The UMD-MSH2 mutations database
Mutation c.IVS13-51A>G (c.2211-51A>G)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Cryptic Donor?	tatgtgtat	65 _	tatgtgtgt	77.2 _ *	15.8 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
2_02-NJ21_718_718	c.2009C>T (p.Pro670Leu)	-	c.IVS1+22C>G (c.260+22C>G) c.IVS2+52T>A (c.457+52T>A) c.186C>A (p.Arg62Arg) c.276A>G (p.Pro92Pro) c.540T>C (p.Asp180Asp)	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
Co-occurrence	MSH6:c.755C>A, p.Ser252X (Patient A)	19/09/09	2 (Villejuif)	---
Ex vivo analysis	Splicing reporter minigene pCAS: normal splicing	29/09/09	19 (INSERM U1079-Rouen)	---

Biological significance	Date	Comment
Neutral	29/09/09	---