The UMD-MSH2 mutations database
Record ID: 2242

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.IVS8-5del (c.1387-5del)

wt codonwt aamutant codonmutant aamutational eventmutation type
GTGValspl-5Spl.del

StructureKey Residue (HCD)Pyrimidin doubletCpG
EXO1 stabilization 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Acceptor
ttctgtttgcagGT
95.1 _
ttctgtttgcagGT
95.1 _
0 %

Patient and sample data


Sample IDPatient status
7_1087811419E092158Relative

Clinical data


Symptom

Reference


Reference IDReference
7Unpublished data