Edtaln : Multiple alignment ------------------------------------------------------------------------------- Le consensus est matrialis par une squence de caractres qui, selon la situation rencontre en une position donne, seront les suivants : "." si le caractre majoritaire a une reprsentation >= 20% ":" si le caractre majoritaire a une reprsentation >= 40% "+" si le caractre majoritaire a une reprsentation >= 60% "*" si le caractre majoritaire a une reprsentation >= 80% le caractre lui-mme, si celui-ci est identique pour l'ensemble des squences. ------------------------------------------------------------------------------- 1 Homo sapiens AAG27034 NCBI 2 Pan troglodytes XP_507839 '' 3 Macaca mulatta ENSMMUP00000017023 Ensembl 4 Mus musculus NP_075859 NCBI 5 Rattus norvegicus P58365 '' 6 Canis familiaris ENSCAFP00000021050 Ensembl 7 Felis catus ENSFCAP00000012101 '' 8 Bos taurus ENSBTAP00000028652 '' 9 Monodelphis domestica ENSMODP00000000382 '' 10 Gallus gallus ENSGALP00000007402 '' 11 Gasterosteus aculeatus ENSGACP00000004573 '' 12 Takifugu rubripes SINFRUP00000146814 '' 13 Orysias latipes ENSORLP00000016841 '' 14 Danio rerio NP_999974 NCBI 10 20 30 40 50 60 1 -----MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQL 55 2 -----MGCHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQL 55 3 -----MGCHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGDSERQM 55 4 -----MRYSLVTCYAVLWLLMLVPGSWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQL 55 5 -----MRHPPVTWCAMLWLLMLVSGSWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQL 55 6 ---------------------------------------------LISSVAIPGSSVTQL 15 7 -----MRCHVATGCLVAWLFVLISGCLGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQL 55 8 -----MRCHVASSCLVVWLSVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQL 55 9 ------------------------------------------------------------ 0 10 -----------------------------------------------------GSSVTQL 7 11 MSWSVGLGGRMAIAKLLFPFLLLHSFCEGSNQPPRFLNFFFSTYLLIYEDAPVGSSVAQL 60 12 MSWSVALGGRMTVVKLLLPVLLLHSFCKGSNQPPRFLNYFFSTYLLIYEDMPVGSSVAQL 60 13 ------------------------------------------------------------ 0 14 ------------------------------------------------------------ 0 C :.....:.:.:.::..+.::.::::+::+:+:+:++:+++++:++:++++++:++ 70 80 90 100 110 120 1 LAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 115 2 LARDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 115 3 MAQTLYMPMLVNGKAHVQASKQTCTALDTLCDIMRFPLEPETKSEFTVEFSVSDHQGVIT 115 4 LARDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 115 5 LARDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 115 6 LARDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 75 7 LARDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 115 8 LARDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 115 9 ------------------------------------------------------------ 0 10 LARDLDNDPLVFGVVGEEASRFFAVESVTGVVWLRQPLDRETKSEFTVEFSVSDSQGVIK 67 11 NALDPEGEPLIYGVSGEEAVRYFSVNKDTGVVWLRQQLDRETKSEMQVEFFVSDSQEVVK 120 12 KATDPEGEPLIYGVSGEEAMKYFSVNKDTGVVWLRQQLDRETKSEMQVEFYVSDIQEVVK 120 13 ------------------------------------------------------------ 0 14 ------------------------------------------------------------ 0 C :+:+::::+++:+++++++++:+:+::+++++++++++++++++++++++++++:++++: 130 140 150 160 170 180 1 RKVNIQVGDVNDNAPTFHNQPYSVRIPEN-----TPVGTPIFIVNATDPDLGAGGSVLYS 170 2 RKVNIQVGDVNDNAPTFHNQPYSVRIPEVGATRNTPVGTPIFIVNATDPDLGAGGSVLYS 175 3 RKVNIQVGDVNDNAPTFHNQPYSVRIPEN-----TPVGTPIFIVNATDPDLGAGGSVLYS 170 4 RKVNIQVGDVNDNAPTFHNQPYSVRIPEN-----TPVGTPIFIVNATDPDLGAGGSVLYS 170 5 RKVNIQVGDVNDNAPTFHNQPYSVRIPEN-----TPVGTPIFIVNATDPDLGAGGSVLYS 170 6 RKVNIQVGDVNDNAPTFHNQPYSVRIPEVGAPRNTPVGTPIFIVNATDPDLGAGGSVLYS 135 7 RKVNIQVGDVNDNAPTFHNQPYSVRIPEVGAPSNTPVGTPIFIVNATDPDLGAGGSVLYS 175 8 RKVNIQVGDVNDNAPTFHNQPYSVRIPEN-----TPVGTPIFIVNATDPDLGAGGSVLYS 170 9 ------------------------------------------------------------ 0 10 GTVNIQVGDVNDNAPRFHNQPYSVRIPEN-----TPVGTPIFIVNATDPDQGAGGSVLYS 122 11 DTVNIQIGDVNDNAPVFHGQPYTVRIPEN-----TAVGRSVFMVNATDPDQGTGGSVLFS 175 12 DTVNIQIGDVNDNAPIFHGQPYTVHIPEN-----TPVGRSIFMVNATDPDQGTGGSVLFS 175 13 ------------------------------------------------------------ 0 14 ------------------------------------------------------------ 0 C ::+++++++++++++:++++++++++++:.. .++++++++++++++++:+++++++++ 190 200 210 220 230 240 1 FQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLA------NLAI 224 2 FQPPSQFFAIDSAHGIVTVIRELDYETTQAYQLTVNATDQ-------------------- 215 3 FQPPSQFFAIDSARGIITVIRELDYETTQAYQLTSNGAFQWDTDPVAHTRGSVITIVVTV 230 4 FQPPSPFFAIDSARGIVTVIQELDYEVTQAYQLTVNATDQDKTRPLSTLAN------LAI 224 5 FQPPSQFFAIDSARGIVTVIRELDYEVTQAYQLTVNATDQDKTRPLSTLAN------LAI 224 6 FQPPSPFFAIDSARGIVTVVRELDYETTQAYQLTVNATDQDKTRPLSTLAN------LAI 189 7 FQPPSLFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLAN------LAI 229 8 FQPPSQFFAVDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLAN------LAI 224 9 ------------------------------------------------------------ 0 10 FQPPSSFFAIDSGRGIVTVIRELDYEVTQAYQLQVNATDQDKNKPLSTLAN------LAI 176 11 FQPPSAFFSIDGARGTVTVIKPLDYETTSAYTLTVNATDQDKVRPLSRLAN------LAI 229 12 FQPPSSFFTIDGARGTVTVTKPLDYETTSAYQLTVNATDQDKLRPLSRLAN------LAI 229 13 ------------------------------------------------------------ 0 14 ------------------------------------------------------------ 0 C +++++.++++++++++++++:+++++:+++++++++++++++::+++:++: +++ 250 260 270 280 290 300 1 IITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGY---TIVS--GN 279 2 ---------------------------GTTVRIITAIDQDKGRPRGIGY---TIVSVAGN 245 3 MIEMRLALLRLHSSQGIQTQVPPLFCQGTTVRIITAIDQDKGRPRGIGY---TIVS--GN 285 4 IITDMQDMDPIFINLPYSTNIYEHSPPGTTVRVITAVDQDKGRPRGIGY---TIVS--GN 279 5 IITDVQDMDPIFINLPYSTNIYEHSPPGTTVRVITAVDQDKGRPRGIGY---TIVS--GN 279 6 IITDVQDMDPIFINLPYSTNIYEHSPPGTTVRVITAIDQDKGRPRGIGY---TIVSVAGN 246 7 IITDVQDMDPIFINLPYSTNIYEHSPPGTTVRVITAIDQDKGRPRGIGY---TIVSVAGN 286 8 IITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGY---TIVS--GN 279 9 -----------------------------------------------------LVSIPGN 7 10 TITDVQDMDPIFINLPYSTNIYENSPPGTTVRMITAIDQDKGRPRGIGY---TIVS--GN 231 11 TITDVQDMDPIFTNLPYSTNIEEDVPLGFEVRKITAIDQDLGQPRGIGYTIIS-----GN 284 12 SITDVQDMDPIFTNLPYSTNIEEDVPLGYEVRKITAIDQDLGRPRGIGYTIVS-----GN 284 13 ------------------------------------------------------------ 0 14 ------------------------------------------------------------ 0 C :+++:+++++++:++++++++:+::+:+++++.++++++++++++++++ ++++..** 310 320 330 340 350 360 1 TNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI 339 2 TNSIFALDYISGALTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI 305 3 TNSIFALDYISGALTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI 345 4 TNSIFALDYISGALTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI 339 5 TNSIFALDYISGALTLNGLLDRENPLYSHGFILTVKGTELNDDRSPSDATVTTTFNILVI 339 6 TNSIFALDYISGALTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDASVTTTFNILVI 306 7 TNSIFALDYISGALTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI 346 8 TNSIFALDYISGALTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI 339 9 TNSIFALDYISGALTLNGVLDRENPLYSHGFILTVKGTELYDDRTPSDASCITTFNILVI 67 10 TNSIFALDYISGALTLNGPLDRENPFYSSGFILTVKGTELNDDRTPSNATVTTTFNILVI 291 11 TNSVFALDYISGSLTVNGQLDRENPLYSAGFSLTVRATELNDDRSPSGATVRTTFTILLI 344 12 TNSVFALDYISGSLTVSGQLDRENPLYSAGFTLTVKATELRADRFPSDATVMTTFTILLI 344 13 ------------------------------------------------------------ 0 14 ----------------------------------LQATELNDDRTPSSATVTTTFTILLI 26 C ***+********+**++*:******+**+**+***++***+***+**+*+*+***+**+* 370 380 390 400 410 420 1 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFI 399 2 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE--GLNSMFEVYLVGNNSHHFI 363 3 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEDWGLNSMFEVYLVGNNSHHFI 405 4 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEDLGLNSMFEVYLVGNNSHHFI 399 5 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENAGLNSMFEVYLVGNNSHHFI 399 6 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE--GLNSMFEVYLVGNNSQHFI 364 7 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE--GLNSMFEVYLVGNNSQHFI 404 8 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDETQGLNSMFEVYLVGNNSHHFI 399 9 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE--GLNSMFEVYLVGNNSHHFI 125 10 DVNDNAPEFNSSEYSVAIPELAQVGFALPLFIQVQDKDE--GPNSVFEVYLVGNNSNHFI 349 11 DKNDNAPTFNSSEYRVLITELAQVGFALPLFIQAEDKDE--GVNSMFQVFLRGNNSDYFT 402 12 DKNDNAPKFNSSEYRVRITELAQVGFALPLFIQAEDKDE--GVNSMFQVFLTGNNSEYFT 402 13 ------------------------------------------------------------ 0 14 DKNDNPPRFNSSEYRVLITELAQVGFALPLYIQVEDKDE--GVNSMFQVFLTGNNSDHFS 84 C *+*****+******+*+****************++**** *+****+*+*+****:+*+ 430 440 450 460 470 480 1 ISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPI 459 2 ISPTSVQGKADIRILVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPI 423 3 ISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPI 465 4 ISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPI 459 5 ISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPI 459 6 ISPTSVQGKADIRIRVAVPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPI 424 7 ISPTSVQGKADIRIRVAVPLDYETVDRYDFDLFANESVPDHVGYAKVKIALINENDNRPI 464 8 ISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPI 459 9 VSPTSIQGKADIRMRVAQPLDYETVPRYEFDMFANESVPDHVGYAKVKISLINENDNRPI 185 10 ISPTSIQGKADIRVRVAVPLDFETIPRYEFSLFANESIPEHVGFARVKISLINENDNRPV 409 11 ISPTAVQGRADIRVRVALPLDFENIRSYSFSLYANESMSDHVGFARVFIDLINENDNRPI 462 12 LSPTAVQGRADIRMRVAMPLDYEHIRSYSFSLYANESMSDHVGFARVFIELINENDNRPI 462 13 ------------------------------------------------------------ 0 14 ISPTSVQGRADLRLRVAIPLDYETIRSYSFSLYANESLSEHVGFARVFIDLINENDNRPI 144 C +***++**+****:***:***+*++:+*:*+*+****+++***+*+*+*:********** 490 500 510 520 530 540 1 FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIA 519 2 FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVNYFFSDDPDRFSLDKDTGLIMLIA 483 3 FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVNYFFSDDPDR-ALDWKLEPMGTVA 524 4 FSQPLYNVSLYENITVGTSVLTVLATDNDVGTFGEVNYFFSDDPDRFSLDKDTGLIMLIA 519 5 FSQPLYNVSLYENITVGTSVLTVLATDNDVGTFGEVNYFFSDDPDRFSLDKDTGLIMLIA 519 6 FSQPLYNVSLYENVTVGTSVLTVLATDNDVGTFGEVNYFFSDDPDRFSLDKDTGLIMLIA 484 7 FSQPLYNVSLYENVTLGTSVLTVLATDNDVGTFGEVNYFFSDDPDRFSLDKDTGLIMLIA 524 8 FSQPLYNVSLYENVTVGTSVLTVLATDNDVGTFGEVNYFFSDDPDRFSLDKDTGLIVLIA 519 9 FSQPLYNVSLYENVTVGTTILTVLATDNDAGTYGDVYYFLSDDSDRFSLDKDTGLITLIG 245 10 FSKALYNVSLPENATVGTTVLQVHATDNDVGSYGKVSYFFSDDPDRFSLDKDTGVILLMA 469 11 FSTPLYNISLPENTRPGTSLLRILATDRDAGIFGIVRYYFSDEPDQFSLDEETGWVILRD 522 12 FSKPLYNISLPENTAPGTSLLHILATDADAGTFGIVRYYFSDEPDQFSLDEETGWVILRA 522 13 ------------------------------------------------------------ 0 14 FSQTLYNISLPESIEPGASLLQIKATDNDIGTFGVVRYYFSDEPDQFSLDAETGWVTLRG 204 C **++***:**+**:++**++*+++***+*:*++*:*:*+***+**+****++**:+:*:+ 550 560 570 580 590 600 1 RLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ 579 2 RLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNMPTFQKDAYVGALRENEPSVTQ 543 3 GLTLIVAQPCTRGASRVPGPGQDPGLDHPIKELSAGPAFPSLAAAHPLLVLSLLQAHGSC 584 4 RLDYELIQRFTLTVIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ 579 5 RLDYELIQRFTLTVIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ 579 6 KLDYELIQRFTLTVIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ 544 7 RLDYELIQRFTLTVIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGSLRENEPTVTH 584 8 RLDYELIQRFTLTVIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ 579 9 RLDYELIQRFTLTIIARDGGGEETTGRVRVNVLDVNDNIPTFQKDAYVGALRENEPSVTQ 305 10 RLDFETMQRYTLTVIARDGGGEETAGRIRINVLDVNDNVPTFQKEAYLGALRENEPSVTQ 529 11 SLDYELMRRFTLTVLARDGGGEETTGRVRVNVLDVNDNAPLFQKDAYAGSLRENEQAVQV 582 12 SLDYELMRRFTLTVLAKDGGGEETTGRIRVNVLDVNDNGPLFQKEAYVGSLRENEQAVQP 582 13 ------------------------------------------------------------ 0 14 RLDYELMRRFTLTILARDGGGEETTGRLRINVMDVNDNAPVFQKEAYTGSLMENEQAPQQ 264 C +**+*+:+*+***:+*+*******+**+*+********:*+***+**+*:*+***+:+++ 610 620 630 640 650 660 1 LVR-LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIY 638 2 LVR-LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIY 602 3 LPSSFQATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIY 644 4 LVR-LRATDEDSPPNNLITYSIVNASAFGSYFDISIYEGYGVISVSRPLDYEQIPNGLIY 638 5 LVR-LRATDEDSPPNNLITYSIVNASAFGSYFDISVYEGYGVISVSRPLDYEQIPNGLIY 638 6 LVR-LRATDEDSPPNNQITYSIVNASAFGSYFDISVYEGYGVISVSRPLDYEQIPNGLIY 603 7 LVR-LWATDEDSPPNNQITYSIVNASAFGSYFDISVYEGYGVISVSRPLDYEQIPNGLIY 643 8 LVR-LRATDEDSPPNNQITYSIVNASAFGSYFDISVYEGYGVISVSRPLDYEQIPNGLIY 638 9 LVR-LRATDEDSPPNNQITYSIVNASLFGSYFDISVYEGYAVISVNRPLDYEQIPNGMIY 364 10 VVR-LRASDEDSPPNNQITYSIVHASAFREYFDITVSEGYGVISVNHPLDYEQVVNGVIY 588 11 VAR-VRATDEDSPPNNVLTYTITSTSAFPSFFSIIMVEGYAVISVTRPLDYEQVPDGVVH 641 12 VAR-VRATDEDSPPNNFLTYTVASASAFAGYFSIIMVDGYAVISVTRPLDYEQVPNGMIH 641 13 ------------------------------------------------------------ 0 14 VIR-ARATDEDSPPNNILTYSIIYASQFRSFFSISIAEGYAVITVTRPLDYEQVPGGLIF 323 C ++* ++**********:+**+*+:**+*+++*+*+:+***+****:*******+++*+*+ 670 680 690 700 710 720 1 LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAG-ATVLFLNATD 697 2 LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPSYFVSVVENIMAG-ATVLFLNATD 661 3 LTVMAKDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAG-ATVLFLNATD 703 4 LTVMAKDAGNPPLYSTVPVTIEVFDENDNPPTFSKPAYFVSVLENIMAG-ATVLFLNATD 697 5 LTVMAKDAGNPPLYSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAG-ATVLFLNATD 697 6 LTVMAKDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAG-ATVLFLNATD 662 7 LTVMAKDAGNPPLNSTVPVTVEVFDENDNPPTFSKPAYFVSVVENIMAG-ATVLFLNATD 702 8 LTVMAKDAGNPPLNSTVSVTIEVFDENDNPPTFSKPAYFVSVVENIMAEGATVLFLNATD 698 9 LSVMAKDAGNPPLNSTVPVTIEVFDENDNPPTFSKPSYSVTVVENIMAG-ATVLFLNATD 423 10 LTVMAKDAGNPPLNSTVPVTIEVFDENDNPPTFSKPSYVIAVMEDIMAG-ATVLFLNATD 647 11 LTVMAKDGGNPALNSTVPVRVEVIDENDNPPEFSKQSYIIKIQENIIAG-ATVLLVNATD 700 12 LTVMAKDGGIPALNSTVPITVEVIDENDNPPEFSKSSYIVKILENINAG-ATVLLVNATD 700 13 ------------------------------------------------------------ 0 14 LTLMAKDGGNPSLNSTVPVIIELIDQNDNPPEFSLPSYIVNIPENIVAG-ATVLFVNATD 382 C *****+*+***+*+*****++**+*******+***+:*:+:+:***+** ****++**** 730 740 750 760 770 780 1 LDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 757 2 LDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 721 3 LDRSREYGQESIIYSLEGSAQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 763 4 LDRSREYGQESIIYSLEGSSQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 757 5 LDRSREYGQESIIYSLEGSSQFRINARSGEITTTSLLDRETKAEYILIVRAVDGGVGHNQ 757 6 LDRSREYGQESIIYSLEGSSQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 722 7 LDRSREYGQESIIYSLEGSSQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 762 8 LDRSREYGQESIIYSLEGSSQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 758 9 LDRSREYGQESIIYSLEGSSQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 483 10 LDRSREYGQESIIYSLEGSSHFRINARSGEITTTSLLDREAKSEYILIVRAVDGGVGHHQ 707 11 LDASREYGQASLIYSLEGSSQFRLNSRSGEITTTALLDRELKSEYILIVRAVDGGVGPQQ 760 12 LDASREFGQASLIYSLEGSSQFRLNSRSGEITTTALLDRELKSEYILIVRAVDGGVGPQQ 760 13 ----------------------------GEITTTALLDREQKSEYILIVRAVDGGVGPQQ 32 14 LDASREFGQTSLIYSLQGSSQFRLNTRSGEITTTALLDREMKSEYILIVRAVDGGVGPQQ 442 C **+***+**+*+*******+***+*+**GEITTT+LLDRE+K*EYILIVRAVDGGVG++Q 790 800 810 820 830 840 1 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI 817 2 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI 781 3 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI 823 4 KTGIATVNVTLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI 817 5 KTGIATVNVTLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI 817 6 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI 782 7 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVT------------------- 803 8 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDVGENGTLVYSI 818 9 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLAENGTLVYSI 543 10 KTGIAMVNITLLDINDNYPTWKDAPYFINLVEMTPPNSDVTTVVAVDPDLGENGTVVYSI 767 11 KTGIATVNITILDINDNAPVWRNEPYLTNIVEMSPMNTDVFSVLAFDPDNGENGTVVYRI 820 12 KTGIATVNITILDINDNAPVWRDEPYHANVVEMSPINTDVISVLAVD-DNGENGTVVYSI 819 13 KTGIATVNITILDINDNAPMWLDEPYNANVVEMSPINTDVITVTALDLDNGENGTVVYSI 92 14 KTGIATVNITVLDINDNAPVWRDEPYQANVVEMSPIDTDVITVFAVDPDYGDNGTVVYSI 502 C KTGIA*VN*T+LDINDN+P+W+*+PY++N+VEM+P+++DV++*+*+*+*:*****:**** 850 860 870 880 890 900 1 QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877 2 QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLRATSSATVF 841 3 QPPNKFYSLNGTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLRATSSATVF 883 4 HPPNKFYSLNSTTGKIRTTHVMLDRENPDPVEAELMRKIIVSVTDCGRPPLKATSSATVF 877 5 QPPNKFYSLNSTTGKIRTTHVMLDRENPDPVEAELMRKIIVSVTDCGRPPLKATSSATVF 877 6 QPSNKFYSLNSSTGKIRTTHVMLDRENPDPDEAELMRKIVVSVTDCGRPPLRATSSATVF 842 7 ------------------------------------------------------------ 803 8 QPPNKFYSLNSSTGKIRTTHVMLDRENPDPHEAELMRKIIVSVTDCGTPPLKATSSATVF 878 9 HPPNKFYSINSTTGKIRTTNVMLDRENPDPEEAELMRKIIVSVTDCGTPPLRATSSATVF 603 10 RPPNKFYSLNSTSGKIRTSGVQLDRENPNPQEAELMRRIVVSVTDCGRPPLRATSSATVF 827 11 SPENPFYTISSSTGKIRTSGLTLDRESSNARDTQLMRSIIISAADNGTTPLHASASATVF 880 12 RPDNPFYTINSSTGKIRTSGVTLARESSDP-SAALMGTIIISAVDRGMPQLRATASTTVF 878 13 NPENPFYTIDNRTGRIRTSGLTLDRESTNVRDSVPMRNIIISAVDRGSPPLRASASTTVF 152 14 NPENPFYTINRNTGKIRTSGAVLDRESQDARSAQLMRTIIISATDRGTPPLRSSASATVF 562 C :*:*+**+:++:******::::****++++.+++***:*:+*++*+*:***:*++*+*** 910 920 930 940 950 960 1 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD 937 2 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD 901 3 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD 943 4 VNLLDLNDNDPTFRNLPFVAEILEGTPAGVSVYQVVAIDLDEGLNGLVSYRMQVGMPRMD 937 5 VNLLDLNDNDPTFQNLPFVAEVLEGTPAGVSVYQVVAIDLDEGLNGLVSYRMQVGMPRMD 937 6 VNLLDLNDNDPTFQNLPSVAEVLEGTPAGVSVYQVVAIDLDEGLNGLVSYRMQVGMPRMD 902 7 ------------------------------------------------TYRIQVGMPRMD 815 8 VNLLDLNDNDPTFQNLPFVAEVLEGTPAGVSVYQVVAIDLDEGLNGLVSYRMQVGMPRMD 938 9 VNLLDLNDNDPTFQNLPAIAEVLEGTLAGVPVYHVVAIDLDEGLNGLVTYRMQVGMPRMD 663 10 VNLLDLNDNDPTFQNLPFIAEISEGLPAGTSVFQVLAIDLDEGPNGWVTYRMQVGMPRMD 887 11 VNLLDLNDNDPTFLNLPFVAEVPEGLPIGSSVFRVQVEDPDEDANGLITMALQMGMPRLD 940 12 VNLLDLNDNDPKFLNLPFVAEVPEGLLNGSAVFKVQVEDPDHDKNGLITMALQMGMPRLD 938 13 VNLLDLNDNDPTFVNLPFVAELSEGLSIGTSFFRVRVEDPDEGKNGEITMALQVGMPRLD 212 14 VNLLDLNDNDPAFLNLPFVAEVPEGLPIGSSVFRVQVQDPDEAANGAVTMALQMGMPRLD 622 C ***********+*:***++**+:**.++*:++::*:++*+**+:**++:+++++GMPR+D 970 980 990 1000 1010 1020 1 FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH---VLDVNDETPT 994 2 FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH---VLDVNDETPT 958 3 FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH---VLDVNDEMPT 1000 4 FVINSTSGVVTTTAELDRERIAEYQLRVVASDAGTPTKSSTSTLTVR---VLDVNDETPT 994 5 FVINSTSGVVTTTAELDRERIAEYQLRVVASDAGTPTKSSTSTLTIR---VLDVNDETPT 994 6 FLINSSSGVVVTTSELDRERIAEYQLRVVASDAGTPTKSSTSTLTIR---VLDVNDETPT 959 7 FLINSSSGVVVTTAELDRERIAEYQLRVVASDAGTPTKSSTGTLTVR---VLDVNDETPT 872 8 FVINSSSGVVVTTAELDRERIAEYQLRVVASDAGTPTKSSTSTLTIR---VLDVNDETPT 995 9 FVINSSSGVVTTTTELDRERIAEYYLRVVASDAGTPTKSSTSTLTIR---VLDVNDETPT 720 10 FLINSTSGLIISTTVLDRERITEYYLRVVASDAGTPSKSSTSTLTVK---VLDVNDESPT 944 11 FYLNTSTGVLRSVAVLDREQIGQYHLRIIAYDAGKFPRTSTSTLTVTSGSVLDVNDETPT 1000 12 FYLNTSTGVLTSTSVLDREQIGLYHLRIIAYDAGKFPRTSTSTLTVK---VLDVNDETPT 995 13 FFLNTSSGVLTSMAVLDREQIQQYYLRLIAYDAGKFPRTSTSTLTVL---VLDVNDETPT 269 14 FRLNITTGILVSTVVLDREQIGQYYLRIIAYDAGQFPRTSTSTLTIT---VLDVNDETPT 679 C F:+N+++G*+:+*:+LDRE+I++Y:LR++A+DAG+++++ST*TLT:: VLDVNDE*PT 1030 1040 1050 1060 1070 1080 1 FFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRT 1054 2 FFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRT 1018 3 FFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRT 1060 4 FFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITAGNVDGKFSVGYRDAVVRT 1054 5 FFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITAGNVDGKFSVGYRDAVVRT 1054 6 FFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRT 1019 7 FFPATYNVSVSEDVPREFRVAWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRT 932 8 FFPAVYNVSVSEDVPREFRVVWLNCTDSDVGLNAELSYFITGGNVDGKFSVGYRDATVRT 1055 9 FFPAVYNVSLLEDIPRDFRVVWLNCTDNDVGLNAELSYFITGGNIDGKFKIGYRDAVVRT 780 10 FFPAIYNVSLPENVARDFKVVRLNCTDADVGLNAELSYFITGGNQDGKFSVGFRDGVVRT 1004 11 FNPRVYNVSLKEDVPRDHIVARLSCSDNDAGLNAELSYFITGGNQDGKFSVGFRDGVVRT 1060 12 FNPRLYNVSLKESVPRDHIVSRLACSDNDAGLNAELSYFITGGNQDGKFSVGFRDGIVRT 1055 13 FNPRVYNVSLKENIPRDFVVTLLSCSDNDTGLNAELSYFITGGNQDGKFSVGFRDGVVRT 329 14 FFPSVYNVSLEESVPRDYLVVRLNCTDNDAGLNAELSYFITAGNQDGKFSVGFRTGVVRT 739 C F+P++YNVS::E+**R:++V++L+C+D*D+GLNAELSYFIT+GN:DGKF**G+R*+*VRT 1090 1100 1110 1120 1130 1140 1 VVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPED 1114 2 VVGLDRETTAAYTLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPED 1078 3 VVSLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPED 1120 4 VVGLDRETTAAYTLVLEAIDNGPVGKRRTGTATVFVTVLDVNDNRPIFLQSSYEASVPED 1114 5 VVGLDRETTAAYTLVLEAIDNGPVGKRRTGTATVFVTVLDVNDNRPIFLQSSYEASVPED 1114 6 VVSLDRETTAAYTLVLEAIDNGPVGKRRTGTATVFVTVLDVNDNRPIFLQSSYEASVPED 1079 7 VVSLDRETTAAYMLVLEAI----------------------------------------- 951 8 VVNLDRETTATYTLVLEAIDNGPVGKRRTGTATVFVTVLDVNDNRPIFLQSSYEASVSED 1115 9 VVNLDRETTAAYTLIVEAIDNGPVGKRRTGTATIYVTVLDVNDNRPIFLQSSYEASVPED 840 10 VVSLDRETVASYALILEAIDNGPTGNRRTGTATVYVTVLDVNDNRPIFLQSSYEASVPED 1064 11 VVGLDRETQEAYTLVVEAIDNGPAGSRRTGTATVFVEVQDVNDNRPIFLQNSYETSILES 1120 12 VVRLDRETQAAYTLIVEAIDNGPAGSRRTGTATVFVEVQDVNDNRPIFLQNSYETGILES 1115 13 VVSLDREAQAAYSLVVEAIDNGPAGSRRTGTATVFVEVLDVNDNRPIFLQNSYETSVLET 389 14 VVGLDRETQASYRLVIEAIDNGPAGGRRTGTATVYVEVLDVNDNRPIFLQNSYETSVLEN 799 C VV:LDRE*+*+Y:L:+EAI****:*:*+******+*+*+***********+***+*+:*+ 1150 1160 1170 1180 1190 1200 1 IPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSH 1174 2 IPEGHSIVQ---------------------NHGNNFRIHVSNGLLMRGPRPLDRERNSSH 1117 3 IPEGHSILK--ATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSH 1178 4 IPEGHSIVQLKATDADEGEFGRVWYRILHGNHGNNFRIHVGSGLLMRGPRPLDRERNSSH 1174 5 IPEGHSIVQLKATDADEGEFGRVWYRILHGNHGNNFRLHVSSGLLVRGPRPLDRERNSSH 1174 6 IPEGHSIVQLKAADADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDREQNSSH 1139 7 ---------LKATDADEGEFGRVWYRILHGNHGNNFRIHVGNGLLMRGPRPLDRERNSSH 1002 8 IPEGHSIVQLKATDADEGEFGRVWYRIVHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSH 1175 9 IPEGSSILM--ATDADEGDNGRVWYRILHGNHGNNFRIHVSSGLLVRGPRPLDREQNSSH 898 10 IPAASSIVQVKATDADEGVNGRVWYRIVKGNEHNNFRINPSSGLLMRGVRPLDREQNSSH 1124 11 VPQRTSILKVQATDADQGENGKVLYRILTGNSNNLFSIDNQTGLVTRGPRALDRETSSSH 1180 12 VPQGTSILQVQATDADQGENGRVLYRILTGNSNNLFSIDRQTGLVSRGPRPLDRETSNSH 1175 13 VPQGTSILQVQATDADQGENGRVLYRILSGNSNNLFSIDRQSGLVTRGPKALDRETSSSH 449 14 IPRGTSILQVQATDADQGENGKVLYRILSGN-NGQFSMDSLSGLISRGSVALDRETRSSN 858 C +*:+:**:+::*****+*+:*+*+***+:*N++*+F+*++::GL+:RG**+LDRE:+*S* 1210 1220 1230 1240 1250 1260 1 VLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQAT 1234 2 VLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSHLGLRETAGIGTSVIVVQAT 1177 3 VLIVEAYNHDLGPMRSSVRVIVYVEDVNDEAPVFTQQQYSRLGLRETAGIGTSVIVVRAT 1238 4 VLMVEAYNHDLGPMRSSVRVIVYVEDVNDEAPVFTQQQYNRLGLRETAGIGTSVIVVRAT 1234 5 VLMAEAYNHDLGPMRSSVRVIVYVEDVNDEAPVFTQQQYNRLGLRETAGIGTSVIVVRAT 1234 6 VLIVEAYNHDLGPMRSSVRVIVYVEDVNDEAPVFTQQQYSRLGLRETAGVGTSVIVVRAT 1199 7 VLIVEAYNHDLGPMRSSVRVIVYVEDVNDEAPVFTQQQYSRLGLRETAGIGTSVIVVRAT 1062 8 VLIVEAYNHDLGPMRSSVRVIVYVEDVNDEAPVFTQQQYSRLGLRETTGIGTSVIVVRAT 1235 9 VLVVEAYNYDLGPMRSSVRVIVYVEDVNDEVPVFTQQQYSRLGLRETAGIGTSVIVVRAT 958 10 VLEVEAYNTEHGPMRSSVRVIVYVEDVNDEVPVFTQRQYNRLGLRETAGIGTSVAVVRAT 1184 11 VLEVVAYNSDEGSMRSSVRVIIYVDDANDEVPVFTQQQYNRLGLRETAGIGTSVIVVRAT 1240 12 VLEVEAYNSDEGNMRSSVRVIIYVNDANDEVPVFTQQQYNRLGLRETAGIGTSVIVVRAT 1235 13 VLEVEAYNSDEGSMRSSVRVIVYVDDANDEFPVFTQQQYNRLGLRETAGIGTSVIVVRAT 509 14 VLEVEAYNSDLGSMRSTVRVIVYVEDVNDEFPVFTQSQYNRLGLRETAGIGTSVVVVRAT 918 C VL:**AYN:*+G+MRS*VRVI*YV+D+NDE:PVFTQ*QY:*LGLRET*G*GTSV*VV*AT 1270 1280 1290 1300 1310 1320 1 DRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ 1294 2 DRDSGDGGLVNYRILSGTEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ 1237 3 DRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVDYLDYETKTSYMMNVSATDQAPPFNQ 1298 4 DKDTGDGGLVNYRILSGAEGKFEIDESTGLIVTVDYLDYETKTSYLMNVSATDGAPPFNQ 1294 5 DRDTGDGGLVNYRILSGAEGKFEIDESTGLIVTVDYLDYETKTSYLMNVSATDGAPPFNQ 1294 6 DRDTGDGGLVSYRILSGAEGKFEIDESTGLIITVDYLDYETKTSYLMNVSATDQAPPFNR 1259 7 DRDTGDGGLVNYRILSGAEGKFEIDESTGLIITVDYLDYETKTSYLMNVSATDQAPPFNQ 1122 8 DRDTGDGGLVNYRILSGAEGKFEIDESTGLIITVDYLDYETKTSYLMNVSATDQALPFNQ 1295 9 DRDTGDGGLVIYRILSGSEGKFEIDESTGLIITIDYLDYETKTSYLMNVSATDQAPPFNQ 1018 10 DRDTGNGGLVSYQILSGAEGKFEIDESTGLITTIDYLDYETKTSYLMNVSATDQAPPNNQ 1244 11 DPDTGDGGAVAYALVSGSDRKFEVDVSTGLITTVDYLDYETKTTYLMNVSATDQAPPFHQ 1300 12 DPDTGDGGAVAYAVVSGSDRKFEVDVSTGLVTTVDYLDYETKTTYLMNVSATDQAPPFHQ 1295 13 DRDTGDGGAVAYRLVSGSDRKFEVDVSTGLVTTVDYLDYETKTTYTMNVSATDQAPPFHQ 569 14 DPDTGDGGAVAYSLVSGSDRKFEVDVSTGLLTTVDYLDYETKTSYLMNVSATDQSPPFHR 978 C D+D+G*GG+V:Y+++SG:++KFE+D+STGL+:T**YLDYETKT+Y+MNVSATD***P*+* 1330 1340 1350 1360 1370 1380 1 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFDAYT 1354 2 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFDAYT 1297 3 GFCSVYITLLNELDEAVQFSNASYEVAILENLALGTEIVRVQAYSIDNLNQIMYRFDAYT 1358 4 GFCSVYVTLLNELDEAVQFSNASYEAVIMENLALGTEIVRVQAYSIDNLNQITYRFDAYT 1354 5 GFCSVYVTLLNELDEAVQFSNASYEAVIMENLALGTEIVRVQAYSIDNLNQITYRFDAYT 1354 6 GFCSVYVTLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFDAYT 1319 7 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFDAYT 1182 8 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFDAYT 1355 9 GFCSVYITLLNELDEAVQFSNASYEAAIMENLPWGSEVVRVQAFSIDNINPIVYRFDPYT 1078 10 GFCSVYVSLLNELDEAVQFSNSSYEAVIMENIPLGSEVLRVQARSIDNLNQITYKFDPNT 1304 11 RFCTVYVTLLNELDEAVAFFSAGYEASLRENIATGTEVVQVRAQSADNLNQLTYRFDPDT 1360 12 GFCTVYVTLLNELDEAVAFFSAGYEASLRENIATGMEVVQVQAQSADNLNQLTYRFDPDT 1355 13 SFCMVYVTLLNELDEAVAFLSGGYEASVRENIATGTEVIQVRAQSADNLNQLTYRFDPDT 629 14 SYCTVYVTLLNELDEAVAFLSAGYEVSLRENIATGTEVVQVKAQSADNLNQLSYRFDPDT 1038 C +*C+VY:*LLNELDEAV+F++*+YE*:+:EN+*+G+E:*+V+A:S+DN*N*++Y*FD:+T 1390 1400 1410 1420 1430 1440 1 STQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVK--------VYI 1406 2 ITQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVK--------VYI 1349 3 STQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVA--------VYI 1410 4 SAQAKALFKIDAITGVITVKGLVDREKGDFYTLTVVADDGGPKVDSTVK--------VYI 1406 5 SAQAKALFKIDAITGVITVKGLVDREKGDFYTLTVVADDGGPKVDSTVE--------VYV 1406 6 SAQAKALFKIDSVTGVITVKGLVDREKGDFYTLTVVADDGGPKVDSTVK--------VYI 1371 7 STQAKALFKIDSITGVITVKGLVDREKGDFYTLTVVADDGGPKADSTVK--------STV 1234 8 SAQAKALFKIDAITGVITVKGLVDREKGDFYTLTVVADDGGPKVDSTVVPS-----QVYI 1410 9 SPQARALFKIDSVTGVITVKGLVDREKGDFYTLTVVADDGGPKIDSTVV---------YI 1129 10 NAQALSLFKINGITGVITVKGQVDREKGDFYTLTVVADDGGPKVDSTVK--------VTI 1356 11 SPAALALFKIDSVTGRITVTGQLDREKGDVYTLTVVADDGGPKKDSTVK--------VSI 1412 12 SPAALALFKIDSVTGRITVTGLLDREKGDLYTLTVVADDGGPKKDSTVITYDDISQQVSI 1415 13 SPAALALFKIDSVTGRITVTGLLDREKGDFYTLTVVADDGGPKKDSNVQ--------VSI 681 14 SPAALALFKIDSVTGRITVTGLLDRERGDSYTLTVVADDGGPKRGSTVK--------VSI 1090 C *.+A:*LFKI*::TG+ITV:G*+DRE*GD+YTLTVVADDGGPK:*S*V: *:* 1450 1460 1470 1480 1490 1500 1 TVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGA 1466 2 TVLDENDNSPRFDFTSDSAVSIPEDCLVGQRVATVKAWDPDAGSNGQVVFSLVSGNIAGA 1409 3 TVLDENDNRPRFDFISDSSIIIPEDCPVGQRVATVKARDPDAGSNGQVVFSLASGNIAGA 1470 4 TVLDENDNSPRFDFTSDSAISVPEDCPVGQRVATVKARDPDAGSNGQVVFSLASGNIAGA 1466 5 TVLDENDNSPRFDFTSDSAISVPEDCPVGQRVATVKARDPDAGSNGQVVFSLASENHSDV 1466 6 TVLDENDNSPRFDFTSDSAVSVPEDCPVGQRVATVKARDPDAGSNGQVVFSLASGNIAGA 1431 7 SVED---------------------CPVGQRVATVKARDPDAGSNGQVVFSLASGNIAGA 1273 8 TVLDENDNSPRFDFTSDSAISVPEDCTVGQRVATVKAQDPDAGSNGQVVFSLAAGNIAGA 1470 9 TVLDENDNSPQFDPTSDSAVNVPEDYAVGRRVAVVTARDADIGSNGQVSFYLASGNIGGA 1189 10 TVLDENDNSPQFDITSDSAVSVPEDSVVGRRVAVVLARDPDAGSNGQVTFSLTAGNVGQA 1416 11 TILDENDNSPEFDITSDTSVDILESTPMGKRVAVVLGRDKDAALNGLVNFTLVAGNMEDV 1472 12 TILDENDNSPVFDITSDTSVDITEKTPMGEKVAVVLARDIDAGLNGLINFTLVAGNMEDV 1475 13 TILDENDNSPEFDITSDTSVSIPEDTPLGKKVAVVLGRDRDAGLNGLVNFTLVAGNMQDV 741 14 TILDENDNSPEFDITSDLSVNIPEDTAIGKRVAVVLARDKDAGRNGLVNFTLIAGNMQDV 1150 C *+*D******:**:***+:+::+*+:++G:*VA:V:*+D+D**+NG+*:F+L::*N:::+ 1510 1520 1530 1540 1550 1560 1 FEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPV 1526 2 FEIVTTNDSIGEVSVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPV 1469 3 FEIVTTNDSIGEVFVARPLDREELDHYILKVVASDRGTPPRKKDHILQVTILDVNDNPPV 1530 4 FEIITSNDSIGEVFVAKPLDREELDHYILKVVASDRGTPPRKKDHILQVTILDVNDNPPV 1526 5 FLAPPVPSVLRIEILNR--YSPSTQPSISVVKNRDPGTPFFFKHTLFVTSLLSR--EIPT 1522 6 FDIVTTNDSIGEVFVARPLDREELDHYILKVVASDRGTPPRKKDHILQVTILDVNDNPPV 1491 7 FDIVTTNDSIGEVFVARPLDREQLDRYILKVVASDRGTPPRKKDHILQVTILDVNDNPPV 1333 8 FEIVTTNDSIGEIFVARPLDREELDHYILKVVASDRGTPPRKKDHILQVTILDINDNPPV 1530 9 FEILTSNDSVGEVFVARPLDREELDHYILKIVAIDGGSPPRKKDHILRITILDVNDNPPI 1249 10 FEIRTTNDTYGEVLVARPLDRELLDHYTLRIQASDGGVPPRRKEHTLRVTVLDVNDNPPI 1476 11 FKIKTLNDTYGEVFVNAALDRESVDRYLLKVRAIDNGSPPRYTDHSLTINILDINDNAPV 1532 12 FKIKTVNHTYGEVYVNAELDRESVDRYLLKVRATDNGSPPRHTDHSLTINILDVNDNAPV 1535 13 FKIKTVNNTYGEVFLNALLDRESVDRYLLRVRATDNGTPPRYTDHSLTINILDVNDNAPV 801 14 FKINTVNNTYGEVYLNAPLDRESVDRYLLKVRAMDNGSPPRYTDVSLTVNIVDVNDNPPV 1210 C F:*:*:*+::***+++++****:+*:*+*+*:*:D:G+P**:+**:*:++***+***+P+ 1570 1580 1590 1600 1610 1620 1 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMTFRMDRISGEIA 1586 2 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMTFRMDRISGEIA 1529 3 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMTFRMDRVSGEIA 1590 4 IESPFGYNVSVNENVGGGTSVVQVRATDRDIGINSVLSYYITEGNEDMTFRMDRISGEIA 1586 5 IASDWQSSHLSSQNVGGGTSVVQVRATDRDIGINSVLSYYITEGNEDMTFRMDRISGEIA 1582 6 IESLFGYNVSVNENVGGGTAVVQVRATDHDIGINSILSYYITAGNEDMTFRMDRISGEIV 1551 7 IESPLGYNVSVNENVGGGTAVVQV-----------------------MTFRMDRISGEIA 1370 8 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITGGNEDMTFRMDRVSGEIA 1590 9 IESPFGYNVSVNENVGGGTAVVQVIATDRDIGINSVLSYYITDGNEDMTFRMDRVTGEIS 1309 10 IDSPLGYNVSVSENVGGGTAVVQVRATDRDAGLNSVLSYYITHGNEDLTFRMDRVTGEIA 1536 11 IESQRGYNVSISENVGGGTSVLRVIATDKDIGPNAMLFYYITAGNQDLTFRMDRVTGEMV 1592 12 IESQKGYNVSISENVGGGTSVLRVMATDRDIGPNAMLFYYITAGNQDLTFRMDRMTGEMV 1595 13 VESPRGYNVSVSENVGGGTSVLRVVATDRDMGPNALLSYYITNGNQDLTFRMDRMTGEMV 861 14 LQSPRGYNVSVSENVGGGTSVLRVVATDRDIGANAMLSYYITAGNQDLTFRMDRMTGEIV 1270 C *+S+:*****+:*NVGGGT:V++V:***+*+*:*+:*+****.**:*+TFRMDR::GE+: 1630 1640 1650 1660 1670 1680 1 TRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEG 1646 2 TRPAPPDRERQSFYHLVVTVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEG 1589 3 TRPAPPDRERQSFYHLVVTVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEG 1650 4 TRPAPPDRERQNFYHLVVTVEDEGTPTLSATTHVYVTIVDENDNAPVFQQPHYEVVLDEG 1646 5 TRPAPPDRERQNFYHLVVTVEDEGTPTLSATTHVYVTIVDENDNAPVFQQPHYEVVLDEG 1642 6 TRPAPPDRERQSFYHLGVTVEDEGTPTLSATTHVYVTIVDENDNAPVFQKPYYEILLDEG 1611 7 TRPAPPDRERQGFYHLVVTVEDEGTPTLSATTHVYVTIVDENDNAPVFQQPHYEILLDEG 1430 8 TRPAPPDRERQSFYHLVVTVEDEGTPTLSATTHVYVTIVDENDNAPVFQQPHYEILLDEG 1650 9 TRPSPPDRERQSFYHLVVTVEDEGTPTLSATTHVYVTIVDENDNAPVFQQPQYEILLDEG 1369 10 TRPSPPDRERQSSYCLLVTVEDEGTPSLSATTKVFVTILDENDNAPVFQQQLYEVTLDEG 1596 11 TRPAPPDRERQQEYRLTVTVEDDGAPPLSTSTTIYVHIVDENDNAPEFPEEDYVTVLSEG 1652 12 TRPAPPDRERQQEYILNVTVEDDGTPPLSSPTTIYVHIVDENDNAPEFPEEEYVTVLSEG 1655 13 TRPAPPDRERQQQYVLTVTVEDDGTPPLSTSTTVYVWIVDENDNAPEFPEEEYVTVLSEG 921 14 TRPSPPDREKQQQYTLTVTVEDDGTPTLSTSTTVWVRIIDENDNAPEFPEEEYVTELREG 1330 C TRP+PPDRE*Q:+Y+L:*TVED+G*P+LS++T+**V+I*DENDNAP:F+++:Y+::L+EG 1690 1700 1710 1720 1730 1740 1 PDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGR 1706 2 PDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIINTFRIDRHMGVITAAKELDYEISHGR 1649 3 PDTLNTSLITIQALDLDEGPNGTVIYAIVAGNIINTFRIDRHMGVISTAKELDYEISHGR 1710 4 PDTINTSLITVQALDLDEGPNGTVTYAIVAGNIINTFRINKHTGVITAAKELDYEISHGR 1706 5 PDTVNTSLITVQALDLDEGPNGTVTYAIVAGNIINTFRINRRTGVITAAKELDYEISHGR 1702 6 PDTINASLITIQALDLDEGPNGTVNYAIVAGNIINTFYIDRHTGIISAAKELDYEISHGR 1671 7 PDTINASLITIQALDLDEGPNGTVNYAIVAGNIINTFRIDRHTGIISAAKELDYEISHGR 1490 8 PDTINTSLITIRALDLDEGPNGTVTYAIVAGNIISTFRINRHTGIIRAAKELDYEISHGR 1710 9 PDTLNISLITIQALDLDEGPNGTIAYAIIAGNIINTFQIDSVTGVISTLKELDYEISHGR 1429 10 PATLNATLVTVQALDRDEGPNSTVTYAITEGNILGTFYINSTTGQIRTLKELDYEISHGR 1656 11 PETVGATIATVTAIDPDEGLNGTLRYAIAKGNLIQTFNINNITGRITAVKELDYEISNGH 1712 12 PDTVGATIATVTAIDPDEGLNGTLRYAITQGNLIQTFHINSITGRITAVKELDFEISNGH 1715 13 PETVGATIATVTAVDPDEGLNGTLRYAITQGNLNQTFNINSITGRITAVKALDYEISHGS 981 14 PNTVGAIIATVTAIDPDEGLNGTIRYAISKGNLAQTFQINSVTGQIVVVSALDYEISNGH 1390 C P+T.+:+++T:+A+D+DEG+N*T+:YAI:+GN++:TF:I:::+G:I:+:**LD*EIS+G+ 1750 1760 1770 1780 1790 1800 1 YTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTF 1766 2 YTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTF 1709 3 YTLIVTATDQCPILSRRLTSTTTVLVNVNDINDNMPTFPRHYEGPFEVTEGQPGPRVWTF 1770 4 YTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTF 1766 5 YTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTF 1762 6 YTLIVTATDQCPIVSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTF 1731 7 YTLMVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFDVTEGQPGPRVWTF 1550 8 YTLIVTATDQCPLLSHRLTSTTTVLVNVNDINDNAPTFPRDYEGPFDVTEGQPGPRVWTF 1770 9 YTLIVTATDQCPILSRRLTSTTTVLVNVNDINDNVPIFPRDYEGPFDVTEGQPGPRVWTF 1489 10 YTLVVTATDQCPIASRRLTSTTTVLVNLNDINDNCPTFPRPYEGPFDVTEGQPGPRIWTF 1716 11 YALVVTATDQCPKPALRLTSSTTVQVNVLDVNDVTPTFPRAFEGPFEVTEGQPGPRVWTL 1772 12 YALVVTATDQCPNRDLRLTSSTTVLVNVLDVNDVTPSFPRTYEGPFEVTEGQPGPRVWTL 1775 13 YALVVTATDQCPKPALRRTSSTTVLVNVLDVNDVTPTFPRAYEGPFEVTEGQPGPRVWTL 1041 14 YVLTVTATDQCPIPLLRLTSSTTVLVNVIDVNDNPPIFPRPFEGPFEITEGQPGPRVWTV 1450 C Y+L:VTATDQCP+:+:R*TS+TTV*VN*+D+ND+:P+FPR:*EGPF:*TEGQPGPR*WT+ 1810 1820 1830 1840 1850 1860 1 LAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1826 2 LAHDRDSGPNGQVEYSIMDGDPL------------------------------------- 1732 3 LAHDRDSGPNGQVEYSIVDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1830 4 LAHDRDSGPNGQVEYSVVDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1826 5 LAHDRDSGPNGQVEYSVVDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1822 6 LAHDQDSGPNGQVEYSIVDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTVCARDR 1791 7 LAHDQDSGPNGQVEYSIVDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1610 8 LAHDQDSGPNGQVEYSIVDGDPLGEFLISPVEGVLRVRKDVELDREAIAFYNLTICARDR 1830 9 LARDLDSGPNGQVEYSIVDGDPLSEFLISPVEGELRVRKDVELDRENIAFYNLTICARDR 1549 10 LAHDGDSGPGGQVEYSIIAGDPLGEFVISPVEGELRVRKDAELDRENIPFYNLTISARDR 1776 11 RAIDEDSGLNGKVEYSITGGDPQSEFTVSPVEGELRVRKDVELDRETTAFYNITVTARDL 1832 12 RASDEDSGLNGKVEYSITGGDHQNEFMISPVEGELRVRKDVELDRETTAFYNITVTARDL 1835 13 KASDEDSGLNGKVEYSITGGDLQNEFTISPVDGELRARKDVELDREAIAFYNITVTARDL 1101 14 KATDADSGSNGKVEYSITAGDLKNEFVISSVEGELRVRKDIELDRETIAYYNITITAKDL 1510 C +A+D.DSG+*G+VEYS*:+GD++:**:******:******+*****++****+*+:***+ 1870 1880 1890 1900 1910 1920 1 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1886 2 --------MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNAHL 1784 3 GVPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1890 4 GVPPLSSTMLVGIRVLDINDNDPVLLNLPMNVTISENSPVSSFVAHVLASDADSGCNALL 1886 5 GVPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNALL 1882 6 GVPPLSSTMMVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVTHILASDADSGCNALL 1851 7 GVPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHILASDADSGCNALL 1670 8 GVPPLSSTMLVGIRVLDINDNDPVLLNLPMNVTISENSPISSFVARILASDADSGCNALL 1890 9 GIPPLSSTMLVGIRVLDINDNDPVLLNLPMKITISENSPVASFVAHILASDADSGPNALL 1609 10 GVPPLSSTMLVGVRVLDINDNDPVLLNLPMNITLSEHAPVSSFVTRILAQDADQGPNALL 1836 11 GTPSRNSSVLVGVNVRDINDNDPVLLNLPYNTSVSEGAAVHTSVARVQARDADSGPNALL 1892 12 GTPSRNSSVVVGVHVRDINDNDPVLLNLPHNTSVREGAPIHTSVARVQAEDADSGRNALL 1895 13 GTPSLNSSVVVGVLVLDINDNDPVILNLPYNTSVSEGAPIYTSVGRVQARDADSGRNALL 1161 14 GTPSLNATVVVGILVLDINDNDPILLNLPANTSVSEGAAVQTFIIQVRAQDSDSGRNALL 1570 C *:*+++*+++VG++V*DINDNDP**LNLP+*:++*E++*++++*+:++A+D*D*G:NA+L 1930 1940 1950 1960 1970 1980 1 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946 2 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1844 3 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1950 4 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYRLTVSVKDNPENPRIARKDFDLLL 1946 5 TFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYRLTVSVKDNPENPRIARKDFDLLL 1942 6 TFNITAGNRERAFSINATTGVITVNRPLDRERIPEYKLTISVKDNPENPRIARRDFDLLL 1911 7 TFNITAGNRERAFSINATTGVITVNRPLDRERIPEYKLTVSVKDNPENPRIARRDFDLLL 1730 8 TFNITAGNRERAFSINATTGIITVNRPLDRERIPEYRLTISVKDNPENPRIARRDFDLLL 1950 9 TFNITAGNRNNAFFINATTGIITVNRPLDRERIPEYKLTISVKDNPENPRIARRDFDLLV 1669 10 TFDITAGNKESAFYINSTTGIIYVNRPLDREQVAEYRLTITVKDNPENIRNARRDFDLLV 1896 11 TYNITAGNQDGAFYVNDTTGVVQVNRPLDRERVAEYTLTITVKDNPENPRIARRDSELLV 1952 12 TYNITAGNLDGAFYINDTSGVVQVNRPLDRERVAEYRLTITVKDNPENSRIARRDSDLLV 1955 13 TYNITAGNPGGAFYINDTTGVVSVNRPLDRERVAEYTLTITVKDNPENPRIARRDSDFLV 1221 14 TYSITAGNSDGAFYINETSGVVQVNRPLDRERVAEYSLTITVKDNPDNPRIARRDSELLT 1630 C T+*ITAGN++:AF:*N+T*G:++VNRPLDRE*++EY:LT++VKDNP*N*R*AR*D:**L: 1990 2000 2010 2020 2030 2040 1 IFLSDENDNHPLFTKSTYQ-AEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGA 2005 2 IFLSDENDNHPLFTKSTYQ-AEVMENSPAG------------------------------ 1873 3 IFLSDENDNHPLFTKSTYQ-AEVMENSPAGTPLTVLNGPILALDADEDIYAVVTYQLLGA 2009 4 VSLADENDNHPLFTEGTYQ-AEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQLLGT 2005 5 VSLADENDNHPLFTEGTYQ-AEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQLLGT 2001 6 IFLADENDNHPLFTESTYQ-AEVMENSPAGTPLTVLNGPILALDADLDVYAVVTYKLLGS 1970 7 VFLADENDNHPLFTQSTYQ-AEVMENSPAGTPLTVLNGPILALDADLDIYAVVTYQLLGS 1789 8 IFLADENDNHPVFTESTYL-AEVMENSPAGTSLTVLNGPVLALDADLDVYAVVTYQLLGA 2009 9 ISLEDENDNHPLFTQSTYQ-AEVMENSPAGTPITVLNGPILALDDDLGINAVVTYKLLGT 1728 10 ISIADENDNHPLFTQSSYQAAEVMENSPAGTPVTMLNGPILALDSDQGSNAVVTYQLLGT 1956 11 ITIMDENDNRPIFTRTSYR-AEITENSEAGSTVVVLNGPVLAEDKDIGPNAVVKYNLLGA 2011 12 IAILDENDNRPVFTRTTYR-AEIMENSLAGNTVTVLNGPVLAKDNDIGPNAVVKYQLLGA 2014 13 ITILDENDNRPIFTVTNYR-AEVVENSAAGTTVTVLNGPVLAVDNDIGPNAVVKYRLLGP 1280 14 VTLLDVNDNRPIFSQSSYR-GEISENSPTGTTVLILNGPVLAEDKDIGVNAVVSYGLLGT 1689 C +:+:D*NDN+P+F*.++Y+ *E++ENS+*G+::++****:**+*:*.:.:***+*:***. 2050 2060 2070 2080 2090 2100 1 QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDN 2065 2 ------------VVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDN 1921 3 QSGLFDINSSTGVVTVRSGVIIDREAFLPPILELLLLAEDIGLLNSTAHLLITILDDNDN 2069 4 HSDLFVIDNSTGVVTVRSGIIIDREAFSPPFLELLLLAEDIGQLNGTAHLFITILDDNDN 2065 5 HSDLFVIDNSTGVVTVRSGVIIDREAFSPPFLELLLLAEDVGQLNGTAYLFITILDDNDN 2061 6 QSGLFDINNSTGVVTVKSGVTIDREAFSPPVLELLLLAEDIGLLNGTAGLLVTILDDNDN 2030 7 QGGLFDIDNSTGVVTVRSGVIIDREAFSPPVLELLLLAEDIGLLNGTADLLVTILDDNDN 1849 8 QSGLFDIDNSTGVVTVRSGIIIDREAFSPPVLELLLLAEDIGLLNGTADLLVTILDDNDN 2069 9 ESGLFDIDHATGVVVVKPGVVIDREAFFPPILELLLLAEDIGLLNGTAELIITILDDNDN 1788 10 SPDLFIINNRTGVVSVKPGGVIDREALLDPLLEFTLIALDTGGLNSTASLTVTILDDNDN 2016 11 RVDLFTVERYSGVILVRQGAKLDREAFQEPRVELFLVAEDIGGLNSSVPLTVTILDQNDN 2071 12 RVDLFTVDPNTGVILVRPGSRLDREAFQEPRVELFLVAEDIGGLNSSVPLTVAILDENDN 2074 13 RVDLFTVDPNTGSLLVRQGAKLDREAFQDPRVELILVGEDIGGLNSSVPLTITILDQNDN 1340 14 RVDIFSIDSRTGVVSVRGGAVLDREAFSVPRVELFLVSVDVGGLNSSVPLTITILDVNDN 1749 C .::**:+:::***+:V+:G::+DREA*:+P.+E*+L+**D+G:LN:++.L::*ILD+NDN 2110 2120 2130 2140 2150 2160 1 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVI 2125 2 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVI 1981 3 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFFIHPVTGVI 2129 4 WPTFSPPTYTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHPVTGVI 2125 5 WPTFSPPAYTVHLLENCPPGFSVLQITATDEDSGLNGELVYRIEAGAQDRFLIHPVTGVI 2121 6 WPTFSPSTLTVHLLENCPPGFSVLQVTATDRDSGLNGELIYRIEAGAQDRFLIHPITGVI 2090 7 WPTFSHPTLTVHLLENCPP----------------------------------------- 1868 8 WPTFSPAAVTVHLLENCPPGFSVLQITATDEDSGLNGELIYRIEAGAQDRFLIHPVSGIV 2129 9 RPIFTPSTLTVHLQENCPPGLSVLQVTATDEDSGLNGQLVYRIQAGAQDRFMIHPLTGVI 1848 10 RPVFQPVSITARLRENSPPGFSVLQVTATDADSGLNKQLDYRIEGGGQDRFLIDATTGVI 2076 11 PPVFSPSSFSVRLPENSPSGVVVTQLSATDADSGSNGWLVYRLVSGAQDRFVVDPLSGAV 2131 12 PPVFSPSSYSVRLPENSPTGVVVTQLSATDADSGSNGWLMYRLESGAQDRFVVEPLSGAV 2134 13 PPVFSPSSFSVRLPENSPTGVVVTQLSATDADSGSNGWLTYRLESGAQDRFVVDSLSGAV 1400 14 PPVFNPSSFTVRLPENSPTGVVVTQLSATDADAGSNGWLQYRLDSGAQDRFIVDALSGAV 1809 C .P:F+*:::+*+L:EN+P+*:+*+*:+***:***+**:*:**++:******:+::::*:: 2170 2180 2190 2200 2210 2220 1 RVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLE 2185 2 RVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLE 2041 3 RVGNATIDREEQESYRLTVVATDRGTVPLSGTAIITILIEDINDSCPEFLNPIQTVSVLE 2189 4 RVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLE 2185 5 RVGNATIDREEQESYRLTVVATDRGTVPLSGTATVTILIDDINDSRPEFLNPIQTVSVLE 2181 6 RVANATIDREEQESYRLTVVATDRGTVPLSGTAIITVLIDDVNDSRPEFLKPIQTVSVLE 2150 7 ------------------------------------------------------------ 1868 8 RVGNATIDREEQESYRLTVVATDRGAVPLSGTAIITVLIDDINDSRPEFLNPIQTVSVLE 2189 9 RVGNITIDREEQESYRLVVVAADRGTVPLSGTAIITILIDDINDSRPEFINPIQTVSVLE 1908 10 RVANLSIDREERDAYQLTVVAVDQGTPALSGTATVSIFIDDVNDCRPEFINPIQTVSVPE 2136 11 LVGNSTLDREERGSYRLVVMATDRGTPTMSGTATLTVILDDVNDSRPRFIEPVTMINVNE 2191 12 LVGNTSLDREDRGSYRLVVTATDRGTPPMSGTATLTVILDDVNDSRPRFIEPVTMINVNE 2194 13 LVGNTTLDREERASYRLVVVAIDRGTPPLSGTATLTVILDDVNDSRPRFIEPITMINVNE 1460 14 LVGNATLDREERSSYRLVVIATDRGTPSLSGTATLTVVLDDVNDSRPRFIQPVQTISVNE 1869 C +*+*:++****::****:*+*+****:++****:.*::+**:*****+*::*+++++*:* 2230 2240 2250 2260 2270 2280 1 SAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSP 2245 2 SAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPDQEDAFAVNINTGSVMVKSP 2101 3 SAEPGTVIANVTAIDRDLNPKLEYHIVGIVAKDDTDLLVPDQEDVFAVNINTGSVMVKSP 2249 4 SAEPGTIIANVTAIDLDLNPKLEYHIISIVAKDDTDRLVPDQEDAFAVNINTGSVMVKSP 2245 5 STEPGTVIANVTAIDLDLNPKLEYHILSIVAKDDTDRLVPDQEDAFAVNINTGSVIVKSP 2241 6 SAEPGTIIANITAIDRDLNPRLEYHIIGIVAKDDTDRLVPDQEDAFAVNINTGSVMVKSP 2210 7 ----------------------------------------------------GSVMVKSP 1876 8 SAEPGTVIANVTAIDRDLNPELEYHIIDIVAKDDTDRLVPDQEDAFAVNINTGSVMVKSP 2249 9 SVDPGTVIANVTAIDRDLNPELEYYIIDIVAKDDTDRLVPNQEEAFAVNINTGSVMVKSP 1968 10 SATPGTVVAEVTAIDRDLHPRLEYYLLEIVARDDTDALVSDQQGTFTVDFRTGAVKIKNP 2196 11 STPPGVVVTTLTAEDPDLNPRLEYYIISVEAKDDGNKAVDGLQESFGIDLHTGAVFVRNP 2251 12 STPPGVVVATLTAEDPDQHPRLEYYIISVEAKDDGNNPVDGLQESFGIDLHTGAVFVRNP 2254 13 STPPGVVVATLTAEDPDLNPRLEYYIISVEAKDDGNKPVNGLQQSFGIDLHTGAVFVRNP 1520 14 STPPGVVVATLAAEDPDLKPRLEYYIISVEAKDDGNNAVDGLQQSFGIDFHTGAVFVRNP 1929 C *::**++:*::**+*.**+*:***:*::++****++:+*::+:::*:+:::*G+V:*++P 2290 2300 2310 2320 2330 2340 1 MNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERI 2305 2 MNRELVATYEVTLSVIDNASDLPEHSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERI 2161 3 LNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYTERI 2309 4 LNRELVATYEVTLSVIDNASDLPEHSVSVPNAKLTVNILDVNDNTPQFKPFGITYYTERV 2305 5 LNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNILDVNDNTPQFKPFGITYYTERV 2301 6 LNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNILDVNDNTPQFKPFGITYYTERI 2270 7 LNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNILDVNDNTPQFKPFGITYYTERI 1936 8 LNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNILDVNDNTPQFKPFGITYYTERI 2309 9 LNRELVATYEVTISVIDNASDLPENAVSVPNAKLTVNILDVNDNTPQFRPFGITYYTERI 2028 10 LNRELVATYEVTISVHDNASEVTDRSVSVPNAKLTVNVLDVNDNTPRFRPFGVTYFTERI 2256 11 INRELVATFEIIVSVHDNASEVIDTSGSVPNARLTINVLDVNDNAPRFRPFGVSNFTEKI 2311 12 INRELVATFEIIVSVHDNASDVIDKSGSVPNARLTINVLDVNDNAPRFRPFGVSNFTEKI 2314 13 INRELVATFDIIVSVHDNASDVIDKSTSVPNARLTINVLDVNDNAPRFRPFGVTNFTEKI 1580 14 LNRELVATFEIIVSVHDNASDVIEMSVSVPNAKLTINVLDVNDNAPRFRPFGVANFSESI 1989 C +NRELVAT+*++:SV+DNAS*+++:*+SVPNA+LT+N:LDVNDN+P+F:PFG+++++E+* 2350 2360 2370 2380 2390 2400 1 LEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEV 2365 2 LEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEV 2221 3 LEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEV 2369 4 LEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLTPPGYVQLEDSSAGKVIANRTVDYEEV 2365 5 LEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLIPPGYVQLEDSSAGKVIANRTVDYEEV 2361 6 LEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLMPPGYVQLEDASAGKVIANRTVDYEEV 2330 7 LEGATPGTTLIAVAAVDPDKGLNGLITYTLLDLTPPGYVQLEDSSAGKVIANRTVDYEEV 1996 8 LEGATPGTTLIAVAAVDPDKGLNGLITYSLLNLMPPGYVQLEDSSAGKVIANRTVDYEEV 2369 9 LEGATPGTTLIAVSAYDPDKGVNGQITYTLLNMVPPGYVQLEDSSAGKIISKRTVDYEEV 2088 10 LEGATQGTTLISISAVDPDKGANGQITYELLDLSPEGYACLEDQSAGKVVANRTVDYEEV 2316 11 LEGAQPGTTLLSVSAVDPDKGPNGQVIYQLLHLPRGEYVRLEDTSTGKIVANRTVDFEQV 2371 12 LEGAQPGTTLLSVSAVDPDKGPNGQVIYQLLHLPRGGYVRLEDPSTGKIIANQTVDFEQV 2374 13 LEGAQPGTTLLSVSAVDPDKGPNGQVTYQLLNLPRGEYIRLEDPSTGKIVANKTVDFEQV 1640 14 LEGAVPGTTLLSVTAVDPDKGPNGQIIYQLLNLPRGNYIRLEDPSTGKIVANRTVDFEQV 2049 C LEGA+*GTTL++*:A*DPDKG:NG::+Y:LL:*.+++Y++LED:S+GK++***TVD+E+V 2410 2420 2430 2440 2450 2460 1 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVT 2425 2 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVT 2281 3 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTVILTVT 2429 4 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDIAVGTVILRVT 2425 5 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQLSYQEAVFEDVAVGTVILRVT 2421 6 HWLNFTVRASDNGSPPRAAEIPVYLEIVDVNDNNPIFDQPSYQEAVFEDVPVGTVILTVT 2390 7 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTVILTVT 2056 8 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQLSYQEAVFEDVPVGTVILTVT 2429 9 HWVNFTVQAADNGSPPRAAEIPVYLEIVDINDNNPIFDQLSYQESVFEDTPVGTVILTVT 2148 10 QWLNFTVRASDNGSPRRSAEIPVYLQIVDINDNNPIFSQPSYQKAVFEDVPLGTVILRVK 2376 11 QWLNFTIRAQDHGTPPRITELPVYLQIVDVNDNNPFFLQPSYQEPVFENVDLGTIIVRVK 2431 12 QWLNFTIRAQDHGSPPRIAELPVFLRIVDVNDNNPVFLQPSYQEPVFENVDLGTTIVRVS 2434 13 QWLNFTIQARDQGSPPRSVELPVYLQIVDVNDNNPVFLQPSYQEPVFENVDLGTTIVRVR 1700 14 QWLNFTVRAQDHGSPPRFTELPVYLRIIDVNDNNPVFQQPLYQKSIFEDVALGTIIVSVR 2109 C +W*NFT+*A+D+G*P*R++E+PV*L+I*D+NDNNP+F+Q+*YQ*+*FE+*:+GT:I+:V+ 2470 2480 2490 2500 2510 2520 1 ATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVA 2485 2 ATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVA 2341 3 ATDADSGNFALIEYSLGDGEGKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVA 2489 4 ATDADSGNFALIEYSLVDGEGKFAINPNTGDISVLSSLDREKKDHYILTALAKDNPGDVA 2485 5 ATDADSGNFALIEYSLVDGEGKFAINPNTGDIYVLSSLDREKKDHYILTALAKDNPGDVA 2481 6 ASDADSGNFALIEYSLGDGEGKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDIA 2450 7 ATDADSGNFALLEYSLGDGEGKFAINPATGDIYVLSSLDREKKDHYILTALAKDNPGDIA 2116 8 ATDADSGNFALIEYSLVDGEGKFAISPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVA 2489 9 ATDADSGAFALIEYSLVDGEGKFGINPTTGDIYVLSSLDRETKAHYILTALAKDNPGDIP 2208 10 ATDADSGRFAVIQYSLGDGEGKFGINPDTGDIYILSALDREKKDHYTLTAVARDNPGDIS 2436 11 ATDADSGLFAVIEYSLVDGEGKFGIKPSTGEIYILSPLDRETKDHYTLTAVARDNPGGSP 2491 12 ATDADSGRFAAIEYSLVDGEGKFAIKPSTGEIYILSPLDRETKDHYTLTAVARDNPGSSP 2494 13 ATDADSGLFAAIEYSLVDGEGKFAIRPTTGEIYILSPLDRETKDHYTLTAVARDNPGGSS 1760 14 ATDADSGLFSVIEYGLVDGEGKFGITPTTGDIYILSALDRETKDRYTLTAYARDNPGGSP 2169 C A*DADSG:F*+**Y*L:DGE*KF+I+P:TG+I*+LS+LDRE+K**Y+LTA+A+DNPG+:: 2530 2540 2550 2560 2570 2580 1 SNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELT 2545 2 SNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELT 2401 3 SNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELT 2549 4 SNRRENSVQVVIRVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMLATDQDEGSNSQLT 2545 5 SNRRENSVQVVIRVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMLATDQDEGSNGQLT 2541 6 SNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDAGSNGELA 2510 7 SNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGSNGELA 2176 8 SNRRENSVQVVIQVLDVNDCRPQFSKLQFSTSVYENEPAGTSVITMMATDQDEGSNAELA 2549 9 SNRRENSVQVVIQVLDVNDCRPQFSKPQYSTSVYENEPAGTSVITMMATDQDEGENGELA 2268 10 SNRRENSVQVLITVLDINDFRPQFSKSQFSTSVYENEPAGTSVITMTATDLDEGDNGVVT 2496 11 NNRRENSIQVLVTVLDINDYRPRFTERVFNTSVFENEPSGTSVITVKANDLDEGENGVVL 2551 12 NNRRENSVQVLVTVLDVNDYRPRFTERVYNTSVFENEPSGTSVITVRATDLDEGENGAVL 2554 13 NNRRENSVQVLVTVLDVNDYRPRFTKRLYNVSVFENEPSGTSVVTVTAVDLDEGENAAVF 1820 14 NNRRENSVQVQLTVLDVNDFRPRFSERVFTTSVFENEPVGTSVITMKATDLDEGENALLT 2229 C +NRRENS*QV++:VLD*ND+RP+F++:+++*SV+ENEP+GTSV*T+:A*D+D*G.N+:+: 2590 2600 2610 2620 2630 2640 1 YSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVN 2605 2 YSLEGPGVEAFHVDMDSGLVTTQRPLQSYERFNLTVVATDGGEPPLWGTTMLLVEVIDVN 2461 3 YSLEGPGVEAFHVDMDSGLVTTQRPLQSYERFNLTVVATDGGEPPLWGTTMLLVEVIDVN 2609 4 YSLEGPGMEAFSVDMDSGLVTTQRPLQSYERFNLTVVATDGGEPPLWGTTMLLVEVIDVN 2605 5 YSLEGPGMEAFSVDMDSGLVTTQRPLQSYERFNLTVVATDGGEPPLWGTTMLLVEVIDVN 2601 6 YSLEGPGVEAFHVDMDSGLVTTKRPLQSYERFNLTVVATDGGQPPLWGTTMLLVEVIDVN 2570 7 YSLEGPGVEAFHVDLDSGLVTTKRPLQSYERFNLTVVATDGGQPPLWGTTMLLVEVIDVN 2236 8 YSLEGPGVEAFHVDMDSGLVTTKRPLQSYERFSLTVVATDGGQPPLWGTTMLLVEVIDVN 2609 9 YSIEGPGVEAFQVDKDSGLVTTRRPLQSYERFNLTVVATDGGQPPLWGTTMLYVEVIDVN 2328 10 YSIEGPGAEAFKINKDSGLITSRRRLQSYERFNLTVVATDKGRPPLWGTTMLHIEVIDIN 2556 11 YRLLGFHSDAFSLDPNTGLIRSRRLLQSSEHFNLTVVATDQGRPPLWSTADLIITVIDVN 2611 12 YSMLGPHSEAFILDPNTGLVRSRRLLQSSEQFNLTVVATDQGRPPLWGTADLIITVIDVN 2614 13 YSMLGSRLDAFSLDPITGLIRSQRLLQSTESFNFTVVATDQGRPPLWGTADLIITVIDVN 1880 14 YSLQGPGADAFSLDPDTGLIRSLRLLQSFERFNLTVVATDQGRPPLWGTASLQITVIDVN 2289 C Y*++G*+:+AF:+*:++GL+++:R+LQS+E+F**TVVATD+G.PPLW*T++L:++VID*N 2650 2660 2670 2680 2690 2700 1 DNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT-AGNRDWEFF 2664 2 DNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT-AGNRDWEFF 2520 3 DNRPVFWLMPEPSSPHFPQEIPLSSNVYEVYATDKDEGLNGAVRYSFLKT-AGNRDWEFF 2668 4 DNRPVFVRPPNGTILHIKEEIPLRSNVYEVYATDNDEGLNGAVRYSFLKT-TGNRDWEYF 2664 5 DNRPVFVRPPNGTILHIKEEIPLRSNVYEVYATDKDEGLNGAVRYSFLKS-TGNRDWEYF 2660 6 DNRPVFMRPPNGTVLHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT-AGNRDWEYF 2629 7 DNRPVFVRPPNGTVLHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT-AGNRDWEYF 2295 8 DNRPVFVRPPNGTVLHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT-TGNRDWEYF 2668 9 DNRPVFVRPPNGTILHILEEIPLRSNVYEVYATDQDEGLNGAVRYSFLKT-TGNRDWEYF 2387 10 DNRPVFVRPPNGTILHIKEEIPLRSNVYEVYATDKDEGLNGAVLYSLLKTGAGNKDWEYF 2616 11 DNRPLFVRPANGTIIHIAEEQPPGLPVYEVHATDSDEGVNGEVRYGFLQTGAGNRDWENF 2671 12 DNRPVFVRPANGTIIHITEEQPPGLPVYEVHATDSDEGVNGEVRYAFLQTGASNRDWENF 2674 13 DNRPVFVRPVNGTIIHIYEEQPPSVLVYEVYATDSDAGVNGEVRYAFLQTG----DWENF 1936 14 DNRPIFVRPANGTIMHILEEQPPGLVVYEVFATDEDEGVNGEVRYSFLQTGAGNRDWENF 2349 C DNRP*F***+***++H*.*E+P++++VYEV+ATD:D*G+NG+V*Y+*L+*.+***DWE:F 2710 2720 2730 2740 2750 2760 1 IIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVR 2724 2 TIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVR 2580 3 TIDPLSGLIQTAQRLDRETQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVR 2728 4 TIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVR 2724 5 TIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVR 2720 6 TIDPVSGLIQTAQRLDREKQALYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVR 2689 7 TIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVR 2355 8 TIDPISGLIQTAQRLDREKQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVR 2728 9 TIDPISGLIQTAKRLDREQQPMYSLILVASDLGQPVPYETMQPLLVALDDIDDNEPIFVR 2447 10 SIDAVSGLIQTAMRLDREKQAEYNLIIVASDQGQPA-YETMQPLQVALDDIDDNEPIFLR 2675 11 HIDAMSGVIVTTVKLDREKQALHSLIIMARDMGQPVPYETTQPLQVALLDIDDNEPVFLK 2731 12 HIDPISGVITTTVKLDREKLALYSLIIVARDMGQPVPYETTQPLQVALLDIDDNEPVFLK 2734 13 HIDALSGVITTTVKLDREKQALYSLIIVAHDLGQPVPYETTQPLQVALLDIDDNEPVFLK 1996 14 HIDAVTGVITTAVKLDREKQALYSLVVVAYDLGQPVPYETMQPLQVALSDIDDNEPVFLK 2409 C :ID+:*G+I+T+:+LDRE+**:**L*+*A+D+GQP**YET+QPL*VAL:DIDDNEP:F++ 2770 2780 2790 2800 2810 2820 1 PPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGC 2784 2 PPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGH 2640 3 PPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGLNAIVYYFIAVGNEEKNFHLQPDGR 2788 4 PPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGDEDKNFHLQPDGR 2784 5 PPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEDKNFHLQPDGR 2780 6 PPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGR 2749 7 PPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGR 2415 8 PPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGSNAIVYYFIAVGNEEKNFQLQPDGR 2788 9 PPKGSPQYQLLSVPEHSQPGTLVGNITGAVDADEGPNAIVYYFIAAGNEEENFLLKKDGR 2507 10 PSRDSPQYQALSVPEHSQPGTVVGNVTGAVDADEGSNAIVYYFIAAGNRESNFQLSREGK 2735 11 PPRGSLPYHRLAVPEHSRPGTVVGNVTRAVDADEGSNAIVYYFIAGGNSDGNFGLSLDGE 2791 12 PPRGSLPYQKMTIPEHSPPGTMVGNVTRAVDADEGSNAVVYYFIAGGNSDGNFGLSLDGE 2794 13 PPRGSLPYQVLSVPEQSPPGTIVGNVTRAVDADEGSNAIVFYFIAGGNSDGNFGLSLEGE 2056 14 PPRGSLPYQSLSVPEHSSPGTVVGNVTGAVDADEGSNAIVYYFIAGGDTGGNFALSVSGV 2469 C P*+*S++Y*+*+*PE*S+:GT+VGN*T+AVDADEG:NA*V*YFIA:G*+::NF:L::+G: 2830 2840 2850 2860 2870 2880 1 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGP----SPTLDLVADLTLQEVRVVLEDIN 2840 2 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGP----SPTLDLVADLTLQEVRVVLEDIN 2696 3 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGP----SPTLDLVADLTLQEVRVVLEDIN 2844 4 LLVLRDLDRETEATFSFIVKASSNRSWTPPRGP----SPALDLLTDLTLQEVRVVLEDIN 2840 5 LLVLRDLDRETEAIFSFIVKASSNRSWTPPRGP----SPALDLLTDLTLQEVRVVLEDIN 2836 6 LLVLRDLDREREAVFSFIVKASSNRSWTPPHGP----SPALDLVADLTLQEVRVVLEDIN 2805 7 LLVLRDLDREREAVFSFIVKASSNRSWTPPRGP----SPALDLVTDLTLQEVRVVLEDIN 2471 8 LLVLRDLDRECEAVFSFIVKASSNRSWTPPRRP----SPALDLVTDLTLQEVRVVLEDIN 2844 9 LLVIRDLDREREALFSIIVKASSNRSWTLPRGPGA--SQALDLMTDLTLQEVRIVIEDIN 2565 10 LQVLRDLDREKEPYYSIIVKASSQRNWSPPRGQRAGRAQHWDLSTDLTLQEVRIFLDDIN 2795 11 LKVLKDLDREEIPVYSIIIKASSNRSWTPTRGQRAARAKALDPANDPSLLEVHIELEDIN 2851 12 LKLYRDLDREEIPVYSIIIKASSNKSWTPPRAQRAARTRILDPSHDPSLLEVQIELEDIN 2854 13 LRVLKELDREVTPSYSIIIKASSNRSWTPPKGQRSSGTKALDPALDPSLLAVRIELEDIN 2116 14 LRVKKDLDREEIPVYSIIVKASSNRNWTPPKGQRSQRAQVLDPSRDPTLQEVRIFLEDIN 2529 C L+*++*LDRE:++:+S:I+KASS***W***+*+.. .+::*D+::D++L+*V*:+**DIN 2890 2900 2910 2920 2930 2940 1 DQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSED 2900 2 DQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSED 2756 3 DQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFQALANDSED 2904 4 DQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYGILAIHYFRALANDSED 2900 5 DQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYGILAIHYFRALANDSED 2896 6 DQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSED 2865 7 DQPPRFTKAEYTAGVATDAKVGSELIQVLALDADVGNNSLVFYSILAIHYFRALANDSED 2531 8 DQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFQALANDSED 2904 9 DQPPRFTKSEYTAGVATDAKVGSELIQVLATDDDIGNNSLVFYSILAIHYFREHSNDSED 2625 10 DQSPQFTKSEYTAGVATDAKVGSELIRVLAVDADVGNNSLVLYSILGIRYIKQHSNDSEE 2855 11 DQKPRFTKAEYTAGVAASAKVGSDLIKVVAIDNDIGNNSVVQYHIVTIRYFQSQSNGSED 2911 12 DQTPRFTKMEYTAGVASNAKVGSELIKVAAVDNDVGNNSLVQYHIVTIRYFQSQSNGSED 2914 13 DQTPRFTKAEYTAGVAANAKVGSELIKVLAIDNDIGNNSVVLYHIITIHYFQSQSNGSED 2176 14 DQSPRFTKLEYTTGVAADAKVGSDLIRVQAIDNDIGNNSLVLYHILSIRYIKLHSNDSEE 2589 C DQ+P*FTK+EYT*GVA++AKVGS*LI+V+A:D+D+GNNS*V+Y:I++I+Y*::::N+SE* 2950 2960 2970 2980 2990 3000 1 VGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIV 2960 2 VGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVAQDLAGHNDTAIVGIYILRDDQRVKIV 2816 3 VGQVFTMGSVDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIV 2964 4 VGQVFTMGSVDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIV 2960 5 VGQVFTMGSVDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIV 2956 6 VGQVFTMGSVDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIV 2925 7 VGQVFTMGSVDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIV 2591 8 VGQVFTMGSVDGILRTFDLFMAYSPGYFVVDIMARDLAGHNDTAVIGIYILRDDQRVKIV 2964 9 VGQVFTMGSVDGILRTFDLFMVYSPGYFVVDIIALDLAGHNDTAIVGIYILRDDQRVKII 2685 10 VANIFSIGTLDGILRTFDLFTAYNPGYFVVDIMASDLVGHNDTAIVGIYILRDDQRVKII 2915 11 VGSIFIIGLADGIIRTYDLFTAYNPGYFQLEILACDFAGHSTTTNVNIYILRDDQRVKIV 2971 12 MGNIFTIGLRDGIIRTYDLFTAYSPGYFQLEILACDFAGHSTTTNVNIYILRDDQRVKIV 2974 13 VGSVFTIGLTDGVIRTYDLFTAYNPGYFQLEILARDYAGHSTTANVNIYILRDDQRLKIV 2236 14 MGNVFIIGETDGIICTFDLFMAYAPGYFIVEVLARDLAGHSDVALVSIYILRDDQRVKIV 2649 C **++F++G+:DG*+*T+DLF+*Y+PGYF+++*:A+D+*GH++**+:+IYILRDDQR*KI* 3010 3020 3030 3040 3050 3060 1 INEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNR 3020 2 INEIPDRVRGFEEEFIHLLSNITGAIVNTDDVQFHVDKKGRVNFAQTELLIHVVNRDTNR 2876 3 INEIPDRVRSFEEEFIHLLSNITGAIVNTDDVQFHVDKKGRVNFAQTELLIHVVNRDTNR 3024 4 INEIPDRVRGFEEEFIRLLSNITGAIVNTDDVQFHVDMKGRVNFAQTELLIHVVNRDTNR 3020 5 INEIPDRVRGFEEEFIRLLSNITGAIVNTDDVQFHVDMKGRVNFAQTELLIHVVNRDTNR 3016 6 INEIPDRVRGFEEEFIRLLSNITGAIVNTDDVQFHVDKKGRVNFAQTELLIHVVNRDTNR 2985 7 INEIPDRVRGFEEEFIRLLSNITGAIVNTDDVQFHVDKKGRVNFAQTELLIHVVNRDTNR 2651 8 INEIPDRVRGFEEEFIRLLSNITGAIVNTDDVQFHVDKKGRVNFAQTELLIHVVNRDTNH 3024 9 INEIPDRVRGFEEEFIRLLSNITGAIVNTDDVQFHVDQRGRVNFAQTELLIHVVNRDTNR 2745 10 INEIPDKVRQFEEEFISLLSNITGAIVNTDDVQFHVDKKGRVNFAQTELLIHVVNRETNR 2975 11 FNEIPDIVRENQDEFINLLSNITGAIVNLDDIQFHVDKKGRVSYDKTDMLIHVVNNQSNT 3031 12 FNEIPDLVRENQEEFITLLSNITGAIVNLDDIQFHVDKKGRVNYAQTDMLMHVVNNQTNT 3034 13 FNEIPDFVRANKEEFLNLLSNITGSIVNLDDIQFHVDNKGRVSYSQTDMLIHVVNNQTNA 2296 14 INEIPERVRLFQEEFINLLSNITGAIVNTDDVQFHVDKKGRVNFAQTDVLIHVVNKQTNR 2709 C +NEIP*+VR:++*EF*:LLSNITG*IVN+D*+QFHVD+*GRV*+**T++L*HVVN++*N+ 3070 3080 3090 3100 3110 3120 1 ILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPDDMSALQMAIIVLAILLFLAA 3080 2 ILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPDDMSALQMAIIVLAILLFLAA 2936 3 ILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPDDMSALQMAIIVLAILLFLAA 3084 4 ILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVQLPDDMSALQMAIIVLAILLFLAA 3080 5 ILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVQLPDDMSALQMAIIVLAILLFLAA 3076 6 ILDVDRVIQMIDENKEQLRNIFGRYNVMDGQPAISVRLADSMSALQMAIIVLAILLFLAA 3045 7 ILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISARLPDDMSALQMAIIVLAILLFLAA 2711 8 ILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRPPDDMSALQMAIIVLAILLFLAA 3084 9 ILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAITPRLPEDMSNLQMAIIILAILLFLAA 2805 10 ILDVERVIQMIDENKEQLRNLFRNYNVLDVQPAITAHAPDDLSALQMAIIVLAVLLFLAA 3035 11 ILDVIRVIKMIDENQEQLRNLFRKYNVVDVQPAVTDKLPDDITTLQLVVIILAVLLCLAG 3091 12 ILDVERVIQMIDENKDQLRNLFRKYNVVDVQPAVNDKLPDDITTLQLVIIILAVLLCLAG 3094 13 ILDVERVIQMIDENKEQLRKLFRTYNVVDVQPAVGDKVPDDISTLQLVIIILAVLLCLAG 2356 14 ILDVEKVIQMIDENKEQLRNLFRNYNILDVQPAVTARAPDDLTTLQMAIIILAVLLFLAA 2769 C ILDV+*VI*MIDEN**QLR**F*+YN*+D*QPA+:::+***+++LQ++*I+LA+LL+LA+ 3130 3140 3150 3160 3170 3180 1 MLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNL 3140 2 MLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNL 2996 3 MLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNL 3144 4 MLFVLMNWYYRTIHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGSNPVWLDPFCRNL 3140 5 MLFVLMNWYYRTIHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNL 3136 6 MLFILMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNL 3105 7 MLFILMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGANSVWLDPFCRNL 2771 8 MLFILMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNL 3144 9 MLFILMNWYYRTVHKRKLKAIVAGSTGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNL 2865 10 MLFILMNWYYRTVHKRKLKAIVAGSTGNRGFMDIMDMPNTNKYSFDGANPVWLDPFCRTM 3095 11 VLFVTMNWHYQRVHQRKLKAIVAGSTGNQGLMDILDMPNTNKYSFEGANPVWLDPFCRNL 3151 12 ICFVTMNWHYRRVHQRKLKAIVAGSTGNQGLMDILDMPNTNKYSFEGANPVWLDPFCRNL 3154 13 ILFVTMNWHYRRVET-NPEVLIFRHTGNQGLMDVLDMPNTNKYSFEGANPVWLDPFCRNL 2415 14 MLFILMNWYYRTVHKRKLKAVVAGSTGNQGLMDILDMPNTNKYTFEGANPVWLDPFCRNL 2829 C +*F:+MNW+Y*+**+**********:GN+G++D*+DMPNTNKY*F+G*N*VWLDPFCR** 3190 3200 3210 3220 3230 3240 1 ELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAVKPDDDRYLRAAIQEYDNIAK 3200 2 ELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAVKPDDDRYLRAAIQEYDNIAK 3056 3 ELATQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAVKPDDDRYLRAAIQEYDNIAK 3204 4 ELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAVKPDDDRYLRAAIQEYDNIAK 3200 5 ELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAVKPEDDRYLRAAIQEYDNIAK 3196 6 ELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAVKPDDDRYLRAAIQEYDNIAK 3165 7 ELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAVKPDDDRYLRAAIQEYDNIAK 2831 8 ELAAQAEHEDDLPENLSEVADLWNSPTRTHGTFGREPAAVKPDDDRYLRAAIQEYDNIAK 3204 9 ELAAQAEHEDDLPENLSEITDLWNSPARTHGTFGREPSAVKPEDDRYLRAAIQEYDNIAK 2925 10 ELAAQAEHEDDLPENLSEITDLWNSPARTHGTFGREPSAAKPEDDRYLRAAIQEYDNIAK 3155 11 ELAAQADHEDDLPENLSEITDLWNSPARTHGTFGREPQAK-PEDDRYLRAAIQEYDNIAK 3210 12 ELANQADHEDDLPENLSEITDLWNSPARTHGTFGREPQAK-PEDDRYLRAAIQEYDNIAK 3213 13 ELAVQADHEDDLPENLSEITDLWNSPARTHGTFGREPQAR-PEDDRYLRAAIQEYDNIAK 2474 14 ELAAQAEHEDDLPEDLSDIADLWNSPARTHGTFGREPQATKPEDDRYLRAAIQEYDNIAK 2889 C ELA+QA+HEDDLPE*LS**+DLWNSP:RTHGTFGREP:A++P:DDRYLRAAIQEYDNIAK 3250 3260 3270 3280 3290 3300 1 LGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC--HSSISELIQTELDEEPGD 3258 2 LGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC--HSSISELIQTELDEEPGD 3114 3 LGQIIREGPIK-------------------------------------LIQTELDEEPRD 3227 4 LGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC--HSSISELIHTDLEEEPGD 3258 5 LGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC--HSSISELIHTDLEEEPGD 3254 6 LGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC--HSSISELIQTELDEEPGE 3223 7 LGQIIREGPIKGSLL-----------KLFAQRMVQKASSC--HSSISELIQTELEEEPGE 2878 8 LGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSS--HSSISELIQTELEEEPGE 3262 9 LGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMMQKATSC--HSSISELIQTELEEEVAD 2983 10 LGQIMREGPIK-------------------------------------LIQKDLEED-EE 3177 11 LGQIMREGPIKGSLLNVVLDDYLRLKKLFAARLVTVSTSQGDHSSVTELIQSDLDDDEDE 3270 12 LGQIMREGPIKGSLLKVVLDDYLRLKKLFAARMVTVSTSQEDRSSITELIQSDLDDEEDE 3273 13 LGQIMREGPIKGSLLKVVLDDYLRMKKLFAARLVTASTGPGDRSSVTELIQSDLDEDEDE 2534 14 LGQIMREGPIKGSLLNVVLDDYLRLKKLFAARLVTKSTSQGDRSSVTELIQSDLDEDDEE 2949 C LGQI+REGPIK****++++:++++++****:*++:+::+:..+**+:*LI*+:L:*+::: 3310 3320 3330 3340 3350 3360 1 HSP---GQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSLPEEDQKGLGRSLETL 3315 2 HSP---GQGSLRFHHKPPVELKGPDGIHVVHDSTGTLLATDLNSLPEEDQKGLGRSLETL 3171 3 HSP---GQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSLPEDDQKGLGRSLETL 3284 4 HSP---GQGSLRFRHKPPMELKGQDGIHMVHGSTGTLLATDLNSLPEDDQKGLDRSLETL 3315 5 HSP---GQGSLRFRHKPPTELKGPDGIHIVHGSTGTLLATDLNSLPEDDQKGLDRSLETL 3311 6 RSP---GQGSLRFRHKPPTELKGPDGIHMVHGSTGTLLATDLNSLPEDDQKGLGRSLETL 3280 7 HSP---SQGSLRFRHKPPTELKGPDGIHAVHGSTGTLLATDLNSLPEDDQKGLGRSLETL 2935 8 RSP---GQGSLRFCHKPPTELRGPDGIHVMHGSTGTLLATDLNSLPEDDQKGLGRSLETL 3319 9 RSL---GQGSLRFRHKQPIELKGPDGIHVVHGSTGTLLAADLNSLPEDDQKVLGRSLETL 3040 10 RSP---SQGSLRFRHKQPVELKGPDGIHVVHGSTGTLLASDLNSLPEDDQKVLGRSLETL 3234 11 QLGMGGGRGTLRFKHKLPMELKGPDGVHVVHGSTGTLLTSDLNSLPEDDQRALARSLEAL 3330 12 RLGLGGGRGTLRFKHKLPVELKGPEGVHVVHGSTGTLLTSDLNSLPEDDQRALARSLEAL 3333 13 NLDVGGGHGPLRFKHKLPVELKGPEGVHVVHGSTGTLLTSDLSSLPEDDQRALARSLEAL 2594 14 RI---GGRGTLRFKHKLPIELRGPDGVHAVHGSTGTLLTSDLNSLPEDDQRALARSLEAL 3006 C :++ ..*+G+LRF:HK:P:EL*G**G+H+*H*STGTLL+:DL*SLPE*DQ+:L:RSLE+L 3370 3380 3390 3400 1 TAAEATAFERNARTESAKSTPLHKLR--DVIMETPLEITEL 3354 2 TAAEATAFERNARTESAKSTPLHKLR--DVIMETPLEITEL 3210 3 TAAEATAFERNARTESAKSTPLHKLR--DVIMESPLEITEL 3323 4 TASEATAFERNARTESAKSTPLHKLR--DVIMESPLEITEL 3354 5 TASEATAFERNARTESAKSTPLHKLR--DVIMESPLEITEL 3350 6 TTAEASAFERNARTESAKSTPLHKLR--DVILESPLEITEL 3319 7 TTTEASAFERNARTESAKSTPLHKLR--DVILESPLEITEL 2974 8 TTAEASAFERNARTESAKSTPLHKLR--DVIMESPLEITEL 3358 9 TAEAGAYNERNARTESAKSTPMHKMR--EVIMESPLEITEL 3079 10 TADCG-AYDHNARTESAKSTPLHKMR--EVIMESPLEITEL 3272 11 NSDGGLYSERNARTESAKSTPMHRHKGENTLSEIPLEITEL 3371 12 NADGGLYNERNARTESAKSTPMHRHKDGDILSESPLEITEL 3374 13 NADGGLYSERNARTESAKSTPMHRQKDGDALSGSPLEITEL 2635 14 HADGGLYAERNARTESAKSTPLHRNKGSDTLSESPLEITEL 3047 C ++.::.+:**NARTESAKSTP+H+:+ +++:*+PLEITEL