The UMD-MLH1 mutations database
Mutation c.IVS6-2A>T (c.546-2A>T)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Acceptor	tttcttttccagGT	97.1 _	tttcttttcctgGT	68.2 _ *	-29.8 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MLH1	MSH2	MSH6	MUTYH	APC
4_CH00158358695423	-	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
MMR function in tumor cells	MSI-H / MLH1-PMS2- (CH00158-35869)	26/08/15	4 (Lyon)	---

Biological significance	Date	Comment
Causal	11/09/15	---