The UMD-MSH2 mutations database
Record ID: 3080

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.IVS6+2T>A (c.1076+2T>A)

wt codonwt aamutant codonmutant aamutational eventmutation type
AGAArgspl+2Spl.T>A

StructureKey Residue (HCD)Pyrimidin doubletCpG
 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Donor
GAGgtatgt
89.4 _
GAGgaatgt
62.6 _ *
-30 %

Patient and sample data


Sample IDPatient status
37_L13.08322814141041Relative

Clinical data


Symptom

Reference


Reference IDReference
37Unpublished data