The UMD-MSH2 mutations database
Mutation c.IVS15+5G>T (c.2634+5G>T)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Donor	GAGgtttgt	84.4 _	GAGgttttt	72.1 _ *	-14.6 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
19_13815_13815-001_13815-	-	-	-	-	-
19_13815_13815-002_13815-	-	-	-	-	-
19_13815_13815-003_13815-	-	-	-	-	-
19_13815_13815-004_13815-	-	-	-	-	-
19_2428724287.00124287.001	-	-	-	-	-
SO_-5446---G08403	-	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
Ex vivo analysis	Splicing reporter minigene pCAS: major loss of exon 15	6/02/07	19 (INSERM U1079-Rouen)	---
MMR function in tumor cells	MSH2- (patient A)	23/09/04	SO (Marseille)	---

Biological significance	Date	Comment
Likely Causal	28/01/13	---