The UMD-MYO7A mutations database
Record ID: 942

Mutation description (Allele #2)


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.999T>Gp.Tyr333XHeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
TATTyrTAGStopT->GTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
Motor domain NoNo

Mutation(s) on the other allele: c.6025delG

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): BsiY I, EcoN I
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionGeographic origin
FR0401000012ProbandUnknownFRANCE

Phenotypic groupDisease
TypeI Usher 

Clinical data


Symptom

Reference


Reference IDPubMed IDReference
3316400615
Gerber - Kaplan 2006