The UMD-MSH2 mutations database
Record ID: 784

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.IVS14-3T>G (c.2459-3T>G)

wt codonwt aamutant codonmutant aamutational eventmutation type
GGTGlyspl-3Spl.T>G

StructureKey Residue (HCD)Pyrimidin doubletCpG
ATPase 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Cryptic Acceptor?
caaatttcttatagG
44.8 _
caaatttcttaGagG
73.8 _ *
39.2 %

Patient and sample data


Sample IDPatient status
19_13168_13168-001_13168-Relative

Clinical data


Symptom

Reference


Reference IDReference
19Unpublished data