The UMD-TGFBR2 mutations database
The protein

The TßR-II protein is encoded by 567 codons (Takenoshita et al. 1996). The translated product of the TGFBR2 gene is composed of several subdomains (figure 2). Starting from the N-terminus, there is a signal peptide (1 to 22) (Lin et al. 1992), a relatively short cysteine-rich extracellular domain (51 to 142), serine/threonine protein kinase catalytic domains (codons 246-544), and the C-terminus. The extracellular region is N-glycosylated (Wells et al. 1997) and contains 12 cysteines probably involved in the general folding of this region. Three of these cysteines form a characteristic cluster near the transmembrane sequence (Childs et al. 1993 and Massague et al. 1992). The transmembrane region and the cytoplasmic juxtamembrane region have no singular structural features. The cytoplasmic region contains kinase domains conform to the canonical sequence of a serine/threonine protein kinase domain (Hanks, SK, 1988). TbR-II is regulated intricately by autophosphorylation on at least three serine residues (Ser213 in the juxtamembrane region and Ser409 et Ser416 in the T-loop region of the kinase domain (Luo et al. 1997)). The TbR-II exists in an alternative form arising from the presence of a 25–amino acid insert following the signal sequence (Suzuki et al. 1994 and Hirai et al. 1996).

Table of domains coordinates  (Show/Hide)

Schematic representation of the TGFBR2 protein  (Show/Hide)