The UMD-THAP1 mutations database
Record ID: 172

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.230_231insAp.Pro78AlafsX8HeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
GTGValins1cFs.Stop at 85Fr.

StructureKey Residue (HCD)Pyrimidin doubletCpG
L4-THAP dom. AVPTIF motif

Mutation impact


At the mRNA levelOn restriction map
No mechanism suspectedNew restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient IDFamily IDPatient statusGenderTransmissionGeographic origin
TAI01TAO F0001 I0002father of case 1ProbandMaleFamilialTAIWAN

Phenotypic groupDisease
NASegmental dystonia

Clinical data


Symptom
Age at last examination
Age of onset
Cranial
Larynx
Neck
Speech

Reference


Reference IDReference
24Unpublished data