The UMD-MSH2 mutations database
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Last update 18/11/15

This database includes 3231 mutations ( 638 different mutations and 359 proteic variants)

The UMD-MMR databases have been set up in a joined national effort through the network of 16 diagnostic laboratories to provide up-to-date information about mutations of the MLH1, MSH2 and MSH6 genes identified in patients with colorectal and/or endometrium cancer. These databases currently contain published and unpublished information about the MLH1, MSH2 and MSH6 mutations reported in French diagnostic laboratories. The databases of MLH1, MSH2 and MSH6 mutations were built using the "Universal Mutation Database" tool. For each mutation, information is provided at several levels:   - at the gene level: exon and codon number, wild type and mutant codon, mutation event, mutation name and,   - at the protein level: wild type and mutant amino acid, binding domain, affected domain.

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Reference	Laboratory name	City	Name	First Name	e-mail
2	Institut Gustave Roussy	Villejuif	Guillaud-Bataille	Marine	marine.guillaudbataille@gustaveroussy.fr
			Cabaret	Odile	odile.cabaret@gustaveroussy.fr
4	Centre Leon Bérard	Lyon	Wang	Qing	wang@lyon.unicancer.fr
5	Institut Bergonié	Bordeaux	Bonnet	Françoise	bonnet@bergonie.org
6	Institut Claudius Regaud	Toulouse	Toulas	Christine	toulas.christine@claudiusregaud.fr
7	Institut Paoli-Calmettes	Marseille	Popovici	Cornel	popovicic@ipc.unicancer.fr
8	CHRU Nancy Brabois	Vandoeuvre-les-Nancy	Bronner	Myriam	m.bronner@chu-nancy.fr
14	CHU Nantes	Nantes	Airaud	Fabrice	fabrice.airaud@chu-nantes.fr
17	Institut Curie	Paris	Rouleau	Etienne	etienne.rouleau@curie.net
19	CHU Charles Nicolle	Rouen	Tinat	Julie	julie.tinat@chu-rouen.fr
			Baert-Desurmont	Stéphanie	stephanie.baert-desurmont@chu-rouen.fr
20	Centre Jean Perrin	Clermont-Ferrand	Uhrhammer	Nancy	nancy.uhrhammer@cjp.fr
25	CHU Strasbourg	Strasbourg	Maugard	Christine	christine.maugard@chru-strasbourg.fr
31	CHU Arnaud de Villeneuve	Montpellier	Rey	Jean-Marc	jm-rey@chu-montpellier.fr
33	Groupe Hospitalier Pitié-Salpêtrière	Paris	Coulet	Florence	florence.coulet@psl.aphp.fr
			Guillerm	Erell	erell.guillerm@psl.aphp.fr
37	CHRU Lille	Lille	Buisine	Marie-Pierre	mp-buisine@chru-lille.fr
			Leclerc	Julie	julie.leclerc@chru-lille.fr
38	Institut Cochin de Génétique Moléculaire	Paris	North	Marie-Odile	marie-odile.north@cch.aphp.fr
41	Hôpital Européen Georges Pompidou	Paris	Burnichon	Nelly	nelly.burnichon@egp.aphp.fr
42	Hôpital Avicenne	Paris	Schischmanoff	Olivier	olivier.schischmanoff@avc.aphp.fr

Data from diagnostic laboratories (blue dots) are sent to Marseille for inclusion and curation into the database. Data from the curation center (red dots) are updated by the Bioinformatics team of INSERM UMR_S910 into the UMD-MLH1, MSH2 and MSH6 French databases.
If you want to submit a mutation, please contact S. Olschwang., P. Grandval. or A. Fabre.

This work was supported by grants from INCA

The French National Committee of Informatics and Liberty (CNIL) authorized this database registered under number 1800785v0 on October 2014.

The UMD-MSH2 Locus Specific Database constitutes the intellectual property of the curators of the database. Any unauthorized copying, storage or distribution of this material without written permission from the curators would lead to copyright infringement with possible ensuing litigation.

For further details, please refer to Directive 96/9/EC of the European Parliament and of the Council of 11 March 1996 on the legal protection of databases.