The UMD-MSH2 mutations database
Record ID: 82

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.IVS13-6C>A (c.2211-6C>A)

wt codonwt aamutant codonmutant aamutational eventmutation type
AGGArgspl-6Spl.C>A

StructureKey Residue (HCD)Pyrimidin doubletCpG
ATPase 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Cryptic Donor?
tatgtgctt
64.9 _
tatgtgatt
73.7 _ *
11.9 %

Patient and sample data


Sample IDPatient status
2_02-DDM2166_15274_15274Relative

Clinical data


Symptom

Reference


Reference IDReference
2Unpublished data