The UMD-MYO7A mutations database
Record ID: 438

Mutation description (Allele #2)


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.3260T>Cp.Leu1087ProHeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
CTGLeuCCGProT->CTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
 Yes, coding strandNo

Mutation(s) on the other allele: c.3265delG

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): Alu I, Pst I, Sfe I

Pathogenicity (bioinformatics predictions)
Conservation (0-1)SIFT (0-1)UMD predictor (0-100)
10.02 (pathogenous)75 (Pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionGeographic origin
YE0100100011ProbandMaleYEMEN

Phenotypic groupDisease
TypeI Usher 

Clinical data


Symptom

Reference


Reference IDPubMed IDReference
1310425080
Cuevas - Najera 1999