The UMD-MSH2 mutations database
Mutation c.IVS14+36G>A (c.2458+36G>A)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Cryptic Acceptor?	ttcagaacttggtaa	44.3 _	ttcagaacttAgtaa	73.2 _ *	39.5 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
7_1916418E01103	c.IVS1+9C>G (c.211+9C>G) c.IVS1-4del (c.212-4del) c.IVS9+29delAAT (c.1510+29delAAT)	-	-	-	-
7_2231569E01257	c.IVS1+9C>G (c.211+9C>G) c.IVS1-4del (c.212-4del) c.IVS5+28del2 (c.942+28del2)	-	c.IVS7+35del4 (c.3646+35del4) c.116G>A (p.Gly39Glu)	-	-
7_2600581E01271	c.IVS1-4del (c.212-4del) c.IVS5+28del2 (c.942+28del2) c.IVS10+12G>A (c.1661+12G>A)	-	c.IVS7+35del4 (c.3646+35del4)	-	-
7_2746633E02054	-	c.IVS15-19T>A (c.1732-19T>A) c.655A>G (p.Ile219Val)	c.IVS2-8C>T (c.458-8C>T) c.186C>A (p.Arg62Arg) c.276A>G (p.Pro92Pro)	-	-
7_2764626E02022	c.IVS1-4del (c.212-4del) c.IVS5+28del2 (c.942+28del2)	-	c.3549A>G (p.Ile1183Met) c.IVS7+35del4 (c.3646+35del4)	-	-
7_444453E01139	c.2647dup (p.Ile883AsnfsX16) c.IVS1+9C>G (c.211+9C>G) c.IVS1-4del (c.212-4del) c.741C>T (p.Gly247Gly) c.IVS5+28del2 (c.942+28del2)	-	-	-	-

Biological significance	Date	Comment
UV	6/06/07	---