The UMD-MSH2 mutations database
Record ID: 61

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.IVS12-42delAGAA (c.2006-42delAGAA)

wt codonwt aamutant codonmutant aamutational eventmutation type
GGCGlyspl-42Spl.delAGAATv

StructureKey Residue (HCD)Pyrimidin doubletCpG
ATP binding 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Cryptic Acceptor?
tagtagcagaaagaa
44.5 _
tagtagcagaagttt
69.9 _ *
36.4 %

Patient and sample data


Sample IDPatient status
2_02-DDM4664_23588_23588Relative

Clinical data


Symptom

Reference


Reference IDReference
2Unpublished data