The UMD-MEN1 mutations database
Record ID: 951

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.IVS9-4C>T (c.1351-4C>T)HeterozygousLIKELY NEUTRAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GTGValspl-4Spl.C->TTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Pem,NM,CH 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Acceptor
ccactggcccagGT
84.9 _
ccactggctcagGT
84.2 _
-0.8 %

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-HA02-A14D-ProbandMale68

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
31 10647896
MEN I gene mutations in sporadic adrenal adenomas. Schulte KM1, Heinze M, Mengel M, Simon D, Scheuring S, K*hrer K, R*her HD. Hum Genet. 1999 Dec;105(6):603-10.