The UMD-THAP1 mutations database
Record ID: 156

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.213dupp.Leu72ThrfsX14HeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
CTGLeuins1aFs.Stop at 85Fr.

StructureKey Residue (HCD)Pyrimidin doubletCpG
L4-THAP dom. 

Mutation impact


At the mRNA levelOn restriction map
DuplicationNew restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient IDFamily IDPatient statusGenderTransmissionGeographic origin
CHI02CHE F0001 I0001ProbandMaleNo family historyCHINA

Phenotypic groupDisease
NAFocal dystonia

Clinical data


SymptomSeverityAge
Age at last examination27
Age of onsetneck26
Neck26

Comments


publication name c.214_215insA

Reference


Reference IDPubMed IDReference
21 21839475
Song W, Chen Y, Huang R, Chen K, Pan P, Yang Y, Shang HF. Novel THAP1 gene mutations in patients with primary dystonia from Southwest China. J Neurol Sci. 2011 Oct 15;309(1-2):63-7.