The UMD-MSH2 mutations database
Mutation c.IVS7-67A>G (c.1277-67A>G)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Cryptic Acceptor?	tatctcagtcaaaat	53.7 _	tatctcagtcaGaat	82.7 _ *	35 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
2_02-ACT3042_19355_19355	c.IVS7+51C>A (c.1276+51C>A) c.573C>T (p.Leu191Leu)	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
Ex vivo analysis	Splicing reporter minigene pCAS: normal splicing	19/03/09	19 (INSERM U1079-Rouen)	---

Biological significance	Date	Comment
Neutral	13/12/11	---