The UMD-MSH2 mutations database
Mutation c.454delA

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MSH2	MLH1	MSH6	MUTYH	APC
20_20-47794779-54---	-	-	-	-	-
37_L04.10_2211_22615	-	-	-	-	-
37_L04.10_3131_33787	-	-	-	-	-
37_L04.10_3132_33789	-	-	-	-	-
37_L04.10_3133_33790	-	-	-	-	-
37_L04.10_3135_33796	-	-	-	-	-
37_L08.049_6958_65993	-	-	-	-	-
37_L08.049_9112_79514	-	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
Clinical phenotype	Index case (20-4779-54) : colorectal cancer at the age of 25 and ovarian cancer at the age of 42. Father : colorectal cancer at the age of 43. Nephew : colorectal cancer at the age of 34. Brother : prostatic cancer at the age of 55. Sister : glioma at the age of 35. Great-nephew : glioma at the age of 8	27/08/15	20 (Clermont-Ferrand)	---

Biological significance	Date	Comment
Causal	21/02/14	---