The UMD-MSH2 mutations database
Tyr to Stop mutations

Protein nomenclature	cDNA Nomenclature	Exon	Codon	Structure	HCD	Rearrangement	Mutation type	Mutational event	# records
p.Tyr66X	c.198C>G	1	66	Mismatch binding		Small rearrangement	Tv	C->G	3
UMD_id Sample ID Gender Mutation status Geographic origin Phenotypic group References 749 19_2543_2543-001_2543-001 - 19 750 19_2543_2543-002_2543-002 - 19 751 19_2543_2543-006_2543-006 - 19
p.Tyr563X	c.1689T>G	11	563	Lever		Small rearrangement	Tv	T->G	8
UMD_id Sample ID Gender Mutation status Geographic origin Phenotypic group References 3244 8_460339647108-413241 - 8 425 8_44620_83689_08-397321EG - 8 426 8_44620_83274_08-397321EG - 8 427 8_F491_17041967_08-819101 - 8 428 8_44620_77930_08-921411EG - 8 2945 4_BCR1103260763594 - 4 3006 8_460338645208-571131EGS - 8 3205 2_02-DDM1054635079213105462 - 2
p.Tyr570X	c.1710T>G	11	570	EXO1 stabilization		Small rearrangement	Tv	T->G	4
UMD_id Sample ID Gender Mutation status Geographic origin Phenotypic group References 429 8_F195_B042539_04-1619 - 8 430 8_F195_B050523_05-0418 - 8 2678 SO_-5069---G07759 - 71 2832 SO_-50693102G09032 - 71
p.Tyr656X	c.1968C>G	12	656	ATPase		Small rearrangement	Tv	C->G	4
UMD_id Sample ID Gender Mutation status Geographic origin Phenotypic group References 747 19_7124_7124-001_7124-001 - 19 748 19_7124_7124-002_7124-002 - 19 1237 37_L11.112_16549_127685 - 37 2948 19_L11.11216549121291 - 19
p.Tyr757X	c.2271C>G	14	757	ATPase		Small rearrangement	Tv	C->G	1
UMD_id Sample ID Gender Mutation status Geographic origin Phenotypic group References 2518 SO_1554---G05092 - 71