Edtaln : Multiple alignment ------------------------------------------------------------------------------- Le consensus est matrialis par une squence de caractres qui, selon la situation rencontre en une position donne, seront les suivants : "." si le caractre majoritaire a une reprsentation >= 20% ":" si le caractre majoritaire a une reprsentation >= 40% "+" si le caractre majoritaire a une reprsentation >= 60% "*" si le caractre majoritaire a une reprsentation >= 80% le caractre lui-mme, si celui-ci est identique pour l'ensemble des squences. ------------------------------------------------------------------------------- 1 Homo sapiens Q13402 NCBI 2 Pan troglodytes ENSPTRP00000007055 Ensembl 3 Felis catus ENSFCAP00000013401 '' 4 Macaca mulatta ENSMMUP00000023917 '' 5 Bos taurus ENSBTAP00000005191 '' 6 Canis familiaris XP_542292 NCBI 7 Mus musculus NP_032689 '' 8 Rattus norvegicus NP_703203 '' 9 Gallus gallus ENSGALP00000001044 Ensembl 10 Gasterosteus aculeatus ENSGALP00000001044 '' 11 Orysias latipes ENSORLP00000002419 '' 12 Takifugu rubripes SINFRUP00000157324 '' 13 Danio rerio CAC05419 NCBI 14 Tetraodon nigrovidis GSTENP00005745001 Ensembl 15 Ciona intestinalis ENSCINP00000018713 '' 16 Ciona savignyi ENSCSAVP00000008075 '' 17 Aedes aegypti AAEL001220-PA '' 18 Caenorhabitis elegans NP_508420 NCBI 10 20 30 40 50 60 1 MVILQQGDHVWMDLRLGQE-FDVPIGAVVKLCDSGQVQVVDDEDNEHWISPQNATHIKPM 59 2 -ALLQKGDHVWMDLRSGQE-FDVPIGAVVKLCDSGQVQVVDDEDNEHWISPQNATHIKPM 58 3 ---HRMGDYVWMDLRSGQE-FDVPIGAVVKLCDSGQIQVVDDEGNEHWISPQNATHIKPM 56 4 -ALLQKGDYVWMDLRSGQE-FDVPIGAVVKLCDSGQIQVVDDEGNEHWISPQNATHIKPM 58 5 -----------MDLRSGQE-FDVPIGAVVKLCDSGQIQVVDDEGNEHWISPQNATHIKPM 48 6 ---MDSGDYVWMDLRSGQE-FDVPIGAVVKLCDSGQIQVVDDEGNEHWISPQNATHIKPM 56 7 MVILQKGDYVWMDLKSGQE-FDVPIGAVVKLCDSGQIQVVDDEDNEHWISPQNATHIKPM 59 8 MVILQKGDYVWMDLKSGQE-FDVPIGAMVKLCESGQIQVVDDEGNEHWISPQNATHIKPM 59 9 STLCLQGDYVWMDLKTGRE-FDVPIGAVVKLCDSGQIQVVDDEGNEHWISPQNASHIKPM 59 10 IYSSAQGDFVWLDLKTGRE-FEVPVGAVVKLCDSGQIQVQDDEGNEHWISPQNATNIKPM 59 11 SSTFVQGDYVWLDLKTGRE-FEVPIGAVVKLCDSGQIQVVDDEGNEHWISPQNATNIKPM 59 12 ---LFQGDYVWLDLKSGRE-FEVPIGAVVKLCDSGQIQVTDDEGNEHWISPQNATNIKPM 56 13 MVILQQGDYVWLDLKTGHE-FEVPIGAVVKLCDSGQIQVLDDEGNEHWISPQNATNIKPM 59 14 ---LLQGDYVWLDLKTGRE-FDVPVGAIVKLCDSGQIQVADDEGREHWISPQNATNIKPM 56 15 TFNVFQGDHIWLLDKATQNGTKVPLGAVVKMSDSGQVKVIDDEGTEHWLKSP-LTNIKVM 59 16 FELFFQGDHIWLLDKATQNGTKVPLGAVVKMSDSGQVKVVDDEGNEHWLKSP-LTNIKVM 59 17 -----MGDYIWIEPVSGRE-FDVAIGARVISAEGRRIQVRDDDGNELWLTPE--RRIKAM 52 18 MVLVSKGDFIWIEPGKTEG--SIPIGARVIDQDHGRLKVIDDLGNEQWLSAD--RRVRLM 56 C ...:.:**++*:++::*:* *+**+GA+V*++****+*V+DD***E*W+**+++*:**+M 70 80 90 100 110 120 1 HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHI 119 2 HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIY------------------------ 94 3 HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHI 116 4 HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHI 118 5 HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHI 108 6 HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHI 116 7 HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHI 119 8 HPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSSEHI 119 9 HPTSIHGVEDMIRLGDLNEAGILRNLLIRYREHLIYTYTGSILVAVNPYQLLPIYSPEQI 119 10 HPTSIHGVEDMIRLGDLNEAGILRNLLIRYREKLIYTYTGSILVAVNPYQLLPIYTADQI 119 11 HPTSIHGVEDMIRLGDLNEAGILRNLLIRYREKLIYTYTGSILVAVNPYQLLPIYTADQI 119 12 HPTSIHGVEDMIRLGDLNEAGILRNLLIRYREKLIYTYTGSILVAVNPYQLLPIYTADQI 116 13 HPTSIHGVEDMIRLGDLNEAGILRNLLIRYREHLIYTYTGSILVAVNPYQLLPIYTADQI 119 14 HPTSIHGVEDMIRLGDLNEAGILRNLLIRYNEHSIYTYTGSILVAVNPYQLLPIYAADQI 116 15 HPTSVEGVEDMIRLGDLNEAGILRNLLIRYNDDQIYTFTGSILVAVNPYQVLPLYDIDSI 119 16 HPTSVEGVEDMIRLGDLNEAGILRNLLIRYNEDHIYTFTGSILVAVNPYQELPLYDIDAI 119 17 HASSVQGVEDMISLGDLHEAGILRNLLIRYNDNLIYTYTGSILVAVNPYQILPIYTADQI 112 18 HPTSVQGVEDMCQLGDFHESAILRNLFIRYREKLIYAYTGSILIAVNPYMDIAIYTADEI 116 C H**S++GVEDM**LGD**E**ILRNL*IRY+:+*IY**************+*:**:.:.* 130 140 150 160 170 180 1 RQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIIS-GESGAGKTESTKLILQFLAAI 178 2 ------------------------------------------------------------ 94 3 RQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIIS-GESGAGKTESTKLILQFLAAI 175 4 RQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIIS-GESGAGKTESTKLILQFLAAI 177 5 RQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIIS-GESGAGKTESTKLILQFLAAI 167 6 RQYTNKKIGEMPPHIFAIADNCYFNMKRNSRDQCCIIS-GESGAGKTESTKLILQFLAAI 175 7 RQYTNKKIGEMPPHIFAIADNCYFNMKRNNRDQCCIIS-GESGAGKTESTKLILQFLAAI 178 8 RQYTNKKIGEMPPHIFAIADNCYFNMKRNNRDQCCIIS-GESGAGKTESTKLILQFLAAI 178 9 RLYTNKKIGEMPPHIFAIADNCYFNMQRNNKDQCCIIS-GESGAGKTESTKLILQFLAAI 178 10 RLYTNKKIGEMPPHIFAIADNCYFNMQRNNRDQCCIISSGESGAGKTESTKLILQFLAAI 179 11 RLYTNKKIGEMPPHIFAIADNCYFNMQRNNRDQCCIIS-GESGAGKTESTKLILQFLAAI 178 12 RLYTNKKIGEMPPHIFAIADNCYFNMQRNNRDQCCIIS-GESGAGKTESTKLILQFLAAI 175 13 RLYTNKKIGEMPPHIFAIADNCYFNMQRNNKDQCCIIS-GESGAGKTESTKLILQFLAAI 178 14 RLYTNRKIGELPPHIFAIADNCYCNMQRNNKDQCCIIS-GESGAGKTESTKLILQFLAAI 175 15 RKYTQKKLGELPPHIFAIADNAYNNMLRNEHDQCVIVS-GESGAGKTESTKLVLQYLAAI 178 16 RKYTKRKLGE-PPHIFAIADNAYNNMLRSKQDQCVIVS-GESGAGKTESTKLVLQYLAAI 177 17 KLYKERKIGELPPHIFAIGDNSYANMRRYGQDQCIVIS-GESGAGKTESTKLILQYLAAI 171 18 RMYKRKRIGELPPHIFAIADNAYTNMRREKKNQSVIIS-GESGAGKTESTKLVLQFLATI 175 C *.**++****+**********+*+**.*+::***+*** *************+**+**** 190 200 210 220 230 240 1 SGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 238 2 ------------------------------------------------------------ 94 3 SGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 235 4 SGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 237 5 SGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGARIEQYLLE 227 6 SGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 235 7 SGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 238 8 SGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 238 9 SGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 238 10 SGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 239 11 SGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 238 12 SGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 235 13 SGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLE 238 14 SGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGARIEQYLLE 235 15 SGQHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKFIDIRFNQEGIIQSAKIDQYLLE 238 16 SGQHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKFIDIRFNQDGIIQSAKIDQYLLE 237 17 SGKHSWIEQQILEANPILEAFGNAKTVRNDNSSRFGKYIDIHFNNSGVIEGAEIEQYLLE 231 18 SGQHSWIEQQVLEANPVLEAFGNAKTIRNDNSSRFGKYIDVHFNESGSIEGAKIEQYLLE 235 C **********+***:*****************************++*+****+******* 250 260 270 280 290 300 1 KSR--VCRQALDERNYHVFYCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVDSQ 296 2 -----------------------LEMSEDQKKKLGLVQASDY-YLAMGNCITCEGRVDSQ 130 3 KSR--VCRQAPDERNYHVFYCMLEGMSADQKKRLGLGQATDYNYLAMGNCITCEGREDSQ 293 4 KSRSRVCRQAPDERNYHVFYCMLEGMSEDQKKKLGLGQASDYNYLAMGNCITCEGRVDSQ 297 5 KSR--VCRQAPDERNYHVFYCMLEGMNEEQKKKLGLGQATDYNYLAMGNCVICEGREDSQ 285 6 KSR--VCRQAPDERNYHVFYCMLEGMSADQKKKLGLGQATDYNYLAMGNCTVCEGREDSQ 293 7 KSR--VCRQAPDERNYHVFYCMLEGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQ 296 8 KSR--VCRQAPDERNYHVFYCMLEGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQ 296 9 KSR--VCRQAQDERNYHVFYCMLRGMTMEQKKKLGLGKATDYNYLAMGNCTTCDGRDDSK 296 10 KSR--VCRQALDERNYHVFYCMLKGMTAEEKKKLGLSKATDYNYLTIGNCTVCDGRDDMK 297 11 KSR--VCRQAHDERNYHIFYCMLKGMTAEEKKKLGLSKATDYTYLTIGKCTVCDGRDDLK 296 12 KSR--VCRQACDERNYHIFYCMLNGMTADEKKKLGLSRAGDYTYLTMGNCTTCDGRDDMK 293 13 KSR--VCRQARDERNYHIFYCMLKGMTPDQKKQLGLSKATDYTYLTIGNCTVCDGRDDQK 296 14 KSR--VCRQAPDERNYHIFYCMLRGMSPEMKGKLGLGLARDYSYLTMGRCTACDGRDDLG 293 15 KSR--LVHQTTDERNYHVFYCMLAGMPPAKKQELGLGKPSEYVNLTQGSCLECAGRNDKE 296 16 KSR--LVHQTTDERNYHVFYCMLAGMAANKKQELGLGKPSEYVNLTQGSCLQCAGRNDKE 295 17 KSR--IVSQNAEERNYHIFYCLLAGLSSDEKRKLNLGYASDYRYLTGGGCIKCDGRNDAA 289 18 KSR--IVTQSENERNYHIFYCLLAGLSREEKSELELGTAADYYYLIQGKTLTAEGRDDAA 293 C *** +++*+.******+*****.**:.::K++L*L+:*.*Y:*L:+G+*.:*:GR.D:: 310 320 330 340 350 360 1 EYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQYEAR-TFENLDACEVLFSPSLATA 355 2 EYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQYEAR-TFENLDACEVLFSPSLATA 189 3 EYANIRSAMKVLMFTDTENWEISKLLASILHLGNLQYEAR-TFENLDACEVLFSPSLTTA 352 4 EYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQYEAR-TFENLDACEVLFSPSLATA 356 5 EYANIRSAMKVLMFTDTENWEISKLLAAILHLGNLQYEDR-TFENLDACEVLFSPSLATA 344 6 EYASIRSAMKVLMFTDTENWEISKLLAAILHLGNLQYEAR-TFENLDACEVLFSPSLATA 352 7 EYANIRSAMKVLMFTDTENWEISKLLAAILHMGNLQYEAR-TFENLDACEVLFSPSLATA 355 8 EYANIRSAMKVLMFTDTENWEILKLLAAILHMGNLQYEAR-TFENLDACEVLFSPSLATA 355 9 EYANIRSAMKVLMFTDTENWEISKLLAAILHMGNLKYETR-TYDNLDACEVVQSASLITA 355 10 EYSNIRSAMKVLMFTDKENWEISKLLASILHMGNLRYEAR-TYDNLDACEVVRSSHLTTA 356 11 EYSNIRSAMKVLMFTDRENWEISKLLAAILHMGNLQYEIHFDFQNXDACEVVRSPHLTTA 356 12 EYSNIRSAMKVLMFTEKENWEISKLLAAILHMGNLRYDAR-TYDNLDACEVVRSPHLTTS 352 13 EYSNIRSAMKVLMFTDKENWEISKLLAAILHMGNLRYEAR-TYDNLDACEVVRCSALTTA 355 14 DYSSIQSAMKVLMFTETESWEISKLLAAILHMGNLRFQAR-TFDNLDACMVVRSPDLVTA 352 15 EYGDIVRGMKVLLFSETEIYEIFRLLAGILHTGNFKFRET-MTDNLDSVELIHNSGVKRT 355 16 EYGDIVRGMKVCSVAILIIYEIFRLLAGILHTGNFQFRET-MTDNLDSVELIHNSGVKRT 354 17 EFADIRSAMKVLCFSDHEIWEILKLLAALLHTGNITYRAT-VIDNLDATEIPEHINVERV 348 18 DLAEIRSAMRVLMINEQEIGSIFKLLASLLHIGNIRFRQN-TNDNMESVDVADPSTLVRI 352 C **++I***M*V***+++*+**I+*LLA+*LH:GN+:++++ +::N***+**::++:*.++ 370 380 390 400 410 420 1 ASLLEVNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKIN 415 2 ASLLET--------------------VSTPLSREQALDVRDAFVKGIYGRLFVWIVDKIN 229 3 ASLLEVNPPDLMNCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKIN 412 4 ASLLEVNPPDVMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKIN 416 5 ASLLEVNPRDLMNCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKIN 404 6 ASLLEVNPPDLMNCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVDKIN 412 7 ASLLEVNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKIN 415 8 ASHLEVNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKIN 415 9 ASLLEVDSQDVMNCLTSRTIITRGETVSTPLSMEQALDVRDAFVKGIYGRLFVWIVEKIN 415 10 AMLLEVDGKDLMNCLTSRTLITRGETVSTPLSMEQALDVRDAFVKGIYGRLFVWIVEKIN 416 11 SALLEVDFKDLMNCLTSRTLITRGETVSTPLSIEQALDVRDAFVKGIYGRLFVWIVEKIN 416 12 AALLEVDCKDLMNCLTSRTLITRGETVSTPLSMDQALDVRDAFVKGIYGRLFVWIVEKIN 412 13 AVLLEVDLKDLMNCLTSRTIITRGETVSTPLSIEQALDVRDAFVKGIYGRLFVWIVEKIN 415 14 AALIEVEPKDVMLCLTTRTLITRGESVVTPLSVGQGLDVRDAFVKGIYGRLFVWIVDKIN 412 15 AQLLGVNEQSLMRALTQRTIITREDTVISPMNLEQANDVKDAFIKGMYGRMFVWIVDKIN 415 16 AQLLGVNEQSLMRALTQRTIITREDTVTSPMNLEQSNDVKDAFIKGIYGRMFVWIVDKIN 414 17 ANLLEVPFQPFIDALTRKTLFAHGETVVSTLSRDQSMDVRDAFVKGIYGRLFVLIVKKIN 408 18 AKLLQLHEQNLLDAITTKSLVTREERVISRLNGQQAVDARDALAKAIYGKLFIHIVRRVN 412 C *:****::.++*:+**+**+***+**V++***:+Q*+D**DA**K**YG**F**IV:**N 430 440 450 460 470 480 1 AAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQE 475 2 AAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQE 289 3 AAIYKPPSQEVKSSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQE 472 4 AAIYKPPSQDVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQE 476 5 AAIYKPPSQEVKNSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQE 464 6 AAIYKPPSQEVKSSRRSIGLLDIFGFENFAVNSFEQLCINFANEHLQQFFVRHVFKLEQE 472 7 AAIYKPPPLEVKNSRRSIGLLDIFGFENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQE 475 8 AAIYKPPSQEVTNSRRSIGLLDIFGFENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQE 475 9 AAIYRPPSQELKSVRRSIGLLDIFGFENFTVNSFEQLCINFANENLQQFFVRHVFKLEQE 475 10 AAIYKPTSSQPKALRRSIGLLDIFGFENFTVNRFP--CCLFVDA--VCLVIWYLCKLEQE 472 11 AAIYKPPSSQPKAGRRCIGLLDIFGFENFVVNSFEQLCINFANENLQQFFVRHVFKLEQE 476 12 AAIYKPMFSQPKYARRSIGLLDIFGFENFTVNSFEQLCINFANENLQQFFVRHVFKLEQE 472 13 AAIYKPPSLELKAVRRSIGLLDIFGFENFMVNSFEQLCINFANENLQQFFVRHVFKLEQE 475 14 AAIYRPPSSESTVLRRSIGLLDIFGFENFIVNSFEQLCINFANENLQQFFVRHVFKLEQE 472 15 SAIFKDPKSKRK-HWYSMGLLDIFGFENFGNNSFEQLCINFANENLQQFFVRHVFKLEQE 474 16 SAIFKDSKTKKK-HWNTIGLLDIFGFENFGNNSFEQLCINFANENLQQFFVRHVFKLEQE 473 17 SAIYKPKS----STRSAIGVLDIFGFENFKHNSFEQFCINFANENLQQFFVRHIFKLEQE 464 18 DAIYKPSQSR----RTSIGILDIFGFENFESNSFEQLCINFANETLQQFFVHHVFKMEQK 468 C +AI***++:::+.:*+**G*LDIFGFENF.+N*F***C**F***:**********K*EQ* 490 500 510 520 530 540 1 EYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKLNSQHKLN 535 2 EYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKLNSQHKLN 349 3 EYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKMNSQHKLN 532 4 EYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKLNSQHKLN 536 5 EYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKLNSQHKLN 524 6 EYDLESINWLHIEFTDNQDALDMIANKPMNIISLIDEESKFPKGTDTTMLHKLNSQHKLN 532 7 EYDLESIDWLHIEFTDNQEALDMIANRPMNVISLIDEESKFPKGTDATMLHKLNSQHKLN 535 8 EYDLESIDWLHIEFTDNQEALDMIANRPMNVISLIDEESKFPKGTDATMLHKLNSQHRLN 535 9 EYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESKFPKGTDATMLHKLNSQHKLN 535 10 EYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESRFPKGTDTTMLNKLNFQHKLN 532 11 EYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESKFPKGTDATMLNKLNFQHKLN 536 12 EYNLEHINWQHIEFTDNQDALDMIAIKPMNIISLIDEESRFPKGTDATMLNKLNFQHKLN 532 13 EYNLENINWQHIEFTDNQDALDMIAIKPMNIISLIDEESKFPKGTDTTMLNKLNSQHKLN 535 14 EYNLEDINWQHIEFTDNQDALDMIALKPMNIISLIDEESKFPKGSDATMLYKLNSQHKLN 532 15 EYNKEAIEWKHITFKDNQDVLDMIAVKPMNILALINEESMFPRGSDGSMLNKLIKQHGKN 534 16 EYNKEAIEWKHITFKDNQDVLDMIAVKPMNILALISEEAMFPR------VRNLIRQHGKN 527 17 EYNHESINWQHIEFVDNQDALDLIAIKQLNIMALIDEESKFPKGTDQTMLAKLHKTHGTH 524 18 EYDEEHINWRHIKFVDNQATVDLIAQRPLNILSLIDEESIFPKGTDKTMLLKLHSTHGRN 528 C EY:+E:I:W:HI*F+DNQ***D*IA:***N*+*LI*EE*+FP****:***:**++*H++* 550 560 570 580 590 600 1 ANYIPPKNNHETQFGINHFAGIVYYETQG-FLEKNRDTLHGDIIQLVHSSRNKFIKQIFQ 594 2 ANYIPPKNNHETQFGINHFAGVVYYETQG-FLEKNRDTLHGDIIQLVHSSRNKFIKQIFQ 408 3 SNYIPPKNNHETQFGINHFAGVVYYESQG-FLEKNRDTLHGDIIQLVHSSRNKFIKQIFQ 591 4 ANYIPPKNNHETQFGINHFAGVVYYETQG-FLEKNRDTLHGDIIQLVHSSRNKFIKQIFQ 595 5 SNYIPPKNNYETQFGINHFAGIVYYESQG-FLEKNRDTLHGDIIQLVHSSRNKFIKQIFQ 583 6 SNYIPPKNNHETQFGINHFAGVVYYESQG-FLEKNRDTLHGDIIQLVHSSRNKFIKQIFQ 591 7 ANYVPPKNSHETQFGINHFAGVVYYESQG-FLEKNRDTLHGDIIQLVHSSRNKFIKQIFQ 594 8 ANYVPPKNSHETQFGINHFAGIVYYESQG-FLEKNRDTLHGDIIQLVHSSRNKFVKQIFQ 594 9 TNYIPPKNNYETQFGINHFAGIVYYETKG-FLEKNRDTLHGDIIQLVHSSKNKFIKQIFQ 594 10 TYYIPPKNNHETQFGIQHFAGVVYYETKAGFLEKNRDTLYGDIIQLVHSSKNKFIKQIFQ 592 11 TNYIPPKNNHETQFGIQHFAGVVYYETKG-FLEKNRDTLYGDIIQLVHSSKNKFIKQIFQ 595 12 SNYIPPKNNHETQFGIHHFAGVVYYETRG-FLEKNRDTLYGDIIQLVHSSKNKFIKQIFQ 591 13 TNYIPPKNTYETQFGIQHFAGVVYYETRG-FLEKNRDTLHGDIIQLVHSSKNKFIKQIFQ 594 14 SNYIPPKNNHETQFGIQHFAGVVYYETRG-FLEKNRDSLHMDIIQLVHSSKNKFIKQIFQ 591 15 ILFKNPKNQFDETFGIEHFAGPVRYCCVG-FLERNRDTFHRDLTTLIEGTKNKFLKLLFH 593 16 ILFKNPKNQFDETFGIEHFAGAVRYSCAG-FLERNRDTFHRDLMNLIQGSKNKFLKLLFY 586 17 RNYLKPKSDINTSFGLNHFAGVVFYDTRG-FLEKNRDTFSADLLQLISSSTNRFLQMVFA 583 18 ELYLQPKSELQRAFGVTHFAGNVFYNTRG-FLEKNRDSFSADLSVLISSSKMPFLARLFD 587 C .+*++PK*+++*+FG*:HFAG+V+Y++:* FLE*NRD*+++D++*L++**:**F+*++F+ 610 620 630 640 650 660 1 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNE 640 2 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNE 454 3 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNE 637 4 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNE 641 5 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNE 629 6 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNE 637 7 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNE 640 8 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNE 640 9 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNE 640 10 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNE 638 11 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNE 641 12 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNE 637 13 ADVAM--------------GAETRKRSPTLSSQFKRSLELLMRTLSVCQPFFVRCIKPNE 640 14 ADVAMFLCGYQQPSTPAAKGVETRKRSPTLSSQFKRSLEMLMRTLSVCQPFFVRCIKPNE 651 15 QDLKNF----------GSKSSSTRRRNNTLCEQFKKSLDALMRTLSSCQPFFVRCIKPNE 643 16 QDS-------------GSKSNSHRR-NHTLCEQFKKSLDSLMRTLSACQPFFVRCIKPNE 632 17 EDIGM--------------GAETRKRTPTLSTQFKKSLDSLMKTLSSCQPFFIRCIKPNE 629 18 DIEYD----------------TSSRKKVTVGNQFRRSLEQLMSQLTQTHPFFIRCIKPNE 631 C +*++* *+*****+*T**+QF**SL*+LM**L::**PFF*RCIKPNE 670 680 690 700 710 720 1 FKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGD 700 2 FKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGD 514 3 FKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQDD 697 4 FKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQGD 701 5 FKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQDD 689 6 FKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQDD 697 7 FKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQGD 700 8 FKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQDD 700 9 YKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQGD 700 10 NKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQED 698 11 YKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQED 701 12 YKKPMLFDRDLCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQED 697 13 YKKPMLFDRELCVRQLRYSGMMETIRIRRAGYPIRYTFVEFVDRYRVLMPGVKPAYKQED 700 14 LKKPMSFDRELCIRQLRYSGMMETIRIRRAGYPIRYTFVEFVERYRVLMPGIKPAHIQED 711 15 TKAAHDFDRELVARQLRYSGMMETIRIRRAGYPIRYSFSEFIDRYRMIVRGLKPSKLENN 703 16 TKSAHNFDRELVARQLRYSGMMETIRIRRAGYPIRYSFSEFIDRYRMTVRGIRPSKLEND 692 17 LKKPMMFDRALCCRQLRYSGMMETIRIRRAGYPIRHKFKDFVERYRFLISGIPPAHR-TD 688 18 MKRALVMDRDLVLRQLRYSGMMETIKIRRSGYPIRHDYYPFVFRYRVLVSSIQGPVNRID 691 C :K***+*DR:L*+RQLRYSGMMETI*IR**GYPIR*:*+*F*:RYR**:+*+***+++.* 730 740 750 760 770 780 1 LRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKD 760 2 LRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKD 574 3 LRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKD 757 4 LRGTCQRMAETVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKD 761 5 LRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKD 749 6 LRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKD 757 7 LRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKD 760 8 LQGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKD 760 9 LRGTCQRIAEAVLGKDDDWQIGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKD 760 10 LRGTCQRIAEAVLGRDDDWKMGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKD 758 11 LRGTCQKIAEAVLGRDDDWQMGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGYKD 761 12 LKGTCQRISEVVLGRDDDWQMGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKD 757 13 LRGTCQRIAEAVLGRDDDWQMGKTKIFLKDHHDMLLEIERDKAITDKVILIQKVVRGFKD 760 14 LRGTCQQIVLARLGKHDDWQIGKTKIFLKDHHDTQLEIERDEAITDKVILIQKSIRGHRQ 771 15 HIAACKKIIIGALGETSDCQVGKTKVFLKDAHDARLEIERDSAISRWVIVIQRAVRGWYC 763 16 HIAGCKRIISEALGENSDCQVGKTKVFLKDAHDARLEIARDAAISRWVIVIQRAVRGWYC 752 17 CRLATSKICASVLGR-SDYQLGHTKVFLKDAHDLFLEQERDRVLTRKILILQRSIRGWVY 747 18 LHDAAKKICHMILGTNADYQLGKTKVFLKDKHDLVLEQEYYRILKDKAIVIQKNVRRWLV 751 C *+++*++:++++LG::+D+*:G*TK+FLKD+HD++LE:***+****:**+:Q*+:R*+++ 790 800 810 820 830 840 1 RSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQF 820 2 RSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSQKLHQQYRLARQRIIQF 634 3 RSNFLKLKNAATLIQRHWRGHNCRRNYELMRLGFLRLQALHRSRKLHQKYRLARRRIIGF 817 4 RSNFLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQALHRSRKLHQQYRLARQRIIQF 821 5 RSNFLKLKNAATLIQRHWRGHNCRRNYGLMRLGFLRLQALHRSRKLHQQYCLARRRIIGF 809 6 RSNFLKLKNAATVIQRHWRGHNCRRNYELMRLGFLRLQALQRSRKLQQQYRLARRHIIEF 817 7 RSNFLRLKSAATLIQRHWRGHHCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQRIIEF 820 8 RSNFLRLKSAATLIQRHWRGHHCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQRIIKF 820 9 RSNFLKVRNSVLMIQRYWRGHNCRKNYGAMRIGFLRLQALYRSRKLHKQYHMARRRIIEF 820 10 RSNFLKMRKSAVFIQKTWRGYHCRKNYGAMRAGFSRLQALVRSRKLCASYNVARQRITGF 818 11 RSNFLKMRKSAVFIQKTWRGYHCRKNYGAMRAGFSRLQALVRSRKLCASYHVARQRITVF 821 12 RSNFLKMRKSAVLIQKTWRGYQCRKNYGAMRAGFSRLQALVRSRKLCASYHVARRRIAYF 817 13 RSNFLKMKKSAMLIQKTWRGYYCRKNYGAMRGGFSRLQALYRSRKLYQTYHVARQRIMLF 820 14 RLNFLRLRTSATTIQRFWRGHRCRRNYRTMKTGFLRLQAIFRSRKFFISYQATRLRVTLI 831 15 RHRYVLMRKSAIQIQSAWRKYTVQRQYFTIKNGYSRLQALWRARRLAFRYNFARKRIIRF 823 16 RHRYLTQRKSAIRIQSAWRKYTVQKQYFVIKNGYSRLQALWRARRLAFRYNFARKRIIRF 812 17 RRRFLRMRQAAVTIQKFWKGYAQRQRYKKMKIGYMRLQALIRSRVLSHRFRHLRGHIVRL 807 18 RKDFEKQRQAAVTIQTAWRGFDQRKRYRQIISGFSRLQAVLRSRQLVSHYQTLRKTIIQF 811 C R++**+::.:*::IQ::W**:.+*++Y::++:G*:RLQA*.R**+*:.:*::*R:**+.* 850 860 870 880 890 900 1 QARCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLWRLEAEKMRLAEEEKL 880 2 QARCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLRRLEAEKMRLAEEEKL 694 3 QARCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHRRLRAEYLQRQEAEKMRLAEER-- 875 4 QARCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHQRLRAEYLRRLEAEKMRLAEEEKL 881 5 QARCRAYLVRKAFRHRLWAVITVQAYARGMIARRLHRRLRAEYLRRLEAEKMRLAEEEKL 869 6 QARCRAYLVRKAFRHRLWAVLTVQAYARGMIARRLHRRLRAEYLRRLEAEKMRLAEEEKL 877 7 QARCRAYLVRKAFRHRLWAVITVQAYARGMIARRLHRRLRVEYQRRLEAERMRLAEEEKL 880 8 QARCRAYLVRRAFRHRLWAVITVQAYARGMIARRLHRRLRVEYWRRLEAERMRLAEEEKL 880 9 QARCRGYLVRRAFRHRLWAVLTVQAYARGMIARRLYKRLRGEYHRRLEAEKLRLAEEERL 880 10 QGRCRGFLVRRAFRHRLWAVITVQAYTRGMIARRLYNRLKGEYRRRLEAEKMRLAEETKL 878 11 QGRCRGYLVRRAFRHRLWAVITIQAYTRGMIARRLFRRLKGEYRRRLEAEKMRLAEETKL 881 12 QGRCRGFLVRWAFRRRLQAVITIQAYTRGMIARRLYKRLRGEYHRRLEAEKMRLAEEVKL 877 13 QGRCRGFLVRRAFRHRLWAVITIQAYTRGMIARRLYKRLKGEYRRRLEAEKLRLAEEQKL 880 14 QARCRGFLVRQMFWRHLRAVLTLQAYTRGMIARRLCHRLRAERHQRQEAERQRLAEEERL 891 15 QVQCRGFLARKNFRHKLWAIIKLQSCIRG-------------YIARQEYR--KLKNLRKV 868 16 QVQCRGFLARKNVRHKLWAIIKIQSCIRGGGCMCVIYISLAGYIARQEYR--KLKNLRKV 870 17 QARIRGYLVRREYGLKMWAVIKIQSHVRRMIAMNRYQKLKLEYRRHHEALRLRRMEEEEL 867 18 QAVCRGSLVRRQVGE-----------------------------KRKRGEKAPLTEVSST 842 C Q+**R:+L*R:+**++****:+:*++:*****+++:.+*+:**.+*+***++**+**:++ 910 920 930 940 950 960 1 RKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEAARRKKELLEQMERARHEPVNHS 940 2 RKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEAARRKKELLEQMERARHEPVNHS 754 3 --------------------LAQLAREDAERELKEKEEARRKKELLEQMERARHEPINHS 915 4 RKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEAARRKKELLEQMERARHEPVNHS 941 5 RKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEEARRKKELLEQMERARHEPINHS 929 6 RKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEEARRKKELLEQMERARHEPINHS 937 7 RKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEEARRKKELLEQMEKARHEPINHS 940 8 RKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEEARRKKELLQQMERARHEPINHS 940 9 RKEMSAKKAKEEAEKKHQVRLAQLAREDAEREVKEKEEARRKKELLEKMERARNEPVNDS 940 10 RNQMSAKRAKAEAERKHQERLAQLAKEDAER--------------------ARLEPVNDS 918 11 KNQMSAKRAKAEAERKHQERLAQLAKEDAER--------------------ARKEPVNDS 921 12 RNQMSAKRAKAEAERNHQERLAQLAKEDAEREKKAREDARKKKEMVEQMEKARLEPVNDS 937 13 RNQMSARKAKEEAEKMHQERLAQLAREDAEREKKERQEARRKMEMLDQMEKARQEPVNDS 940 14 LAQMTAQRAKAEADRKHQERLDQLAQQQEEREREEREEARRKKELLEQMERDKEQPVDHS 951 15 KKLPKGQQKAALARLEQEQ----VQAQEDIKRKNELVN-------DAEKRRKISMAIDHT 917 16 KKLPRGQQKVQNNKIKHYECMLYISKDVKMLKKKGLSYGRSSGYLMSEKRRKMSLAIDHT 930 17 KHQ-GNKRAKEIAEQHYRDRLNEIERKEIEQELEERRRVEVKKNIINDAARKADEPVDDS 926 18 ASVISDS---------------------------------------------------HE 851 C +::++++:++:+*+++++++*++++++++*++:++:+:++++++++:++++++:+*:++* 970 980 990 1000 1010 1020 1 DMVDKMFGFLGTSGG--LPGQEGQAPSGFEDLERGRR--EMVEEDLDAALPLPDE-DEED 995 2 DMVDKMFGFLGTSGG--LPG-EGQAPSGFEDLERGRR--EMVEEDLDAALPLPDE-DEED 808 3 DMVDKMFGFLGTSGG--LPGQEGQAPSGFEDLERGRR--EMVEEDLDAALPLPDE-DEED 970 4 DMVDKMFGFLGTSGG--LPGQEGQAPSGFEDLERGRR--EMVEEDLDAALPLPDE-DEED 996 5 DMVDKMFGFLGTSGG--LPGQEGQAPSGFEDLERGRR--EMVEEDLDAALPLPDE-DEED 984 6 DMVDKMFGFLGTSGG--LPGQEGQAPSGFEDLERGRR--EMVEEDLDAALPLPDE-DEED 992 7 DMVDKMFGFLGTSGS--LPGQEGQAPSGFEDLERGRR--EMVEEDVDAALPLPDE-DEED 995 8 DMVDKMFGFLGTSSG--LPGQEGQAPSGFEDLERGRR--EMVEEDVDAALPLPDE-DEED 995 9 EMVDKMFGFLGTTSS--LPGQEGQAPNGFEDLERAQK--ELEEEDLDAALPLPEE-EEED 995 10 DMVDKMFGFLGTTVS--FPGQEGQAPTGFEDLERSHR--ELEEEDLDEALPLPEDDEEED 974 11 DMVDKMFGFLGTTSS--LPGQEGQAPAGFEDLERTHH--ELMEEDLDEALPLPDDDEEED 977 12 DMVDKMFGFLGTTSS--LPGQEGQAPAGFEDLERTHR--ELEEEDLDEALPLPED-EEED 992 13 DMVDKMFGFLGTTNS--FPGQEGQAPAGFEDLERTHR--ELEVEDLDESLPLPED-DLED 995 14 DMVDQVFGFLGNTGP--LPNREGQAPAGFEDLEKTPRWDECEEEVLSEAPPLPHD-EHED 1008 15 EMVDKIFGYL--------------------DMEEENA------DVADTSIPYMEE--KED 949 16 EMVDKIFGYL--------------------DLEDGNG------EAADTSIPHMEE--KED 962 17 KLVEAMFDFLPDSSSEAPTPHGGRETSVFNDLPVNQD----NHEDIIGPIHTISE-DEED 981 18 ELVGHLFDFLPSDGKDSGNENDSADSSRRGSYSRLHT----SPVMPPANIPRVDSYVDED 907 C +*V**+F**L++::. +++++*+++:+*+***+::+ +::+*++*:++*++:+ :+ED 1030 1040 1050 1060 1070 1080 1 LSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEP 1055 2 LSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEP 868 3 LSEYKFAKFAATYFQGTTTHTYTRRPLRQPLLYHDDEGDQLAALAVWITILRFMGDLPEP 1030 4 LSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEP 1056 5 LSEYKFAKFAATYFQGTTTHTYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEP 1044 6 LSEYKFAKFAATYFQGTTTHTYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEP 1052 7 LSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEP 1055 8 LSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEP 1055 9 LSEYKFAKFAATYFQGTTTHTYIRRPLKQPLLYHEDEGDQLAALAVWITILRFMGDLPEP 1055 10 LSEYKFAKYAATYFQGTTTHTYVRRPLKQPLLFHDDEGDQLAALAVWITVLRFMGDLPEP 1034 11 LSEYKFAKYAATYFQGTSTYTYVRRPLKQPLLFHDDEGDQLAALAVWITVLRFMGDLPEP 1037 12 LSEYKFAKFAATYFQGTTSYTYVRRPLKQPLLFHDDEGDQLAALAVWITILRFMGDLPEP 1052 13 LSEYKFAKFSATYFQGTSTHTYMRRPLKQPLLFHEDEGDQLAALAVWITVLRFMGDLPEP 1055 14 LSEYKFFKFAATYFQGVSTHTYIRRPLKQPLLFHEDEGDQLAALAVWITILRFMGDLAEP 1068 15 ISEFKFAKFAATYFQSNATNAHTKRQLKTPLLHHDIEGDRIASLAVWITILRFMGDLPEP 1009 16 ISEYKFSKFAATYFQANATNAHTKRQLKTPLLHHENEGDKMASLAVWITILRFMGDLPEP 1022 17 LSEFKFQKFAATYFQGNITHFYSRKPLKHPLLPLHTQGDQLAAQALWITILRFTGDLPEP 1041 18 LSKYQFGKYAATFFQAQATATHVKKPLKTALLTHTEPSAQLAALTAWTTILRFMGDLADV 967 C *S***F+K**AT*FQ*++*+:*:***L*+*LL:*++*****A****W*T*LRF*GDL*** 1090 1100 1110 1120 1130 1140 1 K-YHTAMSDGSEKIPVMTKIYETLGKKTYKR-ELQALQGEG-EAQLPEGQKKSSVRH-KL 1111 2 K-YHTAMSDGSEKIPVMTKIYETLGKKTYKR-ELQALQGEG-EAQLPEGQKKSSVRH-KL 924 3 K-YHTAMSDGSEKIPVMTKIYETLGKKTYKR-ELQALQGEG-EAQLPEGQKKSSMRH-KL 1086 4 K-YHTAMSDGSEKIPVMTKIYETLGKKTYKR-ELQALQGEG-EAQLPEGQKRSSVRH-KL 1112 5 R-YHTAMSDGSEKIPVMTKIYETLGKKTYKR-ELQALQGEG-EAQLPDGQKKSSVRH-KL 1100 6 K-YHTAMSDGSEKIPVMTKIYETLGKKTYKR-ELQALQGEG-EAQLPEGQKKSSMRH-KL 1108 7 K-YHTAMSDGSEKIPVMTKIYETLGKKTYKR-ELQALQGEG-ETQLPEGQKKTSVRH-KL 1111 8 K-YHTAMSDGSEKIPVMTKIYETLGKKTYKR-ELQALQGEG-EAQLSEGQKKTSVKH-KL 1111 9 K-YHTAMSDGGEKIPVMTKIYETLGKKTYKK-ELQALQGEG-ESTHIDGHKKNSVRH-KL 1111 10 K-YHTAISDGSEKIPVMTKIYETLGKKTYKR-ELQALEAEVHQTPPTDNHKKNSVRH-KL 1091 11 K-YHTAINDGSEKIPVMTKIYETLGKKTYKR-ELQALQANG-ETPLSDSNKKTSVRH-KL 1093 12 K-YHTAIIDGSEKIPVMTKIYETLGKKTYKR-ELQALQREG-EIPQSDGHKKNSVRH-KL 1108 13 K-YHTAISDGSEKIPVMTKIYETLGKKTYKR-ELQALQGEG-ENTNIESHKKSSVRH-KL 1111 14 K-CQMVINDGSEKIPVMTKIYETLGKRTYKR-ELQELQVEAEVRMPFENQKRSSVRH-KL 1125 15 Q-KKENGPKGKDNVPVMVKIHDTLGRSYAKN-AKQIEDMHSTAVSFISRRRKSSSKQ-KL 1066 16 V-KRDNAPK-RDNVPVMNKIHDTLGRSYAKN-AKQIEEMHSTE----SRRRKSSSKQNRL 1075 17 R-YHT---MDRDNTSVMSKVTATLGRNFIRSKEFQEAQMMGLDPEAFLKQKPRSIRH-KL 1096 18 KPGSTNGSEVYDKTPVMIKLYATLGKKFSAH-DLEEAMLSS-EYGGAKTLKKGMGRK--L 1023 C + ++*+:++*++*+*VM+K**+TLG*+++*+ ***+++:++ +.::.:::**:*+** *L 1150 1160 1170 1180 1190 1200 1 VHLTLKKKSKLTEEVTKRLHDGESTVQ--GNSMLEDRPTSNLEKLHFIIGNGILRPALRD 1169 2 VHLTLKKKSKLTEEVTKRLHDGESTVQ--GNSMLEDRPTSNLEKLHFIIGNGILRPALRD 982 3 VHLTLKKKSKLTEEVTKRLHDGESTVQ--GNSMLEDRPTSNLEKLHFIIGNGILRPALRD 1144 4 VHLTLKKKSKLTEEVTKRLHDGESTVQ--GNSMLEDRPTSNLEKLHFIIGNGILRPALRD 1170 5 VHLTLKKKSKLTEEVTKRLHDGESTVQ--GNSMLEDRPTSNLEKLHFIIGNGILRPALRD 1158 6 VHLTLKKKSKLTEEVTKRLHDGESTVQ--GNSMLEDRPTSNLEKLHFVIGNGILRPALRD 1166 7 VHLTLKKKSKLTEEVTKRLNDGESTVQ--GNSMLEDRPTSNLEKLHFIIGNGILRPALRD 1169 8 VHLTLKKKSKLTEEVTKRLHDGESMVQ--GNSMLEDRPTSNLEKLHFIIGNGILRPALRD 1169 9 VSLTLKKKSKLTEEVTKRLHDGESTLQ--GNSMLEDRPTSNLEKLHFIIGNGILRPALRD 1169 10 VSLTLKKKSKITEEVTKRLNDGEPGLH--GNSMLEDRPTSNLEKLHFIIGNGILRPGLRY 1149 11 VSLTLKKKSKITEEVTKRLNDGEYGLH--GNSMLEDRPTSNLEKLHFIIGNGILRPGLRD 1151 12 VSLTLKKKSKITEEVTKRLNDGEYSLH--GNSMLEDRPTSNLEKLHFIIGNGILRPALRD 1166 13 VSLTLKKKSKITEEVTKRLNDGEYTVH--GNSMLEDRPTSNLEKLHFIIGNGILRPGLRD 1169 14 VSLTLKRKSKITEEVTRRLTEGDHRME--GNSMLEERPTSNLEKLHFIIGNGILRPTLRD 1183 15 ISMTLKKKSKLTGEVANRLKSGDDIADDGENVMVIDRPTTNLEKLHFIIGNGILRPNIRN 1126 16 ISMTLKKKSKLTGEVANKLRSGEDWID-VINSMVMDRPTTNLEKLHFIIGNGILRPNIRN 1134 17 VSLTLKRKNKLGEDVRRRLQDEEYTADS-YQSWLESRPTSNLEKLHFIIGHGILRAELRD 1155 18 ISMTLKRKGKINGSDTSSISSDSVYSS--FNAMLENKPMTSLDKLHYIIGLGILREDLRD 1081 C *:*TLK*K*K+*****+**:+**:::: +*******P***L*KLH**IG*GILR*:*R* 1210 1220 1230 1240 1250 1260 1 EIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHG-GPP--GYAPY 1226 2 EIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHG-GPP--GYAPY 1039 3 EIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHG-GPP--GYAPY 1201 4 EIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHG-GPP--GYAPY 1227 5 EIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHG-GPP--GYAPY 1215 6 EIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHG-GPP--GYAPY 1223 7 EIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHG-GPP--GYAPY 1226 8 EIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHG-GPP--GYAPY 1226 9 EIYCQICKQLTQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFING-GPP--GYAPY 1226 10 THKLVHCKQLSQNPSKSSHARGWILISLCVGCFAPSDKFVKYLRNFINS-GPP--GYAPY 1206 11 EIYCQICKQLTQNPSKSSHARGWILISLCVGCFAPSDKFVKYLRNFISN-GPP--GYAPY 1208 12 EIYCQICKQLSQNPSKSSHARGWILISLCVGCFAPSDKFVKYLRNFISN-GPP--GYAPY 1223 13 EIYCQICKQLNQNPSKSSHARGWILMSLCVGCFAPSEKFVKYLRNFISE-GPP--GYAPY 1226 14 EIYCQICKQLTQNPSKSSHARGWILLSLCVGCFAPSEKFVKYLRTFLNN-GPP--GYAPY 1240 15 EIYCQICKQLTNNVFKSSHSRGWILLSLCVGCFAPNEDFVKYLQNFIRD-GPS--NYAPY 1183 16 EIYCQICKQLTNNVFKSSHSRGWILLSLCVGCFAPNEDFVKYLQNFIRG-GPL--NYAPY 1191 17 EIYCQICKQLTNNPSKSSHARGWILLSLCVGCFAPSEKFVNYLRSFIRE-GPP--GYAPY 1212 18 EIYCQLCKQLSNNPSKLSAARGWILLSLCVGCFAPSERFIKYLFCFIRERGPAGTGYSKY 1141 C ******:KQL+:N**K*S:*RGWIL:SLCVGCFAP***F**YL**F*:: GP* *Y**Y 1270 1280 1290 1300 1310 1320 1 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNA 1286 2 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNA 1099 3 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNA 1261 4 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNA 1287 5 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNA 1275 6 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNA 1283 7 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTARELCNA 1286 8 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLADSATTAKELCNA 1286 9 CEERLRRTFANGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNS 1286 10 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNA 1266 11 CEERLRRTFVNGTRTQPPSWLELQATKSKKPVMLPVTFMDGTTKTLLTDSATTAKELCNA 1268 12 CEERLRRTFVNGTRTQPPSWLE--ATKSKKPIMLPVTFMDGTTKTLLADSATTAKELCTA 1281 13 CEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTAKELCNA 1286 14 CEERLRRTFVNRTRTQPPSWLELQATKSKKPIILPVTFMDGTTKTLLADSATTASELCNA 1300 15 CEKRLLRTFANGARSQPPSWLELQATKSRKMIMLPITFMDGATSTFLADSATTAKELCDV 1243 16 CEQRLLRTFANGPRSQPPSWLELQATKSRKMIMLPITFMDGATNTFLADSATTAKELCDV 1251 17 CEERLKRTFNNGTRNQPPSWLELQATKSKKPIMLPITFMDGNTKTLLADSATTARELCNQ 1272 18 IEDRLRRTQVNGTRHQPPSYVELQANKSQKPVVLAVTFMDGSVKTLCADSATTAAELCKQ 1201 C *E*RL*RT*+N**R+QPPS**E**A*KS*K***L**TFMDG+**T**+DSATTA+ELC++ 1330 1340 1350 1360 1370 1380 1 LADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFF 1346 2 LADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFF 1159 3 LADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFF 1321 4 LADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFF 1347 5 LADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFF 1335 6 LADKISLRDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFF 1343 7 LADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFF 1346 8 LADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFF 1346 9 LADKISLKDRFGFSLYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFF 1346 10 LSDKINLRDRFGFSLYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFF 1326 11 LSDKVNLRDRFGFSLYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFF 1328 12 LSDKVNLQDRFGFSLYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFF 1341 13 LSDKISLQDRFGFSLYIALFDKVSSLGSGNDHVMDAVSQCEQYAKEQGAQERNAPWRLFF 1346 14 LADKINLRDRFGFSLYIALFDKVSSLGSGSDHVMDAVSQCEQYAKEQGAQERNAPWRLFF 1360 15 LAKKINLADQFGFSLYIALFDKVSSLGSSGDHVMDAISQCEQYAKEQGAQEKHAQWRLFY 1303 16 LAKKIGLTDQFGFSLYIALFDKVSSLGSSGDHVMDAISQCEQYAKEQGAQEKHAQWRLFY 1311 17 LSDKIALKDQFGFSLYIALFDKVSSLGSGGDHVMDAISQCEQYAKEQGAQERNAPWRLFF 1332 18 LAEKVGLTNSFGFSLYIALFDKVSSLGSGTDHVMDAISQCEQYAKEQGRQERNAPWRLFF 1261 C L+*K*:L:*+FGFSLYIALFDKVSSLGS*:DHVMDA+SQCEQYAKEQG*QE**A*WRLF* 1390 1400 1410 1420 1430 1440 1 RKEVFTPWHSPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMIL 1406 2 RKEVFTPWHSPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMIL 1219 3 RKEVFTPWHNPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMIL 1381 4 RKEVFTPWHSPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMIL 1407 5 RKEVFTPWHNPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMIL 1395 6 RKEVFTPWHNPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMIL 1403 7 RKEVFTPWHNPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMIL 1406 8 RKEVFTPWHNPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMIL 1406 9 RKEIFTPWHNPSEDNVATNLIYQQIVRGVKFGEYRCDKEEDLAELASQQYYVDYGSEMVL 1406 10 RKEIFTPWHSPTEDQVATSLIYQQTVRGVKFGEYRCDR-DDLAELASQQYYVDYGSEILL 1385 11 RKEIFTPWHDPTEDQVATNLIYQQIVRGVKFGEYRCDRQDDLAELASQQYYVDYGSEILL 1388 12 RKEIFTPWHCPSDDLIATNLNYQQIIRGVKFGEYRCDR-DELAELASQQYYIDYGSEVLL 1400 13 RKEIFTPWHDPAEDAVATNLIYQQIVRGVKFGEYRCDR-EDLAELASQQYYVDYGSEILV 1405 14 RKEIFSPWHDPADDDVATNLIYQQIVRGVKFGEYRCEREEDLAELASQQYYVDYGSDILL 1420 15 RKEIFTPWHDPTIDKVSTTLIYQQIARGVKFHEYRCDTDLELAQLASKQYYVEHGAAIQA 1363 16 RKEIFTPWHDPCIDKVSTTLIYQQIVRGVKFNEYRCNTDLELAQLASKQYYVEHGASIQT 1371 17 RKEIFAPWHNPIEDQVATNLIYQQVVRGVKFGEYRCDKEEDLAMIAAQQYYIEYNTDMSM 1392 18 RKEIFSPWHDPRDDPVSTNLIYQQVIRGIKYGEYRCDKDEELAAICAQQYYIDEG-TMDV 1320 C RKE:F*PWH.P:+D:**T*L*YQQ:*RG*K**EYRC:++++LA+****QY:****+++:+ 1450 1460 1470 1480 1490 1500 1 ERLLNLVPTYIPDREIT-PLKTLEKWAQLAIAAHKK---GIYAQRRTDAQKVKEDVVSYA 1462 2 ERLLNLVPTYIPDREIT-PLKTLEKWAQLAIAAHKK---GIYAQRRTDAQKVKEDVVNYA 1275 3 ERLLNLVPTYIPDREIT-PLKTLEKWAQLAIAAHKK---GIYAQRRTDAQKVKEDVVNYA 1437 4 ERLLNLVPTYIPDREIT-PLKTLEKWAQLAIAAHKK---GIYAQRRTDAQKVKEDVVNYA 1463 5 ERLLNLVPTYIPDREIT-PLRTLEKWAQLAIAAHKK---GIYAQRRTDAQKVKEDVVNYA 1451 6 ERLLNLVPTYIPDREIT-PLKTLEKWAQLAIAAHKK---GIYAQRRTDAQKVKEDVVNYA 1459 7 ERLLSLVPTYIPDREIT-PLKNLEKWAQLAIAAHKK---GIYAQRRTDSQKVKEDVVNYA 1462 8 ERLLSLVPTYIPDREIT-PLKNLEKWAQLAIAAHKK---GIYAQRRTDAQKVKQDVVNYA 1462 9 ERLLNLIPSYIPDREIT-ASKTVEKWAQLIIAAHKK---GIYTQKRTDPKKVKEEVVDFA 1462 10 ERLLSLIPSYIPDREIS-SSRTVEKWSHFIMAAHKK---GIYAQKRFDPQKVKEEVVDFA 1441 11 ERLLSLIPSYIPDREVS-SSKTVEKWAHFIMAAHKKKFPGLFVPVLSDFNRIFHFKTSFP 1447 12 ERLLSLIPSYIPDREIS-TSRTVEKWAHFIMAAHKK--AGIYAQKRFDPQKVKEEVVDFA 1457 13 ERLLSLIPSYIPDREIS-SAKTVERWAQFIMAAHKK---GVYTQKRVDPQKVKEEVVDFA 1461 14 ERLLGLVPTYIPDREIS-STKTAEKWMQLIASAHKK---GVHTKRRLDPHKVKEDVVDFA 1476 15 TSLAPLISSYLPDRIVT-SQKTLSYWSNMIMKQHKE---AIYTRERWEPHRVREDVVKLA 1419 16 TSLAPLISSYLPDRIVT-SQKPLSHWSSMIMKQHKE---AIYTRERWEPLRVREDVVKQA 1427 17 DRLYTLLPNFIPDYCLTGIEKAIDRWAALVLQAYKK---SYYLKDKAAALKVKEDVVSYA 1449 18 NKLENNLPSYLPDFEMSGKEMALEKWTQTIMHQYRK----KFTGRLPSQIEVKENVVSVA 1376 C +*L+:*:*:**PD**++ ::+++*+W+++::+**** ++*:+:*:+:++***+**.:* 1510 1520 1530 1540 1550 1560 1 RFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSS 1522 2 RFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSS 1335 3 RFKWPLLFSRFYEAYKFSGPNLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSS 1497 4 RFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSS 1523 5 RFKWPLLFSRFYEAYKFSGPNLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSS 1511 6 RFKWPLLFSRFYEAYKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSS 1519 7 RFKWPLLFSRFYEAYKFSGPPLPKSDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSS 1522 8 RFKWPLLFSRFYEAYKFSGPPLPKSDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSS 1522 9 RFKWPLLFSRFYEAFKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEITAVSSS 1522 10 RHKWPLLFSRFYEAFKFSGPSLPKNDLIVAVNWTGVYFVDEQEQVLLELSFPEITAVSSS 1501 11 LHSRPLLS-RYVSFLCLSGPNLPKDDLIVAVNWTGVYFVDEQEQVLLELSFPEITAVSSS 1506 12 RHKWPLLFSRFYEAFKFSGPSLPKNDLIIAVNWTGVYFVDEQEQVLLELSFPEITAVSSS 1517 13 RYKWPLLFSRFYEAFKFSGPSLPKNDVIVAVNWTGVYFVDEQEQVLLELSFPEITAVSSS 1521 14 RLKWPLLFSRFYEAFKFSG-------------WSHGSSVG-------------------- 1503 15 RFSWPMMFSRFYEAYRISGLSLPTDEVVIALNWTGVFFLDDQEQILLELPFVEVTGVVAN 1479 16 RFSWPMMFSRFYEAYRLSGLPLPTNEVLIAVNWTGVFFLDDQEQVLLELPFAEMTGITAN 1487 17 KYKWPLLFSRFYEAYRNSGPNLPKNDVIIAVNWTGVYVVDDQEQVLLELSFPEITAVSSQ 1509 18 KTKWPLLFSRFYEALKFAGPPLPKNEVIIAVNWTGVYVVDDREHVMLEFSFPEISTAYYG 1436 C *+**P****R****+++*G*:***+++*+***W*******+*************:+*+++ 1570 1580 1590 1600 1610 1620 1 RECRVWLSLGCSDLGCAAPHSGWAGLTPAGPCSPCWSCRGAKTTAPSFTLATIKGDEYTF 1582 2 RECRVWLSLGCSDLGCAAPHSGWAGLTPAGPCSPCWSCRGAKTTAPSFTLATIKGDEYTF 1395 3 RECRVLLSLGCSDLGCAAPHSGWAGLTPAGPCSPCWSCRGAKLVAPSFTLATIKGDEYTF 1557 4 RECRVWLSLGCSDLGCAAPHSGWAGLTPAGPCSPCWSCRGAKTTAPSFTLATIKGDEYTF 1583 5 R--------------------------------------GAKLAAPSFTLATIKGDEYTF 1533 6 R--------------------------------------GAKLVAPSFTLATIKGDEYTF 1541 7 R--------------------------------------GTKMMAPSFTLATIKGDEYTF 1544 8 R--------------------------------------GAKLMAPSFTLATIKGDEYTF 1544 9 R--------------------------------------GGKLQGQSFTLATIKADEYTF 1544 10 --------------------------------------RGGKLQSQSFTLATIKGDEYTF 1523 11 RCLNIVLNLTQNFFSSCFC---------------CCFIRGGKMQSQSFTLATIKGEEYTF 1551 12 LKNDHFFTCDNLDLSS----------------------RGSKLQSQSFTLATIKGDEYTF 1555 13 --------------------------------------KGGKLQAQSFTLATIKADEFTF 1543 14 ----------------------------------------GKLQGQSFTLATIKGDEYTF 1523 15 K-------RSIKGFISFYIKFKNPFFFSS-----------EKMKAATITLSTVRGDELVM 1521 16 KGFLSEMTLNINNFFDLQSVLSLEILKPSE--CIKTEAVSEKMKAATITVTTVRGDALTM 1545 17 K--------------------------------------TNKVFTQTFSLSTVRNEEFTF 1531 18 K--------------------------------------GKRSTTDTCTVRTVVGDEYTF 1458 C :.... .................................+.*:.+:+***+T++***+** 1630 1640 1650 1660 1670 1680 1 TSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPA---GEESGFLSFAKGDLIILD-HD 1638 2 TSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPA---GEESGFLSFAKGDLIILD-HD 1451 3 TSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPA---GEESGFLSFAKGDLIILD-HD 1613 4 TSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPA---GEESGFLSFAKGDLIILD-HD 1639 5 TSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPA---GEESGFLSFAKGDLLILD-HD 1589 6 TSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPA---GEESGFLSFAKGDLIILD-HD 1597 7 TSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPA---GEESGFLSFAKGDLIILD-HD 1600 8 TSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPA---GEESGFLSFAKGDLIILD-HD 1600 9 TSNNAEDIRDLVVTFLEGLRKRSKYVVTLQDNPNPV---GEESGFLSFLKGDLIVLD-QD 1600 10 TSNNAEDIRDLVVTFLEGLRKRSKFVVALQDNPNPT---GEESTFLSFMKGDLILLD-QD 1579 11 TSSNAEDIRDLVVTFLEGLRKRSKFVVALQDNPNPVPTAGEESTFLSFLKGDLIVLD-QD 1610 12 TSNNAEDIRDLVVFFLEGLRKRSTFVVALQDNPNPI---GEESTFLSFMKGDLIVLD-QD 1611 13 TSNNAEDIRDLVVTFLEGLRKRSKFVVALQDNPSPA---ADDSTFLSFLKGDLIVLD-QD 1599 14 TSNNAEDIRDLVVTFLDGLRKRSKFVVGLLDCANPA---GVDSTFLSFSKGDLIILD-EH 1579 15 TSSSSDDICSHVNLFIDGLKERSRYAVTLNVNP-KAG---DESTILNFKKGDLIVLT-QP 1576 16 TSSSSDDVCELVNLFIDGLKERSRYVVTLNTNPNKVM---DESSILKFKKGDLLVLN-QP 1601 17 QSPNAEDIRDLVVYFLEGLKKRSKFVIALQDYKAPG----EGTSFLSFLKGDLIILEDES 1587 18 QSPNADDITNLIVMFLEGLKKRSRYLVAIKSQKGDE-----KNNFLEFEKGDLLILVNEF 1513 C *S+***D******+F**GL+*RS++**+*+***+*+ +++*:*L*F:KGDL*+L+ :+ 1690 1700 1710 1720 1730 1740 1 TGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTMPPREIVALVTMTPDQRQDVVRLL 1698 2 TGEQVMNSGWANGINERTKQRGDFPTDSVYVMPTVTMPPRDIV----------------- 1494 3 TGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTLPPREIVALVTMTP---------- 1663 4 TGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTMPPREIVALVTMTP---------- 1689 5 TGEQVMNSGWASGINERTKQRGDFPTDCVYVMPTVTMPPREIVALVTMTPDQRQDVIRLL 1649 6 TGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTMPPREIVALVTMTPDQRQDVIRLL 1657 7 TGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTLPPREIVALVTMTPDQRQDVVRLL 1660 8 TGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTLPPREIVALVTMTPDQRQDVVRLL 1660 9 TGEHVMNSGWANGFNERTKQKGDFPTDSVYVLPTVTMPPLEIVALVTMTPDQRQDVIRTS 1660 10 TGEQVLNSGWAHGINERTNQRGDFPADCVYVLPSVTRPQQEILALVTMTPDQRQESVRVS 1639 11 TGEQVLNSGWAHGINERTNQKGDFPVDCIYVLPAMTRPQQDIVALITMTPDQRQESVRSS 1670 12 TGEQVLNSGWAHGVNERSKQRGDFPADCVYVLPTMIRPQQELVALVTMTPAQRQESVRVS 1671 13 TGEQVMTSGWAHGTNDRTKQRGDFPADCVYVLPTVVRPPHDVVAFVTMTPDQRQESLRIS 1659 14 DGEHVMNSGWAHGINDRTKLKGDFPADCVYILPTITRPQYELVALVTMTPDQRRESMGLS 1639 15 AGSEFNASTWRTGVNDRTGASGDFPTDSVYVLPTLVKPMEDLVNMFTMSPGELAKHGKRF 1636 16 AGADFNSSAWRPGRNERTGVSGDFPTDCVYVIPTLVKPLDDLVNMFTMSPGELAQHGRRV 1661 17 TGESVLNSGWCIGCCERTQERGDFPAEIVYVLPSLTKPPPDILALFSVEDAHHGKRLNSI 1647 18 TGNTLLTESVVKGENSRTCLFGLIRAENVYVLPTLVKPSKNTLQIFPKDMDLSLDLFNNN 1573 C *G*+*++***+:G+*+R*+++G***+*+*Y*:P*++.P+:++*+++**+*+++:...+.. 1750 1760 1770 1780 1790 1800 1 QL-RTAEPEVRAKPYTLEEFSYDYFRPPPKHTLSRVM---VSKARGKDRLWSHTREPLKQ 1754 2 --------------------------PPPKHTLSRVM---VSKARGKDRLWSHTREPLKQ 1525 3 --------------------------DQRQDVIRLLQ---LRTAEPEVRAKPYTLEEFSY 1694 4 --------------------------DPRQDVVRLLQ---LRTAEPEVRAKPYTLEEFSY 1720 5 QL-RTAEPEARTKPYTLEEFSYDYFRPPPKHTLSRVM---VSKARGKDRLWSHTREPLKQ 1705 6 QL-RTAEPEVRAKPYTLEEFSYDYFRPPPKHTLSRVM---VSKARGKDRLWSHTREPLKQ 1713 7 QL-RTAEPEVRAKPYTLEEFSYDYFRPPPKHTLSRVM---VSKARGKDRLWSHTREPLKQ 1716 8 QL-RTAEPEVRTKPYTLEEFSYDYFRSPPKHTLSRVM---VSKARGKDRLWSHTREPLKQ 1716 9 QM-AISDSEERVKPYTLEEFSYDYFRPPPKHTLSRVM---ITKSRGKDKLWCYTREPIKQ 1716 10 QL-VLPESDDRMKAYTLEEFSYDYFRPPPKHTLSRVM---VTKNRGKDKMWSCTREPLKQ 1695 11 QI-ILPDTEGKLKPYTLEEFSYDYFRPPPKHTLSRVM---VTKNRGKDKLWSCTREPLKQ 1726 12 QL-VLPESVDRVKPYTLEEFSYDYFRAPPKHTLSRVM---VTKNRGKDKLWSCTREPLKQ 1727 13 HVPALTETEERVKPYTLEEFSYDYFRPPPKHTLSRVM---ITKNRGKDKLWCCTREPIKQ 1716 14 TS-DLADEEEKLKAYTLEEFSYDHFRPPPKNTLSRVM---ISKSRGKERLWSCTREPIKQ 1695 15 SKVGDADFDLDEKPYTLEEYAADFFRAPIPQTINRAP---PSR-RGKDKLYAMSREPIRQ 1692 16 SKVGDNDFDLDEKPYTLEEYADEFFRAPIPQTINRAP---PSR-RGKEKLYAMSREPIKQ 1717 17 HS--NGGTETREHPHTLADYSLDHFRPPPKRTMSKALST-LSSKRGGDELWRYSREPLKQ 1704 18 KQ--VTVVDYNAEPYTLENFAEDNFNSQVKRVGSQISLMTLRKKESQIECWRFSREHIDQ 1631 C :. ...:.:.:.+++**++++++:*++*+++*+++++ ::+:**++:++:.+*E*:+* 1810 1820 1830 1840 1850 1860 1 ALLKKLLGSEELSQEACLAFIAV-------------------------LKYMG--DYPSK 1787 2 ALLKKLLGSEELSQEACLAFIDIP-----------------------VLKYMG--DYPSK 1560 3 DYF--------------------------------------------MLKYMG--DYPSK 1708 4 DYFPRWLLGKDGSHRARSCRLPLPSGCVLGILLSQLQVMQALWGSPPVLKYMG--DYPSK 1778 5 ALLKKILGSEELSQEACMAFTGSP----------------------PVLKYMG--DYPSK 1741 6 ALLKKILGSEELSQEACMAFIA-------------------------MLKYMG--DYPSK 1746 7 ALLKKILGSEELSQEACMAFVA-------------------------VLKYMG--DYPSK 1749 8 ALLKKIVGSEELSQEACMSFIA-------------------------VLKYMG--DYPSK 1749 9 PLLKKILGSEELSQEACMAFIA-------------------------VLKYMG--DYPSK 1749 10 PLLKKVVNHEELAQDACMSFIA-------------------------MMKYMG--DYPSK 1728 11 PLLKKVVNHEDLAQEACMAFIA-------------------------MMKYMG--DYPSK 1759 12 PLLKKVVNHEDLSQEACLSFID-------------------------ILKTVQSCDYPSK 1762 13 ALLKKCGGHEELSQEACMAFIA-------------------------VMKYMG--DYPSK 1749 14 PLLKKVLAHEELTQEACVAFMD-------------------------ILYWAHQDGHTGL 1730 15 PLLKKLEHNHEMTQEALTFLHFDIFILFLN-------------SCAPLMKYMG--DYPSK 1737 16 PLLKKLEHNHDMTQEAITP---NLNYFDLN-------------SFAPIMKYMG--DYPSK 1759 17 PLLKKLLAKEELAEEACLAFIA-------------------------IMKYMG--DLPSK 1737 18 PLLKKLNGREDACRGAIEIFAA-------------------------IMKYMG--DEPSK 1664 C :****.::.+++:++*+::+:: ..+**** ***** 1870 1880 1890 1900 1910 1920 1 RTRS-VNELTDQIFEGPLKAEPLKDEAYVQILKQLTDNHIR--------------YSEER 1832 2 RTRS-VNELTDQIFEGPLKAEPLKDEAYVQILKQLTDNHIR--------------YSEER 1605 3 RTRS-VNELTDQIFEGALKAEALKDEVYVQILKQLTDNHIR--------------YSEER 1753 4 RTRS-VNELTDQIFEGPLKAEPLKDEAYVQILKQLTDNHIR--------------YSEER 1823 5 RMRS-VNELTDQIFEGALKAEPLKDEVYVQILKQLTDNHIR--------------YSEER 1786 6 RMRS-VNELTDQIFEGSLKAEPLKDEVYVQILKQLTDNHIR--------------YSEER 1791 7 RMRS-VNELTDQIFEWALKAEPLKDEAYVQILKQLTDNHIR--------------YSEER 1794 8 RTRS-VNELTDQIFEWAVKAEPLKDEAYVQILKQLTDNHIR--------------YSEEK 1794 9 RTRS-VNELTDQIFEGALKAEPLKDEIYCQTLKQLTDNHIK--------------YSEEK 1794 10 RTRS-VNELTDQIFEGALKAEPLKDEIYCQTIKQLTDNHVK--------------YSEEK 1773 11 RTRS-VNELTDQIFEGALKAEPLKDEIYCQILKQLTDNHVK--------------YSEEK 1804 12 RTRS-VNELTDQIFEAALKAEPLKDEIYSQIIKQLTDNHIK--------------YSEEK 1807 13 RTRS-VNELTDQIFEGALKAEPLKDEIYCQILKQLTENHIK--------------YSEEK 1794 14 RVCAPINELTDQIFEGALKAEPLKDEIFCQILKQLTDNNIKYTHTCHTTTTDTNRYSEER 1790 15 RPRH-GNEQTDQIFEPPLKHEQLRDEVYCQIMKQLTNNKQS--------------YSEER 1782 16 KQRH-GNEQTDQIFEAPLKHEQLRDEVFCQIMKQLTNNKQS--------------YSEER 1804 17 RPRI-GNEITDHIFDGPLKHEILRDEIYCQLMKQLTDNRNR--------------MSEER 1782 18 RSRL-GTHLTDHIFKLPISMEALRDELYCQLVKQLTLNPSI--------------MSEER 1709 C *:*+ +***TD*IF*+:**+E+L+DE.*:Q++KQLT+N++: *SEE+ 1930 1940 1950 1960 1970 1980 1 GWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEV 1892 2 GWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKAL-------------- 1651 3 GWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEV 1813 4 GWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEV 1883 5 GWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEV 1846 6 GWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEV 1851 7 GWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEV 1854 8 GWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEV 1854 9 GWELLWLCTGLFPPSNILLPHVQRFLQSRKHHPLAADCIQRLQKALRNGSRKYPPHLVEV 1854 10 GWELLWLCTGLFPPSNVLLPHIQRFLQSKKHHPLSGDCMQRLHKALRNGSRKYPPHLVEV 1833 11 GWELLWLCTGLFPPSNVLLPHIQRFLQSKKHHPLSADCMQRVHKALRNGSRKYPPHLVEV 1864 12 GWELLWLCTGLFPPSNVLLPHIQRFLQSKKHHPLSGDCMQRLHKALRNGSRKYPPHLVEV 1867 13 GWELLWLCVGLFPPSNVLLPHVQRFLQSKKHHPLALDCMQRLQKALRNGSRKYPPHLVEV 1854 14 GWELLWLCTGLFPPSNVLLPHMQKFLQAKKHHPLAADCMQRLQKALRNGSRKYPPHLVEV 1850 15 GWELMWLATGVFAPSNQLMPHLQKFLGTRRANPMANDCYHRYKRPVTHGQRKYPPHLVEV 1842 16 GWELMWLATGVFAPSNQLMPHLHKFLGTRRENPMANDCYHRYKRPTTHGHRKYPPHLVEV 1864 17 GWELMWLSTGLFACSQQLLKELTVFLRTRR-HPISQDSLHRLQKTIRNGQRKYPPHQVEV 1841 18 GWELLWMATGLFAPSAALAKEISHFLKSRP-HPIALDCQNRMQKLAKGGSRKYPPHLVEV 1768 C GWEL*W*+*G*F+*S*:L***:*+FL+++++:P++:D*:+R++*++++*+********** 1990 2000 2010 2020 2030 2040 1 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTKAKDFCQNIATRLLLKSSEGFS 1944 2 ------------------------------------------------------------ 1651 3 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTKAKDFCQNIAARLLLKSSEGFS 1865 4 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTKAKDFCQNIATRLLLKSSEGFS 1935 5 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTKAKDFCQNIAARLLLKSSEGFS 1898 6 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTRAKDFCQNIAARLLLKSSEGFS 1903 7 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTKAKDFCQNIASRLLLKSSEGFS 1906 8 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTKAKDFCQNIASRLLLKSSEGFS 1906 9 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTKAKDFCQNISNRLLLKSSEGFS 1906 10 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESGTKAKDFCQNISTRLLLKSPEGFS 1885 11 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTKAKDFCKNISTRLLLKSAEGFS 1916 12 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTRAKDFCQNISTRLLLKSAEGFS 1919 13 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESSTKAKDFCLNISSRLLLKTPEGFS 1906 14 EAIQHKTTQIFHKVYFPDD----------------------------------------- 1869 15 EAIQHKTTQIFHKVYFPDDTDEA--------FEVESCTRAKDFCQNIANRLRLKSADGFS 1894 16 EAIQHKTTQIFHKVYFPDDTDEARIKFFFQAFEVESSTRAKDFCQNIANRLRLKSADGFS 1924 17 EAIQHKTTQIFHKVYFPDDTDEA--------FEVDSSTRAKDFCQNISQRLNLRSSEGFS 1893 18 EAIQHKTTQIFHKVFFPDNTDEA--------IEVDSATRARDFCHKIGYRLGLKSSDGFS 1820 C *********************** ***+*+*:*****+**:.**+***:+*** 2050 2060 2070 2080 2090 2100 1 LFVKIADKVISVPEND-FFFDFVRHLTDWIKKARPI-KDGIVPSLTYQVFFMKKLWTTTV 2002 2 --------VISVPEND-FFFDFVRHLTDWIKKARPI-KDGIVPSLTYQVFFMKKLWTTTV 1701 3 LFVKIADK--------------------------------IVPSLTYQVFFMKKLWTTTV 1893 4 LFVKIADKVISVPEND-FFFDFVRHLTDWIKKARPI-KDGIVPSLTYQVFFMKKLWTTTV 1993 5 LFVKIVDKVISVPEND-FFFDFVRHLTDWIKKARPV-RDGVVPSLTYQVFFMKKLWTTTV 1956 6 LFVKIADKVISVPEND-FFFDFVRHLTDWIKKARPV-KDGIVPSLTYQVFFMKKLWTTTV 1961 7 LFVKIADKVISVPEND-FFFDFVRHLTDWIKKARPI-KDGIVPSLTYQVFFMKKLWTTTV 1964 8 LFVKIADKVISVPEND-FFFDFVRHLTDWIKKARPI-KDGIVPSLTYQVFFMKKLWTTTV 1964 9 LFVKISDKVISVPEGD-FFFDFVRHLTDWIKKARPA-KDGIVPSLTYQVFFMKKLWTNTT 1964 10 LFVKISDKVGSQQVFIRNFMRLFRFLAKWMDRLSSQ-NDSLCECFTYKIFDGKKFLV--- 1941 11 LFVKISDKVISVPEGD-FFFDFVRHLTDWIKKSRPA-KDGIVPSLTYQVFFMKKLWTSTV 1974 12 LFVKISDKVISVPEGD-FFFDFVRHLTDWIKKSRPATKDGIIPCLTYQVFFMKKLWTSTV 1978 13 LFVKISDKVISVPEGD-FFFDFVRHLTDWIKKARPA-KDGIVPSLTYQVFFMKKLWTTTV 1964 14 -----SDKVISVPDGD-FFFDFVRHLTDWIKKARHV-KEGAGPSLTYQVFFMKKLWTNTV 1922 15 LFVKIADKVISVPESD-FFFDFVRHLTDWLKKARPT-KDGSNPTLSYQVFFMKKLWATTK 1952 16 LFVKIADKVISVPEND-FFFDFVRHLTDWLKKARPT-KDGSTPTLTYQVFFMKKLWATTK 1982 17 LFVKIADKVISVPEGD-FFFDFVRHLTDWIKKARPT-RDGTNPQFTYQVFFMKKLWTNTV 1951 18 LFVKIKDKVLAVPESE-FFFDYVRSLSDWVHTNHATQKDATMIPINYQVYFMRKLWYNFV 1879 C *****:********:* ************+**+*+. +**++*+**Y******K**++*+ 2110 2120 2130 2140 2150 2160 1 PGKDPMADSIFHYYQ--------------------------------------------- 2017 2 PGKDPMADSIFHYYQ--------------------------------------------- 1716 3 PGKDPMADSIFHYYQ--------------------------------------------- 1908 4 PGKDPMADSIFHYYQ--------------------------------------------- 2008 5 PGKDPMADSIFHYYQ--------------------------------------------- 1971 6 PGKDPMADSIFHYYQ--------------------------------------------- 1976 7 PGKDPMADSIFHYYQ--------------------------------------------- 1979 8 PGKDPMADSIFHYYQ--------------------------------------------- 1979 9 PGKDSMADSIFHYYQ--------------------------------------------- 1979 10 -GTDSVADSRYTHYH--------------------------------------------- 1955 11 PGKDSFADSIFHYYQ--------------------------------------------- 1989 12 PGKDSFADSIFHFYQ--------------------------------------------- 1993 13 PGKDSFADSIFHYYQ--------------------------------------------- 1979 14 PGKDSMADSIFHYYQKNLGEATLRLMSCGLWSSSLWAFCCYHVPQAHVFFFFWPFAWWRV 1982 15 PGKDPNADNIFHYYQ--------------------------------------------- 1967 16 PGKDPNADNIFHYFQ--------------------------------------------- 1997 17 PGKDKNADLIFHYHQ--------------------------------------------- 1966 18 AGADPQADIIFHYHQ--------------------------------------------- 1894 C *G*D+:AD+****** 2170 2180 2190 2200 2210 2220 1 --------ELPKYLRGYHKCTREEVLQLGALIYRVKFEEDK-SYFPSIPKLLRELVPQDL 2068 2 --------ELPKYLRGYHKCTREEVLQLGALIYRVKFEEDK-SYFPSIPKLLRELVPQDL 1767 3 --------ELPKYLRGYHKCTREEVLQLGALIYRVKFEEDK-SYFPSIPKLLRELVPQDL 1959 4 --------ELPKYLRGYHKCTREEVLQLGALIYRVKFEEDK-SYFPSIPKLLRELVPQDL 2059 5 --------ELPKYLRGYHKCTREEVLQLGALIYRVKFEEDK-SYFPSIPKLLRELVPQDL 2022 6 --------ELPKYLRGYHKCTREEVLQLGALIYRVKFEEDK-SYFPSIPKLLRELVPQDL 2027 7 --------ELPKYLRGYHKCTREEVLQLGALIYRVKFEEDK-SYFPSIPKLLRELVPQDL 2030 8 --------ELPKYLRGYHKCTREEVLQLGALIYRVKFEEDK-SYFPSIPKLLRELVPQDL 2030 9 --------ELPKYLRGYHKCTREEVLQLAALIYRVKFEDDK-SYFPSIPKLLKELVPQDL 2030 10 --------ELPKYLRGYHKCSREEVFQLAALIYRVKFEDDK-SHFPTIPKMLRELVPQDL 2006 11 --------ELPKYLRGYHKCSREEVFQLGALIYRVKFEEDK-SHFPTIPKMLRELVPQDL 2040 12 --------ELPKYLRGYHKCSREEVFQLAALIYRVKFEDDK-SHFPTIPKMLRELVPQDL 2044 13 --------ELPKYLRGYHKCSREEVFQLGALIYRVKFEDDK-SHFPSIPKMLKEMIPQDL 2030 14 TPPPMTQQELPKYLRGYHKCPREEVNQLAALIYRAKFEDDK-SHFQNTSKILKELVPQDQ 2041 15 --------ERPKYLRGYQKCSKEDAFELAALIYRVQFGDDK-SQFPNIPRMLKDLAPIYL 2018 16 --------EKPKYLRGYHKCSKEDAYELAALIYRVQFGDDK-SQFPNIPRMLKELAPLFL 2048 17 --------ELPKLLRGYHKCSKEEAVKLAALVYRVRFGESK-QELQAIPQMLRELVPSDL 2017 18 --------ESQKYLLGYHKTTKNDVIELAALILRSMTKDGKNAPLAQIPQLLDEIIPKDS 1946 C E**K*L*GY*K*:+***:+L:AL**R*+*+:*K *:**:**+:L+**+P+** 2230 2240 2250 2260 2270 2280 1 IRQVSPDDWKR-------SIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTT 2121 2 IRQVSPDDWKR-------SIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTT 1820 3 IRQVSPDDWKR-------SIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTT 2012 4 IRQVSPDDWKR-------SIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTT 2112 5 IRQVSPDDWKR-------TIISFQVREKGQVSSEGDLSFCRGIFFSPSCGS--FNILSNL 2073 6 IRQISPDDWKR-------SIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGS--AFFEQTT 2078 7 IRQVSPDDWKR-------SIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTT 2083 8 IRQVSPDDWKR-------SIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTT 2083 9 VRQLSPDDWKR-------SIVAYYNKHAGKTREEAKLAFLKIIFKWPTFGSAFFEVKQTT 2083 10 IRQMSPDDWKR-------SVVAYFNKQAGKTREEAKLMFLKTIYKWPTFGSAFFEVKQTT 2059 11 IRQMSPDDWKR-------SIVAHFNKHAGKSREEAKLMFLKIIYKWPTFGSAFFEVKQTT 2093 12 IRQMSPDDWKR-------SVVAYFNKQAGKSREEAKLMFLKIIYKWPTFGSAFFEVKQTT 2097 13 IRQLSPDDWKR-------SIVAYFNRHAGKSREEAKLMFLKIIFKWPTFGSAFFEVKQTT 2083 14 IRNLSPDDWRRVRMMRNQSIMSLFNKHSGTSREEAKLSFLKIIYKWPTFGSAFFEVKQTT 2101 15 LRQASPDDWKR-------NIIHHYNKSTVRTKEDAKLAFLNIIFKWKTFGSAFFEVRQTT 2071 16 LRQASPDDWKR-------NIVQHYNKSTIRTKDEAKLAFLNIIFKWKTFGSAFFEVRQTT 2101 17 IKLQTTNDWKR-------SIVAAYNQDAGMSPEDAKVTFLKIVYRWPTFGSAFFEVKQTT 2070 18 LKMYSASEWRK-------TISNAYARIEHLKSDQAKIEFLNYICRWPTFGSAFFPVSQYS 1999 C +**.****W** +*++++*+++*++:*****:F*+:*+*****GS*****+*** 2290 2300 2310 2320 2330 2340 1 EPNFPEILLIAINKYGVSLIDPKTKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 2177 2 EPNFPEILLIAINKYGVSLIDPKTKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 1876 3 EPNFPEILLIAINKYGVSLIDPRTKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 2068 4 EPNFPEILLIAINKYGVSLIDPRTKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 2168 5 VPNLPHGVLLHISSYRDSMLQSTSKPLNSSFYTTLRTNTILGGNSYFQPSLSNLIRQ--- 2130 6 EPNFPEILLIAINKYGVSLIDPRSKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 2134 7 EPNFPEILLIAINKYGVSLIDPRTKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 2139 8 EPNFPEILLIAINKYGISLIDPRTKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 2139 9 EPNYPEILLIAINKHGVSLIDPKTKDILITHPFTKISN-WSSGNTYFHITIGNLVRG--- 2139 10 EPNFPEILLIAINKHGVSLIDPKTKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 2115 11 EPNYPEILLIAINKHGVSLIDPKTKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 2149 12 EPNFPEILLIAINKHGVSLIDPKTKDILTTHPFTKISN-WSSGNTYFHITIGNLVRG--- 2153 13 EPHFPEILLIAINKYGVSLIDPKNKDILTTYPFTKISN-WSSGNTYFHITIGNLVQG--- 2139 14 DPNYPESLVIAINKHGVSLIDPRSKDILITHPFTKISN-WSSGNTYFHITIGNLVRG--- 2157 15 EPSYPENLIIAINKHGVSLIDPKTKAILVTYHFANISN-WSSGNSYFHMSIGSLVKG--- 2127 16 EPSFPENLIIAINKHGVSLIDPKTKTVLVTYHFAKISN-WSSGNSYFHMTIGNLVKG--- 2157 17 EPNYPEMLLIAINKHGVSLIHPSSKDILVTHPFTRISN-WSSGNTYFHMTIGNLVRG--- 2126 18 DLNLPDRLLLAINQTGVNIYHLDTKNLLVQYPFNVICN-WTSGNTYFNMTVGNMLKGNEG 2058 C ***+P*+****I**:*******:+K+**+*+***+**N ***GN*YF*+******+* 2350 2360 2370 2380 1 SKLLCETSLGYKMDDLLTSYISQMLTAMSKQRGSRSGK-- 2215 2 SKLLCETSLGYKMDDLLTSYISQMLTAMSKQRGSRSGK-- 1914 3 SKLLCETSLGYKMDDLLTSYISQMLTAMSKQRGSRSGK-- 2106 4 SKLLCETSLGYKMDDLLTSYISQMLTAMSKQRGSRSGK-- 2206 5 YKP-CSMDLGYKMDDLLTSYISQMLTAMSKQRGSRSGK-- 2167 6 SKLLCETSLGYKMDDLLTSYISQMLTAMSKQRGSRSGK-- 2172 7 SKLLCETSLGYKMDDLLTSYISQMLTAMSKQRNSRSGR-- 2177 8 SKLLCETSLGYKMDDLLTSYISQMLTAMSKQRNSRSGR-- 2177 9 SKLLCETSLGYKMDDLLTSYISQMLTAMSKQRSAKGSK-- 2177 10 SKLLCETSLGYKMDDLLTSYISQMLTTMNKQRSGPRLSK- 2154 11 SKLLCETSLGYKMDDLLTSYISQMLTTMNKQRSGRGHS-- 2187 12 SKLLCETSLGYKMDDLLTSYISQMLTTMNKQRSGRS---- 2189 13 SKLLCETSLGYKMDDLLTSYISQMLTTMSKQRNSRGGSSK 2179 14 SKLLCETSLGYKMDDLLTSYISQMLTTMTKQRSSRG---- 2193 15 NKLLCETTLGYKMDDLLTSYISLMLNFVTRNNKRKL---- 2163 16 NKLLCETSLGYKMDDLLTSYISLMLNMVQKNSKRKL---- 2193 17 SKLLCETSLGYKMDDLLTSYISLMLTNMNKQRTIRIK--- 2163 18 KKLLLDTTVGYKMDDLLTSYISLLISNQNNHPSKTREVAL 2098 C +K*******GYKMDDLLTSYIS+***:*:***.:+::.