The UMD-MSH2 mutations database
Record ID: 2715

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.127T>Cp.Tyr43His

wt codonwt aamutant codonmutant aamutational eventmutation type
TATTyrCATHisT->CTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Mismatch binding Yes, coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0.920.00 (pathogenous)59 (Probable polymorphism)

Patient and sample data


Sample IDPatient status
SO_-53483133 (G08182)G081Relative

Clinical data


Symptom

Reference


Reference IDReference
71Unpublished data