The UMD-MSH6 mutations database
Mutation c.973C>T

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH6	MLH1	MSH2	MUTYH	APC
8_474129315208-296041	-	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
Clinical phenotype	Index case (47412-93152) : endometrium cancer at the age of 64 + colon cancer at the age of 67. Two sisters with breast cancers at the ages of 50 and 57	25/09/15	8 (Nancy)	---
MMR function in tumor cells	MSI-H / MLH1+MSH2+MSH6+PMS2+ (endometrium, 47412-93152)	25/09/15	8 (Nancy)	---

Biological significance	Date	Comment
Causal	25/09/15	---