The UMD-THAP1 mutations database
Record ID: 49

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.197_198delAGp.Glu66ValfsX19HeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
GAGGludel2bFs.Stop at 84Fr.

StructureKey Residue (HCD)Pyrimidin doubletCpG
L4-THAP dom. 

Mutation impact


At the mRNA levelOn restriction map
Deletion of a repeated sequenceNew restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient IDFamily IDPatient statusGenderTransmissionGeographic origin
GER02TUE F0008 I0001Case 8-ProbandFemaleUnknownGERMANY

Phenotypic groupDisease
NAAsymptomatic control

Clinical data


Symptom
Asymptomatic

Reference


Reference IDPubMed IDReference
1220669277
S*hn AS, Gl*ckle N, Doetzer AD, Deuschl G, Felbor U, Topka HR, Sch*ls L, Riess O, Bauer P, MŸller U, Grundmann K. Prevalence of THAP1 sequence variants in German patients with primary dystonia. Mov Disord. 2010 Sep 15;25(12):1982-6.