The UMD- MSH2 mutations database
The protein

MSH2 is a protein involved in the mismatch repair process after DNA replication. It contains a DNA binding domain and two interaction domains, one for MSH3 or MSH6 and the other for MutL homologs (MLH1 and PMS2, PMS1 or MLH3).
MSH2 can bind to MSH6 or to MSH3 to form the MutSα or the MutSβ complexes respectively. While MutSα complex binds to single base and small insertion-deletion mismatches, MutSβ binds to larger insertion-deletion mismatches. Upon binding to the mismatch, the MutS complex associates with the MutL complex (composed of MLH1 and PMS2, PMS1 or MLH3), and recruits the proteins needed for DNA excision and repair.

Here is presented a short description of the Mutation Mismatch Repair system: