The UMD-MSH2 mutations database
Mutation c.IVS7-11delCTT (c.1277-11delCTT)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Acceptor	actttcttttagGA	84.4 _	atcttttagGAAAA	46.9 _ *	-44.4 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
14_NANTES?_04C065_04C065	-	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
MMR function in tumor cells	MSS	12/06/14	31 (Montpellier)	---
Clinical phenotype	Sporadic colorectal cancer < 50 years old	12/06/14	14 (Nantes)	---
Ex vivo analysis	Splicing reporter minigene pCAS: normal splicing	27/03/09	19 (INSERM U1079-Rouen)	---

Biological significance	Date	Comment
Neutral	13/12/11	---