The UMD-MSH2 mutations database
Record ID: 2364

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.IVS5+19del11 (c.942+19del11)

wt codonwt aamutant codonmutant aamutational eventmutation type
CAGGlnspl+19Spl.del11

StructureKey Residue (HCD)Pyrimidin doubletCpG
EXO1 stabilization 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Cryptic Donor?
aaaaaaaaa
20.3 _
agggttaaa
74.7 _ *
72.8 %

Patient and sample data


Sample IDPatient status
SO_-2209---G01052Relative

Clinical data


Symptom

Reference


Reference IDReference
71Unpublished data