The UMD-MSH2 mutations database
Mutation c.2106_2135del

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
2_PLP-HEGP EXT57_15605_15	-	-	-	-	-
41_HNPCC109_HNPCC109001_-	c.2014_2033del (p.Met672TyrfsX20)	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
Co-occurrence	MSH2 : c.2014_2033del, p.Met672TyrfsX20 (HNPCC109-001)	25/06/15	41 (HEGP)	---
Clinical phenotype	Amsterdam II +	10/12/12	41 (HEGP)	---
MMR function in tumor cells	MSH2-	10/12/12	41 (HEGP)	---
Ex vivo analysis	Splicing reporter minigene pCAS: normal splicing	23/03/12	19 (INSERM U1079-Rouen)	---

Biological significance	Date	Comment
Likely Causal	9/07/15	---