The UMD-MLH1 mutations database
Record ID: 475

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation status
c.IVS9+3A>T (c.790+3A>T)

wt codonwt aamutant codonmutant aamutational eventmutation type
CATHisspl+3Spl.A>T

StructureKey Residue (HCD)Pyrimidin doubletCpG
MutL transMLH1 transducer 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Donor
ACCgtaagt
78.4 _
ACCgttagt
70.6 _
-9.9 %

Patient and sample data


Sample IDPatient status
17_F05213_5870_---Relative

Clinical data


Symptom

Reference


Reference IDReference
17Unpublished data