 C ::P:*.*+*:+*+E++W.+P::P*G:I::YE+*R**.:+*. G:++*Y+D*: L: 4750 4760 4770 4780 4790 4800 1 PGVEYSYTVTASNSQGGILS-PLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTN 4559 2 PGVEYGYTVTASNSQGGILS-PLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTN 4559 3 PGVEYSYSVTATNSRGSVLS-PLVKGQTSPSAPSGLQPPKLHSGDALELLADWDPPVRTN 4551 4 PGVQYGYTVTATNSRGSVLS-PLVKGQTSPSAPSGLQPPKLRAGEALELLVNWNPPVRTN 4549 5 PGVEYGYTVTAHNSQGGVLS-PLVKDRTDPSAPSGIEPPKLKAQGPQEILVNWDAPVRTN 4557 6 SGKEYGYTVTATNSQGSTSS-PLVKVRTNPSAPSGMAPPELQAWNSQEIKVNWDPPVKTS 4562 7 PGMEYSYTVTANNSQGSVTS-PSAQIKTNPSAPSGMLPPRLQAWSSKEILVAWDPPIKVN 4579 8 PNVRYSYTLRANNSKGAASS-VAATAKTHPSAPSGVGLPTLTPLGPNEVKVWWNSPARPN 4553 9 PSVEYSYVVRANNSKGAVSS-TAATAKTPPSAPSGVGLPTLTPLGPDQVRVDWSTPARPN 4608 10 PGQQYSYVITAFNSRGHAIS-DAAVITTSSSSPAGLSPPIVSPLSSQIIGATWQPPAFPN 4426 11 PGTEYTYVVIAYNSRGSVSSEPPVSETTYQSAPAGLDAPTLTPTSGRYMLVEWTSPVNPN 4612 12 PGTQYSYVIVAYNSQGSVSSDPPVSETTHQSAPAGLAPPTLTATSGRFMRADWSTPVNPN 4578 C **:+Y:Y:++A.NS:G:::S +:+:..T:+S*P+G:.+P:*.:.:::+::+:W::P+::* 4810 4820 4830 4840 4850 4860 1 GDIINYTLFIRELFERETKIIHINTTHNS--FGMQSYIVNQLKPFHRYEIRIQACTTLGC 4617 2 GDIINYTLFIRELFERETKIIHINTTHNS--FGTQSYIVNQLKPFHRYEIRIQACTTLGC 4617 3 GKIINYTLFVREMFEGKTRAMSINTTHSS--FGTRSLTVKHLKPFHRYEVRVQACTALGC 4609 4 GKITNYTLFIRELLEGEIRTMCINTTHSS--FGTRSLAVKHLKPFHRYEVRVQACTALGC 4607 5 GQIVNYSLFIRELFEEETKILPINTTHNS--FDTRSFVVDQLKPFHRYEVRIQACTALGC 4615 6 GDIINYTLRIWDPVETEAEAIHMNTTHNS--FAKRSFMVTQLKPFHRYEIRIQGCTLLGC 4620 7 GDIKNYTISIHRPAETGKKTVDFDASHSS--FVRRSFIVAGLQPYSWYEVQLQACTELGC 4637 8 GDIVSYAVYQKDPVQLSITSTVITPDQSG--FSDRHITLHGLTAYHRYEVRVEACTVLGC 4611 9 GDIVSYTVYQRDPVQLRITSTVFTPEDGD--FSDKHTTLRGLAPHHRYEVRVEACTVLGC 4666 10 GEIQNYTLYVDNSIVYSGRLFSFD--------------IRNLDFYALYEIRVGACTTSGC 4472 11 GVILNYTLYVRHVAIRTERVR-HFSYEFS--AETFSFELGGLEPYEEYYFWLQTCTLLGC 4669 12 GVILNYTLFVRHVTRRTETVGDDFIYFFSTVSNTFSFELGGLEPHEEYFFWLKTCTLLGC 4638 C G:I.*Y*+::+:..:.:.....:::::.+ +.::+:.: :L:*:++Y*:+:++CT.*GC 4870 4880 4890 4900 4910 4920 1 ASSDWTFIQTPEIAPLMQPPPHLEVQMAPG-GFQPTVSLLWTGPLQPNGKVLYYELYRRQ 4676 2 ASSDWTFIQTPEIAPLMQPPPHLEVQMAPG-GFQPTVSLLWTGPLQPNGKVLYYELYRRQ 4676 3 TSSEWTSTQTSEVPPLRQPAPHLEVQTATG-GFQPIVAVWWAGPLQPNGKIICFELYRRQ 4668 4 TSSEWTPTQTSEIPPLLQPAPHLEVQTAAG-GFQPIVAVWWAGPLQPHGKIVRFELYRRQ 4666 5 ASSDWTSLQTPEVAPLMQPPPHLEVRMAPG-GFQPVVALLWTGPLQPNGKVIYYELYRRQ 4674 6 ASSDWSSIQTPETSPMLQPPPILDVQMGPR-GFQPRVSLQWTGPLQPNGKILYFELYRRQ 4679 7 ASSEWASVQTLEAPPAAQPAPLIEIQTTAR-GFQTVSSVLWTGPQQPNGKILHYELYRRR 4696 8 SSSDWSSVLTLEAPPAGQSAPLLDLQPDTLTGLQTTFLVTWSPPTQPNGKVLHYELLRRH 4671 9 SSSDWASALTLDAPPAGQSAPLLDLQPDTHTGLQTTFLLTWSPPAQPNGRVLHYEVYRRL 4726 10 ALSDSVEARTFEHTPSDQVAPSLEPLADNL-GIASGIRAVWNAPSNDNGIILGYELYRRS 4531 11 VMSERNMKRTLEDSPTNLNPPSVVIPQQNQ----MVLEVSWTPPLNTNGVIRYYWLFRRR 4725 12 VMSERVMERTLEIPPANQNPPSVVLPHRDQ----VPLDISWSPPVNTNGVIRFYKLYRRR 4694 C :+S:+::.:T:*.:P:.*::P:+::+.:.: *:+:.:.:.W::P:++*G+:::+***RR: 4930 4940 4950 4960 4970 4980 1 IA---TQPRKSNPVLIYNGSSTSFIDSE--LLPFTEYEYQVWAVNSAGKAPSSWTW-CRT 4730 2 IA---TQPGKSNPVLIYNGSSTSFIDSE--LLPFTEYEYQVWAVNSAGKAPSSWTW-CRT 4730 3 VA---AWPGTSSSLLIYNGSFRSFMDSE--LLPFTEYEYQVWAVNSAGKAASNWTR-CRT 4722 4 TA---SWPGTSSPLLIYNGSLSSFTDRE--LLPFTEYEYQVWAVNSAGKVASNWTW-CRT 4720 5 IA---AHPGKSNPVLTYNGSSSSFTDFE--LSPFTEYEYQVWAVNSAGKAPSTWAW-CRT 4728 6 VT---ALPGTSSPVLVYNGTLTSFTDSE--LLPFTEYEYQVWSGNSAGKSPSSWVQ-CKT 4733 7 MT---QALINLDLVLVYNGSSTFFRDDQ--LLPYTEYEYQVWSVNLAGRTPSGWTR-CRT 4750 8 TS---DNNTGDTTVLVYRNISSTYKDEA--LQPYSLYQYQVWAANSVGRSPSPWAS-GRT 4725 9 GP---TTDRRDAAALVYRNISTTCKDES--LQPFTVYEYQVWVVNLAGRSASSWVD-GRT 4780 10 VDR--TTGGRSDPTLLVNTTLREYVDMDSALIPDETYEYLVVSFNSVGEASSPWAS-VRM 4588 11 IIDNDLASGMLERRLIANTTETTYTDDN--VVPYSMYEYQVNARNGAGETTSSWSPPVLS 4783 12 LLDDESATEMLERRLAANVTGTSYTDSD--LLPYTRYRFQVTALNGAGETTSLWSAPMRS 4752 C .: ..::.:.::L:+*:::::::D:: *:P:+:Y***V++:N+*G:::S:W:. :*+ 4990 5000 5010 5020 5030 5040 1 GPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSS--AHGAETVLSEGMAT 4788 2 GPAPPEGLRAPTFHAISSTQAVVNISAPGKPNGIVSLYRLFSSS--AHGAETVLSEGMAT 4788 3 GPAPPEGLQAPTFHTVSSTRAVVNISVPSRPNGNISLFRVFSN---SSGTHVTLSEGTAT 4779 4 GPAPPEGLKAPTFHTVSSTQAVVNISAPSKPNGNISLFRVFSN---SSGTHVMLSEGMAT 4777 5 GPAPPEGLGAPKFHAVSSTHAVVNISAPEKPNGIINIYRLFSN---TSGVETVLSEGTAT 4785 6 GPAPPEGLQAPKFHAIFSTQAVVNISPPLKPNGIVSLYRLFSNH--TRGTENVLSEGMAT 4791 7 GPAPPEGLTAPLFHTVASTVAIVNINPPLKPNGVVSIYRLFSND--TRGTEVVLSEGTAT 4808 8 GPAPPEGLGPPVFLRVSATTAVLDIHPPPRPNGIISLYRVFSL---HRNNRTLLSEGTSP 4782 9 GPAPPEGLGTPVFLHVSATSALVEIHPPAQPNGVVSLYRVFSV---NYNNHTLLSEGTSH 4837 10 LEAPPQGLLPPVVSELEATSLTLTIQEPSQPNGAIQRYVIYRN-------STVLSQTTLT 4641 11 GEAPPNGVPAPTFQDVTARSVRVTAQDPERENGEIRTVAIYMKQNDSDDQMARVTSGSRQ 4843 12 GEATPSGVPAPTFQDVSARSIQVVALDPERKNGIIRGVSIYMKQNNSDDAMQLVTSGTGQ 4812 C *+A*P+G*.+P:*:.++:*.+:*:*:.P.:*NG::+:++:++: ..:.:::**+*::+ 5050 5060 5070 5080 5090 5100 1 QQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFR 4848 2 QQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIETLASRTASFR 4848 3 QQTLHDLSPFTTYTIGVEACTCFNCCSRGPTAELRTHPAPPSGLSPPQVQTLGSRMASVH 4839 4 QQTLHDLRPFTTYAIGVEACTCFNCCSRGPTAELRTHPAPPSGLSPPQVQTLGSRMASFQ 4837 5 QQTLHGLQPFTTYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIQMLSSRTASFQ 4845 6 QQTIHDLEPFTTYSIGVEACTCFNCCSKGPVAQLTTHPAPPSQQPPPQIQTLTSRTASFQ 4851 7 QQTIHGLKPFTTYSIGVEACTCFNCCSKGPTAQITTQPAPPSEQPPPQIRAVTSRNASFQ 4868 8 QLTLHDLQPYTRYRVAAEACTCYQCCSQGPMAELRTLAAAPALQPPPRPVSLTSRSVQME 4842 9 QQTLHGLRPYTQYWVGAEACTCYQCCSRGPLSELYTLAAPPAQQPPPRPLTLTSRSVQLE 4897 10 SYRDSDLLPFTTYSYSVEACTSG-GCTTSHAVTVTTIQMAPSGLSAPVVMQADSTWIQLT 4700 11 AYPLVGLQPATTYRVAVEMCTLGSMCTRGPSGFVTTLSAPPSGQSAPTVDKVTAVNMSLS 4903 12 QFSLVSLNPVTTYQIAIEMCTLDTLCVRGPSAFVTTLSAPPSGQSVPIVDEVTTSNLSIS 4872 C *++++:L:*+T+Y:+++E*CT+::+C+:**:+:+:T::**P*+:+:P::.:+:*+.:+:. 5110 5120 5130 5140 5150 5160 1 WSPPMFPNGVIHSYELQFHVACPP---DSALPCTPSQIETKYTGLGQKASLGGLQPYTTY 4905 2 WSPPMFPSGVIHSYELQLHVACLP---DSALPCTPSQIETKYTGLGQKASLGGLQPYTTY 4905 3 WTPPLLPNGVIHSYELQLQRACPP---DSAPRCPPSHTERKYWGPGHRASLAGLQPNTAY 4896 4 WAPPQLPNGVIHSYELQLHRACPP---DSAPHCPPSPTERKYWGPGHRASLAGLQPNTAY 4894 5 WSPPLLPNGVIQSYELQLHVACPP---DLAAPCAPSQAETKYSGLGQTASLEGLQPYTTY 4902 6 WNPPSSPNGIVESYELELYIPCPL---TAEMPCTPGPTEIKYTGQSQSASIGDLQPYTSY 4908 7 WSGPQSPNGIVTSYELHVYMACPLNLQPAVKACSPGPTEVKYTGNGQSANVSNLEPYTTY 4928 8 WDEPLAPNGVIESCELHLRSSCPQPLQPVPIPCVEGPGEICFFGKRQHYNVTGLRPYSTY 4902 9 WDEPLAPNGVIESCELHLRSPCPQPLQPVPLPCIKGPMEITFFGKRRSYNVTGLQPYTNY 4957 10 WDYPTNTNGIITKFELLFGPGCPLTTQPFEQTCPVEDYIPINKDLALTHNVTGLKPYTRY 4760 11 WREPTHPNGRISRYELMYRRGCRDT--YPPVECHVSPTVVGYSGLSTSTVLRNLVPYTRY 4961 12 WTEPAHLNGEISRYEILYRRGCQVT--FPPVECHVSPTVVGYSGTSTQTVLRNLHPYTRY 4930 C W.:P..**G:*.++E*::..:C+:...:.:.:C.::::+.:+.*:::.:::.+L:P**:Y 5170 5180 5190 5200 5210 5220 1 KLRVVAHNEVGSTASEWISFTTQKELPQYRA----PFSVDSNLSVVCVNWSDTFLLNGQL 4961 2 KLRVVAHNEVGSTASEWISFTTQKELPQYRA----PFSVDSNLSVVCVNWSDTFLLNGQL 4961 3 GVQVVAYNEAGSTASGWTNFSTKKEMPQYQA----LFSVDSNASMVWVDWSGTFLLNGHL 4952 4 GVQVVAHNEAGSTASGWTSFRTKKEMPQYQA----LFSVDSNASTVWVDWSGTFVLNGQL 4950 5 KLRVLAHNEVGSTASEWISFTTQRELPQYRA----PFLVDSNLSLVRVDWSGSFLLNGPL 4958 6 MLRVVAYNMVGSTASEWISFTTEKEFPQYRA----PFSVASNLSVVYINWSGTFLLNGKL 4964 7 NLRVVSYNSVGSSASEWVGFTTEKEPPRYMA----PFSVVSNLSTIHIDWSRTFVLNGRL 4984 8 QLRAACFNNMGSAASNWTTVTTLSEAPQYMS----PFLVDSNLTVIWLDWTGSFAINGYL 4958 9 QLRAACSNNMGSTASNWTSVTTLSEAPQYVS----PFPVDSNLTVIWLDWTGSFSLNGYL 5013 10 DFVVAAYNDAGQVESSPVQENTLSALPFFVSGTKPSITSNTNNSLITVSWAQSFVLNSML 4820 11 DFKVNSYNEFGSTGSSWGTAITGKLPPTYIT----HFSVTSNSSHVNVDWQSTFHINSVL 5017 12 DFKVKSFNEYGSTESSWETVITRKSAPKYIT----HFIVSSNSSYVKVAWPSTFDLNSVL 4986 C .::*:::N::G*++S:*.:::T.++.P+*.: :*:*:*N:*:+.+:W::+F:*N+.L 5230 5240 5250 5260 5270 5280 1 KEYVLTDGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVL 5021 2 KEYVLTDGGRRVYSGFDTTLYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVL 5021 3 KEYVVTDGGRRVYSGLDTTLYIPRMVDKIFFFQVTCTTDIGSVKTPLVQYDAATGSGLVL 5012 4 KEYVVTDGGRRVYSGLDTTLYIPRTVDKTFFFQVTCTTDIGSVKTPLVQYDATTGFGLVL 5010 5 KEFVVMDGGQRVYSGFDTTLYIPRTADKTFFFQIICTTDEGSVKTPVVQYDTSTGFGLVL 5018 6 KEYVLTDGGQRLYSGLDTSLYIPRTADRTFLFQVTCTTDEGSVKTPLIQYDTSTGLGPEL 5024 7 KEYALTESGQRIYSGFDTELYLPRTSDKTFLFQVTCITDEGSAMTPVIKYSAADGLGLIL 5044 8 REFSVTESQLRVYTGFYSQLQIPRTSQKTLSFQVTCTTNSGSVSTPTVRYSPALGIG--- 5015 9 KEFSVTESQLRVYTGFYSYLHIPRTSQKTLSFQVTCTTNSGSASTPTIRYSPATGLGSAN 5073 10 REYILVENGDTVYSGIATAVTRP-LKDMEYEFTVTCVTSTGSISYPTIIYQP-------- 4871 11 IRYELSDRRQVVYGGLGTELYEPLLSFTVHKFRVTVHTDMGTISSPVILYDTRNEQPITR 5077 12 TRFELSDRGRVIYAGLNTVYHYRRTGPSVHKFRLTVYTDTGTTRSPVIIYNT-------- 5038 C +*+::++:+:++Y+G::*:*++**+.+++::F+*+*+T+:G*::+P:+:Y::.:+:+::: 5290 5300 5310 5320 5330 5340 1 TTPGKKKGSRSKSTEFYSELWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVP 5081 2 TTPGEKKGSRSKSTEFYSELWFIVLMAMLGLILLAIFVSLTLQRKIHKEPYIRERPPLVP 5081 3 TTPGEKKGAGTKSTEFYSELWFIMVMAVVGLILLAIFLSLILQRKIHKEPCIRERPPLVP 5072 4 TTPGGKKGAGTKSTEFYSELWFIMVMAILGLILLAIFLSLILQRKIHKEPCIRERPPLVP 5070 5 TTPGEKRGSGSKSTEFYNELWFIVLMAVLGLILLAIFLSLLLQRKIHKEPYIRERPPLVP 5078 6 TTPGEKMGAGSKHAEFYNELWFIILMATLGLILLAIFLSLILQRKIHKEPYIRERPPLVP 5084 7 TTPGEKDKAESKSVKFYNELWFAVLMVVLGLILLAILLSLILQRKVHKQPYARDRPPLVP 5104 8 ------------------------------------------------------------ 5015 9 THTTNKEGLSMSATPVYSELWFILLLSLLGLFLLALLLGLVLQRALRKNPSARERPPLVM 5133 10 --PSTGGTLPEAQTQWYSSVWFIAIMVLLGVVIIFILIAVVLSRTGTRKPYARERTPLPP 4929 11 ISGVDITGVAAASVPFFQQTWFTIVMVIVSMIVMSLVIGVIFRR---------------- 5121 12 ------------------------------------------------------------ 5038 C +:+::+.+..:::::++:++**+.:+:.++++++++:::+:++*:::+:+::++++++++ 5350 5360 5370 5380 5390 5400 1 LQKRMSPLNVYPPGENHMGLADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSL 5141 2 LQKRMSPLNVYPPGENHMGLADTKIPRSGTPVSIRSNRSACVLRIPSQSQTSLTYTQGSL 5141 3 LQKRMTPLSVYPPGETHVGLADTRLPRSGTPMSIRSSQSVSVLRIPSQSQLSHAYSQSSL 5132 4 LQKRMAPLSVHPPGETHVGLADTRLPRSGTPVSIRSSQSVSVLRIPSQSQLSHAYSQGSL 5130 5 IQKRMSPLNVYPPGETHVGLADTKIPHSGTPVSIRSNRSISVLRIPSQSQISQTYSQGSL 5138 6 LQKRMTPLSVYPPGETHMGLADTKIPGTGTPMSIRSNRSMSVLRIPSQSQMSRTYSQPSL 5144 7 LQKRTSPMSVYSTGETHPGLADTKIPGVGSPTSSRGIYNASGGRRPSQSQLNRTYSPASL 5164 8 ------------------------------------------------------------ 5015 9 LQKTRKAG-----GEAYMGLTDTKIVGSSSRFS-----PMSVLRVPSQTDLSQAYSQHSL 5183 10 RQRKAHNFTFSSMLPRYP---ESESILDPIPQAISRQSSMHSLHNTYYNPSFPAPSPPRP 4986 11 ------------------------------------------------------------ 5121 12 ------------------------------------------------------------ 5038 C :++::.::.::::++::.++:++:::.:::+.+:::..:.::++:+++::.: :++:.++ 5410 5420 5430 5440 5450 5460 1 HRSVSQLMDIQDKKVLMDN---SLWEAIMG----HNSGLY-VDEEDLMNAIKDFSSVTKE 5193 2 HRSVSQLMDIQDKKVLMDN---SLWEAVMG----HSSGLY-VDEEDLMNAIKGFSSVTKE 5193 3 HRSVSQLMDMADKKVVTED---SLWETIMG----HSSGLY-VDEEELMNAIKGFSSVTKE 5184 4 HRSVSQLMDSPDKKALTED---SLWETIMG----HSSGLC-VDEEELMNAIKGFSSVTKE 5182 5 HCSVSQLMDLQDKKVLVDD---SLWETIMG----HDSGLY-VDEEDLMNAIKGFSSVTKE 5190 6 HRSVSQLMDIQDKKVLTDD---SLWETIMG----HDSGLY-VDDEDLMNAIKGFSSVTKE 5196 7 HRSVSQLLDIYDKKSFADE---LPWDTIIRNHRAGGRGLY-AEEDDLVNVIKGFSTVTKE 5220 8 ------------------------------------------------------------ 5015 9 HRSVSQLID--RKSLMLEE---GSWDNPLG----HDSGLC-VEEEEFVDAIKSLRGGKKE 5233 10 TSRTSEVMDKNSLKYLDEDDGVAAWDNTAPLPLKMDSGMVSLYEDDAMTHISQPYSYTKE 5046 11 ------------------------------------------------------------ 5121 12 ------------------------------------------------------------ 5038 C +:+++++:+..:++::.:: ::+::::: :.+++: ::+::::::++:::::+++ 1 RTTFTDTHL 5202 2 RTTFTDTHL 5202 3 HTAFTDTHL 5193 4 HTAFTDTHL 5191 5 HTTFTDTHL 5199 6 HTTFTDTHL 5205 7 HTTFTDTHL 5229 8 --------- 5015 9 QTMFTDTHL 5242 10 QTMFTDTHL 5055 11 --------- 5121 12 --------- 5038 C :+:++++++