The UMD-THAP1 mutations database
Record ID: 173

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.394_396delTTCp.Phe132delHeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
TTCPhedel3aInFIn frame delInF

StructureKey Residue (HCD)Pyrimidin doubletCpG
 

Mutation impact


At the mRNA levelOn restriction map
No mechanism suspectedNew restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient IDFamily IDPatient statusGenderTransmissionGeographic origin
USA01NYO F0015 I0001ProbandUnknownUnknownU.S.A.

Phenotypic groupDisease
NAUnknown

Clinical data


Symptom
No clinical data available

Reference


Reference IDPubMed IDReference
28 21752024
Sengel C, Gavarini S, Sharma N, Ozelius LJ, Bragg DC. Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain. J Neurochem. 2011 Sep;118(6):1087-100.