Edtaln : Multiple alignment ------------------------------------------------------------------------------- Le consensus est matrialis par une squence de caractres qui, selon la situation rencontre en une position donne, seront les suivants : "." si le caractre majoritaire a une reprsentation >= 20% ":" si le caractre majoritaire a une reprsentation >= 40% "+" si le caractre majoritaire a une reprsentation >= 60% "*" si le caractre majoritaire a une reprsentation >= 80% le caractre lui-mme, si celui-ci est identique pour l'ensemble des squences. ------------------------------------------------------------------------------- 1 Homo sapiens Q96QU1 NCBI 2 Pan troglodytes XP_507798 '' 3 Macaca mulatta ENSMMUP00000012820 Ensembl 4 Canis familiaris ENSCAFP00000022856 '' 5 Mus musculus Q99PJ1 NCBI 6 Rattus norvegicus ENSRNOP00000000744 Ensembl 7 Gallus gallus NP_001038119 NCBI 8 Xenopus tropicalis ENSXETP00000041095 Ensembl 9 Danio rerio A NP_001012500 NCBI 10 Danio rerio B AAW50924 '' 10 20 30 40 50 60 1 --MFRQFYLWTCLASGIILGSLFEICLGQYDD-----DCKLARGGPPATIVAIDEESRNG 53 2 --MFRQFYLWTCLASGIILGSLSEICLGQYDD-----DCKLARGGPPATIVAIDEESRNG 53 3 --MFRQFYLWTCLASGIILGSLVKICLGQYDD-----DCKLARGGPPATIVAIDEESRNG 53 4 -----------------------------------------------------------G 1 5 --MFLQFAVWKCLPHGILIASLLVVSWGQYDDDWQYEDCKLARGGPPATIVAIDEESRNG 58 6 -----------------------------------------------------------G 1 7 --MLQQFCLWKWLAVGIAVATILASSLAQNDE-----DCKLARTGPPATIVPIDEESRNG 53 8 -------------------------------------DCKLARGGIPATIVPIDEESANG 23 9 --MRRRWWRLDCLGSAIALFVIISQISAQNTEDWHYEECKLSRSGPPATIVTIDEESPNG 58 10 MKMRQRSWLYKWLGIGIGVLLLTAASYSQDSEDWQYEECKLSRTGPPATIVAIDEQSPNG 60 C +::::.::.:+::++.:.::....::+:::.....+***+*:*+*****:***+*:*G 70 80 90 100 110 120 1 TILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHS 113 2 TILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHS 113 3 TILVDNMLIKGTAGGRDPTIELSLKDNMDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHS 113 4 TILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHS 61 5 TILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHS 118 6 TILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHS 61 7 TILVDNMLIKGTAAGPDPTIELSLKDNVDYWVILDPISQRLYLNSTGRVLDRDPPMSIQS 113 8 TIIVDNMQIKGTAGVPDATIELSLKDNTDYWVILEPKTQRLYLNSTGRVLDRDPPSSIQS 83 9 TILVENMQINGRARDPDRTISLTLLDNYDYWVILDPALQRLFLNSTGRVLDRDPPSSITT 118 10 TLLVENMQINGRAEDPDRTISLSLRDNNDYWVILDPVKQRLYLNSTGRVLDRDPPSYIQS 120 C T**V*NM+I*G*A++*D+TI*L*L*DN+DYWV++*P++Q+L+LNSTGRVLDRDPP++I+* 130 140 150 160 170 180 1 IVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD 173 2 IVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD 173 3 IVVQVQCVNKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD 173 4 IVVQVQCINKKVGTVIYHEVRIVVRDRNDNSPTFKHDSYYATVNELTPVGTTIFTGFSGD 121 5 IVVQVQCVNKKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD 178 6 IVVQVQCVNKKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFAGD 121 7 IVVQVQCVNKKVGTIINHEVRIVVRDRNDNSPQFQQQRYYVAVNELTPVGTTIFTGFSGN 173 8 IVVLVQCVNKKVGSIINHEVRIVVRDKNDNSPKFQMQNYRAVVNELTPVGTTIFTGFSGD 143 9 IVVQIQCTNELVGTVILHEVRIVVRDRNDNTPRFQQPRYYVSVNELTPVGTTIFTGFSGN 178 10 IVVQVQCTNELVGTVILHEVRIVVRDRNDNAPRFQQPRYYVAVNELTPVGTTIFSGFTGN 180 C IVV**QC:N**VG*:I+HEVRIVVRD*NDN*P+F++:+Y*++VNELTPVGTTIF*GF*G+ 190 200 210 220 230 240 1 NGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQ 233 2 NGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQ 233 3 NGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYFVIIQ 233 4 NGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYFVIIQ 181 5 NGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQ 238 6 NGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQ 181 7 NGATDIDDGPNGQIEYVIQYNPNDKTSNRTFDIPLTLSGAVVLRERLNYEEKTRYFVIVQ 233 8 GGATDIDDGPNGQIEYVIQYNPNDTASNQTFDIPLTLSGAVVLRRRLNYEEKTRYFVIVQ 203 9 NGATDIDDGPNGQIEYAIQYNPNDPMSNRTVRIAGTLSGNIVLAERLNYEERTRYLIIVQ 238 10 NGAVDIDDGPNGQIEYTIQYNPRDPTTNRTFDIPLTLSGSVVLRERLNYEEITRYLVIIQ 240 C *GA*DIDDGPNGQIEY*IQYNP:D***N+T*+I**+L+G++VL*+RLNYE+*TRY+*I+Q 250 260 270 280 290 300 1 ANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPE 293 2 ANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPE 293 3 ANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPE 293 4 ANDRAQNLNERRTTTTTLTVDILDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPE 241 5 ANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPE 298 6 ANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPE 241 7 ANDRAQNLHERRTSTTTLTVDVLDGDDLGPMFLPCVLVNNTRDCRPLTYQASLPELTDPV 293 8 ANDRTPNPNERRTSTTTLTVDILDGDDLGPMFLPCVLVDKTRDCRPLTYNAVIPELRSPA 263 9 ANDRAPYPGTRRTATTTLTLDVLDGDDLGPMFLPCVLVNNTQDCNPVTYRVAIPELTDPN 298 10 ANDRAPNPKDRLTATTTLTVDVLDGDDLGPMFLPCSLVDNTRDCKPLTYRASILELTDPS 300 C ANDR*+*++*R*T+TTTLT*D*LDGDDLGPMFLPC*LV+*T*DC*P*TY+*+**EL++P+ 310 320 330 340 350 360 1 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353 2 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353 3 ELNPIVVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353 4 ELNPIIVTPPIQAVDQDRNIQPPSDRPGILYSILVGTPEDYPRFFQMHPRTAELSLLEPV 301 5 ELNPILVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELTLLEPV 358 6 ELNPILVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFLHMHPRTAELTLLEPV 301 7 HVNPISVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPQYFHMNLTTAELTLLKPI 353 8 AVNPVNVTPAIQAIDQDRDIQPASDRPGIIYSILIGTPQNYAEYFSMNQTTAVLRLLKPV 323 9 KLNPLNVTPPIRAIDQDRNIQPPSDRPGILYFILVGTPSTYPEFFTLNRSTAELRLLKSV 358 10 RVNPVNVTPPIQAVDQDRNIQPPSDRPGILYSILIGKPETYGEFFWMNRSTAELQLLKAI 360 C ++NP+.VTP*I*A*DQDR*IQP*SDRPGI*Y*IL*G*P*+Y*+**+*+++TA*L:LL+** 370 380 390 400 410 420 1 NRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 413 2 NRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 413 3 NRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYIPESAPVGAT 413 4 NRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 361 5 NRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 418 6 NRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 361 7 NRDLHQKFDLVIKAEQDNGHPLPAFANLHIEVLDENNQKPYFTKSTYEGFILESSPVGTT 413 8 NRDLIQKFDLVIKAEQDNGHPLPAFANLHIDILDENNQAPYFTFVTYQGYILESSPVGTT 383 9 DRELYQRFSLVIKAEQDNGHPLPAYSKLEIEILDENNQAPYFQQSSYRGFVSESSSVGTT 418 10 SREKYQHFDLVIKAEQDNGHPLPAFANLHIEVLDENNQAPYFQVATYHGFISESAPLGTT 420 C *R*++Q*F*LVIKAEQDNGHPLPA**:L*I**LDENNQ+PYF*+++Y+G+*+ES+**G+T 430 440 450 460 470 480 1 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 473 2 ISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 473 3 IADSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 473 4 ISDSLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE 421 5 ISESLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTPTGITRYLTLLQPVDREE 478 6 ISESLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTPTGITRYLTLLQPVDREE 421 7 ISDSRNLTSPLQITVLDNDVEETKDPQLHLFLNDYNTFFTVTQSGITRYLTLLQPVDREA 473 8 ISDSQNLTAPLKFVALDNDIEETKDPQLYLYLNAFSTVFSVTPTGITRYLTLLQPVDRET 443 9 ISASANLTAPLAIIALDNDIEETKDPQLKITLNEYTSIFTITTSGITRFLTLLKPVDREI 478 10 ISSSANLSTPLAIIVLDNDIEETKDPMVRISLDNYNGIFAVTAGGIVRYLTLLRPVDHEE 480 C I*+S+NL*:PL+*+*LD+D*E+TKDP+*+*+L*+*+++F**T:+GI*R*LTLL*PVD*E+ 490 500 510 520 530 540 1 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533 2 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533 3 QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTA 533 4 QQTYTFSITAFDGVQESEPVIVNIRVMDANDNTPTFPEISYDVYVYTDMSPGDSVIQLTA 481 5 QQTYTFLITAFDGVQESEPVVVNIRVMDANDNTPTFPEISYDVYVYTDMSPGDSVIQLTA 538 6 QQTYTFLITAFDGVQESEPVVVNIRVMDANDNTPTFPEISYNVYVYTDMSPGDSVIQLTA 481 7 QQLYTFSMIASDGVQESTPVTVNIVVIDANDNSPTFSNISYNVKIYTDMGPGEGVIKLTA 533 8 QQIYQFSMIASDGTQESFPVTVNIIVIDANDNTPTFSNISYNVKIYTDVKAGESIIRLTA 503 9 QTNYTLTLVATDGVQQSRPVTVDILVIDANDNTPTFAQVSYSVEIFTNMLPGETVLQLMA 538 10 QPTYAFTMIASDGVQESAPVTINITVIDANDNTPTFPNVSYGVSVYTDMQPGDPVLQLTA 540 C Q*+Y**+++A+DG*Q*S+PV:**I.V+DANDN*PTF++*SY:V++*T**.*G++***L*A 550 560 570 580 590 600 1 VDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593 2 VDADEGSNGEITYEILVGAQGDFIINKTTGLITMAPGVEMIVGRTYALTVQAADNAPPAE 593 3 VDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593 4 VDADEGPNGEITYDILVGAQGDFAINRTSGLVTVAPGRALTVGRTYALTVQAADNAPPAE 541 5 VDADEGSNGEISYEILVGGKGDFVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPPAE 598 6 VDADEGSNGEISYEILVGSKGDFVINRTTGLVSIAPGVELVVGQTYALTVQASDNAPPAE 541 7 VDADEGPNGQIVYEILAGDQGDFIINDRTGLIAIAPGVVLSVGRSYALTVKASDSAPPAQ 593 8 LDADEGVNGQITYEILAGSQGKFEINGRTGVVSISPGVTVLVGEMFALTVKAYDNAPLNQ 563 9 QDADAGLNGLITYAILAGDHGDFIINNRTGRITLAPGVMLTVGRSYALTVRAADNAPDTE 598 10 LDADDGPNGLVSYKILAGDQGHFTINDCTGVITVLPSVNLTVGRSYALTVRATDNGPTAQ 600 C +DAD*G:NG+*+Y+IL+G:+G*F:IN:+*G++++*P**:+:VG++*ALTV+A:D**P+*+ 610 620 630 640 650 660 1 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIE 653 2 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIE 653 3 RRHSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDPITYAIE 653 4 RRHSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRIGAVLLNLQATDREGDPITYAIE 601 5 RRHSICTVYTEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAILLNLQATDREGDPITYAIE 658 6 RRHSICTVYIEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAVLLNLQATDREGDPITYAIE 601 7 RRSSITTVYIEVLPPNNQSPPRFPQLMYSLEVSEAMRTGAILLNLQAFDREGDPIRYLIE 653 8 RRSSITTVYIEVLPPNNQSPPRFSQLMYSLEVSEAMRIGAILLNLQATDREGDPITYLIE 623 9 RRSSITTVYIEVLPPNNQSPPRFPLQTYNLEISEAMRIGAILLNLQATDRELDPITYRIE 658 10 RRSSITTVYIEVLPPNNQSPPRFHQLVYSLEISEAMRTGATLLNIQATDREKDPVTYSIQ 660 C RR:SI+TVY*EVLPPNNQSPPRF****Y*LE+SEAMR:GA:LLN*QA*DRE*D***Y+I* 670 680 690 700 710 720 1 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDN 713 2 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDN 713 3 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNVVVTDVNDN 713 4 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIVTASDGRPDGTSTATVNVVVTDVNDN 661 5 NGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDGTSTATVNIVVTDVNDN 718 6 NGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDGTSTATVNIVVTDVNDN 661 7 NGDPQQVFNLSQSSGLLALGKPLDRESTDRYILIVTASDGRPDGTSTATVNIVVTDVNDN 713 8 NGDPQKVFNLSVSSGLLMLAKALDRESTDRYILIVTASDGRADGTSTATVNVVVTDVNDN 683 9 TGDPQEVFNLSRTIGLLLLAKPLDRETIDQYRLIVTASDGHPGGISTATVSIVITDVNDN 718 10 KGDPNNVFEVSQTSGLLLLAKTLDREITDXYTLTVTASDGKPDGTSTTTVNIAVTDVNDN 720 C *GDP*+VF**S+*+G+L:L+K+LDRE**D*Y*L*+TASDG***G*ST*TV*+**TDVNDN 730 740 750 760 770 780 1 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYT 773 2 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYT 773 3 APVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYT 773 4 APMFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYT 721 5 APVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYT 778 6 APVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYT 721 7 GPVFDMFLPKNLSVQEEEANAFVGQVRATDPDAGVNGQVHYSLANFKNLFRITSNGSIYT 773 8 DPVFDLYLPRNLSVQEEELNAFVGQVRATDPDAGVNGQVRYSLANLNNIFRITANGSIYT 743 9 DPTFDLTLPRNLTVREEEANVFVGQVRATDPDGGLNGQVRYRLLSFASLFSINSTGSIFT 778 10 DPEFDPLLPLNLTVQEEEANAFVGQVKATDLDLGINGQVRYRLVSYPDLFRISPNGSIFT 780 C +P+FD++LP*NL*V+EEE*N*FVGQV+ATD*D*G+NGQV+Y*L+**+**F*I***GSI*T 790 800 810 820 830 840 1 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833 2 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTILVEENLP 833 3 AVKLNREVRDYYELVVVATDGAVHPRHSTVTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833 4 AVKLNREVRDSYQLVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVVVEENLP 781 5 AVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLP 838 6 AVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLP 781 7 AVKLNREVRDYYELIVEATDGAVDPRRSTLTLAIKVLDIDDNSPVFTNASYSVLVPENLP 833 8 SVKLDRETKDSYELVVEATDGAVDPRRSTITLTIKVIDIDDNSPQFTNSTYSVSVPENMI 803 9 AVPLDRETRSRYDLIVEASDGAVDPRRTTITLLVEVLDINDNSPVFSQPVYTVNVPENTP 838 10 AMPLDREERAQYDLIVQASDGAKDPRRTTITLSITVLDVDDNSPVFSPPAYHATLPENSP 840 C ***L+RE:**:Y+L+V+A*DGA*+PR+*T+TL:**V*D**DNSP*F**++Y+*:*+EN+* 850 860 870 880 890 900 1 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893 2 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893 3 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893 4 AGTTFLQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYESFPEQEASIT 841 5 AGTSFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASIT 898 6 AGTAFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASIT 841 7 PGTVFLQIEAKDVDLGSNVTYRIRTQEALEYFALNKYTGELSLLKSLDYESFSDTDATFT 893 8 PGTVFLRVQAKDADLGANITYRIRSQDVLQFFAMNQSTGELSLLKALDYELFTNMEAAYM 863 9 AGSIILRLTAVDADLVSNVTYRIKTEAALQLFAVNRLTGVISVLQALDFESLAAGNSTYT 898 10 VGTVILNISALDPDLDANVTYRIRTKEARELFAVNSLTGELKVLRSLDFEKLLPNATTQT 900 C +G*::L+*+A*D+DL**N*+YRI*++*+++:FA++++TG****L+*LD*E:*++++*++* 910 920 930 940 950 960 1 FLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952 2 FLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952 3 FLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952 4 FLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 900 5 FLAEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 957 6 FLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 900 7 FLVEAFDSK-GTMPPGLATVTVRVKDMNDYSPVFSKTLYRGMVAPDAVKGTVITTVSAED 952 8 FIIEAFDAA-GTMPPGLATVTVRVKDMNDYSPVFTKALYWGMVAPDALKGTLVATVAAED 922 9 FEVEALDHG-GVLPPGTATVSVRITDMNDFSPVFRQALYKGLVAPNAEKGTVITTVLAED 957 10 FVVEALDGGSGKMPPGLASVTVTVLDMNDFPPVFSQTLYRGMVAPNAVKGTIVTAVHAED 960 C F+*EA*D++ G**PPG+A*V*V+**DMND*+PVF**++Y+G*VAP*A*KGT+***V+AED 970 980 990 1000 1010 1020 1 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012 2 ADPPGLPASRVRYRVDDVQFPYPASIFDVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012 3 ADPPGLPASRVRYRVDDVQFPYPASIFDVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012 4 ADPPGLPASRVRYRVDDVQFPYPASIFDVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 960 5 ADPPGMPASRVRYRVDDVQFPYPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAFDDG 1017 6 ADPPGLPASRVRYRVDDVQFPYPASIFDVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 960 7 QDPPGTPASRVRYKVDVVQFPYSASIFDVEENSGRVVTRVNLNEEPSTVFKLVVIAYDDG 1012 8 KDPPGTPASKVRYKVDVVQFPYSASIFDVEENTGRVLTRVNLNEEPSTIFRLGVIAYDDG 982 9 QDPPGTPASKVRYRVDQELSPYSGSIFDVETDTGLVITKVNLNEQPTTVFKLVVMAYDDG 1017 10 LDPPGTAASRVHYKADLEQFPYSTSIFDVEENSGNIFTRVNLNEEPNTKFSLAVIAYDDG 1020 C +DPPG:*AS*V*Y+*D+***PY+*SIF*VE*+*G**+T*VNLNE*P+T+F*L*V+A+DDG 1030 1040 1050 1060 1070 1080 1 EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN-QSIVYSI 1071 2 EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGAISAAAIN-QSIVYSI 1071 3 EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN-QSIVYSI 1071 4 EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATRGTMVGVISAAAIN-QSIVYSI 1019 5 EPVMSSSATVRILVLHPGEIPRFTQEEYRPPPVSELAARGTVVGVISAAAIN-QSIVYSI 1076 6 EPVMSSSATVRILVLHPGEIPRFTQEEYRPPPVSELAARGTVVGVISAAAIN-QSIVYSI 1019 7 DPVKFNTTTVEIAVLQPSVIPRFTQDEYRPPPVSESAPKGTVVTVVMAAALN-QTIVYSI 1071 8 DPVKSNSTTVIITVLQPSVIPRFTQDEYSPPPKSSLVPPTHVTHSLDSTEVNQQNKTDSL 1042 9 EPVKTNRTTVEITVLQPSRIPIFTEEEYRFSPVSENAPIGTPVGLILAAATN-TTVVYSI 1076 10 EPMKFNKSLVEITVLQXSIIPVFTQEEYRFAPVSENAPVGTVAGVILAAAIN-QTIVYSI 1079 C *P*+++++*V:I+VL+*++IP*FT**EY***P*S*+*::**:**+*+***+N *+***S* 1090 1100 1110 1120 1130 1140 1 VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVY 1131 2 VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVY 1131 3 VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVY 1131 4 VAGNEEDMFGINNITGVIYVNAPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVY 1079 5 VAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVY 1136 6 VAGNEDDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVY 1079 7 VSGNEEDVFAINNRTGVISVKKPLDYERVTSYELRVQADSLQVVRSNLRVPSKSNTAKVF 1131 8 ITSDEAGIFAIDNSTGVITVAKPLDYENTTSYELRIQADSMEVTKYNLRAASKSNTAIVF 1102 9 VSGNEGGVFTVNKSTGIIYTNKSLDYENVTSYVLRVQADSLTVILANLRAPSKTNTAKVF 1136 10 IEGNEGGEFVVNNNTGVISTAKPLDYESNSSYVLRVEADSMRVVSSNLRAPAKSNTAKVF 1139 C *:**E++.F+***:TG*I+*+:*LDYE++*SY*LR**ADS*+V*++NLR+**K*NTA*V+ 1150 1160 1170 1180 1190 1200 1 IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG 1191 2 IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG 1191 3 IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG 1191 4 IEIQDENDHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSAMAYRLIIPPIKEG 1139 5 IEIQDENDHPPVFQKKFYIGGVSEDARMFASVLRVKATDRDTGNYSAMAYRLIIPPIKEG 1196 6 IEIQDENDHPPVFQKKFYIGGVSEDARMFTSVLRVKATDRDTGNYSAMAYRLIIPPIKEG 1139 7 IEVKDENDHAPVFTKKMYIGGVSEDAKMFSSVLKVKADDKDTGNYSAMQYRLIIPPIKDG 1191 8 IEVQDENDHAPVFSKKVYLGGVSEDARMFASVLKVKTTDRDTGNFSTNNYKLVIPPIKDS 1162 9 INVQDENDHPPVFSRQVYIGGVTEDTKTFTTVLKIVATDVDTGNYSKMAYRLIIPPTTEG 1196 10 IDVQDENDHPPVFTKPFYLGGVAEDAKTFTSVLQVQALDKDTGNYSAMLYRLIIPPTTDG 1199 C I*+*DEN+H*PVF+**+Y*GGV*ED*+*F+*VL+****D+DTGN*S:*+Y*L*IPP**+* 1210 1220 1230 1240 1250 1260 1 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1251 2 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1251 3 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1251 4 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDNYGQGLSGKADVLVSVVNQLDMQVI 1199 5 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1256 6 KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVI 1199 7 KEGFVIEAYTGLIKTAMLFKNMRRSYFKFQVIATDDYGKGLSSKADVLVSVVNQLDMQVI 1251 8 KEGFVIEIHSGIIKTAMLFKNMRRSYFKFDVIATDDYGKGLSSKAEVIVSVVNQLDMQVI 1222 9 QDSFVIEPYTGVIKSAIMFRNMRRSYFKFQVVATDDYGKGLTSKADVVVSVVNALDMQVV 1256 10 KDGFVIEPFTGVIKTAIMYRNMRRSYFKFDVVATDNYGEGLSSSAQVVVSVVNQLDMQVV 1259 C ***FV+E+**G+IK*A***+NMRRSYFKF*V*ATD*YG*GL*+*A*V+VSVVN*LDMQV* 1270 1280 1290 1300 1310 1320 1 VSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVY 1311 2 VSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVY 1311 3 VSNVPPTLVEKKIEDLTEILDRYVQDQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVY 1311 4 VSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVY 1259 5 VSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAYSLEDYSKCDLTVY 1316 6 VSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYSKCDLTVY 1259 7 VSNVPPTLVEQNKDQLIGILERYVQDQIPGATVVVESIGARRFGDGYSEEDYTKSDLMVY 1311 8 VSNVPPTVIEENIDDLVRILEGYVQDQIPGAAVVVESIGARRYGDGFSQEDYTQSDLMIY 1282 9 VSNVPPTVVEENKEQLISILERYVQDQIPGAKVIVESIGPRRHGEGYELEDYSKSDLQVY 1316 10 VSNVPPTVVEQNKDRLIGILERYVQDQIPGAKVVMESIGARRFGDGYEQEDYTKSDLMVY 1319 C VSNVPPT+*E+++++L++IL+*YVQ:QIPGA*V**ESIG*RR+G*++*+EDY+*+DL+*Y 1330 1340 1350 1360 1370 1380 1 AIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLG 1371 2 AIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLG 1371 3 AIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLG 1371 4 AIDPQTNRAIDRNELFKFLDGKLLDINKDFQPHYGEGGRILEIRTPEAVTSIKKRGESLG 1319 5 AIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLG 1376 6 AIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLG 1319 7 AIDPQTNRAIMRNELFKFLDGKLLDINKEFQPYLGQGGRILEIRTPDVVANVKKQAQAVG 1371 8 AVDPKTNRAISRNELYKFLDGKVLDINKQFQDYIGQGGRILEIRTPDVVANVKKQAQAVG 1342 9 AIDPLTNRAISRQELFKFLDGKILDINKEFQPYLGEGGRILEIRSPDIVATVKKAAQAVG 1376 10 AIDPLTNRALSRQELFKFLDGKLLDINKEFQPYLGRGGRILEIRTPDVVESVTRAVHSVG 1379 C A*DP+TNRA*+R*EL*KFLDGK*LDINK+FQ**+G+GGRILEIR*P++V+++**+++++G 1390 1400 1410 1420 1430 1440 1 YTEGALLALAFIIILCCIPAILVVLVSYRQFKVR-QAECTKTARIQAAL-PAAKPA---- 1425 2 YTEGALLALAFIIILCCIPAILVVLVSYRQFKVR-QAECTKTARIQAAL-PAAKPA---- 1425 3 YTEGALLALAFIIILCCIPAILVVLVSYRHLALR-QAECTKTARIQAAL-PAAKPA---- 1425 4 YTEGALLALAFIIILCCIPAILVVLVSYRQFKVR-QAECTKTARIQEKIKPRTNPF---- 1374 5 YTEGALLALAFIIILCCIPAILVVLVSYRQFKVR-QAECTKTARIQSAM-PAAKPA---- 1430 6 YTEGALLALAFIIILCCIPAILVVLVSYRHYLVKRQAECTKTARIQSAM-PAAKPA---- 1374 7 YTEGALLALAVIIILCCMPAILIVMVSYRQ---R-QAECAKTARIQMAL-PAGKPA---- 1422 8 YTEGALLALAIIIILCCIPAIMIVMVSYRQISVSRQAECAKTARIQMAL-PAGKQS---- 1397 9 YTEGALLALAIIIILCCIPAILIVMVTYKQFKER-QAECAKTARIQMAL-PAGKSTGGGG 1434 10 YTEGALLALAVIIILCCIPAILIVIITYRQFKER-QAECAKTARIQMAL-PTGKS----- 1432 C YTEGALLALA+IIILCC*PAI*+V+**Y**+++*.QAEC+KTARIQ:*+ P*:*++ 1450 1460 1470 1480 1490 1500 1 VPAP-------------------APVAAPPPPPPPP---------PG------------- 1444 2 APAP-------------------APVAAPPPPPPPP---------PG------------- 1444 3 APAP-------------------APVAAPPPPPPPP---------PG------------- 1444 4 QKLP-------------------NNVPNGPDTASPP---------MG------------- 1393 5 APVP-------------------AAPAPPPPPPPPP---------PG------------- 1449 6 APVP-------------------AAP--PPPPPPPP---------PG------------- 1391 7 STAANNLYEELGDSTMRGYAQQEQQQLLRPSLLRPEELSMESGIDPGQEYYGQDYYSYEH 1482 8 TPAAN------------------------------------------------------- 1402 9 G----------------------GGGGGGGGGGAQT------------------------ 1448 10 ------------------------------GGAATN------------------------ 1438 C :+:+. :.::.:+::::++ ++ 1510 1520 1530 1540 1550 1560 1 ----------------AHLYEELGDS--SILFLLYH----------FQQSRGNNS----- 1471 2 ----------------AHLYEELGDS--SIIFLLYH----------FQQSRGNNS----- 1471 3 ----------------AHLYEELGDS--SILFLLYH----------FQQSRGNHS----- 1471 4 ----------------VYFSSSSLSSFLSSLFLLYH----------FQQSRGDKS----- 1422 5 ----------------AHLYEELGESAMHNLFLLYH----------FEQSRGNNS----- 1478 6 ----------------AHLYEELGESAMHNLFLLYH----------FEQSRGNNP----- 1420 7 GYELPQYGSRRRLLSPSGMYDEYGEVMVENDGGYYYSPHGSTAEEGMSQSRGPSSRGISQ 1542 8 -----------------NLYEELGGSTMNRLFLLYH----------FHQSRGKKS----- 1430 9 -----------------NLYEELGDGG------------------MLGLQRRRRS----- 1468 10 -----------------NLYEELGDS---------------------TIPKTKRC----- 1455 C ::******:*..:.++++*+ +:****::* 1570 1580 1590 1600 1610 1620 1 --------------------------VSEDRKHQQVVMPFSSNTIEAHKSA--------- 1496 2 --------------------------VSEDRKHQQVVMPFSSNTIEAHKSA--------- 1496 3 --------------------------VSEDSKHQQVVMPFSSNTIEAHKAA--------- 1496 4 --------------------------VSEDRKSPHSVMPFPSSTIEAHKQA--------- 1447 5 --------------------------VPEDRSSHRDGMAFSSSTTESHEPA--------- 1503 6 --------------------------VPEDRSSHRDGMAFSSSTTESHEPA--------- 1445 7 RAGAQIEGRPLDGGMDLRHGSGRAYRTSQGRRKLKAVMHLSRVAVSAHKPVGRSESAHSP 1602 8 --------------------------VLQEGDRQRLISNLASRAIEAHKLS--------- 1455 9 --------------------------VIEEADRQSLIRNFASRAIAAHKQT--------- 1493 10 --------------------------VLKDGDRQRLISSFASRAITAHKLS--------- 1480 C *:+++:.+:.:+:*+*.+++*H*.+ 1630 1640 1650 1660 1670 1680 1 ------------HVDGSLKSNKLKSARKFTFLSDEDDLSAHNPLYKENISQVSTN---SD 1541 2 ------------HVDGSLKSNKLKAARKFTFLSDEDDLSAHNPLYKENISQVSTN---SD 1541 3 ------------HVDGSLKSNKPKSARTFTFLSDEDALSAHNPLYRENISQVSTN---SD 1541 4 ------------HVDGSLRNNQPKSARKFTLMSEEDAFSLHSTLYKEAVDPRPTN---SD 1492 5 ------------HVEGPLKESQPNPARTFSFVPDEDNLSTHNPLYMESIGQRSTN---SD 1548 6 ------------HVEGPLDN-QANPARTFSFLPDEDDLSTHNPLYMESIGQRSTN---SD 1489 7 WKKAKIFPMILQKVKGSRKDSSYAKLMSARQADGEKSMIIRGSYFQKSTDDRPSMRKLNH 1662 8 ------------GPSGYLNNKLPKSASNITFLSDTNPLTTQNPLYIEGSGQCNDS---IE 1500 9 ------------TGNGQMRSKLPKSESAITFLSDERPLTTQNPIFQDGLSS-SPEPN--- 1537 10 ------------TANGILLNNFPKSESNITFLSDDNPLTTTNPLYRDDVTLGSPEHQNRS 1528 C ++:G:*:::.+++++.++*++**+.*+:+****.+.::+:+++ ++ 1690 1700 1710 1720 1730 1740 1 ISQRTDFVDPFSPKIQAKSKSLRGPRE-----------------------------KIQR 1572 2 ISQRTDFVDLFSPKVQAKSKSLRGPRE-----------------------------KIQR 1572 3 ISLRTDFVDPFLPKIQAKSKSLRGPRE-----------------------------KIQR 1572 4 FLLRTDFIDSFLPKTQARSKSLRGPRE-----------------------------MFQR 1523 5 LQPRTDFEELLAPRTQVKSQSLRGPRE-----------------------------KIQR 1579 6 LQPGTEFGELFVPRTQVKSQSLRGPRE-----------------------------KIQR 1520 7 VLKRISVSRKFQEPTSKDAVHLGGKEEEERDEAKSGVSISITAESEHEESDYEKKKKRRR 1722 8 LAWRSRFALGKPGRKSLKDSLLNSE-------------------------------GIHR 1529 9 --LEVRRISGFLYSDPPSPTSPCGQFT--------------------------------- 1562 10 YLLDMYSPSMRGLSKSIMGFPNSGSGH--------------------------------- 1555 C ..:++:+.:.+.+::+:++:+*+*+++ +++* 1750 1760 1770 1780 1790 1800 1 LWSQSVSLPRRLMRKVPNRPE---IIDLQQWQGTRQKAENENT-----GICTNKRGSSNP 1624 2 LWSQSVSLPRRLMRKVPNRPE---IIDLQQWQGTRQKAENENT-----GICTNKRGSSNP 1624 3 LWSQSVSLPRRLMRKVPNRPE---IIDLQQWQGTRQKAENENT-----GICTNKRGSSNP 1624 4 IWHQPVCFPQRPVWELPRRPE---TLELEPRRSRRPEGGKESP-----GTPPNQRGSRNP 1575 5 VWNQSVSFPRRLMWKAPNRPE---TIDLVEWQITNQRAECESA-----RCHPSQRGSSNV 1631 6 VWNQSVRFPRRLMWKTPNRPE---TIDLVEWQITRQRAECEKT-----RCHPSQQGSSNL 1572 7 KYSSDESSAKSSSSGSESEDKDYLTVTLDQDEATESTVDSDEESGHDIGDSDDGSGSSSS 1782 8 AWTLPTCFSKRHAYDILNSPV---IMDPIQGQHKRTQQQSEPS------ENSHKTDCPRP 1580 9 SWSLPSRIRGRGFYSTLRRQA---LWDPAQWEEQQLKAELTDS-------REELDADQ-- 1610 10 SWTLPSRLHKWDE-SQRSRRV---VMDPVQWELQLLKASLKDS-------KEMIDGFDGL 1604 C .*:+:+::+:*::.:.++*++ ::*+.+++.++::++.+.: :...:::*+++: 1810 1820 1830 1840 1850 1860 1 LLTTEEANL----TEKEEIRQGETLMIEGTEQ---LKSLSSDSSFCFPRPHFSFSTLPTV 1677 2 LLTTEEANL----TEKEEIRQGDTLIMKGREQ---LKSLSSDSSFCFPRPHFSFSTLPTV 1677 3 LLTTEEANL----TEKEEIRQGETLIIKGTEQ---LKSLSSDSSFCFPRPHFSFSTLPTV 1677 4 LPAAGESSV----PETGEARPGQPLLPRGAQH---VESLSSDSSFLSPSSHSSYSTLTTV 1628 5 LLATEDAHE----SEK-EGGHRDTLIVQQTEQ---LKSLSSGSSFSSSWSHFSFSTLPTI 1683 6 MVTTEDARG----SEK-EGGHRDTLIVQQTEQ---LKSLSSGSSFSSSWSHFSFSTLPTI 1624 7 SESEEDSSEEDSDEEESDSDEDDSLSQSSSTQSSFSKSGTSESSSRRSTGRSSTKSRGSS 1842 8 LENVKTNKLS--VKEQARQFEQNALQEVKQVKAE-NKELYSGSTKSTSQASISCHRFPPS 1637 9 SGRSTETKLS--VREQARQFE--ALADRTPRQ-----SRDSYASLDPDDPLLGTIMLSYS 1661 10 GDEDPEPKLT--VKEQARQFEQQALQDVKLRQ-----GQDSRGSLSS------EIILSVF 1651 C +:::++:.+. ..E:.+.:::::L:..:::* :+*++S:**+:::.:+:*:++*++: 1870 1880 1890 1900 1910 1920 1 SRTVELKSEPNVISS--------PAECSLELSPS-RPCVLHSSLSRRETP-ICMLPIETE 1727 2 SRTVELKSEPNVISS--------PAECSLELSPS-RPCVLNSSLSRRATP-ICMLPVETE 1727 3 SRTVELKSEPNVITS--------PAECSLELSPS-RPCVLNSSLSRRETP-ICMLTVETE 1727 4 SRTVELQAEPDVIIS--------PADCSLELSPS-MPCILNSPVFRREMP-TCLLTVEAG 1678 5 SRAVELGSEPNVVTS--------PADCTLELSPPLRPRILNSLSSKRETP-TCASDTEPK 1734 6 SRAVELGSEPDVVTS--------PADCTLELSPPRRPRVLNSLGSKRETP-TCASDTETK 1675 7 SRGRARRSSQKSVSSNT------SGASCRKTSGSSYKSKTSSASLEIEDT-IEEVSEEDE 1895 8 SSLQRLCEVPATDPSIFPSIIITPSDHCDDISPPPTRKPTPPSEKKHLAPGQVYLSNEHD 1697 9 TISVGKDSPPCIIIT---------GDDGETPPPPTAQRPTPPVVRKFSSSISNYMTVEPC 1712 10 ETPHN-SRPPAIIIT---------QSDS-TPPP--SHKPTPPVLRKYTR-LSSYPDLESY 1697 C *+:+++.++*:++.* ++:+:+++**: :+::+:+::::++:+ :+.:.:E:: 1930 1940 1950 1960 1970 1980 1 RNIFENFAHPPNISPSACPLPPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIP 1787 2 RNMFENFAHPPNISPSACPLPPPSPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPP--- 1784 3 RNIFENFAHPPNISPSACP-PPPPPISPPSPPPAPAPLAPPPDISPFSLFCPPPSPPSIP 1786 4 RNIFEILPKPPNI------------LSPPS-------WAP-------------------- 1699 5 RNSFEIAPHPPSIFAPLPHPPLPRPPIAFTTFPLPLSPPNPPPPQLVTFSLPISTPP--- 1791 6 RNSFEMVPHPPSISAPLPQLPLPQPPIAFTTFPLPLSSPNPPRPQLLTFSLPISTTP--- 1732 7 QADAEQVGASPDETIDNTKNKTVSKTSANAKSAKNAATEEDKRRKSGVNSGDNGDESAEE 1955 8 PMLEDPIPDPPNIPPPLPPLPHSVSCSQLLLPPMPSPSDNFMPPPPPFFPAPSRPPS--- 1754 9 EILLEFISDFPGSPPPSPPSLVPSRS-------FLSPPCLELD----------------- 1748 10 EVNVEIIPDPPDVPAPQPPPPPPPPSSPPPPPPPSSPPPLPPS----------------- 1740 C ++.+*..::*P:+:::.:+:+:+.+.+:::::+.+:+.::++:..:.....+...::... 1990 2000 2010 2020 2030 2040 1 LPLPPPTFFPLSVSTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVK 1847 2 -----STFFPLSISTSGPPTPPLLPPFPTPLPPPPPSIPCPPPPSASFLSTECVCITGVE 1839 3 LPLPPSTFFPLSISTSGPPTPPLLPPFPT-LPPPPPSIPCPPPPSASFLSTECVCITGVK 1845 4 -------------------------------------------------STTCVCVPVVK 1710 5 ------------TSSLPLPPPLSLPPPPR----PPAPRLFPQPPSTSIPSTDSISAPAAK 1835 6 ------------ASSLPPPPPPSLPPPPR----PPAPRLFPLPPSTSVPSTDSISTPAAK 1776 7 VDTDASDKEETVSKNGSEISVTSKGTGGIKSTASATSGRTATSPDTETQSSDINWARKKR 2015 8 -----LPEEPLEIPSPSPTPPPLDTPSPAPQSQPTPLAPPPPPFLQDLLTSSSLRNPLFH 1809 9 -------------CTPPPTPPPIQSPEIP-------------------VQCPTFKP---- 1772 10 -------------SSPPPLPPSSSPPLVPPSPSVPPHPAPPPPPPLPPPLSPSFSRPIPP 1787 C .........::..+:.:+::*+::+*.+.:.:.++::.:.+:++:.:.:++.:::.:.:: 2050 2060 2070 2080 2090 2100 1 CTTNLMPAEKIKSSMTQLST-----TTVCKTDPQREPKGILRHVKN-------------- 1888 2 CTTNMMPAEKIKSSMTQLST-----TTVCKTDPQREPKGILRHVKN-------------- 1880 3 CTTNMMPAEEIKSSMTQLSA-----TTVCKTDPRREPKGILKHVKN-------------- 1886 4 HTVSVTPAEDVEPSVAQLPAS----TTVCDTDPQKQPKGILKHIKN-------------- 1752 5 CTASATHARETTFTTQPPAS-----NPQWGAEPHRHPKGILRHVKN-------------- 1876 6 CTASVTHARETMSTTQPPAS-----NPPCGAEPHRHPKGILRHVKN-------------- 1817 7 IKLIVDPEYETSSTGEDSAPDSSQRSRLNNPNIQNNVNGNIYIAQNGSVVRTRRVCLANN 2075 8 IAPSDLSAAKDKLSPIRTSPSE---STQPDPGPRRELKGILKHIHN-------------- 1852 9 -------------------------------------KGILKNSD--------------- 1780 10 SPFVLPPLPSVTSLRPVSLRPAPPPLPSEPEPPKRELKGILKNLQN-------------- 1833 C :+.:..++::.:+:..:::.. ::::.::*:+:+*G**:+:+* 2110 2120 2130 2140 2150 2160 1 --------LAELEKSVANMYSQIEKN-YLRTNVSELQTMCPSEVT--------------- 1924 2 --------LAELEKSVANMYSQIEKN-YLRTNVSELQTMCPSEVT--------------- 1916 3 --------LAELEKSVANMYSQIEKN-YLRTNVSELQTMCPSEVT--------------- 1922 4 --------LADLEKSVANMYSQIEKN-FPATHSWKLETSCPPERE--------------- 1788 5 --------LAELEKSVSNMYSHIEKN-CPPADPSKLHTFCPAEKT--------------- 1912 6 --------LAELEKSVSNMYSHIEKN-CPPTELSKLHPFCPAEKT--------------- 1853 7 LKVTSPVTLGKQFKKLDKLAVTHEEN-VPLNTLSKGSSSSDKVNTRPCSVSFASSIGAEN 2134 8 --------LAEIEKSVANMYNKIDKTNITSKQIPKSRSFTTTPEN--------------- 1889 9 ------------------------------RFGCSPDVKYDNKNDV-------------- 1796 10 --------IADIEKSVANMYSQIDKKQRPLVINPKPQVSVEPEAGVTEAEP--------- 1876 C **++****+***+:*+*+ .:.:..+++::.++.+.+. 2170 2180 2190 2200 2210 1 ------NMEITSEQNKGSLNNIVEGTE-KQSHSQSTSL-------------------- 1955 2 ------NMEITFEQNKENLNNIVEGTE-KQSHSQSTSL-------------------- 1947 3 ------NMEITSEPNKENLNNIVEETE-KQSHSQSTSL-------------------- 1953 4 ------NVDVTSQQPQGNLHSFAEETE-NQSHSQSTSL-------------------- 1819 5 ------GMKITHDQSQETLVRVVEGID-VQPHSQSTSL-------------------- 1943 6 ------NMKITCDQSQETLVRVVEGID-VQTHSQSTSL-------------------- 1884 7 IVTKPGGSKMKSTEEQESVVDNEDTKEPLESHSEHTQSDEEELWMGPWNNLHIPMTKL 2192 8 ---QISETAPEYAKQNGNLSCVVEELE-KRFPSQSTAL-------------------- 1923 9 ---------------------------------------------------------- 1796 10 ------AQEGPPSEPNPSMNSVVEELE-KRFPSQSTVL-------------------- 1907 C ::::+:.:.:::+:.:+*::+ :+:+****+*