The UMD-MSH2 mutations database
Mutation c.IVS14-8T>G (c.2459-8T>G)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Acceptor	aatttcttatagGT	83.2 _	aattgcttatagGT	81.3 _	-2.3 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
6_606058_200600376_S8890	-	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
In vitro analysis	RT-PCR : loss of exon 16 (IGR)	20/09/10	6 (Toulouse)	---
MMR function in tumor cells	MSH2-MSH6-	20/09/10	6 (Toulouse)	---

Biological significance	Date	Comment
Causal	13/12/11	---