The UMD-MSH2 mutations database
Record ID: 479

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.IVS7-11delCTT (c.1277-11delCTT)

wt codonwt aamutant codonmutant aamutational eventmutation type
GGAGlyspl-11Spl.delCTTTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
EXO1 stabilization 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Acceptor
actttcttttagGA
84.4 _
atcttttagGAAAA
46.9 _ *
-44.4 %

Patient and sample data


Sample IDPatient status
14_NANTES?_04C065_04C065Relative

Clinical data


Symptom

Reference


Reference IDReference
14Unpublished data