The UMD-MSH2 mutations database
Nucleotides modifications

This function takes into account only small rearrangements.

For each of the four bases are displayed its number in the MSH2 cDNA at each codon's position as well as the corresponding mutability. For each base are also displayed the various substitutions and small deletions and insertions.

	from A			from C			from G			from T
Position in codon	1st	2nd	3rd	1st	2nd	3rd	1st	2nd	3rd	1st	2nd	3rd
Number in sequence	281	334	275	171	186	152	315	125	209	168	290	299
Mutability	843	1002	328	513	558	160	945	365	331	504	848	355
to A	.	.	.	8	10	1	93	78	20	.	16	2
to C	8	8	3	.	.	.	33	21	3	81	107	18
to G	11	49	19	13	25	15	.	.	.	3	26	38
to T	35	3	8	243	44	21	78	13	2	.	.	.
Deletion	236	27	39	30	17	21	142	64	33	4	22	37
Insertion	8	16	12	12	2	8	15	11	2	8	38	3

Mutability: for each base, the significance of a mutation is defined by the ability to produce a new Amino Acid. In these conditions, the position of the specific base in the codon has a major incidence. If any substitution result in a new Amino Acid, its individual mutability is 3. If only two substitutions result in a new Amino Acid, its mutability is 2... The Mutability at a specific position in the codon (first base=1st, second base=2nd and third base=3rd) is defined by the addition of all individual mutability for this base in each codon of the coding sequence.