The UMD-MSH2 mutations database
Mutation c.IVS3+35C>T (c.645+35C>T)

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
2_DDM1356243058215089465	-	c.1852_1854delAAG (p.Lys618del)	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
MMR function in tumor cells	MSI-H / MLH1-PMS2- (2 tumors, DDM13562-43058)	1/09/15	2 (Villejuif)	---
Co-occurrence	MLH1:c.1852_1854del, p.Lys618del	1/09/15	2 (Villejuif)	---
Clinical phenotype	Index case (DDM13562-43058) : colon cancers at the ages of 35 and 57. Sister : colon cancer at the age of 32. Mother : colon cancer at the age of 74. Maternal uncle : colon cancer at the age of 45.	1/09/15	2 (Villejuif)	---

Biological significance	Date	Comment
UV	9/09/15	---