The UMD-MSH2 mutations database
Record ID: 461

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.IVS3+1G>T (c.645+1G>T)

wt codonwt aamutant codonmutant aamutational eventmutation type
CAGGlnspl+1Spl.G>T

StructureKey Residue (HCD)Pyrimidin doubletCpG
Connector 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Donor
CAGgtaagc
97.8 _
CAGttaagc
71 _ *
-27.4 %

Patient and sample data


Sample IDPatient status
8_F1313_7081959_08-290150Relative

Clinical data


Symptom

Reference


Reference IDReference
8Unpublished data