The UMD-MLH1 mutations database
Mutation c.IVS10-1G>C (c.885-1G>C)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Acceptor	ttttcctgacagTT	90.9 _	ttttcctgacacTT	61.9 _ *	-31.9 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	MLH1	MSH2	MSH6	MUTYH	APC
14_CCS NANTES13C129113C1291	-	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
MMR function in tumor cells	MSI (no hypermethylation of MLH1 promoter) / MLH1- (ICO ANGERS-14C0743)	29/05/15	14 (Nantes)	---
MMR function in tumor cells	MSI (no hypermethylation of MLH1 promoter) / MLH1- (father)	29/05/15	14 (Nantes)	---

Biological significance	Date	Comment
Causal	22/06/15	---