The UMD-MYO7A mutations database
Record ID: 446

Mutation description (Allele #1)


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.721C>Tp.Arg241CysHeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
CGTArgTGTCysC->TTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Motor domain NoYes

Mutation(s) on the other allele: c.6025delG

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): Nla III
Lost restriction site(s): Mae II, Mae III, Pml I

Pathogenicity (bioinformatics predictions)
Conservation (0-1)SIFT (0-1)UMD predictor (0-100)
0,940.00 (pathogenous)100 (Pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionGeographic origin
US0200522162ProbandUnknownU.K.

Phenotypic groupDisease
TypeI Usher 

Clinical data


Symptom

Reference


Reference IDPubMed IDReference
1510930322
Bharadwaj - Dryja 2000