The UMD-MSH2 mutations database
Mutation c.IVS2+1G>T (c.366+1G>T)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Donor	AAGgtaatt	86.7 _	AAGttaatt	59.9 _ *	-30.9 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
37_E-L02.03_1395_10711	-	-	-	-	-
5_20003242_20031073_AAA33	-	-	-	-	-
5_2003242_20031073_AAA335	-	-	-	-	-
8_43911_76721_08-392311EG	-	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
In vitro analysis	RT-PCR: complete loss of exon 2	9/12/13	5 (Bordeaux)	---

Biological significance	Date	Comment
Causal	21/02/14	---