The UMD-USH2A mutations database
Record ID: 476

Mutation description (Allele #2)


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.IVS10-2A>G (c.1841-2A>G)HeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
GGAGlyspl-2Spl.A->GTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
 

Mutation(s) on the other allele: c.2276G>T

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Acceptor
tccctgatgcagGA
88.2 _
tccctgatgcggGA
59.3 _ *
-32.8 %

Patient and sample data


Sample IDPatient statusGenderTransmissionGeographic origin
SP0211200011ProbandMaleSPAIN

Phenotypic groupDisease
nonsyndromic RP 

Clinical data


Symptom

Reference


Reference IDPubMed IDReference
1012525556
Bernal - Baiget 2003