The UMD-MSH2 mutations database
Record ID: 1399

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.2227T>Gp.Ser743Ala

wt codonwt aamutant codonmutant aamutational eventmutation type
TCASerGCAAlaT->GTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
ATPase Yes, coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0.990.00 (pathogenous)59 (Probable polymorphism)

Patient and sample data


Sample IDPatient status
41_HNPCC399_HNPCC399001_-Relative

Clinical data


Symptom

Reference


Reference IDReference
41Unpublished data